Péptidos

A synthetic peptide for use as a blocking control in assays to test for specificity of LIM2 antibody, catalog no. 70R-7174

Fmoc-Aib-OH (Fmoc-alpha-methylalanine) is an alanine acid derivative, which can be used for peptide synthesis and biopharmaceutical design.

Peptide H-QESEVEEPL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-QESEVEEPL^-OH include the following: A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets A Taguchi, AD Taylor, J Rodriguez, M aca‡eliktaÃ…Åž , H Liu - Cancer research, 2014 - AACRhttps://aacrjournals.org/cancerres/article-abstract/74/17/4694/594018

In this special TentaGel resin, the PEG spacer is attached to the polystyrene/DVB matrix by a cleavable linkage. Therefore, the PEGylated compound can easily be cleaved and separated from the insoluble support. This can be achieved with either 10 mL/g of TFA/thioanisole (95:5) for 12 hours at room temperature, or with 10 mL/g of TFA/trimethylsilyl bromide/thioanisole (94:1:5) for 1 hour at room temperature. TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol). The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. Even less soluble peptides may be completely solubilized with this linker. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. (90 µm) 0.2-0.25 meq/g Product Application: Using this resin, cleavage yields the POE-peptide conjugates.

A synthetic peptide for use as a blocking control in assays to test for specificity of PHB2 antibody, catalog no. 70R-2431

A synthetic peptide for use as a blocking control in assays to test for specificity of SUSD4 antibody, catalog no. 70R-6885

Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB is a resin that has been synthesized by the Fmoc group. The resin is used to attach peptides, proteins and other organic molecules to a solid support for use in research. The resin is also an activator of ligands and can be used as a receptor for the binding of antibodies. The resin has high purity and is made from methacrylate polymer. It contains no detectable levels of hydroquinone and 4-Vinylpyridine. Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB can be used as a research tool in cell biology, immunology, pharmacology, protein interactions, receptor binding, ion channel activation and more. CAS No.: 58897-27-6

Peptide H-FPETVLAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-FPETVLAR^-OH include the following: Targeted Mass Spectrometry-Based Approach for the Determination of Intrinsic Internalization Kinetics of Cell-Surface Membrane Protein Targets D Ghosh , H Sugimoto , JY Lee, M Qian - Analytical Chemistry, 2021 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.analchem.1c00146

Protirelin - Thyrotropin-releasing hormone (TRH) (CAS: 24305-27-9) Thyrotropin-releasing hormone (TRH) Thyrotropin-releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone that regulates the release of thyroid-stimulating hormone (TSH), as well as prolactin (for breasts growth and milk production during and after pregnancy). To obtain thyrotropin-releasing hormones, 6 pro-TRH peptides have first to be obtained from the larger preproTRH precursor (UniProt: P20396). These octapeptides are then cleaved between Arginine/Glutamine and Glutamine/Lysine residues to release 6 Gln-His-Pro-Gly peptides that will be enzymatically converted in pGln-His-Pro-NH2 peptides (pGln representing pyroglutamine). After TRH maturation (1) in neurons located in the pituitary gland, the hormone will be transported along axons (2) to reach the hypophyseal portal system via exocytosis (3). Once the thyrotrophs reached, thyrotropin-releasing hormone binds TRH-receptor (4) to enable TSH synthesis and secretion that will stimulate thyroid follicular cells to produce thyroid hormones Triiodothyronine (T3) and Tetraiodothyronine (T4). [Glu2]-TRH_pGluGLuPro-NH2_CAS: 85541-78-2_ and TRH peptide_CAS: 24305-27-9_SB-PEPTIDE scheme: TRH metabolism pathway TRH implication in hypothyroidism and cholinergic neuronal activity TRH being directly involved in TSH release, deficiency of this hormone has been found to be related to secondary hypothalamic hypothyroidism. This condition can affect all body functions, causing various symptoms of different severity from fatigue to brittle nails, cold intolerance or joint pain even. On the contrary, even though no case of excessively high levels of TRH was observed up to now, studies showed the cholinergic effect of TRH in mouse brain. In 1991, for instance, M. G. Giovannini & al. associated TRH administration, s.c. or via local perfusion, with acetylcholine (ACh) release increase from rodents’ cortex and hippocampus, which suggested the strong stimulant action of TRH on cortical and hippocampal cholinergic pathways. TRH applications TRH is indicated as adjunctive agent in the diagnostic of potential thyroid disfunction. Even though TRH stimulation test isn’t yet approved by the U.S. Food and Drug Administration (FDA), the intravenous injection of the hormone to the patient’s bloodstream is sometimes used to distinguish different types of thyroid problems. Due to the concern expressed by the FDA, TRH is primarily used as a research tool mainly in the United States. Besides its role in endocrinology, the ability of TRH to promote wound healing by accelerating skin’s re-epithelization has also been demonstrated a few years ago.

A synthetic peptide for use as a blocking control in assays to test for specificity of RPL14 antibody, catalog no. 70R-10352

Peptide H-VKDLPGVR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-VKDLPGVR-OH include the following: Essentiality of the Escherichia coli YgfZ Protein for the In Vivo Thiomethylation of Ribosomal Protein S12 by the RimO Enzyme T Lund , MY Kulkova, R Jersie-Christensen - International Journal of , 2023 - mdpi.comhttps://www.mdpi.com/1422-0067/24/5/4728 A proteomic and transcriptomic approach reveals new insight into beta-methylthiolation of Escherichia coli ribosomal protein S12 MB Strader, N Costantino, CA Elkins, CY Chen - Molecular & Cellular , 2011 - ASBMBhttps://www.mcponline.org/article/S1535-9476(20)32497-X/fulltext beta-Methylthio-aspartic acid: Identification of a novel posttranslational modification in ribosomal protein S12 from escherichia coli JA Kowalak, KA Walsh - Protein science, 1996 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/pro.5560050816 Fag:" Almenbiologi med henblik paca¥ undervisning i gymnasiet" og kemi. Vejledere: Tove Atlung og Torben Lund. BS Knuhtsen - rucforsk.ruc.dkhttps://rucforsk.ruc.dk/ws/portalfiles/portal/60513599/slut_Speciale__2_november_slut.pdf

CBL-B (22-37) is derived from the CBL-B E3 ubiquitin ligase which targets receptor tyrosine kinases to lysosome degradation. CBL-B and its family member CBL are expressed in hematopoietic cells and as E3 ubiquitin ligases they contain a tyrosine kinase domain and an RF domain joined by a linker domain. The function of the RF domain is to transfer ubiquitin from E2 ubiquitin-conjugating enzymes onto the target protein which is often phosphorylated. Consequently the ubiquitinated substrate, the receptor tyrosine kinases, are ultimately targeted to the lysosome for degradation.EGFR is an example of a receptor tyrosine kinase whose activation is prevented by CBL and CBL-B when they bind and recruit GRb2, the adapter protein to EGFR. Consequently the ubiquitinylation of EGFR occurs and targets it for recognition by the endosomal protein complex and then lysosome degradation.It has also been found that the CBL family can negatively regulate through ubiquitinylation, PI 3-kinases, Rap G-protein guanine nucleotide exchange factor (GEF), C3G and Rho GTPase GEF Vav which are all non-receptors.If CBL or CBL-B becomes non-functional it can be associated with malignancies such as acute myeloid leukemia and myelodysplastic syndrome.

α 1 Antitrypsin Human is a research tool that can be used in the study of protein interactions. It is a high-purity, recombinant, human α 1 antitrypsin with an N-terminal hexahistidine tag. It has been specifically designed for use in antibody production and as a pharmacological agent to inhibit trypsin-like enzymes.

Peptide H-FSLDLDQYPLGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-FSLDLDQYPLGR^-OH include the following: Simultaneous quantification of major capsid protein of human papillomavirus 16 and human papillomavirus 18 in multivalent human papillomavirus vaccines by liquid T Ning, S Sun, J Nie, W Huang, X Li, J Cao - of Chromatography A, 2020 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S002196732030162X

β-catenin peptide(βCATp) acetate is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.

Peptide H-CYVDTNNDGAYEGDEL-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-CYVDTNNDGAYEGDEL-NH2 include the following: Site-specific labelling of proteins with a rigid lanthanide-binding tag XC Su , T Huber , NE Dixon , G Otting - ChemBioChem, 2006 - Wiley Online Libraryhttps://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.200600142 Two-point anchoring of a lanthanide-binding peptide to a target protein enhances the paramagnetic anisotropic effect T Saio , K Ogura , M Yokochi, Y Kobashigawa - Journal of biomolecular , 2009 - Springerhttps://link.springer.com/article/10.1007/s10858-009-9325-z NMR structural biology using paramagnetic lanthanide probe T Saio , F Inagaki - Advanced Methods in Structural Biology, 2016 - Springerhttps://link.springer.com/protocol/10.1007/978-4-431-56030-2_17 Structural study of proteins by paramagnetic lanthanide probe methods T Saio , F Inagaki - Approaches of NMR Spectroscopy: Methodology and , 2018 - Springerhttps://link.springer.com/chapter/10.1007/978-981-10-5966-7_8

Lipoprotein Lipase is a type of enzyme that is involved in the breakdown of fats (lipids) into smaller components like free fatty acids and glycerol. This enzyme is made up of two subunits, an alpha subunit and a beta subunit. The alpha subunit has four domains, while the beta subunit has three domains. Lipoprotein Lipase is found in human plasma and tissue, where it performs its function by attaching to the surface of cells or lipoproteins and releasing free fatty acids. It also binds to cholesterol, which may be due to its ability to form hydrogen bonds with this molecule.

Peptide H-LLVPANEGDPTETLR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-LLVPANEGDPTETLR-OH include the following: TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL H Walczak, MA Degli-Esposti , RS Johnson - The EMBO , 1997 - embopress.orghttps://www.embopress.org/doi/full/10.1093/emboj/16.17.5386