Beta-bloqueante

Stability Hygroscopic Applications A deuterated selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),

Applications Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II). References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984),

Applications A labelled metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Rac-Diacetolol is a racemic mixture of two isomers, (+) and (-), of acebutolol. Rac-Diacetolol is used to treat bowel disease, chronic oral inflammation and cardiac arrhythmias. It is also used as an experimental solubility probe in the study of the interactions between drugs and biological membranes. Rac-Diacetolol has been shown to have a low affinity for cytochrome P450 enzymes, which are responsible for metabolizing many drugs in the body. Rac-Diacetolol has been found to reduce plasma concentrations of PCSK9 antibody in patients with inflammatory bowel disease. The drug also has anti-inflammatory properties that may be due to its inhibition of prostaglandin synthesis.

Impurity Carvedilol Impurity A; Carvedilol USP A Applications An impurity from the process of Carvedilol (C184625). Carvedilol impurity A. Carvedilol USP A.

Amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters, salts thereof, nesoi

Applications Diazoxide reduces status epilepticus neuron damage in diabetes. A potassium channel opener References Baba, A., et al.: J. Neurosci., 23, 7737 (2003), Bancila, V., et al.: J. Neurochem., 90, 1243 (2004), Bancila, V., et al.: J. Biol. Chem., 280, 8793 (2005),

Applications Labelled Dopamine. Endogenous catecholamine with α and β-adrenergic activity. Cardiotonic; antihypotensive. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Carter, J.E., et al.: Anal. Profiles Drug Subs., 11, 257 (1982), Dasta, J.F., et al.: Pharmacotherapy, 6, 304 (1986),

Stability Hygroscopic Applications Labelled Mexiletine (M340800). Antiarrhythmic (class IB). References Singh, E.M., et al.: Br. J. Pharmacol., 44, 1 (1972), Scott, K.N., et al.: Drug Metab. Dispos., 1, 506 (1973), Chew, C.Y.C., et al.: Drugs, 17, 161 (1979), Abounassif, M.A., et al.: Anal. Profiles Drug Subs., 20, 433 (1991),

Applications A Labelled metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension. References Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 958 (1998).

Betaxolol (Kerlone) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

Impurity Atenolol EP Impurity C Applications 4-(2,3-Epoxypropoxy)phenylacetamide (Atenolol EP Impurity C) is an impurity of Atenolol, a cardioselective β-adrenergic blocker. References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984)

Impurity Rosuvastatin EP Impurity B Stability Hygroscopic Applications A diastereomer of Rosuvastatin (R700500) used for treatment, prevention and combination therapy of lipid-related disorders. Rosuvastatin EP Impurity B

Applications Bunitrolol is a beta adrenoceptor antagonist that is used as an antihypertensive and antianginal agent. References Narimatsu, S., et al.: Chirality, 11, 1 (1999); Tsuchihashi, H., et al.: Jpn. J. Pharmacol., 45, 349 (1987)