Moduladores GABA
Los moduladores de GABA son compuestos que influyen en la función de los receptores de GABA (ácido gamma-aminobutírico), los principales receptores inhibitorios de neurotransmisores en el sistema nervioso central. Estos moduladores pueden aumentar o inhibir la actividad GABAérgica, afectando la excitabilidad neuronal y la transmisión sináptica. Los moduladores de GABA son cruciales en el tratamiento y estudio de varios trastornos neurológicos y psiquiátricos, incluyendo ansiedad, epilepsia e insomnio. En CymitQuimica, ofrecemos una amplia gama de moduladores de GABA para apoyar su investigación en neurociencia, farmacología y neuroterapéutica.
Productos de "Moduladores GABA"
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3-Hydroxy Prazepam
CAS:Producto controladoApplications 3-Hydroxy-prazepam is a metabolite of Prazepam (P702250), a benzodiazepine commonly prescribed to treat anxiety. References Kingstone, E.,et al.: Curr. Ther. Res. Clin. E., 8, 159 (1966); Lemoine, P., et al.: Pharmacopsychiatry, No vol. given, No pp. given, (1991);Fórmula:C19H17ClN2O2Forma y color:NeatPeso molecular:340.808-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one
CAS:Pureza:97.0%Peso molecular:241.087997436523447-Hydroxy-furo[3,4-b]pyrazin-5-one, 70%
CAS:Producto controladoApplications 7-Hydroxy-furo[3,4-b]pyrazin-5-one is a derivative of 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one (C379925) which is an impurity of Eszopiclone (E889150), a nonbenzodiazepine hypnotic agent used as a treatment for insomnia. References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),Fórmula:C6H4N2O3Pureza:70%Forma y color:NeatPeso molecular:152.11Eszopiclone
CAS:Producto controladoApplications Eszopiclone is the active stereoizomer of Zopiclone and belongs to the class of drug known as cyclopyrrones. It is a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.This is a controlled substance (depressant) in the US but not in Canada. References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),Fórmula:C17H17ClN6O3Forma y color:Off WhitePeso molecular:388.812,2-Dipropylpentanoic Acid
CAS:Producto controladoFórmula:C11H22O2Forma y color:NeatPeso molecular:186.29Pridinol Methanesulfonate Salt
CAS:Producto controladoApplications Used as an antiparkinsonian agent and as an anticholinergic. References Duperray, B., et al.: Eur. J. Drug Metab. Pharmacokinet., 2, 121 (1977),Fórmula:C20H25NO·CH4O3SForma y color:White To Off-WhitePeso molecular:391.521’-Hydroxy Midazolam (100 ug/mL in methanol)
CAS:Producto controladoFórmula:C18H13ClFN3OForma y color:Single SolutionPeso molecular:341.77Talbutal-d5
CAS:Producto controladoApplications A labelled stuctural isomer of Butalbital (B690100). A short to intermediate-acting barbiturate that act as nonselective depressants of the central nervous system (CNS). Sedative, hypnotic. Controlled Substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Nielsen, C.J. et al.: Pharmacol., 26, 371 (1925); Lien, E.J. et al.: Acta Pharmac. Jug., 34, 123 (1984);Fórmula:C11H11D5N2O3Forma y color:NeatPeso molecular:229.294-Hydroxy Triazolam
CAS:Producto controladoStability Light Sensitive Applications A metabolite of Triazolam (T767380). References Gall, M., et al.: J. Med. Chem., 21, 1290 (1978), Jones, H., et al.: Drug Metab. Dispos., 32, 973 (2004), Hallifax, D., et al.: Drug Metab. Dispos., 33, 1852 (2005).Fórmula:C17H12Cl2N4OForma y color:NeatPeso molecular:359.21Barbituric Acid-13C,15N2
CAS:Producto controladoApplications Parent compound of barbiturate drugs. References Luo, Y., et al.: J. Med. Chem., 53, 3846 (2010), Tomasic, T., et al.: Eur. J. Med. Chem., 45, 1667 (2010), Gilbert, A., et al.: Bioorg. Med. Chem. Lett., 20, 636 (2010),Fórmula:C313CH415N2O3Forma y color:NeatPeso molecular:131.075H-Dibenzo[b,f]azepine (Iminostilbene)
CAS:Producto controladoFórmula:C14H11NForma y color:NeatPeso molecular:193.24Desmethyldiazepam-D5 (Nordazepam-D5), 1mg/ml in Methanol
CAS:Producto controladoFórmula:C152H5H6ClN2OMethylbarbital
CAS:Producto controladoApplications Methylbarbital is a barbituate which displays anticonvulsant/antiepileptic activity. References Lien, E. et al.: J. Pharm. Sci.., 68, 463 (1979); Kesselheim, A. et al.: Drugs, 70, 605 (2010);Fórmula:C9H14N2O3Forma y color:WhitePeso molecular:198.221-Methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Pureza:98%Peso molecular:250.30099487304688Pentobarbital
CAS:Producto controladoApplications Pentobarbital is a narcotic and sedative barbiturate drug formerly used to relieve insomnia. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972), Woster, P.S., et al.: Clin. Pharm., 9, 762 (1990), Evans, A.T., et al.: J. Am. Vet. Med. Assoc., 203, 664 (1993),Fórmula:C11H18N2O3Forma y color:NeatPeso molecular:226.27Allobarbital-d10
CAS:Producto controladoApplications Labelled Allobarbital, a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance. References Tateoka, Y. et al.: Yakug. Zas., 106, 504 (1986); Crawford, J.M. et al.: Neuropharmacology, 9, 31 (1970); Rice, J.M. et al.: Carcinogenesis, 15, 395 (1994);Fórmula:C10D10H2N2O3Forma y color:White To Off-WhitePeso molecular:218.275Clozapine N-Oxide
CAS:Producto controladoImpurity CLOZAPINE N-OXIDE IMPURITY Applications Clozapine N-Oxide is a 5-HT2 antagonist. It is a major metabolite of clozapine (C587500) that can be monitored by HPLC. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Baldessarini, E., et al.: Neuropsychopharmacol., 9, 117 (1993); Lin, G., et al.: J. Pharm. Sci, 83, 1412 (1994); Roth, B.L., et al.: J. Pharmacol. Exp. Ther., 268, 1403 (1994)Fórmula:C18H19ClN4OForma y color:Light Yellow To YellowPeso molecular:342.82Valproic Acid EP Impurity E
CAS:Producto controladoFórmula:C5H11NOForma y color:NeatPeso molecular:101.15Clorazepic Acid Ethyl Ester
CAS:Producto controladoApplications Clorazepic Acid Ethyl Ester is an ethyl ester of Clorazepic Acid (C587365, Dipotassium Salt) which is an anxiolytic. References Cone, E., et al.: J. Pharm. Sci., 73, 243 (1984), Maurer, H., et al.: J. Anal. Toxicol., 25, 237 (2001), Beyer, J., et al.: Ther. Drug Monit., 27, 151 (2005)Fórmula:C18H15ClN2O3Forma y color:White To Light YellowPeso molecular:342.78Flubromazepam (7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one)
CAS:Producto controladoFórmula:C15H10BrFN2O
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