EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
Produits appartenant à la catégorie "EGFR"
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Osimertinib dimesylate
CAS :Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Formule :C30H41N7O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :691.82PD-161570
CAS :PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formule :C26H35Cl2N7ODegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :532.51Ref: TM-T23127
1mg35,00€5mg92,00€10mg149,00€25mg305,00€50mg492,00€100mg700,00€200mg938,00€1mL*10mM (DMSO)125,00€AG 555
CAS :AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.Formule :C19H18N2O3Degré de pureté :100% - 99.51%Couleur et forme :SolidMasse moléculaire :322.36Chamigrenal
CAS :β-Chamigrenal: Anti-inflammatory, inhibits NO and PGE2 in macrophages, PAF antagonist (IC50=1.2x10^-4 M), weakly cytotoxic to MCF-7 (IC50=30.50 uM).Formule :C15H22ODegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :218.33EGFR-IN-76
CAS :EGFR-IN-76 is a potent EGFR inhibitor.Formule :C30H30ClFN6O2Degré de pureté :97.02% - 97.72%Couleur et forme :SolidMasse moléculaire :561.05U3-1565
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.Couleur et forme :LiquidMasse moléculaire :144.82 kDa (Predicted)AV-412 free base
CAS :AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Formule :C27H28ClFN6OCouleur et forme :SolidMasse moléculaire :507Leptomycin B
CAS :Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formule :C33H48O6Degré de pureté :99.04% - 99.71%Couleur et forme :White Crystalline SolidMasse moléculaire :540.73Ref: TM-T15735
1mg202,00€2mg341,00€5mg620,00€10mg882,00€25mg1.320,00€50mg1.776,00€100mg2.403,00€1mL*10mM (DMSO)283,00€PF-6274484
CAS :PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Formule :C18H14ClFN4O2Degré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :372.78Ref: TM-T22396
2mg40,00€5mg60,00€10mg92,00€25mg187,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)66,00€EGFR-IN-1
CAS :EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.Formule :C28H30N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58Anti-EGFR Monoclonal Antibody-AF555
Anti-EGFR Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF555 can be used in FACS.Degré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaAlmonertinib
CAS :Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.Formule :C30H35N7O2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :525.64Ref: TM-T5462
1mg89,00€5mg197,00€10mg311,00€25mg525,00€50mg757,00€100mg1.035,00€500mg2.110,00€1mL*10mM (DMSO)249,00€EBE-A22
CAS :EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.Formule :C17H16BrN3O2Degré de pureté :99.85% - 99.88%Couleur et forme :SolidMasse moléculaire :374.234-Epidoxycycline
CAS :4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.Formule :C22H24N2O8Couleur et forme :SolidMasse moléculaire :444.44EGFR-IN-132
CAS :EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.Formule :C27H31N7O3Couleur et forme :SolidMasse moléculaire :501.58AEE 788
CAS :Formule :C27H32N6Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :440.60Pyrotinib dimaleate
CAS :Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.Formule :C40H39ClN6O11Degré de pureté :98.07% - 99.52%Couleur et forme :SolidMasse moléculaire :815.22Ref: TM-T12594
1mg155,00€5mg457,00€10mg610,00€25mg947,00€50mg1.301,00€100mg1.758,00€1mL*10mM (DMSO)620,00€(E)-AG 556
CAS :AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.Formule :C20H20N2O3Degré de pureté :99.48%Couleur et forme :Light Yellow PowderMasse moléculaire :336.38JAK 3 inhibitor IV
CAS :JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found toFormule :C16H19NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :241.33PP 3
CAS :PP 3 is a Negative control for the Src kinase inhibitor PP 2Formule :C11H9N5Degré de pureté :98.61%Couleur et forme :Whit To Off-White SolidMasse moléculaire :211.22Ref: TM-T23176
5mg51,00€10mg79,00€25mg140,00€50mg202,00€100mg305,00€500mg733,00€1mL*10mM (DMSO)55,00€AG-494
CAS :AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Formule :C16H12N2O3Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :280.28(±)-Norcantharidin
CAS :(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.Formule :C8H8O4Degré de pureté :99.43% - ≥98%Couleur et forme :SolidMasse moléculaire :168.15Mubritinib
CAS :Formule :C25H23F3N4O2Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Gray to Brown powder to crystalMasse moléculaire :468.48A-935142
CAS :A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formule :C18H19F3N2O2Degré de pureté :100% - 100%Couleur et forme :SolidMasse moléculaire :352.35Tyrphostin AG 490
CAS :Formule :C17H14N2O3Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :294.31EGFR-IN-1 hydrochloride
CAS :EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.Formule :C28H31ClN6O4Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :551.04Ref: TM-T11157L
1mg65,00€5mg150,00€10mg215,00€25mg338,00€50mg452,00€100mg620,00€200mg838,00€1mL*10mM (DMSO)202,00€Mavelertinib
CAS :Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Formule :C18H22FN9O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :415.42Lumretuzumab
CAS :Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.Couleur et forme :LiquidEGFR-IN-82
CAS :EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/Formule :C32H41BrN9O2PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :694.6Almonertinib mesylate
CAS :Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Formule :C31H39N7O5SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :621.75Ref: TM-T9865
1mg55,00€5mg116,00€10mg187,00€25mg319,00€50mg449,00€100mg638,00€200mg840,00€1mL*10mM (DMSO)170,00€EGFR-IN-126
CAS :EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.Formule :C28H28BrFN4O3Couleur et forme :SolidMasse moléculaire :567.45Gefitinib-based PROTAC 3
CAS :Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).Formule :C47H57ClFN7O8SDegré de pureté :97.29% - 98.25%Couleur et forme :SolidMasse moléculaire :934.51HKI-357
CAS :HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.Formule :C31H29ClFN5O3Degré de pureté :95.11%Couleur et forme :SolidMasse moléculaire :574.05Ref: TM-T11569
1mg79,00€5mg153,00€10mg227,00€25mg462,00€50mg662,00€100mg938,00€1mL*10mM (DMSO)187,00€Vandetanib
CAS :Formule :C22H24BrFN4O2Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :475.36EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formule :C50H49N11O5SCouleur et forme :SolidMasse moléculaire :916.062-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
CAS :Formule :C18H13BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.226Osimertinib
CAS :Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Formule :C28H33N7O2Degré de pureté :100% - 99.83%Couleur et forme :SolidMasse moléculaire :499.61Ref: TM-T2490
1g154,00€2mg38,00€5mg52,00€10mg62,00€25mg74,00€50mg88,00€100mg103,00€200mg115,00€500mg127,00€1mL*10mM (DMSO)52,00€Barecetamab
CAS :Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Couleur et forme :LiquidWHI-P154
CAS :Formule :C16H14BrN3O3Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Yellow to Orange powder to crystalMasse moléculaire :376.21Dacomitinib hydrate
CAS :Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family ofFormule :C24H27ClFN5O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :487.96Ref: TM-T19965
5mg50,00€10mg80,00€25mg105,00€50mg140,00€100mg212,00€200mg311,00€1mL*10mM (DMSO)60,00€4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-
CAS :Formule :C16H14ClN3O2Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :315.75426000000004Propanedinitrile,2-[(4-methoxyphenyl)methylene]-
CAS :Formule :C11H8N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :184.194EGFR-IN-8
CAS :EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLCFormule :C32H23ClF3N7O4Degré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :662.02GW 583340 dihydrochloride
CAS :GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03PD168393
CAS :PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formule :C17H13BrN4ODegré de pureté :99.13% - 99.7%Couleur et forme :SolidMasse moléculaire :369.22Ref: TM-T6932
1mg39,00€2mg49,00€5mg66,00€10mg89,00€25mg155,00€50mg222,00€100mg310,00€1mL*10mM (DMSO)56,00€MTX-211
CAS :MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.Formule :C20H14Cl2FN5O2SDegré de pureté :100% - 97.28%Couleur et forme :SolidMasse moléculaire :478.33Ref: TM-T4296
1mg64,00€5mg187,00€10mg284,00€25mg467,00€50mg645,00€100mg873,00€200mg1.159,00€1mL*10mM (DMSO)190,00€EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :60-90 KDa (reducing condition)Trastuzumab rezetecan
CAS :Trastuzumab rezetecan (SHR-A1811) is an antibody-drug conjugate (ADC) targeting HER2. It is composed of a humanized anti-HER2 antibody, a cleavable linker MC-Gly-Gly-Phe-Gly, and an effective payload of the topoisomerase I inhibitor Rezetecán. Trastuzumab rezetecan is utilized in the research of HER2-positive breast cancer.Couleur et forme :LiquidEpertinib hydrochloride
CAS :Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.Formule :C30H28Cl2FN5O3Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :596.48Ref: TM-T11213
1mg92,00€5mg188,00€10mg311,00€25mg533,00€50mg755,00€100mg1.017,00€500mg2.043,00€1mL*10mM (DMSO)255,00€Benidipine hydrochloride
CAS :Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.Formule :C28H32ClN3O6Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :542.03Nuvenzepine
CAS :Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.Formule :C19H20N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.39(S)-Afatinib
CAS :(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, L858R, L858R/T790M, HER2, and HER4, respectively.Formule :C24H25ClFN5O3Degré de pureté :100% - 99.96%Couleur et forme :Off-White SolidMasse moléculaire :485.94RG13022
CAS :RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).Formule :C16H14N2O2Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :266.29Neratinib
CAS :Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.Formule :C30H29ClN6O3Degré de pureté :100% - 98.55%Couleur et forme :SolidMasse moléculaire :557.04Tyrphostin A9
CAS :Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitorFormule :C18H22N2ODegré de pureté :98.21% - 99.87%Couleur et forme :Yellow SolidMasse moléculaire :282.38Amivantamab (FUT8-KO)
Amivantamab (FUT8-KO) is a humanized dual-specificity antibody targeting EGFR-MET, exhibiting immunotherapeutic anticancer activity. This compound inhibits ligand binding, enhances the internalization and degradation of receptor-antibody complexes, and stimulates macrophage-mediated phagocytosis and natural killer cell cytotoxicity, both of which are Fc-dependent.Formule :C13H12O4Couleur et forme :LiquidMasse moléculaire :232.23EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.Coprelotamab
CAS :Coprelotamab (GB-221) is an IgG-κ monoclonal antibody that targets EGFR2, frequently produced in CHO DG44 (Chinese Hamster Ovary) cells [1].Degré de pureté :98%Couleur et forme :Liquid4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1)
CAS :Formule :C22H24ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.89666000000005CHMFL-EGFR-202
CAS :CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).Formule :C25H24ClN7O2Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :489.96Ref: TM-T10802
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€1mL*10mM (DMSO)305,00€(2E)-2-Cyano-3-(3,4-Dihydroxyphenyl)-N-[(1S)-1-Phenylethyl]-2-Propenamide
CAS :Formule :C18H16N2O3Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :308.33124000000004Vislarafusp alfa
Vislarafusp alfa is a humanized IgG1κ antibody that targets EGFR/CD47, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour LiquidTyrphostin RG 13022
CAS :Formule :C16H14N2O2Degré de pureté :>98.0%(GC)Couleur et forme :White to Yellow to Green powder to crystalMasse moléculaire :266.30WHI-P154
CAS :Formule :C16H14BrN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.2047Cinrebafusp alfa
CAS :Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM toDegré de pureté :98%Couleur et forme :LiquidWZ4002
CAS :WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.Formule :C25H27ClN6O3Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :494.97Ref: TM-T6238
2mg35,00€5mg52,00€10mg73,00€25mg117,00€50mg187,00€100mg329,00€200mg490,00€1mL*10mM (DMSO)52,00€WHI-P180
CAS :WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formule :C16H15N3O3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :297.31EGFR/CDK2-IN-2
EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively.Formule :C49H32N12O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :884.99EGFR-IN-89
CAS :EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFormule :C26H31FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64E-4031
CAS :E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formule :C21H29Cl2N3O3SDegré de pureté :99.31% - 99.87%Couleur et forme :SolidMasse moléculaire :474.44Panitumumab
CAS :Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).Degré de pureté :95% - 99%Couleur et forme :LiquidMasse moléculaire :147 kDaTAS0728
CAS :TAS0728 is a HER2 inhibitor, with antitumor activityFormule :C26H32N8O3Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :504.58Ref: TM-T7819
1mg50,00€5mg111,00€10mg170,00€25mg321,00€50mg512,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)117,00€FIIN-3
CAS :FIIN-3 is an irreversible inhibitor of FGFR.Formule :C34H36Cl2N8O4Degré de pureté :97.63% - 98.92%Couleur et forme :SolidMasse moléculaire :691.61Neolinine
CAS :Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.Formule :C23H37NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.55Anti-EGFR Antibody (9S619)
Anti-EGFR Antibody (9S619) is an antibody targeting EGFR. Anti-EGFR Antibody (9S619) can be used in ELISA, IHC, FCM.Couleur et forme :Odour LiquidBrigatinib
CAS :Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Formule :C29H39ClN7O2PDegré de pureté :100% - 99.93%Couleur et forme :SolidMasse moléculaire :584.09Epitinib succinate
CAS :Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formule :C28H32N6O6Degré de pureté :97.43% - 99.47%Couleur et forme :SolidMasse moléculaire :548.59Ref: TM-T35914
1mg75,00€2mg97,00€5mg170,00€10mg271,00€25mg449,00€50mg615,00€100mg843,00€500mg1.691,00€Osimertinib mesylate
CAS :Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.Formule :C29H37N7O5SDegré de pureté :100% - 99.88%Couleur et forme :SolidMasse moléculaire :595.71Anti-EGFR Monoclonal Antibody-Biotin
Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: HumanDegré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaTyrphostin AG 835
CAS :Formule :C18H16N2O3Degré de pureté :>98.0%(HPLC)Couleur et forme :Light yellow to Amber to Dark green powder to crystalMasse moléculaire :308.34BMS-599626
CAS :BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.Formule :C27H27FN8O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :530.55Afatinib Dimaleate
CAS :Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.Formule :C32H33ClFN5O11Degré de pureté :100% - 98.11%Couleur et forme :SolidMasse moléculaire :718.08Ref: TM-T1773
1g467,00€5mg40,00€10mg59,00€25mg87,00€50mg107,00€100mg140,00€200mg188,00€500mg313,00€1mL*10mM (DMSO)66,00€Zorifertinib
CAS :Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.Formule :C22H23ClFN5O3Degré de pureté :98.20% - 99.36%Couleur et forme :White To Off-White SolidMasse moléculaire :459.9(S)-Sunvozertinib
CAS :(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08CGP52411
CAS :CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).Formule :C20H15N3O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :329.35JND3229
CAS :JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.Formule :C33H41ClN8O2Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :617.18Hypericin
CAS :Formule :C30H16O8Degré de pureté :>95.0%(HPLC)Couleur et forme :Black powder to crystalMasse moléculaire :504.45Mutated EGFR-IN-3
CAS :Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formule :C31H29FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.59EGFR-IN-9
CAS :EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formule :C29H24N4O3Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :476.53Mevastatin
CAS :Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formule :C23H34O5Degré de pureté :99.12%Couleur et forme :White-Yellowish To Yellow Powder Solid PowderMasse moléculaire :390.51Oritinib
CAS :Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (Formule :C31H37N7O2Degré de pureté :98.4%Couleur et forme :SoildMasse moléculaire :539.67Ref: TM-T60076
1mg134,00€5mg321,00€10mg469,00€25mg777,00€50mg1.035,00€100mg1.415,00€1mL*10mM (DMSO)374,00€METHYL 2,5-DIHYDROXYCINNAMATE
CAS :Formule :C10H10O4Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :194.184PD158780
CAS :PD 158780 blocks all ErbB receptors: EGFR, ErbB2-4, with IC50s: 8μM, 49-52 nM.Formule :C14H12BrN5Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :330.18Canertinib
CAS :Formule :C24H25ClFN5O3Degré de pureté :>98.0%(HPLC)(qNMR)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :485.94Tyrphostin AG 494
CAS :Formule :C16H12N2O3Degré de pureté :>98.0%(HPLC)(N)Couleur et forme :Light yellow to Amber to Dark green powder to crystalMasse moléculaire :280.28Tyrphostin A1
CAS :Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .Formule :C11H8N2ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :184.19EMI1
CAS :EMI1 targets mutated EGFR in drug-resistant NSCLC research.Formule :C20H18N2O3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :334.37EGFR vIII Protein, Human, Recombinant (His)
EGFR vIII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag.Couleur et forme :Lyophilized PowderMasse moléculaire :61-75 Kda (reducing condition)Lidocaine Hydrochloride hydrate
CAS :Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formule :C14H22N2O·HCl·H2ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :288.82Gefitinib
CAS :Formule :C22H24ClFN4O3Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :446.91AG-1478
CAS :AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.Formule :C16H14ClN3O2Degré de pureté :99.03% - 99.71%Couleur et forme :SolidMasse moléculaire :315.75EGFR-IN-147
CAS :EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.Formule :C13H13N5OCouleur et forme :SolidMasse moléculaire :255.275Neratinib
CAS :Formule :C30H29ClN6O3Degré de pureté :>95.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :557.05Tyrphostin A1
CAS :Formule :C11H8N2ODegré de pureté :>98.0%(GC)Couleur et forme :Light orange to Yellow to Green powder to crystalMasse moléculaire :184.20Lapatinib ditosylate monohydrate
CAS :Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.Formule :C29H26ClFN4O4S·2(C7H8O3S)·H2ODegré de pureté :98% - 99.41%Couleur et forme :Colourless To Light-Yellow CrystalMasse moléculaire :943.47TX1-85-1
CAS :TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Formule :C32H36N8O3Degré de pureté :98.12% - 98.12%Couleur et forme :SolidMasse moléculaire :580.68WHI-P154
CAS :WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formule :C16H14BrN3O3Degré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :376.2Sapitinib
CAS :Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib orFormule :C23H25ClFN5O3Degré de pureté :98.89% - 99.83%Couleur et forme :SolidMasse moléculaire :473.93Alflutinib
CAS :Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.Formule :C28H31F3N8O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :568.59Ref: TM-T22254
1mg213,00€5mg435,00€10mg620,00€25mg938,00€50mg1.320,00€100mg1.786,00€1mL*10mM (DMSO)560,00€EGFR-IN-128
EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.Formule :C27H20N4OCouleur et forme :SolidMasse moléculaire :416.47Nezutatug
CAS :Nezutatug, an anti-HER3 antibody, serves as a research tool in cancer studies [1].Degré de pureté :98%Couleur et forme :LiquidBPI-15086
CAS :BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.Formule :C29H33ClN8O4Couleur et forme :SolidMasse moléculaire :593.08FRF-06-057
FRF-06-057 is an allosteric ATP EGFR inhibitor targeting both wild-type and mutant EGFR, with IC50 values of 17 nM (LR/TM), 29 nM (LR/TM/CS), 220 nM (LR), and >1000 nM (WT).Formule :C19H13N3O3SCouleur et forme :SolidMasse moléculaire :363.39Tyrphostin AG30
CAS :Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.Formule :C10H7NO4Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :205.17Labuxtinib
CAS :Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formule :C20H16FN5O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :377.37Ref: TM-T79851
1mg139,00€5mg338,00€10mg540,00€25mg1.074,00€50mg1.549,00€100mg2.080,00€200mg2.802,00€1mL*10mM (DMSO)374,00€Anti-EGFR Monoclonal Antibody-AF488
Anti-EGFR Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF488 can be used in FACS.Degré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaDacomitinib
CAS :Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.Formule :C24H25ClFN5O2Degré de pureté :100% - 99.72%Couleur et forme :SolidMasse moléculaire :469.94Ref: TM-T2483
1mg38,00€2mg49,00€5mg79,00€10mg127,00€25mg173,00€50mg227,00€100mg354,00€200mg444,00€500mg730,00€1mL*10mM (DMSO)79,00€Rezivertinib
CAS :Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formule :C27H30N6O3Degré de pureté :99.43% - 99.89%Couleur et forme :SolidMasse moléculaire :486.57Ref: TM-T36644
1mg99,00€5mg226,00€10mg364,00€25mg702,00€50mg947,00€100mg1.264,00€200mg1.700,00€1mL*10mM (DMSO)47,00€JH-XI-10-02
CAS :JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.Formule :C53H69N5O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :920.161EGFR/BRAFV600E-IN-2
E07 Aptamer, targeting the human epidermal growth factor receptor (hEGFR), competes with epidermal growth factor (EGF) for binding to a unique epitope on EGFR.Formule :C25H18N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.44BGB-8035
CAS :BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.Formule :C24H31N5O4Degré de pureté :96.74%Couleur et forme :SolidMasse moléculaire :453.53Larotinib
CAS :Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.Formule :C24H26ClFN4O4Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :488.94BEBT-109
CAS :BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.Formule :C27H32N8O3Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :516.6EGFR-IN-61
CAS :EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Formule :C33H37ClN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.15GW 583340
CAS :GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.Formule :C28H25ClFN5O3S2Degré de pureté :98.68%Couleur et forme :SoildMasse moléculaire :598.11Ref: TM-T22827L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Biochanin A
CAS :Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.Formule :C16H12O5Degré de pureté :97.1% - 98.97%Couleur et forme :SolidMasse moléculaire :284.26BKI-1369
CAS :BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51Anti-EGFR Monoclonal Antibody-PE
Anti-EGFR Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-PE can be used in FACS.Degré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaPD 153035 Hydrochloride
CAS :Formule :C16H14BrN3O2·HClDegré de pureté :>97.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :396.67Calotatug ginistinag
CAS :Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate (ADC) aimed at targeting HER2. It is connected by a linker (XMT-1519 conjugate-1) to an effective payload that includes a STING agonist (STING agonist-20), presenting potential in immune activation and anti-tumor activity.Couleur et forme :LiquidEGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :90-120 KDa (reducing condition)EGFR-IN-90
EGFR-IN-90 (compound 34), an orally active EGFR inhibitor, demonstrates potent activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and effectivelyDegré de pureté :98%Couleur et forme :Odour SolidEpertinib
CAS :Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formule :C30H27ClFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02SU5204
CAS :SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFormule :C17H15NO2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :265.31PAT-505
CAS :PAT-505 is an autologous epidermal growth factor inhibitor.Formule :C23H18ClF2N3O2SDegré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :473.92Tesevatinib
CAS :Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.Formule :C24H25Cl2FN4O2Degré de pureté :97.89% - 97.89%Couleur et forme :SolidMasse moléculaire :491.39Ref: TM-TQ0166
1mg107,00€2mg156,00€5mg236,00€10mg457,00€25mg750,00€50mg1.026,00€1mL*10mM (DMSO)255,00€NS-062
CAS :NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.Formule :C28H30Cl2F2N6O4Couleur et forme :SolidMasse moléculaire :623.48ZD-4190
CAS :ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.Formule :C19H16BrFN6O2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :459.27Ref: TM-T5475
1mg85,00€5mg183,00€10mg275,00€25mg437,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)185,00€TAK-285
CAS :TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formule :C26H25ClF3N5O3Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :547.96Depatuxizumab MMAF
Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.Couleur et forme :LiquidMasse moléculaire :148.24 kDaCP-724714
CAS :CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2Formule :C27H27N5O3Degré de pureté :97.10% - 98.82%Couleur et forme :SolidMasse moléculaire :469.54Ref: TM-T4014
1mg44,00€2mg58,00€5mg95,00€10mg157,00€25mg273,00€50mg454,00€100mg660,00€1mL*10mM (DMSO)89,00€EAI001
CAS :EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formule :C19H15N3O2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :349.41Lazertinib
CAS :Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Formule :C30H34N8O3Degré de pureté :98.7% - 99.53%Couleur et forme :SolidMasse moléculaire :554.64Self-assembling peptide pY1
Self-assembling peptide pY1, which aggregates around cancer cells, specifically targets the EGFR receptor. When co-cultured with Ovalbumin (OVA), pY1 effectively inhibits the endocytosis of OVA.Formule :C104H125N24O29PCouleur et forme :SolidMasse moléculaire :2206.22EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :69.8 kDa (predicted). Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result.YS-363
CAS :YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), exhibiting half-maximal inhibitory concentrations (Formule :C30H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.58EGFR-IN-88
CAS :EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosisFormule :C22H18Cl2N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.37JGK-068S
CAS :Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].Formule :C22H23BrFN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.35Tyrphostin AG 1478
CAS :Formule :C16H14ClN3O2Degré de pureté :>98.0%(HPLC)Couleur et forme :Light orange to Yellow to Green powder to crystalMasse moléculaire :315.762H-1-Benzopyran-2-one, 7,8-dihydroxy-
CAS :Formule :C9H6O4Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :178.1415EGFR-IN-7
CAS :EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.Formule :C32H41BrN9O2PDegré de pureté :95.32% - 99.64%Couleur et forme :SolidMasse moléculaire :694.6Chalcone
CAS :Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively asFormule :C15H12ODegré de pureté :97.27%Couleur et forme :SolidMasse moléculaire :208.26Pelitinib
CAS :Formule :C24H23ClFN5O2Degré de pureté :>97.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :467.93ZM39923 hydrochloride
CAS :ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91Tesevatinib tosylate
CAS :Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.Formule :C31H33Cl2FN4O5SCouleur et forme :SolidMasse moléculaire :663.59EGFR-IN-5
CAS :EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.Formule :C31H38FN9ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :571.69Intetumumab
CAS :Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Couleur et forme :LiquidMasse moléculaire :145.6 (kDa)Desmethyl Erlotinib
CAS :Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).Formule :C21H21N3O4Degré de pureté :97.92% - 98.62%Couleur et forme :SolidMasse moléculaire :379.41Ref: TM-T6328
1mg52,00€2mg77,00€5mg115,00€10mg188,00€25mg331,00€50mg497,00€100mg720,00€1mL*10mM (DMSO)127,00€RTC-5
CAS :RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formule :C24H22ClF3N2O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :510.96Ref: TM-T12777
5mg52,00€10mg80,00€25mg169,00€50mg284,00€100mg411,00€500mg867,00€1mL*10mM (DMSO)59,00€Gefitinib hydrochloride
CAS :Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.Formule :C22H25Cl2FN4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :483.36Tyrphostin AG 528
CAS :Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).Formule :C18H14N2O3Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :306.32EGFR-IN-99
CAS :EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Formule :C25H22FN7O3Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :487.49AG1557
CAS :AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formule :C16H14IN3O2Degré de pureté :98.61% - 99.23%Couleur et forme :SolidMasse moléculaire :407.21Afatinib
CAS :Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Formule :C24H25ClFN5O3Degré de pureté :97.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94Ref: TM-T21312
5mg35,00€10mg51,00€25mg86,00€50mg115,00€100mg144,00€200mg177,00€500mg300,00€1mL*10mM (DMSO)52,00€SOS1/EGFR-IN-2
SOS1/EGFR-IN-2 (Compound 4) functions as a dual inhibitor of SOS1 and EGFR, exhibiting IC50 values of 8.3 and 14.6 nM, respectively. It demonstrates significant antiproliferative effects on cancer cells harboring various KRAS mutations.Formule :C25H29F3N4O3Couleur et forme :SolidMasse moléculaire :490.52Laprituximab
CAS :Laprituximab (J2898A) is a humanized anti-EGFR antibody used for synthesizing ADC compound Laprituximab emtansine.Degré de pureté :>95%Couleur et forme :LiquidCetuximab
CAS :Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).Formule :C107H179N35O36S7Degré de pureté :100.00% - SDS-PAGE:98.4%；SEC-HPLC: 99.7%Couleur et forme :LiquidMasse moléculaire :152 kDaEndoxifen (Z-isomer)
CAS :Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.Formule :C25H27NO2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :373.49Azerutamig
Azerutamig is a dual-specificity antibody targeting KLRK1/ERBB2 of type (H-γ1_L-κ)_scFvkh-H-γ1(h-CH2-CH3).Couleur et forme :Odour LiquidTyrphostin RG 14620
CAS :Formule :C14H8Cl2N2Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :275.13PD 174265
CAS :PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Formule :C17H15BrN4ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :371.23CH7233163
CH7233163 is a useful organic compound for research related to life sciences and the catalog number is T35334.Degré de pureté :98%Couleur et forme :SolidEGFR-IN-12
CAS :EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.Formule :C21H18F3N5ODegré de pureté :98.30% - 99.19%Couleur et forme :SolidMasse moléculaire :413.4Ref: TM-T5168
1mg82,00€5mg159,00€10mg259,00€25mg520,00€50mg740,00€100mg1.008,00€500mg2.015,00€1mL*10mM (DMSO)168,00€Sulforaphene
CAS :Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formule :C6H9NOS2Degré de pureté :98.01% - 99.19%Couleur et forme :Slightly Yellowish LiquidMasse moléculaire :175.27Ref: TM-TL0016
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg227,00€50mg338,00€100mg500,00€1mL*10mM (DMSO)69,00€SDZ281-977
CAS :SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formule :C18H20O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :316.35EGFR-TK-IN-5
EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.Formule :C26H20ClFN4OSCouleur et forme :SolidMasse moléculaire :490.98Mubritinib
CAS :Formule :C25H23F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.4709295999999Mutated EGFR-IN-2
CAS :Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formule :C29H35FN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.64Nazartinib
CAS :Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (Formule :C26H31ClN6O2Degré de pureté :98.31% - ≥95%Couleur et forme :Solid PowderMasse moléculaire :495.02Ref: TM-T3506
1mg37,00€5mg79,00€10mg119,00€25mg187,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)87,00€CL-387785
CAS :CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Formule :C18H13BrN4ODegré de pureté :96.68% - 98.09%Couleur et forme :SolidMasse moléculaire :381.23EGFR mutant-IN-1
EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.Formule :C34H39ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.17BMS-690514
CAS :BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.Formule :C19H24N6O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :368.43Astragaloside VI
CAS :Astragaloside VI could improve wound healing by activating the EGFR/ERK signaling pathway.Formule :C47H78O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :947.122EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-120 kDa based on Tris-Bis PAGE result.PD 158780
CAS :Formule :C14H12BrN5Degré de pureté :>97.0%(HPLC)Couleur et forme :White to Yellow to Green powder to crystalMasse moléculaire :330.19WAY-270360
CAS :WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.Formule :C22H19N3O3Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :373.4Protopine hydrochloride
CAS :Protopine inhibits thromboxane, lowers intracellular calcium, and reduces cell adhesion by altering adhesive factors.Formule :C20H20ClNO5Degré de pureté :98%Couleur et forme :Prisms From Alc SolidMasse moléculaire :389.83MAPK-IN-2
MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cellFormule :C20H11Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.23JCN037
CAS :JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Formule :C16H11BrFN3O2Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :376.18Ref: TM-T8431
2mg40,00€5mg74,00€10mg105,00€25mg178,00€50mg273,00€100mg391,00€200mg557,00€1mL*10mM (DMSO)84,00€Rilzabrutinib
CAS :Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).Formule :C36H40FN9O3Degré de pureté :97.87% - 99.76%Couleur et forme :SolidMasse moléculaire :665.76Ref: TM-T12542
1mg99,00€5mg235,00€10mg376,00€25mg655,00€50mg944,00€100mg1.320,00€500mg2.642,00€1mL*10mM (DMSO)344,00€WZ-3146
CAS :WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).Formule :C24H25ClN6O2Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :464.95Ref: TM-T6733
1mg52,00€2mg74,00€5mg97,00€10mg180,00€25mg319,00€50mg510,00€100mg730,00€1mL*10mM (DMSO)106,00€EGFR-IN-123
CAS :EGFR-IN-123 (compound D06) is an effective EGFR inhibitor. It exhibits inhibitory activity against several cell lines including PC-9G, A549, A431, and HCT116, with IC50 values of 0.74, 1.36, 1.20, and 2.53 μM respectively.Formule :C24H27F3N6OCouleur et forme :SolidMasse moléculaire :472.51BGB-102
CAS :BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.Formule :C22H25BrN4O2Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :457.36Erlotinib Hydrochloride
CAS :Formule :C22H23N3O4·HClDegré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :429.90WS3
CAS :WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formule :C28H30F3N7O3Degré de pureté :97.93% - 98.81%Couleur et forme :SolidMasse moléculaire :569.58DBPR112
CAS :DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formule :C32H31N5O3Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :533.62NSC 228155
CAS :NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formule :C11H6N4O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :290.25Ref: TM-T6908
2mg35,00€5mg50,00€10mg66,00€25mg125,00€50mg205,00€100mg369,00€200mg495,00€1mL*10mM (DMSO)52,00€SU5214
CAS :SU5214 is a modulator of tyrosine kinase signal transduction.Formule :C16H13NO2Degré de pureté :99.45% - 99.55%Couleur et forme :SolidMasse moléculaire :251.28JBJ-07-149
CAS :JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 μM when used alone, and 0.148 μM when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].Formule :C28H26N6O2SCouleur et forme :SolidMasse moléculaire :510.61
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