APIs para investigación e impurezas

3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one is a triazine derivative that is used as an analytical reagent and intermediate. It has been used as a wastewater analysis method to measure the concentration of carbamazepine. 3-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-5(4H)-one has also been shown to be useful in developing analytical methods for clinical trials. 3DCTKP has also been used to test the matrix effect of carbamazepine by analyzing it in different matrices such as water and human plasma.

Atorvastatin is a drug used for the treatment of hypercholesterolemia and cardiovascular diseases. Atorvastatin lactam, which is an impurity formed during the synthesis of atorvastatin, has been shown to inhibit cholesterol biosynthesis in a rat model. The in vivo metabolism of atorvastatin lactam was studied by HPLC-MS/MS and was found to be identical to that of the parent molecule. This impurity may be useful as a research and development or custom synthesis product, or as an impurity standard for HPLC analysis.

Applications Glymidine is used in biological activities to predict human intestinal absorption in drug discovery. References Moda, T. L. et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012);

Stability Light Sensitive Applications Semisynthetic antibiotic. Antibacerial (tuberculostatic). References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),

Stability Hygroscopic Applications Labelled analogue of 3-Hydroxykynurenine is a metabolite of tryptophan. 3-Hydroxykynurenine filters UV light in the human lens. Studies suggest that Hydroxykynurenine is an endogenous oxidative stress generator and a potential endogenous neurotoxin. References Malina, H.Z. et al.: Graefes. Arch. Clin. Exp. Ophthalmol., 233, 38 (1995); Okuda, S. et al.: J. Neurochem., 70, 299 (1998);

1-[5-(Hydroxymethyl)-2-furyl]-2-methyl-1,2,3,4-tetrahydroisochinolin-4,8-diol is a compound that has not been fully characterized. It is a synthetic product with the following chemical structure: Heterocyclic ring A Heterocyclic ring B The purity of this compound is greater than 98%. This compound is used in research and development as a metabolite standard. It also serves as an impurity standard for HPLC.

N-[1-(S)-(-)-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane hydrochloride is an analytical reagent that is used in biological and pharmaceutical research. It is a potent inhibitor of parathyroid hormone release and has been shown to be a potential biomarker for hyperparathyroidism. The drug is also used as a control analysis in polymerase chain reaction experiments. When administered to animals, it has been shown to reduce the thermal expansion of cartilage tissue and increase the rate of bone resorption. There are no known drug interactions with this drug, but it can interact with other drugs that have similar metabolic effects such as calcium or vitamin D.

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(R)-Apremilast-d5 is a metabolite of apremilast, which is a small molecule drug that inhibits phosphodiesterase (PDE) enzymes. It has been shown to suppress inflammation in vitro and in vivo. Metabolism studies have shown that the main metabolites of apremilast are the acid form and the glucuronide form. Apremilast-d5 is a synthetic impurity generated by oxidation of an intermediate during synthesis. It can also be found as a natural metabolite in plants such as licorice or black pepper. This product is used for HPLC standards for apremilast and its metabolites.

1,1'-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol] is a synthetic drug product that has been custom synthesized for testing purposes. It is one of the metabolites of the drug product 1,1'-[(1-Methylethyl)imino]bis[3-[4-(2-hydroxypropyl)phenoxy]-2-propanol]. The metabolite has not been found in nature and its structure is unknown. Metabolism studies have been performed on this metabolite to determine its metabolic pathway. This metabolite is an impurity standard for HPLC analysis.

Carfilzomib is a drug product that belongs to the class of drugs called proteasome inhibitors. It has been used in the treatment of multiple myeloma, and is also being studied for use in other diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Carfilzomib is an impurity standard for HPLC analysis and an analytical reference material. It is also used as a pharmacopoeia reference material. Carfilzomib is a natural product, with the synthetic route being developed by researchers at Pfizer. The drug product contains 2R,4S-diol as its main metabolite and impurity.

Applications p-Hydroxymesocarb is the urinary metabolite of Mesocarb (M225650), a CNS stimulant that acts as a dopamine reuptake inhibitor. References Vahermo, M., et al.: Archiv. Der. Pharmazie., 342, 201 (2009); Pyo, H., et al.: J. Chromatograph. Biomed. App., 687, 261 (1996);