
Moduladores GABA
Los moduladores de GABA son compuestos que influyen en la función de los receptores de GABA (ácido gamma-aminobutírico), los principales receptores inhibitorios de neurotransmisores en el sistema nervioso central. Estos moduladores pueden aumentar o inhibir la actividad GABAérgica, afectando la excitabilidad neuronal y la transmisión sináptica. Los moduladores de GABA son cruciales en el tratamiento y estudio de varios trastornos neurológicos y psiquiátricos, incluyendo ansiedad, epilepsia e insomnio. En CymitQuimica, ofrecemos una amplia gama de moduladores de GABA para apoyar su investigación en neurociencia, farmacología y neuroterapéutica.
Productos de "Moduladores GABA"
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6-Chloro-1-methyl-4-phenyl-2(1H)-quinazolinone
CAS:Producto controladoImpurity Diazepam EP Impurity E Applications 6-Chloro-1-methyl-4-phenyl-2(1H)-quinazolinone (Diazepam EP Impurity E) is an impurity of Temazepam (T017200), which is a pharmacologically active metabolite. It is used as a sedative and hypnotic drug. References Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972), Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974), Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976), Heel, R.C., et al.: Drugs, 21, 321 (1981)Fórmula:C15H11ClN2OForma y color:Light YellowPeso molecular:270.71Zaleplon
CAS:Producto controladoApplications Selective non-benzodiazepine GABAA receptor agonist. References Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993), Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994), Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999), Elie, R., et al.: J. Clin. Psychiatry, 60, 536 (1999), Heydorn, W.E., et al.: Expert Opin. Invest. Drugs, 9, 841 (2000)Fórmula:C17H15N5OForma y color:Off-WhitePeso molecular:305.33Pentanoic Acid (Valeric Acid)
CAS:Producto controladoFórmula:C5H10O2Forma y color:NeatPeso molecular:102.13Flunitrazepam
CAS:Producto controladoApplications Flunitrazepam is used as an hypnotic. This is a controlled substance (depressant). References Sternbach, L.H., et al.: J. Med. Chem., 6, 261 (1963), Eidelberg, E., et al.: Neurology, 5, 223 (1965), Caplan, Y., et al.: J. Anal. Toxicol., 25, 396 (2001), Wood, M., et al.: Forensic Sci. Int., 150, 227 (2005),Fórmula:C16H12FN3O3Forma y color:Off-WhitePeso molecular:313.28(5RS)-5-Ethyl-2-imino-5-phenyldihydropyrimidine-4,6(1H,3H)-dione (2-Amino-5-ethyl-5-phenyl-4,6(1H,5H)-pyrimidinedione)
CAS:Producto controladoFórmula:C12H13N3O2Forma y color:NeatPeso molecular:231.255-Phenyl-5-ethyl-2-thiobarbituric Acid
CAS:Producto controladoFórmula:C12H12N2O2SForma y color:NeatPeso molecular:248.3Phenobarbital (1.0mg/mL in Methanol)
CAS:Producto controladoFórmula:C12H12N2O3Forma y color:Single SolutionPeso molecular:232.24Chlordiazepoxide-d5 (100ug/ml in Methanol)
CAS:Producto controladoFórmula:C162H5H9ClN3OForma y color:Single SolutionPeso molecular:304.792-Aminomethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine
CAS:Producto controladoApplications An Intermediate for the synthesis of Midazolam. References Walser, A., J. Org. Chem., 43, 936 (1978).Fórmula:C16H15ClFN3Forma y color:NeatPeso molecular:303.76Alprazolam-d3
CAS:Producto controladoApplications Controlled substance (depressant). Anxiolytic. References Sethy, V.H., et al.: Arch. Pharmacol., 301, 157 (1978), Fawcett, J.A., et al.: Pharmacotherapy, 2, 242 (1982),Fórmula:C17H10ClD3N4Forma y color:NeatPeso molecular:311.807-Amino Nitrazepam
CAS:Producto controladoApplications A metabolite of Nitrazepam (N490140). References Randall, L.O., et al.: Biochem. Pharmacol., 8, 15 (1961),Fórmula:C15H13N3OForma y color:Light YellowPeso molecular:251.284-Boc-9-Methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:262.35299682617197-Fluoro-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Fórmula:C10H9FN2O2Pureza:97%Forma y color:SolidPeso molecular:208.18917-Amino Nitrazepam-d5
CAS:Producto controladoApplications A labelled metabolite of Nitrazepam (N490140(M)), which is an anticonvulsant; hypnotic.Controlled substance (depressant). References Randall, L.O., et al.: Biochem. Pharmacol., 8, 15 (1961), Rieder, et al.: Arzneim.-Forsch., 23, 212 (1973), Kangas, L., Acta Pharmacol. Toxicol., 45, 16 (1979), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 9, 487 (1980)Fórmula:C15H8D5N3OForma y color:Light Yellow SolidPeso molecular:256.31(2RS)-2-Ethyl-2-methylbutanedioic Acid
CAS:Producto controladoFórmula:C7H12O4Forma y color:NeatPeso molecular:160.168Gabapentin-lactam 100 µg/mL in Acetonitrile
CAS:Fórmula:C9H15NOForma y color:Single SolutionPeso molecular:153.222,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPIN-8-YLAMINE 2HCL
CAS:Pureza:97.0%Peso molecular:236.139999389648447-Amino-4-Boc-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:263.34100341796875Zolpidem
CAS:Producto controladoApplications A selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant). References Arbilla, S., et al.: Arch. Pharmacol., 330, 248 (1985), Cashman, J.N., et al.: Brit. J. Clin. Pharmacol., 21, 205 (1986)Fórmula:C19H21N3OForma y color:Off-WhitePeso molecular:307.391H-1,4-Benzodiazepine, 2,3,4,5-tetrahydro-
CAS:Fórmula:C9H12N2Pureza:95%Forma y color:SolidPeso molecular:148.2050Clozapine, 97%
CAS:Potent, selective muscarinic antagonist This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H19Cl4Pureza:97%Peso molecular:326.8310H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-
CAS:Fórmula:C17H20N4SPureza:%Forma y color:SolidPeso molecular:312.4325Lamotrigine EP Impurity C
CAS:Producto controladoFórmula:C9H7Cl2N5Forma y color:NeatPeso molecular:256.09N-Hydroxy Amobarbital
CAS:Producto controladoFórmula:C11H18N2O4Forma y color:NeatPeso molecular:242.272Flumazenil
CAS:Producto controladoApplications Flumazenil is an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist. References Hunkeler, W., et al.: Nature, 290, 514 (1981), Pole, P., et al.: Arch. Pharmacol., 316, 317 (1981), Timm, U., et al.: Arzneim.-Forsch., 33, 358 (1983),Fórmula:C15H14FN3O3Forma y color:Off WhitePeso molecular:303.29Butobarbital
CAS:Producto controladoApplications Butobarbital is a barbiturate derivative that is used as a hypnotic agent with sedative and anticonvulsant properties. Butobarbital is a Controlled Substance. References Sitsen, J.M.A. et al.: Pharmac. Week., 109, 1 (1974); Adams, R.G.: Psychopharmacologia, 40, 185 (1974);Fórmula:C10H16N2O3Forma y color:White SolidPeso molecular:212.255-Ethylbarbituric Acid
CAS:Producto controladoApplications 5-Ethylbarbituric Acid is an non-nucleoside inhibitors of HIV-1 reverse transcriptase. References Mitchell, M. L., et al.: Bioorg. Med. Chem. Lett., 20, 1589 (2010); Al-Turkistani, A., et al.: Molecules., 16, 4764 (2011);Fórmula:C6H8N2O3Forma y color:NeatPeso molecular:156.144-Boc-9-Chloro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:282.76998901367191,2,4,5-Tetrahydro-benzo[e][1,4]diazepin-3-one
CAS:Pureza:97.0%Forma y color:SolidPeso molecular:162.19200134277344Benzamide, N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methyl-
CAS:Fórmula:C27H21ClFN3O2Pureza:99%Forma y color:SolidPeso molecular:473.92594-Boc-7-Methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:262.35299682617192H-1,4-Benzodiazepin-2-one, 3-amino-1,3-dihydro-5-phenyl-, (3S)-
CAS:Pureza:98%Peso molecular:251.2894,6(1H,5H)-Pyrimidinedione, dihydro-2-thioxo-
CAS:Fórmula:C4H4N2O2SPureza:97%Forma y color:SolidPeso molecular:144.1518Ref: IN-DA001PPK
Producto descatalogadoMidazolam-D4 Maleate 0.1 mg/ml in Methanol (as free base)
CAS:Producto controladoFórmula:C182H4H9ClFN3·C4H4O4Lormetazepam-13C,d3
CAS:Producto controladoApplications A labelled analog of Lorazepam (L469850). Sedative, hypnotic.Controlled substance (depressant). References Nudelman, A., et al.: J. Pharma. Sci., 63, 1886 (1974), Humpel, M., et al.: Eur. J. Drug Metab. Pharmacokinet., 4, 237 (1979), Girkin, R., et al.: Xenobiotica, 10, 401 (1980),Fórmula:CC15D3H9Cl2N2O2Forma y color:NeatPeso molecular:339.204-Methylimidazole
CAS:Applications 4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results from the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969): Cunha, S.C. et al.: J. Food Comp. Anal., 24, 609 (2011); Chan, P.C. et al.: Arch. Toxicol., 82, 55 (2008);Fórmula:C4H6N2Forma y color:Light YellowPeso molecular:82.109-Methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:162.23599243164062Lorazepam
CAS:Producto controladoImpurity Lorazepam USP Related Compound A Stability hygroscopic Applications Lorazepam is an anxiolytic compound that potentiates GABAergic synaptic transmission by binding at the benzodiazepine site on the GABAA receptor.1,2 This product is intended for forensic and research applications. Lorazepam acts as ananticonvulsant. Lorazepam USP Related Compound A.Controlled substance (depressant). References Rutgers, G., et al.: Anal. Profiles Drug Subs., 9, 397 (1980), Korkmaz, S., et al.: Eur. Neuropsychopharmacol., 8, 175 (1998), D’Onofrio, G., et al.: N. Engl. J. Med., 340, 915 (1999),Fórmula:C15H10Cl2N2O2Forma y color:NeatPeso molecular:321.16Pentobarbital Sodium Salt (>90%)
CAS:Producto controladoFórmula:C11H17N2O3·NaPureza:>90%Forma y color:WhitePeso molecular:248.25Temazepam (100μg/ml in Methanol)
CAS:Producto controladoFórmula:C16H13ClN2O2Forma y color:ColourlessPeso molecular:300.744-Hydroxy Midazolam (1.0 mg/mL in methanol)
CAS:Producto controladoFórmula:C18H13ClFN3OForma y color:Single SolutionPeso molecular:341.77Temazepam
CAS:Producto controladoApplications Temazepam is a pharmacologically active metabolite of Diazepam. It is used as a sedative and hypnotic drug. References Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972), Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974), Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976), Heel, R.C., et al.: Drugs, 21, 321 (1981),Fórmula:C16H13ClN2O2Forma y color:Light YellowPeso molecular:300.744(3H)-Pyrimidinone, 6-hydroxy-2-(propylthio)-
CAS:Fórmula:C7H10N2O2SPureza:97%Forma y color:SolidPeso molecular:186.23157,8-Dimethoxy-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:208.26100158691406Chlordiazepoxide
CAS:Producto controladoApplications Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics. References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978);Fórmula:C16H14ClN3OForma y color:Light YellowPeso molecular:299.75Midazolam-D4.maleate, 0.1mg/ml in Methanol (as free base)
CAS:Producto controladoFórmula:C182H4H9ClFN3·C4H4O4Amino(diphenyl)acetic Acid (2,2-Diphenylglycine)
CAS:Producto controladoFórmula:C14H13NO2Forma y color:NeatPeso molecular:227.26Eszopiclone-d8
CAS:Producto controladoApplications Eszopiclone is the active stereoizomer of Zopiclone and belongs to the class of drug known as cyclopyrrones. It is a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.This is a controlled substance (depressant) in the US but not in Canada. References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),Fórmula:C17H9D8ClN6O3Forma y color:NeatPeso molecular:396.86Oxcarbazepine EP Impurity C (Oxcarbazepine USP Related Compound E)
CAS:Producto controladoFórmula:C14H11NOForma y color:NeatPeso molecular:209.24Zopiclone-d8
CAS:Producto controladoApplications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic. References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),Fórmula:C17H9D8ClN6O3Forma y color:Off-WhitePeso molecular:396.86Dimethyl Phenobarbital-d6
CAS:Producto controladoFórmula:C14H10D6N2O3Forma y color:NeatPeso molecular:266.337-Acetamido Nitrazepam 1.0 mg/mL in Methanol
CAS:Producto controladoFórmula:C17H15N3O2Forma y color:Single SolutionPeso molecular:293.325-Phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:236.2740020751953Etizolam (1.0 mg/mL in Methanol)
CAS:Producto controladoFórmula:C17H15ClN4SForma y color:ColourlessPeso molecular:342.855H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-
CAS:Fórmula:C18H15ClN2O4Pureza:98%Forma y color:SolidPeso molecular:358.77575-Ethyl-5-(1-ethylpropyl)-2-thiobarbituric Acid
CAS:Producto controladoFórmula:C11H18N2O2SForma y color:WhitePeso molecular:242.341',4-Dihydroxy Midazolam
CAS:Producto controladoApplications A metabolite of Midazolam (M343000). References Soucek, P., et al.: Xenobiotica, 22, 83 (1992), Ghosal, A., et al.: Drug Metab. Dispos., 24, 940 (1996), Kobayashi, K., et al.: Biochem. Pharmacol., 63, 889 (2002),Fórmula:C18H13ClFN3O2Forma y color:NeatPeso molecular:357.77Lamotrigine 100 µg/mL in Acetonitrile
CAS:Fórmula:C9H7Cl2N5Forma y color:Single SolutionPeso molecular:256.094-Boc-8-Chloro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:282.76998901367197-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione
CAS:Producto controladoApplications 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione (cas# 4547-02-8) is a positive allosteric modulator for the muscarinic M1 receptor, which could be a potential treament for the Alzheimer's disease or Schizophrenia. References Flohr, A., et al.: Bioorg. Med. Chem. Lett., 27, 5415 (2017)Fórmula:C15H11ClN2SForma y color:BeigePeso molecular:286.77922,3:4,5-Bis-O-(propan-2,2-diyl)-β-D-fructopyranose 1-[N-(diethylcarbamoyl)sulfamate]
CAS:Forma y color:NeatPhenytoin EP Impurity B (Diphenylethanedione)
CAS:Producto controladoFórmula:C14H10O2Forma y color:NeatPeso molecular:210.23(2RS)-2-Ethylpentanoic Acid
CAS:Producto controladoFórmula:C7H14O2Forma y color:NeatPeso molecular:130.18Pirenzepine dihydrochloride
CAS:Fórmula:C19H23Cl2N5O2Pureza:%Forma y color:SolidPeso molecular:424.32422-[[(2-Amino-5-nitrophenyl)(2-chlorophenyl)methylene]amino]acetic Acid Ethyl Ester
Fórmula:C17H16ClN3O4Forma y color:NeatBuspirone EP Impurity J
CAS:Producto controladoApplications Buspirone EP Impurity J is a derivative compound of Buspirone Hydrochloride (B689850), a non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist. References Wu, Y. H., et al.: J. Med. Chem., 15, 477 (1972), Allen, L. E., et al.: Arzneim.-Forsch., 24, 917 (1974), Goa, K. L., et al.: Drugs, 32, 114 (1986),Fórmula:C34H52N6O5Forma y color:NeatPeso molecular:624.81Brallobarbital
CAS:Producto controladoApplications Brallobarbital is a barbiturate derivative and the brominated analogue of Allobarbital (A544500). Brallobarbital has sedative and hypnotic properties and was used for the treatment of insomnia.Brallobarbital is a Controlled Substance. References Maurer, H.H.: J. Chrom Biomed. Appl., 530, 307 (1990); Wollheim, F.: Acta Pharmacol. Toxicol., 15, 1 (1958); Hermans, R.B. et al.: Pharmac. Week., 102, 1123 (1967):Fórmula:C10H11BrN2O3Forma y color:NeatPeso molecular:287.114-Acetoxy Midazolam
CAS:Producto controladoApplications A metabolite of Midazolam (M343000).Fórmula:C20H15ClFN3O2Forma y color:NeatPeso molecular:383.809-amino-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-5-one
CAS:Pureza:95.0%Peso molecular:177.207000732421882-Ethyl-2-phenalacetylguanidine Sulphate
CAS:Producto controladoFórmula:C11H15N3O·H2O4SForma y color:NeatPeso molecular:508.598-Chloro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Pureza:97.0%Forma y color:SolidPeso molecular:210.6199951171875