Sistema complementario
El sistema complementario es una parte crucial de la respuesta inmune, compuesto por una serie de pequeñas proteínas que mejoran la capacidad de los anticuerpos y las células fagocíticas para eliminar patógenos de un organismo. Estas proteínas trabajan juntas para opsonizar patógenos, inducir respuestas inflamatorias y lisar directamente las membranas de los patógenos, desempeñando un papel vital en la inmunidad innata y la función inmunitaria general. En CymitQuimica, ofrecemos proteínas del sistema del complemento de alta calidad para apoyar sus estudios inmunológicos e investigaciones clínicas.
Productos de "Sistema complementario"
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C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated
C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated is expressed in E. coli with N-MBP, C-6xHis-Avi. The accession number is P30993.Forma y color:Lyophilized PowderPeso molecular:52.8 kDa (Predicted)W-54011
CAS:W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).Fórmula:C30H37ClN2O2Pureza:95.62%Forma y color:SolidPeso molecular:493.08Ref: TM-T17250
1mg85,00€5mg127,00€10mg187,00€25mg335,00€50mg518,00€100mg747,00€1mL*10mM (DMSO)165,00€C1s-IN-1 trihydrochloride
CAS:C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC50 of 85 μM and prevents activation of the classical pathway, with an IC50 of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM.Fórmula:C16H22Cl3N5Forma y color:SolidPeso molecular:390.74C5aR2 agonist P32 acetate
C5aR2 agonist P32 acetate (Ac-RHYPYWR-OH), a selective agonist for C5aR2, has been shown to induce various immunomodulatory activities both in vitro and in vivo. It modulates cell signaling via the downregulation of C5aR1-mediated pathways and can also function independently of C5aR1.Fórmula:C54H70N16O11·xC2H4O2Forma y color:SolidPeso molecular:1119.23 (free base)Leukadherin-1
CAS:Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.Fórmula:C22H15NO4S2Pureza:98% - 98.49%Forma y color:SolidPeso molecular:421.49Iptacopan hydrochloride
CAS:Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.Fórmula:C25H31ClN2O4Pureza:98.32% - 99.87%Forma y color:SolidPeso molecular:458.98Ref: TM-T9189
1mg59,00€5mg127,00€10mg205,00€25mg371,00€50mg620,00€100mg1.026,00€200mg1.388,00€1mL*10mM (DMSO)128,00€C3a (70-77)
CAS:C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.Fórmula:C35H61N13O10Pureza:98%Forma y color:SolidPeso molecular:823.94Danicopan
CAS:Danicopan (ACH-4471), an oral factor D inhibitor, binds strongly (Kd 0.54 nM) and may treat PNH and aHUS.Fórmula:C26H23BrFN7O3Pureza:99.94%Forma y color:SolidPeso molecular:580.41Ref: TM-T8509
1mg96,00€2mg136,00€5mg215,00€10mg328,00€25mg557,00€50mg797,00€100mg1.103,00€1mL*10mM (DMSO)274,00€MASP2 Protein, Human, Recombinant (His)
The pathogenesis of severe acute respiratory disease syndrome (SARS) is not fully understood.Forma y color:Lyophilized PowderPeso molecular:46.9 kDa (predicted). Due to autocatalytic cleavage, the protein migrates to 18 kDa&25-30 kDa based on Tris-Bis PAGE result.C1QL1 Protein, Mouse, Recombinant (His)
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.Forma y color:Lyophilized PowderPeso molecular:26.9 kDa (predicted)(Rel)-Factor B-IN-5
CAS:(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.Fórmula:C27H32N2O4Pureza:98.53%Forma y color:SolidPeso molecular:448.55Complement C3 Protein, Mouse, Recombinant (His)
Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:36.34 kDa (predicted); 32.39 kDa (reducing conditions)Greziprubart
Greziprubart is a humanized IgG1κ monoclonal antibody that targets C5a, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Forma y color:Odour LiquidCR1 Protein, Human, Recombinant
CR1 Protein, Human, Recombinant is expressed in E. coli with Tag Free. The accession number is P17927.Forma y color:Lyophilized PowderPeso molecular:21.6 kDa (Predicted)Complement factor B Protein, Mouse, Recombinant (His)
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb.Forma y color:Lyophilized PowderPeso molecular:87.0 kDa (predicted)Cyclosporin A
CAS:Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.Fórmula:C62H111N11O12Pureza:99.00% - 99.85%Forma y color:White PowderPeso molecular:1202.61C1q Protein (human)
C1qProtein (human) serves as a subunit in the complement system. It binds to a variety of ligands from self, non-self, and altered-self, contributing to the balance of the immune system, promoting tissue repair, and defending against pathogens.Fórmula:C19H24N4O3SForma y color:SolidPeso molecular:388.48Complement Factor D/CFD Protein, Human, Recombinant (hFc)
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages.Forma y color:Lyophilized PowderPeso molecular:51.2 kDa (predicted). Due to glycosylation, the protein migrates to 52-60 kDa based on Tris-Bis PAGE result.C1QB Protein, Human, Recombinant (His)
Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system.Forma y color:Lyophilized PowderPeso molecular:25.2 kDa (predicted); 30 kDa (reducing condition, due to glycosylation)Complement C5 Protein, Cynomolgus, Recombinant (His)
Complement C5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:188.1 kDa (predicted); 106.3 and 75.8 kDa (reducing conditions)Complement factor D Protein, Rat, Recombinant (His)
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternateForma y color:Lyophilized PowderPeso molecular:27.8 kDa (predicted)Complement C4-B Protein, Mouse, Recombinant (His)
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway.Forma y color:Lyophilized PowderPeso molecular:39.0 kDa (predicted)Complement C7 Protein, Human, Recombinant (His)
Complement C7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:92.6 kDa (predicted); 92-98 kDa (reducing conditions)C1q Protein (Mouse)
C1qProtein (Mouse) is a subunit of the complement system. It recognizes a variety of ligands and plays roles in maintaining immune system balance, promoting tissue repair, and defending against pathogens.Forma y color:Odour SolidCFI Protein, Mouse, Recombinant (His)
CFI Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:66.75 kDa (predicted); 126.1 kDa, 59.3 kDa and 46.7 kDa (reducing conditions)C1SB Protein, Mouse, Recombinant (His & Myc)
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.Forma y color:Lyophilized PowderPeso molecular:82.4 kDa (predicted)NDT 9513727
CAS:NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.Fórmula:C36H35N3O4Pureza:99.21%Forma y color:SolidPeso molecular:573.68C1QBP Protein, Human, Recombinant (His)
C1QBP Protein, Human, Recombinant (His) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:24.8 kDa (predicted); 36 kDa (reducing conditions)Complement C5 Protein, Rat, Recombinant (His & Myc)
Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:14.0 kDa (predicted)C5AR1 Protein, Human, Recombinant (Cell-Free, His)
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.Pureza:90%Forma y color:Lyophilized PowderPeso molecular:40.7 kDa (predicted)EG01377 2HCl
CAS:EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377Fórmula:C26H32Cl2N6O6S2Pureza:99.56%Forma y color:SoildPeso molecular:659.6Ref: TM-T11154L
1mg145,00€5mg354,00€10mg540,00€25mg869,00€50mg1.188,00€100mg1.596,00€500mg3.202,00€1mL*10mM (DMSO)512,00€CP-289
CAS:CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.Fórmula:C30H35ClN2O2Pureza:99.85%Forma y color:SoildPeso molecular:491.06Ref: TM-T60161
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€1mL*10mM (DMSO)305,00€Complement C5a Protein, Mouse, Recombinant, Biotinylated
Complement C5a Protein, Mouse, Recombinant, Biotinylated is expressed in E.Forma y color:Lyophilized PowderPeso molecular:9 kDa (predicted)C5AR1 Protein-VLP, Human, Recombinant (His)
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.Forma y color:Lyophilized PowderPeso molecular:41.1 kDa (predicted)Complement C8b Protein, Human, Recombinant (His)
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane ofForma y color:Lyophilized PowderPeso molecular:67.0 kDa (predicted)SB290157 trifluoroacetate
CAS:SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).Fórmula:C24H29F3N4O6Pureza:98.93% - 99.89%Forma y color:SolidPeso molecular:526.51Complement C3 Protein, Cynomolgus, Recombinant (His)
Complement C3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:90.3%Forma y color:Lyophilized PowderPeso molecular:186.40 kDa (predicted)C1s-A subcomponent Protein, Mouse, Recombinant (His)
C1s-A subcomponent Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:76.6 kDa (predicted)C3a Receptor Agonist
CAS:C3a Receptor Agonist activates C3aRs, inhibits neutrophil mobilization in ischemia, and promotes neural progenitor differentiation.Fórmula:C27H35N3O2Pureza:97.5%Forma y color:SolidPeso molecular:433.59C1QA Protein, Human, Recombinant (His & Myc)
C1QA Protein, Human, Recombinant (His & Myc) is expressed in E. coli.Forma y color:Lyophilized PowderPeso molecular:30.7 kDa (predicted)C1s Protein, Human, Recombinant (His)
Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses.Forma y color:Lyophilized PowderPeso molecular:76.3 kDa (predicted); 82.06 kDa, 56.59 kDa and 33.36 kDa (reducing condition, due to glycosylation)C1QA Protein, Mouse, Recombinant (His)
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.Pureza:90% - 92%Forma y color:Lyophilized PowderPeso molecular:25.6 kDa (predicted)Complement C5 Protein, Human, Recombinant (His & FLAG)
Complement C5 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag.Pureza:96.1%Forma y color:Lyophilized PowderPeso molecular:188.8 kDa (predicted)(Z)-Leukadherin-1
CAS:(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.Fórmula:C22H15NO4S2Pureza:99.23%Forma y color:SolidPeso molecular:421.49Complement C8a Protein, Human, Recombinant (His)
Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli.Forma y color:Lyophilized PowderPeso molecular:65.8 kDa (predicted)C1QL3 Protein, Mouse, Recombinant (His & Myc)
May regulate the number of excitatory synapses that are formed on hippocampus neurons.Forma y color:Lyophilized PowderPeso molecular:28.6 kDa (predicted)Complement C2 Protein, Human, Recombinant (His)
Complement C2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:98.6%Forma y color:Lyophilized PowderPeso molecular:82.5 kDa (predicted)Eculizumab
CAS:Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5Pureza:98.20%Forma y color:LiquidPeso molecular:148 kDaComplement C5 Protein, Cynomolgus, Recombinant
Complement C5 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells.Forma y color:Lyophilized PowderPeso molecular:8.41 kDa (predicted); 12.42 kDa (reducing conditions)
