Fuente botánica

Palmatine hydrochloride (PaH), a naturally occurring photosensitizer isolated from traditional Chinese medicine (TCM), can induce remarkable cell apoptosis ,significantly increase intracellular ROS level and significantly kill breast cancer MCF-7 cells; it also has potential in photodynamic therapy on colon adenocarcinoma.[1,2]

Beta-Ecdysterone slowly reduces food consumption and then indirectly induces a state of starvation resulting in the elevation of the mRNA levels of InR , IRS , PI3K110 , and PDK in the Bombyx fat body during molting and pupation, and Beta-Ecdysterone inhibits innate immunity in the fat body during Bombyx postembryonic development.[1,2]

Azadirachtin has antifungal activity, it used as insecticides.

Dietary supplementation of aloe components (aloin, aloesin and aloe-gel) can ameliorate intestinal inflammatory responses in a 3% dextran sulfate sodium (DSS)-induced ulcerative colitis rat model, in particular, aloesin is the most potent inhibitor. The extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation.

Calycosin, a major isoflavonoid isolated from Radix Astragal, induces angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro and zebrafish embryos in vivo via the up-regulation of vascular endothelial growth factor (VEGF), VEGFR1 and VEGFR2 mRNA expression;it acts similar to other selective estrogen receptor modulators (SERMs) to promote angiogenesis via activation of MAPK with the involvement of ERK1/2 and ER. , such as raloxifene and tamoxifen, by displaying selective potency and affinity to estrogen receptors ERa and ERb.

Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.

3-Hydroxy-4-methoxycinnamic acid has kinetics governing the inhibitory effect on tyrosinase-catalyzed reactions.

(-)-Epigallocatechin (EGC) can suppress oxidation of plasma low density lipoprotein (LDL) in vitro.

Stevioside - min 75% is a high-purity glycoside compound that functions as a natural sweetener. It is derived from the leaves of the Stevia rebaudiana plant, a member of the Asteraceae family, which is native to Paraguay and Brazil. This compound works by interacting with the sweet receptors on the tongue, specifically the TAS1R2 and TAS1R3 receptors, to provide a sweet taste sensation that is several hundred times sweeter than sucrose, without contributing to caloric intake. The principal applications of Stevioside are in the food and beverage industry, where it is employed as a sugar substitute in products such as soft drinks, desserts, and confectionery. Its non-caloric nature makes it highly valuable for the development of low-calorie and diabetic-friendly products. Moreover, due to its stable nature across a range of pH levels and temperatures, it is an ideal additive for products undergoing various manufacturing processes. In addition to its sweetening properties, Stevioside may offer potential health benefits, such as antihyperglycemic and antihypertensive effects, although these require further research for comprehensive understanding.

Asperulosidic acid has been recently used in chinese medicine as a useful drug against some tumors. It has anticlastogenic activity, since the anticlastogenic irridoids have an alpha-unsaturated carbonyl group, this structure is considered to play an important role in the anticlastogenicity. Asperulosidic acid can inhibit the seed germination and growth of seedlings of large crabgrass. Asperulosidic acid, and 6-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose are effective in suppressing 12-O-tedtradecanoylphorbol-13-acetate (TPA)- or epidermal growth factor (EGF)-induced cell transformation and associated AP-1 activity.

Cyanidin-3- O -glucoside, is one of the main component of mulberry anthocyanins,has protective effects from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure.

Hypaconitine (HA), an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism, the hepatic cytochrome P450-catalyzed metabolism of HA.