APIs para investigación e impurezas

Impurity Beclomethasone Dipropionate EP Impurity D Applications 9-Deschloro-9-bromo Beclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity D) is an impurity of Beclomethasone Dipropionate (B131030). References Shou, M. et al.: J. Pharmac. Biomed. Anal., 50, 356 (2009); Johnston, S. et al.: J. Chrom. Sci., 48, 733 (2010);

Acetamidodiphenyl ether (AEP) is a toxic environmental chemical that is used in the manufacture of plastics, rubber and pesticides. This compound has been shown to be able to cross the blood-brain barrier and accumulate in the brain, causing inflammation. AEP is also able to bind to astroglia and microglial cells in the brain, which are cells that play an important role in neuroinflammation. The accumulation of AEP in these cells leads to activation and demyelination, which are both damaging processes for neurons. Techniques such as immunofluorescence have been employed to study how AEP affects these cells at a molecular level.

4-(2-Hydroxy-3-isopropylaminopropoxy)benzoic acid 2-hydroxyethyl ester is a synthetic drug product that can be used as an HPLC standard. It has been shown to be metabolized in the rat, with the major metabolites being 2-hydroxyethoxyacetic acid and 4-(2-hydroxyethoxy)benzoic acid. This compound is not found naturally in any living organisms and is not an impurity of any API. The purity of this compound is >98%.

Applications Lercanidipine-d3 is a labeled dihydropyridine calcium channel blocker. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994)

1-Hydroxy-3-nitrodeamino fingolimod is a drug product that belongs to the class of drugs known as immunosuppressants. It is a synthetic, non-natural compound that belongs to the family of drugs known as sphingosine analogues. The HPLC standard for 1-hydroxy-3-nitrodeamino fingolimod is available and can be used in research and development or analytical studies. This drug has been shown to have niche applications in the treatment of multiple sclerosis, but it is not yet included in any pharmacopoeia.

Applications 17beta-Dihydroequilin-2,4,16,16,17-d5 is a useful isotopically labeled compound of 17β-Dihydro Equilin (D449130)

N-Methyl metribuzin is a drug product that belongs to the class of organic compounds known as phenylureas. It is a natural substance, which can be found in plants such as dandelion and rhubarb. Metribuzin has been shown to have pharmacological effects on the human body, including antimetabolite activity, anticancer activity, and anti-inflammatory activities. Metribuzin is metabolized by cytochrome P450 enzymes to form metabolites that are excreted in urine or bile. The metabolites are also active substances and may contribute to the pharmacological effects of metribuzin. Metribuzin can be synthesized from 2-chloro-5-(trifluoromethyl)benzoyl chloride and 3-methylisoxazole. Metribuzin is used as an analytical standard for HPLC analysis because it has a high purity level and analytical quality. It is also used in

Stability Hygroscopic Applications Labelled Vildagliptin. It is a new oral anti-hyperglycemic agent of a new dipeptidyl peptidase-IV (DPP-IV) inhibitor class of drugs. Antidiabetic. References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),