Compuestos y metabolitos farmacéuticos y veterinarios

Applications An antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite. Neuroprotective & Neuroresearch Product. References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),

Applications Acetaminophen-d4 (major) is deuterium labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)(3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。

Neuromedin B, a mammalian peptide related to bombesin, is found in the CNS and GI tract, originally purified from pig spinal cords.

Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.

Applications Anabolic Steroid. References Thevis, M., et al.: J. Anal. Toxicol., 32, 232 (2008), Pagonis, T., et al.: Clin. Toxicol., 46, 57 (2008), Zhang, Y., et al.: J. Food Sci., 74, T67 (2009),

Erythronic acid, an endogenous carbohydrate metabolite, is instrumental for research into metabolism-associated disorders.

Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

Applications It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts. References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),

3-Hydroxybutyric acid, a ketone body elevated in ketosis, is key for energy, especially in the brain, and is monitored for diabetic ketoacidosis.

Applications Allopurinol is a xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978); Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005); Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005);

Applications Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Inhibitor of exosome secretion. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986); Scientific Reports 8: 8161 (2018)

4-Hydroxyphenylpyruvic acid is a keto acid that is involved in the tyrosine catabolism pathway. 4-Hydroxyphenylpyruvic acid is an enzyme inhibitor.

Applications Imatinib is an inhibitor of multiple tyrosine kinases. It is a COVID19-related research product.

Cortisone (17-Hydroxy-11-dehydrocorticosterone) is a corticosteroid with potent glucocorticoid activity.

Applications Tricaprin is used to construct solid lipid nanoparticles (SLNs) as delivery system for bromocriptine (B682600, Mesylate salt). It is also used in cationic SLNs to enhance p53 tumor suppressor gene transfer to lung cancer cells. References Esposito, E., et al.: Pharma. Res., 25, 1521(2008); Choi, S., et al.: Eur. J. Pharma. Biopharma., 68, 545 (2008)

3-Ethoxy-3-oxopropanoic acid (Monoethyl malonic acid) belongs to the class of organic compounds known as dicarboxylic acids and derivatives.