APIs para investigación e impurezas

Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic with potent antibacterial activity.

Applications Antineoplastic; one derivative of cyclophosphamide (NSC-26271). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Potel, J., et al.: Arzneim.-Forsch., 21, 1250 (1971), Bria, E., et al.: Cancer Treat. Rev., 32, 583 (2006), Faivre, S., et al.: J. Clin. Oncol., 24, 25 (2006).

Monodes(N-carboxymethyl)valine daclatasvir-d3 is a drug product that is a metabolite of daclatasvir. It is an analytical standard for the determination of daclatasvir in human plasma and urine. Monodes(N-carboxymethyl)valine daclatasvir-d3 has been shown to be a natural metabolite of daclatasvir, which is derived from the hydrolysis of the ester bond between valine and N-carboxymethylated valine. This product can be used as an impurity standard for HPLC analysis.

Applications Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies. References Danilo, P. Jr., et al.: Am. Heart. J., 97, 119 (1979); Atarashi, H., et al.: Circulation. J., 66, 553 (2002);

Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. References Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997), Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (2000), Istvan, E., et al.: Science, 292, 1160 (2001), Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (2003), Bratton, L., et al.: Bioorg. Med. Chem., 15, 5576 (2007),

Hydrocortisone impurity G is a hydrocortisone derivative that has been shown to be an inhibitor of the estradiol dehydrogenase, which is responsible for converting estradiol to estrone. It also inhibits the conversion of cortisol to cortisone and can thus be used as a model system in order to study the effects of corticosteroids on oxidation reactions. Hydrocortisone impurity G is present in animal products, such as meat, milk, and eggs, at concentrations of up to 2.5%. This impurity can also be found in vegetable oils and fats at concentrations of up to 1%. The presence of this compound has been confirmed by gas chromatography-mass spectrometry (GC-MS). Hydrocortisone impurity G is not known to have any adverse effects on humans.