Moduladores GABA
Los moduladores de GABA son compuestos que influyen en la función de los receptores de GABA (ácido gamma-aminobutírico), los principales receptores inhibitorios de neurotransmisores en el sistema nervioso central. Estos moduladores pueden aumentar o inhibir la actividad GABAérgica, afectando la excitabilidad neuronal y la transmisión sináptica. Los moduladores de GABA son cruciales en el tratamiento y estudio de varios trastornos neurológicos y psiquiátricos, incluyendo ansiedad, epilepsia e insomnio. En CymitQuimica, ofrecemos una amplia gama de moduladores de GABA para apoyar su investigación en neurociencia, farmacología y neuroterapéutica.
Productos de "Moduladores GABA"
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Triazolam-d3
CAS:Producto controladoApplications Labelled Triazolam (T767380(M)). Triazolam in an hypnotic drug used in the short term treatment of insomnia. References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).Fórmula:C17H9D3Cl2N4Forma y color:NeatPeso molecular:346.232,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPINE
CAS:Fórmula:C9H12N2Pureza:97%Forma y color:SolidPeso molecular:148.205N-Desmethyl Clobazam-d5
CAS:Producto controladoApplications The major labelled metabolite of Clobazam (C582500). Controlled substance (depressant). References Bardy, A., et al.: Brain Develop., 13, 174 (1991), Patsalos, P., et al.: Epilepsia, 43, 365 (2002), Venisse, N., et al.: J. Anal. Toxicol., 27, 7 (2003),Fórmula:C152H5H6ClN2O2Forma y color:Off-WhitePeso molecular:291.74Nimetazepam (1mg/ml in Methanol)
CAS:Producto controladoFórmula:C16H13N3O3Forma y color:Single SolutionPeso molecular:295.29Pentobarbital Sodium Salt (1.0 mg/mL in Methanol)
CAS:Producto controladoFórmula:C11H17N2O3·NaForma y color:Single SolutionPeso molecular:248.253-Amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS:Pureza:95.0%Peso molecular:251.28900146484375Phenobarbital-d5 (100μg/mL in Methanol)
CAS:Producto controladoFórmula:C122H5H7N2O3Forma y color:Single SolutionPeso molecular:237.27[2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone
CAS:Impurity Clozapine EP Impurity D Applications [2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone (Clozapine EP Impurity D) is used in the synthesis of substituted dibenzodiazepines. Also an impurity in the synthesis of Clozepine (C587500), an antipsychotic. References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)Fórmula:C18H21ClN4OForma y color:Light Red To RedPeso molecular:344.84(S)-Viloxazine Hydrochloride
CAS:Producto controladoApplications The (S)-isomer of Viloxazine (V312440). Antidepressant. References Howe, R., et al.: J. Med. Chem., 19, 1074 (1976), Pinder, R.M., et al.: Drugs, 13, 401 (1977),Fórmula:C13H20ClNO3Forma y color:NeatPeso molecular:273.763-Amino-4-(2-chlorophenyl)-6-nitroquinolin-2(1H)-one
CAS:Fórmula:C15H10ClN3O3Forma y color:NeatPeso molecular:315.71Barbital-d5
CAS:Producto controladoApplications Prototype of the barbiturate hypnotics. This is a controlled substance (depressant). References Michaelis, L., et al.: J. Biol. Chem., 87, 33 (1930),Fórmula:C82H5H7N2O3Forma y color:WhitePeso molecular:189.22Hexobarbital-D3
CAS:Producto controladoApplications Hexobarbital-D3 is a labelled analogue of Hexobarbital (H295350), a barbiturate derivative that exhibits hypnotic and anasthetic effects. References Laroche, M. & Brodie, B.: J. Pharm. Exp. Ther., 130, 134 (1960); Pira, R. & Lieber, L.: J. Nutr., 105, 1544 (1975)Fórmula:C12D3H13N2O3Forma y color:NeatPeso molecular:239.286Isomebumal
CAS:Producto controladoApplications Isomebumal is an impurity of Pentobarbital (P276000), an sedative and hypnotic. References Hoogmartens, J., et al.: J. Chromatograph., 219, 431 (1981); Stuper, A.J., et al.: J. Pharma. Sci., 67, 745 (1978);Fórmula:C11H18N2O3Forma y color:NeatPeso molecular:226.27Clozapine-d8
CAS:Producto controladoApplications An antipsychotic.A representative lot was 92% d8, 8% d7. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)Fórmula:C18H11D8ClN4Forma y color:Light Yellow To YellowPeso molecular:334.87Zolpidem-d6
CAS:Producto controladoApplications Deuterated Zolpidem, a selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant). References Arbilla, S., et al.: Arch. Pharmacol., 330, 248 (1985), Cashman, J.N., et al.: Brit. J. Clin. Pharmacol., 21, 205 (1986)Fórmula:C192H6H15N3OForma y color:NeatPeso molecular:313.437-Chloro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Forma y color:SolidPeso molecular:182.64999389648438Phenobarbital-d5
CAS:Producto controladoApplications This is a controlled substance (depressant). Anticonvulsant; sedative; hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Chao, M.K.C., et al.: Anal. Profiles Drug Subs., 7, 359 (1978),Fórmula:C122H5H7N2O3Forma y color:WhitePeso molecular:237.272-(1-Aminocyclohexyl)acetic Acid
CAS:Producto controladoFórmula:C8H15NO2Forma y color:NeatPeso molecular:157.21Fludiazepam
CAS:Producto controladoApplications Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. References Fang, S.Y., et al.: Drug. Alcohol. Depend., 104, 140 (2009); Esteki, M., et al.: Chem. Biol. Drug. Design., 72, 409 (2008);Fórmula:C16H12ClFN2OForma y color:White To Off-WhitePeso molecular:302.7307(R)-3-amino-9-fluoro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
Pureza:97%Peso molecular:269.27899169921875Mexazolam
CAS:Producto controladoApplications Mexazolam is a benzodiazepine derivative and have been investigated for its therapeutic value in treating anxiety. Mexazolam is known to be metabolized via the CYP3A4 pathway. References Ferreira, L., et al.: Clin. Drug. Investig., 23, 235 (2003); Ishigami, M., et al.: Drug. Metab. Dispos., 30, 904 (2002); Sheridan, R.P., et al.: J. Med. Chem., 50, 3173 (2007);Fórmula:C18H16Cl2N2O2Forma y color:NeatPeso molecular:363.24Alpidem
CAS:Producto controladoApplications A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic. References Min, D., et al.: Pharmacotherapy, 12, 68 (1992), Rothwell, C., et al.: J. Toxicol. Sci., 27, 35 (2002), Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Boelsterli, U., et al.: Curr. Drug Metab., 7, 715 (2006), Rietjens, I., et al.: Chem. Res. Toxicol., 19, 977 (2006),Fórmula:C21H23Cl2N3OForma y color:NeatPeso molecular:404.337-Methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Forma y color:SolidPeso molecular:162.23599243164062Methocarbamol-d3
CAS:Producto controladoApplications Methocarbamol-d3is deuterium labelled methocarbamol (M225950), which is a muscle relaxant (skeletal). References Topliss, J., et al.: J. Med. Chem., 22, 1238 (1979), Walters, W., et al.: Drug Discov. Today., 3, 160 (1998), Baldi, P., et al.: Bioinformatics, 16, 412 (2000), Kouznetsov, V., et al.: J. Arch. Pharm., 337, 127 (2004),Fórmula:C11H12D3NO5Forma y color:NeatPeso molecular:244.267-Acetamido Clonazepam
CAS:Producto controladoApplications Clonazepam (C587080) metabolite. References Huang, W., et al.: J. Anal. Toxicol., 19, 333 (1995), Rittner, M., et al.: J. Anal. Toxicol., 25, 115 (2001),Fórmula:C17H14ClN3O2Forma y color:NeatPeso molecular:327.76Meclonazepam
CAS:Producto controladoApplications Meclonazepam, is a drug of a benzodiazepine class similar in structure to Clonazepam (C587080). It has sedative and anxiolytic properties. It has also shown to have anti-parasitic effects against the parasitic worm Schistosoma mansoni. References O Boyle C., et al.: Euro. J. Clinic. Pharmacol., 29 (1), 105 (1985); Ansseau, M., et al.: Psychopharmacology, 87 (2), 130 (1985);Fórmula:C16H12ClN3O3Forma y color:Off White SolidPeso molecular:329.74Bromazepam (1mg/mL in Methanol)
CAS:Producto controladoFórmula:C14H10BrN3OForma y color:ColourlessPeso molecular:316.155-Allyl-5-methallyl-barbituric Acid
CAS:Producto controladoFórmula:C11H14N2O3Forma y color:NeatPeso molecular:222.247-AMINO-4-BOC-4,5-DIHYDRO-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE
CAS:Pureza:97.0%Peso molecular:277.32400512695311'-Hydroxy Triazolam
CAS:Producto controladoApplications A metabolite of Triazolam (T767380(M)), which is a sedative; a controlled substance (depressant). References Boxenbaum, H., et al.: J. Pharm. Pharm. Sci., 2, 47 (1999), Perloff, M., et al.: J. Pharmacol. Exp. Ther., 292, 618 (2000), Patki, K., et al.: Drug Metab. Dispos., 31, 938 (2003),Fórmula:C17H12Cl2N4OForma y color:Light GreenPeso molecular:359.21Zolpidem Hemitartrate
CAS:Producto controladoFórmula:C19H21N3O·C4H6O6Forma y color:WhitePeso molecular:764.87Cyclobenzaprine-d3 Hydrochloride
CAS:Producto controladoApplications Use as muscle relaxant (skeletal). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Cotton, M.L., et al.: Anal. Profiles Drug Subs., 17, 41 (1988),Fórmula:C202H3H18N·ClHForma y color:White To YellowPeso molecular:314.87Phenobarbital N-Beta-D-Glucoside
CAS:Producto controladoApplications A metabolite of Phenobarbital (P316760). References Soine, W.H., et al.: Drug Metab. Dispos., 12, 792 (1984), Soine, W.H., et al.: J. Pharmac. Sci., 80, 99 (1991),Fórmula:C18H22N2O8Forma y color:NeatPeso molecular:394.38Methohexital (Mixture of Diastereomers)
CAS:Producto controladoApplications Methohexital is a short-acting barbiturate used as a sedative. Methohexital is used an anesthetic for oral surgery and dentistry and is also used to induce anesthesia prior to electroconvulsive therapy (ECT). Methohexital is a Controlled Substance. Analog of secobarbital (S235000). References Avramov, M.N. et al.: Anesth. Analges., 81, 596 (1995); Hamid, S.K. et al.: Br. J. Anaesth., 77, 727 (1996);Fórmula:C14H18N2O3Forma y color:NeatPeso molecular:262.30Butalbital (1.0 mg/mL in Methanol)
CAS:Producto controladoFórmula:C11H16N2O3Forma y color:ColourlessPeso molecular:224.26Nordazepam-d5 (1.0 mg/mL in Methanol)
CAS:Producto controladoFórmula:C152H5H6ClN2OForma y color:Single SolutionPeso molecular:275.74Zopiclone
CAS:Producto controladoStability Hygroscopic Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic. References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),Fórmula:C17H17ClN6O3Forma y color:White To Off-WhitePeso molecular:388.81
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