Sistema complementario
El sistema complementario es una parte crucial de la respuesta inmune, compuesto por una serie de pequeñas proteínas que mejoran la capacidad de los anticuerpos y las células fagocíticas para eliminar patógenos de un organismo. Estas proteínas trabajan juntas para opsonizar patógenos, inducir respuestas inflamatorias y lisar directamente las membranas de los patógenos, desempeñando un papel vital en la inmunidad innata y la función inmunitaria general. En CymitQuimica, ofrecemos proteínas del sistema del complemento de alta calidad para apoyar sus estudios inmunológicos e investigaciones clínicas.
Productos de "Sistema complementario"
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C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated
C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated is expressed in E. coli with N-MBP, C-6xHis-Avi. The accession number is P30993.Forma y color:Lyophilized PowderPeso molecular:52.8 kDa (Predicted)W-54011
CAS:W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).Fórmula:C30H37ClN2O2Pureza:95.62%Forma y color:SolidPeso molecular:493.08Ref: TM-T17250
1mg85,00€5mg127,00€10mg187,00€25mg335,00€50mg518,00€100mg747,00€1mL*10mM (DMSO)165,00€C1s-IN-1 trihydrochloride
CAS:C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC50 of 85 μM and prevents activation of the classical pathway, with an IC50 of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM.Fórmula:C16H22Cl3N5Forma y color:SolidPeso molecular:390.74C5aR2 agonist P32 acetate
C5aR2 agonist P32 acetate (Ac-RHYPYWR-OH), a selective agonist for C5aR2, has been shown to induce various immunomodulatory activities both in vitro and in vivo. It modulates cell signaling via the downregulation of C5aR1-mediated pathways and can also function independently of C5aR1.Fórmula:C54H70N16O11·xC2H4O2Forma y color:SolidPeso molecular:1119.23 (free base)Leukadherin-1
CAS:Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.Fórmula:C22H15NO4S2Pureza:98% - 98.49%Forma y color:SolidPeso molecular:421.49Iptacopan hydrochloride
CAS:Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.Fórmula:C25H31ClN2O4Pureza:98.32% - 99.87%Forma y color:SolidPeso molecular:458.98Ref: TM-T9189
1mg59,00€5mg127,00€10mg205,00€25mg371,00€50mg620,00€100mg1.026,00€200mg1.388,00€1mL*10mM (DMSO)128,00€C3a (70-77)
CAS:C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.Fórmula:C35H61N13O10Pureza:98%Forma y color:SolidPeso molecular:823.94Danicopan
CAS:Danicopan (ACH-4471), an oral factor D inhibitor, binds strongly (Kd 0.54 nM) and may treat PNH and aHUS.Fórmula:C26H23BrFN7O3Pureza:99.94%Forma y color:SolidPeso molecular:580.41Ref: TM-T8509
1mg96,00€2mg136,00€5mg215,00€10mg328,00€25mg557,00€50mg797,00€100mg1.103,00€1mL*10mM (DMSO)274,00€MASP2 Protein, Human, Recombinant (His)
The pathogenesis of severe acute respiratory disease syndrome (SARS) is not fully understood.Forma y color:Lyophilized PowderPeso molecular:46.9 kDa (predicted). Due to autocatalytic cleavage, the protein migrates to 18 kDa&25-30 kDa based on Tris-Bis PAGE result.C1QL1 Protein, Mouse, Recombinant (His)
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.Forma y color:Lyophilized PowderPeso molecular:26.9 kDa (predicted)(Rel)-Factor B-IN-5
CAS:(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.Fórmula:C27H32N2O4Pureza:98.53%Forma y color:SolidPeso molecular:448.55Complement C3 Protein, Mouse, Recombinant (His)
Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:36.34 kDa (predicted); 32.39 kDa (reducing conditions)Greziprubart
Greziprubart is a humanized IgG1κ monoclonal antibody that targets C5a, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Forma y color:Odour LiquidCR1 Protein, Human, Recombinant
CR1 Protein, Human, Recombinant is expressed in E. coli with Tag Free. The accession number is P17927.Forma y color:Lyophilized PowderPeso molecular:21.6 kDa (Predicted)Complement factor B Protein, Mouse, Recombinant (His)
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb.Forma y color:Lyophilized PowderPeso molecular:87.0 kDa (predicted)Cyclosporin A
CAS:Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.Fórmula:C62H111N11O12Pureza:99.00% - 99.85%Forma y color:White PowderPeso molecular:1202.61C1q Protein (human)
C1qProtein (human) serves as a subunit in the complement system. It binds to a variety of ligands from self, non-self, and altered-self, contributing to the balance of the immune system, promoting tissue repair, and defending against pathogens.Fórmula:C19H24N4O3SForma y color:SolidPeso molecular:388.48Complement Factor D/CFD Protein, Human, Recombinant (hFc)
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages.Forma y color:Lyophilized PowderPeso molecular:51.2 kDa (predicted). Due to glycosylation, the protein migrates to 52-60 kDa based on Tris-Bis PAGE result.C1QB Protein, Human, Recombinant (His)
Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system.Forma y color:Lyophilized PowderPeso molecular:25.2 kDa (predicted); 30 kDa (reducing condition, due to glycosylation)Complement C5 Protein, Cynomolgus, Recombinant (His)
Complement C5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:188.1 kDa (predicted); 106.3 and 75.8 kDa (reducing conditions)
