Bcr-Abl
Les inhibiteurs de Bcr-Abl sont des thérapies ciblées qui inhibent la protéine de fusion Bcr-Abl, formée à la suite de la translocation du chromosome Philadelphie et moteur de la leucémie myéloïde chronique (LMC). Cette protéine influence également l'angiogenèse, contribuant à la progression tumorale. Les inhibiteurs de Bcr-Abl sont cruciaux dans le traitement de la LMC et sont explorés pour leur potentiel à inhiber l'angiogenèse dans divers cancers. Chez CymitQuimica, nous offrons des inhibiteurs de Bcr-Abl de haute qualité pour soutenir vos recherches en biologie du cancer, angiogenèse et thérapies ciblées.
Produits appartenant à la catégorie "Bcr-Abl"
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Degrasyn
CAS :Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Formule :C19H18BrN3ODegré de pureté :98.32% - 99.98%Couleur et forme :SolidMasse moléculaire :384.27Ref: TM-T6300
2mg44,00€5mg64,00€10mg97,00€25mg198,00€50mg340,00€100mg532,00€200mg747,00€1mL*10mM (DMSO)69,00€Imatinib
CAS :Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFormule :C29H31N7ODegré de pureté :100% - 99.94%Couleur et forme :Off White PowderMasse moléculaire :493.6Nilotinib hydrochloride
CAS :Nilotinib HCl (AMN-107 HCl), an oral Bcr-Abl inhibitor, targets neuroinflammation, cognitive issues, and chronic myelogenous leukemia.Formule :C28H23ClF3N7ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :565.98PPY A
CAS :PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase and inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl gene-transformed cellsFormule :C22H20N4O2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :372.42cSRC/BCR-ABL-IN-1
cSRC/BCR-ABL-IN-1 (compound 21b) is a potent inhibitor of Bcr-Abl and C-Src, with IC50 values of 56.2 nM and 101 nM, respectively. It exhibits cytotoxicity.Formule :C29H31Cl2N5O4Masse moléculaire :584.494Flumatinib
CAS :Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.Formule :C29H29F3N8ODegré de pureté :99.52% - 99.95%Couleur et forme :SolidMasse moléculaire :562.59Ref: TM-T4320
1mg35,00€5mg66,00€10mg87,00€25mg127,00€50mg163,00€100mg273,00€200mg409,00€500mg677,00€1mL*10mM (DMSO)87,00€Dasatinib monohydrate
CAS :Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.Formule :C22H28ClN7O3SDegré de pureté :100% - 99.68%Couleur et forme :SolidMasse moléculaire :506.03c-ABL-IN-5
C-ABL-IN-5, a selective c-Abl inhibitor, exhibits neuroprotective properties and has favorable characteristics including blood-brain barrier permeability,Formule :C19H17F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :341.35Lyn-IN-1
CAS :Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and LynFormule :C30H31F3N8ODegré de pureté :97% - 99.33%Couleur et forme :SolidMasse moléculaire :576.62Ref: TM-T11916
1mg47,00€2mg56,00€5mg84,00€10mg124,00€25mg250,00€50mg393,00€100mg560,00€200mg815,00€1mL*10mM (DMSO)97,00€Dasatinib N-oxide
CAS :Dasatinib N-oxide is a key metabolite and potential impurity of the kinase inhibitor dasatinib.Formule :C22H26ClN7O3SDegré de pureté :98.54% - 99.85%Couleur et forme :SolidMasse moléculaire :504FGFRs-IN-1
FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.Formule :C28H26Cl2N4O3Couleur et forme :SolidMasse moléculaire :537.44Tyrosine kinase-IN-9
CAS :Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formule :C20H14ClN3O3Couleur et forme :SolidMasse moléculaire :379.796AN-019
CAS :AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic myelogenous leukemia (CML) and breast cancer.Formule :C25H17F6N5ODegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :517.43Flumatinib mesylate
CAS :Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.Formule :C30H33F3N8O4SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :658.69Ref: TM-T7861
1mg37,00€5mg88,00€10mg133,00€25mg250,00€50mg393,00€100mg628,00€500mg1.301,00€1mL*10mM (DMSO)139,00€CZC-8004
CAS :CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.Formule :C17H16FN5Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :309.34Rebastinib
CAS :DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC,Formule :C30H28FN7O3Degré de pureté :99.53% - 99.79%Couleur et forme :SolidMasse moléculaire :553.59GMB-475
CAS :GMB-475, a PROTAC-based BCR-ABL1 inhibitor, tackles drug resistance by promoting VHL-mediated degradation.Formule :C43H46F3N7O7SDegré de pureté :100% - 98.78%Couleur et forme :SolidMasse moléculaire :861.93Ref: TM-T8488
1mg96,00€5mg200,00€10mg350,00€25mg590,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)274,00€CpCDPK1/TgCDPK1-IN-1
CAS :CpCDPK1/TgCDPK1-IN-1 is a inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections.Formule :C18H17N5Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :303.36Dasatinib
CAS :Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Formule :C22H26ClN7O2SDegré de pureté :99.59% - 99.86%Couleur et forme :Pale-Yellow SolidMasse moléculaire :488.01PD173955
CAS :PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR andFormule :C21H16Cl2N4OSDegré de pureté :98.52% - 99.28%Couleur et forme :SolidMasse moléculaire :443.35
