Recombinant HIV-1 group O gp41
Ref. 3D-AI6334-R
1mg
791,00€
Información del producto
Nombre:Recombinant HIV-1 group O gp41
Marca:Biosynth
Descripción:Expressed in E.coli and lyophilised from 20mM Sodium Carbonate buffer at pH 9.6, this full length recombinant HIV-1 group O gp41 antigen is one of two key envelope glycoproteins facilitating the entry of the Human Immunodeficiency Virus (HIV) into CD4 T cells. While the second envelope protein gp120 (FH108439) binds to cell surface receptors on the target cell, the gp41 demonstrates fusogenic properties whereby the refolding of its N-terminal and C-terminal heptad repeat regions into a six-helix bundle, enables the virus to fuse and gain entry into the T cell. These heptad regions are potential points of interest as inhibitor targets and their peptide derivatives which can competitively block the six-helix bundle formation can be used in combination therapy treatment for HIV.
Another segment of the gp41 protein crucial to viral fusion and therapeutic use in vaccines, is the tryptophan-rich Membrane Proximal External Region (MPER). This contains exposed epitopes which can be targeted by broadly neutralising antibodies (bNAbs). The gp41 protein has further assay applications in antibody and antigen detecting assays: ELISA, western blot and lateral flow. In particular it can determine the type of infection to be a HIV-1 group M, O or HIV-2 virus when used in an ELISA assay.
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Consulta técnica sobre: Recombinant HIV-1 group O gp41
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