Información del producto
Nombre:Vadadustat
Producto controlado
Marca:Biosynth
Descripción:Vadadustat is an orally administered hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), which is a synthetic small molecule. Its mode of action involves the inhibition of prolyl hydroxylase enzymes, which normally facilitate the degradation of hypoxia-inducible factor (HIF) under normal oxygen conditions. By stabilizing HIF, vadadustat effectively mimics a hypoxic response, leading to increased endogenous production of erythropoietin (EPO), a key hormone in red blood cell production.
Vadadustat is primarily used for the management of anemia, particularly in patients with chronic kidney disease (CKD), where secondarily elevated EPO levels stimulate erythropoiesis. The stabilization of HIF also results in the upregulation of other genes associated with iron metabolism and erythropoiesis, providing a coordinated approach to correcting anemia. This pharmacological profile makes vadadustat a promising therapeutic option offering a potentially advantageous safety and efficacy profile compared to traditional erythropoiesis-stimulating agents. The continued investigation into its long-term outcomes and comparative benefits remains a significant focus within nephrology and hematology research.
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Propiedades químicas
Peso molecular:306.7 g/mol
Fórmula:C14H11ClN2O4
Pureza:Min. 95%
Color/Forma:Powder
InChI:InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
Clave InChI:InChIKey=JGRXMPYUTJLTKT-UHFFFAOYSA-N
SMILES:O=C(O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O
Consulta técnica sobre: Vadadustat
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