EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
Produits appartenant à la catégorie "EGFR"
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20(S)-Ginsenoside Rg3
CAS :20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formule :C42H72O13Degré de pureté :100% - 99.93%Couleur et forme :SolidMasse moléculaire :785.01EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Couleur et forme :Lyophilized PowderMasse moléculaire :41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.PD153035 hydrochloride
CAS :PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.Formule :C16H15BrClN3O2Degré de pureté :99.39% - ≥95%Couleur et forme :SolidMasse moléculaire :396.67Erlotinib hydrochloride
CAS :Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formule :C22H23N3O4·HClDegré de pureté :99.78% - 99.85%Couleur et forme :White Or Off-White PowderMasse moléculaire :429.9β-Hydroxyisovalerylshikonin
CAS :Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumorFormule :C21H24O7Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :388.41Cavutilide
CAS :Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.Formule :C22H26FN3O3Degré de pureté :99.26% - 99.70%Couleur et forme :SolidMasse moléculaire :399.458Methyl 2,5-Dihydroxycinnamate
CAS :Formule :C10H10O4Degré de pureté :>96.0%(HPLC)Couleur et forme :White to Yellow powder to crystalMasse moléculaire :194.19Falnidamol
CAS :Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formule :C18H19ClFN7Degré de pureté :96.46%Couleur et forme :SolidMasse moléculaire :387.84Ref: TM-TQ0271
2mg42,00€5mg64,00€10mg101,00€25mg192,00€50mg335,00€100mg462,00€200mg645,00€1mL*10mM (DMSO)64,00€Canertinib
CAS :Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.Formule :C24H25ClFN5O3Degré de pureté :100% - 99.18%Couleur et forme :White Or Similar To White Crystalline PowderMasse moléculaire :485.94AZ7550
CAS :AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formule :C27H31N7O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :485.58EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Formule :C25H18N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :422.44TX2-120-1
CAS :TX2-120-1 possesses the ability to bind with Her3, exhibiting an IC50 of 56 nM for Her3. It can be utilized in the synthesis of TX2-121-1.Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.544-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
CAS :Formule :C16H16ClN3O3Degré de pureté :97.0%Masse moléculaire :333.7695EGFR-IN-73
CAS :EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formule :C19H17ClFN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.81WHI-P258
CAS :WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.Formule :C16H15N3O2Degré de pureté :99.64% - 99.95%Couleur et forme :SolidMasse moléculaire :281.31AG490
CAS :AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formule :C17H14N2O3Degré de pureté :98.6% - 99.39%Couleur et forme :Yellow SolidMasse moléculaire :294.3EGFR-IN-81
EGFR-IN-81 (Compound 10i), an EGFR inhibitor, demonstrates potent activity by inhibiting EGFR WT and the L858R/T790M mutation at IC50 values of 4.38 nM and 5.69Formule :C28H24F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :551.52LCH-7749944
CAS :LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Formule :C20H22N4O2Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :350.41Ref: TM-T11826
1mg49,00€5mg108,00€10mg164,00€25mg284,00€50mg424,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)116,00€WHI-P180 Hydrochloride
CAS :Formule :C16H15N3O3·HClDegré de pureté :>97.0%(T)(HPLC)Couleur et forme :White to Light gray to Light yellow powder to crystalMasse moléculaire :333.77Methyl 2,5-dihydroxycinnamate
CAS :Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.Formule :C10H10O4Degré de pureté :98.98%Couleur et forme :CrystallineMasse moléculaire :194.18HG-14-10-04
CAS :HG-14-10-04 is a potent and specific ALK inhibitor.Formule :C29H34ClN7ODegré de pureté :100% - 99.75%Couleur et forme :SolidMasse moléculaire :532.08EGFR Protein, Human, Recombinant (His & Avi)
EGFR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :71.5 kDa (predicted). Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.Necitumumab
Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.Couleur et forme :LiquidMasse moléculaire :145.5 kDaChrysophanol
CAS :Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.Formule :C15H10O4Degré de pureté :97.91% - 99.7%Couleur et forme :Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMasse moléculaire :254.24Ligustroside
CAS :Ligustroside mildly inhibits PGE2, has slight antioxidant and anti-inflammatory effects, and is moderately antiviral against parainfluenza 3.Formule :C25H32O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :524.512-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)-
CAS :Formule :C18H24N2OSDegré de pureté :95%Couleur et forme :SolidMasse moléculaire :316.461CUDC-101
CAS :CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.Formule :C24H26N4O4Degré de pureté :95.76% - 99.17%Couleur et forme :SolidMasse moléculaire :434.49Tucatinib
CAS :Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).Formule :C26H24N8O2Degré de pureté :99.05% - 99.96%Couleur et forme :SolidMasse moléculaire :480.52Ref: TM-T2364
1g1.130,00€2mg35,00€5mg49,00€10mg79,00€25mg124,00€50mg187,00€100mg350,00€500mg825,00€1mL*10mM (DMSO)87,00€EGFR-IN-129
EGFR-IN-129 (Compound 10b) is an effective, selective EGFR inhibitor with an IC50 of 51.2 nM and demonstrates broad-spectrum antiproliferative activity against the NCI tumor panel.Formule :C21H18N4O3SCouleur et forme :SolidMasse moléculaire :406.46EGFR/CDK2-IN-3
EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively.Formule :C30H20N6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.58Sevabertinib
CAS :Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.Formule :C24H25ClN4O5Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :484.93EGFR-IN-122
CAS :EGFR-IN-122 (compound Yfq07) serves as a potent inhibitor of EGFR. It effectively inhibits the proliferation of PC-9GR and HCC827GR cells.Formule :C19H20N4O3Couleur et forme :SolidMasse moléculaire :352.39Butein
CAS :Formule :C15H12O5Degré de pureté :>98.0%(HPLC)Couleur et forme :Light yellow to Brown powder to crystalMasse moléculaire :272.26EGFR-IN-133
CAS :EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.Formule :C27H29F2N7O3Couleur et forme :SolidMasse moléculaire :537.56Lapatinib
CAS :Formule :C29H26ClFN4O4SDegré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :581.06Khellin
CAS :Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Formule :C14H12O5Degré de pureté :99.85% - 99.95%Couleur et forme :Light Yellow CrystallineMasse moléculaire :260.24Lapatinib
CAS :Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formule :C29H26ClFN4O4SDegré de pureté :99.00% - 99.81%Couleur et forme :PowderMasse moléculaire :581.06Depatuxizumab
CAS :Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograftDegré de pureté :98%Couleur et forme :LiquidAnti-EGFR Antibody (3B845)
Anti-EGFR Antibody (3B845) is an antibody targeting EGFR. Anti-EGFR Antibody (3B845) can be used in ELISA, WB, IHC.Couleur et forme :Odour LiquidPetosemtamab (FUT8-KO)
Petosemtamab (FUT8-KO) is a variant of Petosemtamab with the fucosyltransferase 8 gene (FUT8) knocked out. Petosemtamab is a monoclonal antibody (mAb) targeting EGFR (with a Kd of 0.22 nM) and LGR5 (with a Kd of 0.86 nM). This antibody disrupts EGFR signaling and causes receptor degradation in LGR5+ cancer cells. It is applicable in research on solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).Couleur et forme :Odour LiquidMobocertinib
CAS :Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agentFormule :C32H39N7O4Degré de pureté :98.66% - 99.47%Couleur et forme :SolidMasse moléculaire :585.7Saracatinib
CAS :Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.Formule :C27H32ClN5O5Degré de pureté :98% - 99.63%Couleur et forme :SolidMasse moléculaire :542.03SJF 1521
CAS :SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.Formule :C57H61ClFN7O9SDegré de pureté :99.20%Couleur et forme :SolidMasse moléculaire :1074.65TYRPHOSTIN AG 528
CAS :Formule :C18H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.3154HER2-IN-21
CAS :HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.Formule :C20H18N4O3SCouleur et forme :SolidMasse moléculaire :394.4474H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS :Formule :C15H10O5Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :270.2369Cisapride hydrate
CAS :Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.Formule :C23H31ClFN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.96EGFR/CDK2-IN-4
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2.Formule :C24H16N6OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.55Anti-EGFR Monoclonal Antibody
Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: HumanDegré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaPred17
Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.Formule :C27H22BN3OCouleur et forme :SolidMasse moléculaire :415.29
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