Estándares de hidrocarburos aromáticos policíclicos (PAH)

Applications Acenaphthylene-d8 is labelled Acenaphthylene (A130750) which is a polycyclic aromatic hydrocarbons as carcinogenic agents. References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999), Czub, G., et al.: Environ. Sci. Technol., 38, 2406 (2004),

Applications 6-Nitro-1-pyrenol and 8-Nitro-1-pyrenol are urinary hydroxylated metabolites used as a biomarkers of exposure to polycyclic aromatic hydrocarbons. References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999);

Applications Azulene is an isomer of napthalene visibly identifiable by its dark blue hue. As such it is used in the preparation of dyes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Stirling, A. et al.: ChemPhysChem, 5, 1558 (2004); Zhang, X. et al.: J. Mat. Chem., 17, 642 (2007);

Applications Labelled analogue of Benzo[ghi]perylene, one of the polycyclic aromatic hydrocarbons (PAH’s), an environmental pollutant with potential carcinogenic activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Alves, C. et al.: Atmos. Environ., 35, 5485 (2001); Jaward, F. et al.: Environ. Sci. Technol., 38, 2523 (2004); Lee, R. et al.: Environ. Sci. Technol., 39, 1436 (2005); Augusto, S. et al.: Environ. Pollut., 158, 483 (2010);

Applications Protected Naphthylamine. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Barbay, J., et al.: Bioorg. Med. Chem. Lett.,18, 2544 (2008), Konda, S., et al.: J. Chem. Pharm. Res., 2, 187 (2010),

Applications 6-Aminochrysene is a potent inhibitor of transferase activity. Also, it is used for the synthesis of diarylthiourea analogs as novel anti-cancer agents. References Liu, S., et al.: Bioorg. Med. Chem. Lett., 25, 1301-1305 (2015)

Applications Labelled Chrysene (C428000). Chrysene occurs in coal tar. Is formed during distillation of coal, in very small amount during distillation or pyrolysis of many fats and oils. Chrysene is one of the basic polycyclic aromatic hydrocarbon (PAH) which is toxic environmental pollutant and consistently exposed to sunlight. However, little information is available on its photogenotoxicity.  The objective of the present study was to analyze the effects of Chrysene, under environmental intensity of UVB (0.6 mW/cm2) in human skin epidermal cell line (HaCaT). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anderson, D., et al.: Mutat. Res., 307, 261 (1994), Diamond, S., et al.: Environ. Toxicol. Chem., 25, 3015 (2006), Fotakis, G., et al.: Toxicol. Lett., 160, 171 (2006),

Applications 9-Acetylanthracene is a polycyclic aromatic hydrocarbon (PAH) with photo-induced toxicity. Biological studies have shown that 9-Acetylanthracene has plasmid curing activity. References Sinks, G.D., et al.: B. Environ. Contam. Tox., 59, 1 (1997); Molnar, J., Biochem. Pharmacol., 28, 261 (1979)

Applications 7,12-Dimethylbenz[a]anthracene is a highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Huggins, C., et al.: Proc. Nat. Acad. Sci. U.S.A., 58, 2253 (1967); Dipple, A., et al.: N. Cancer Res., 43, 4123 (1983)

Applications Benz[a]anthracene-7,12-dione is a polycyclic aromatic hydrocarbon that is present in the emission soot of biomass fuels combustion. Benz[a]anthracene-7,12-dione is an urban air contaminant and also a potential mutagen & carcinogen. References Durant, J., et al.: Mutat. Res., Gen. Toxicol., 371, 123 (1996); Salamone, M., et al.: Env. Int., 2, 37 (1979); Wu, W., et al.: J. Env. Sci. Health A., A37, 579 (2002)

Applications 5-Chloroacenaphthenone is a chlorinated derivative of 1-Acenphthenone (A130755). 1-Acenaphthenone is a product of the photolysis (and microbial metabolism) of acenaphthene, a polycyclic hydrocarbon that has potential to act as polyploidizing agents in plants. References Kostoff, D.: Nature, 142, 753 (1938); Reyes, C., et al.: J. Photochem. Photobio. A, 112, 277 (1998); Schocken, M. & Gibson, D.: Appl. Environ. Microb., 48, 10 (1984)

Applications 6-Bromobenzo{a}pyrene is the polycyclic aromatic hydrocarbons with significant contribution to inhalation cancer risk. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wang, J., et al.: Environ. Sci. Technol., 46, 9745-9752 (2012)

Stability Air Sensitive Applications 2-AMINOANTHRACENE (cas# 613-13-8) is a useful research chemical.

Applications Dibenz[a,h]anthracene is a polycyclic aromatic hydrocarbon (PAH) and a known carcinogen. Dibenz[a,h]anthracene has produced positive results in bacterial DNA damage and mutagenicity assays and in mammalian cell DNA damage, mutagenicity and cell transformation assays. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Farmer, P.B. et al.: Mutat. Res. Re. Mutat. Res., 544, 397 (2003); Leadon, S. et al.: Carcinogenesis, 16, 3021 (1995); Andrews, A.W. et al.: Mutat. Res., 51, 311 (1978); Kaden, D.A. et al.: Cancer Res., 39, 4152 (1979);

Applications Polycyclic aromatic hydrocarbons as carcinogenic agents. References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999), Czub, G., et al.: Environ. Sci. Technol., 38, 2406 (2004),

Applications An active metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons found in hot mix asphalt paving workers. DBC is the most potent tumorigen that has been identified to date. Dibenzo[def,p]chrysene (DBC) is a carcinogen and should be handled with caution. References Anderson, L., et al.: Toxicol. Appl. Pharmacol., 199, 85 (2004), Yu, Z., et al.: Cancer Res., 66, 755 (2006), Shen, J., et al.: Toxicol. Sci., 95, 313 (2007),

Applications 3,5-Dichloroacenaphthene is a chlorinated derivative of Acenaphthene (D448330); a polycyclic hydrocarbon that has potential to act as polyploidizing agents in plants. References Campbell, K., et al.: J. Org. Chem., 16, 1712 (1951); Reisen, F. & Arey J.: Env. Sci. Tech., 36, 4302 (2002)

Applications 4-Methylquinoline is used as a reagent in the synthesis of azetidine based ene-amides as potent bacterial enoyl ACP reductase inhibitors. Also used as a reagent in the synthesis of cyanine-styryl dyes with enhanced photostability for fluorescent DNA imaging. References Takhi, M., et al.: Eur. J. Med. Chem., 84, 382 (2014); Bohlaender, P.R., et al.: Org. Biomol. Chem., 11, 7458 (2013)

Applications Clenpenterol was detected as a β-agonist residue in foodstuffs sourced from animal meats. References Shelver, W., et al.: J. Immunoassay, 21, 1 (2000), Smith, D., et al.: J. Anim. Sci., 80, 1240 (2002), Shelver, W., et al.: J. Agric. Food Chem., 51, 3715 (2003),

Applications 1,5,6-Trichloroacenaphthene is a chlorinated derivative of acenaphthene, a polycyclic hydrocarbon that has potential to act as polyploidizing agents in plants. References Campbell, K., et al.: J. Org. Chem., 16, 1712 (1951); Reisen, F. & Arey J.: Env. Sci. Tech., 36, 4302 (2002)