CAS: 1000690-91-4

Cetirizine impurity B dihydrochloride is a minor impurity of cetirizine, which is a non-sedating antihistamine. The purity of the compound was determined by high performance liquid chromatography (HPLC) and its bioequivalence to cetirizine was assessed in a population pharmacokinetic study. Cetirizine impurity B dihydrochloride has been shown to have a similar pharmacokinetic profile to cetirizine and can be used as an alternative for the treatment of allergic rhinitis.

Applications De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride, is an impurity of Cetirizine (C281100, 2HCl); a nonsedating type histamine H1-receptor antagonist and a major metabolite of Hydroxyzine (H996500). Pharmacological activity of Cetirizine resides primarily in the (R)-isomer. Also antihystaminic. References De Vos, C., et al.: Ann. Allergy, 59, 278 (1987); Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987); Fadel, R., et al.: Clin. Allergy, 17, 373 (1987); Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)

Cetirizine Impurity B dihydrochloride is a Cetirizine antihistamine byproduct with anti-allergic properties.

Cetirizine Impurity B dihydrochloride