EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
Produits appartenant à la catégorie "EGFR"
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Naquotinib mesylate
CAS :Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFormule :C31H46N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.81SYR127063
CAS :SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.Formule :C23H20ClF3N4O3Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :492.88Icotinib
CAS :Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formule :C22H21N3O4Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :391.42Ref: TM-T6153
1mg48,00€2mg64,00€5mg96,00€10mg155,00€25mg283,00€50mg527,00€100mg712,00€1mL*10mM (DMSO)97,00€KI8751
CAS :KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.Formule :C24H18F3N3O4Degré de pureté :99.22% - 99.9%Couleur et forme :SolidMasse moléculaire :469.41Ref: TM-T2446
2mg37,00€5mg52,00€10mg86,00€25mg156,00€50mg294,00€100mg472,00€200mg670,00€1mL*10mM (DMSO)56,00€PD-089828
CAS :PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Formule :C18H18Cl2N6ODegré de pureté :96.78%Couleur et forme :SolidMasse moléculaire :405.28Mutant EGFR inhibitor
CAS :Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.Formule :C27H30ClN7O2Degré de pureté :96.21% - 98%Couleur et forme :SolidMasse moléculaire :520.03Ref: TM-T2705
1mg37,00€2mg52,00€5mg80,00€10mg97,00€25mg168,00€50mg264,00€100mg379,00€500mgÀ demander1mL*10mM (DMSO)104,00€Cloperastine fendizoate
CAS :Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formule :C40H38ClNO5Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :648.19Avitinib
CAS :Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,Formule :C26H26FN7O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :487.53Tyrosine kinase-IN-7
CAS :Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity.Formule :C16H15N3OSDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :297.38EGFR-IN-130
EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.Formule :C27H25N3O6SCouleur et forme :SolidMasse moléculaire :519.57Trastuzumab
CAS :Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Degré de pureté :98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Couleur et forme :LiquidMasse moléculaire :Approximately 145.53 kDaEGFR-IN-138
EGFR-IN-138 (compound 19) is a potent inhibitor of EGFR, with IC50 values of 37, 2.6, and 1.9 nM for the wild-type, L858R, and T790M EGFR, respectively.Formule :C42H37N7O5Couleur et forme :SolidMasse moléculaire :719.79Modotuximab
CAS :Modotuximab (DS 1024) is a humanized antibody targeting EGFR with antitumor activity that accelerates the internalization and degradation of EGFR.Degré de pureté :95% - 95%Couleur et forme :LiquidAZ7550 hydrochloride
CAS :AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formule :C27H32ClN7O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :522.04N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine
CAS :Formule :C29H26ClFN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.0575Tilatamig
Tilatamig is a humanized antibody of the Ig(G1-κ, G1-λ2) type targeting EGFR/MET.Couleur et forme :Odour LiquidEGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Couleur et forme :Lyophilized PowderMasse moléculaire :41.6 kDa (predicted). Due to glycosylation, the protein migrates to 60-78 kDa based on Tris-Bis PAGE result.Anti-EGFR Monoclonal Antibody-AF647
Anti-EGFR Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF647 can be used in FACS.Degré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaNeptinib
CAS :Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.Formule :C22H23ClFN5O2Couleur et forme :SolidMasse moléculaire :443.90EGFR-IN-84
EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 μM and is utilized for lungFormule :C25H20N6O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.59Serclutamab
CAS :Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).Degré de pureté :98%Couleur et forme :LiquidAnti-Phospho-EGFR (Tyr1068) Antibody (3Q245)
Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) is an antibody targeting Phospho-EGFR (Tyr1068). Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) can be used in ELISA, WB.Couleur et forme :Odour LiquidAZD8931 diFuMaric acid
CAS :AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).Formule :C31H33ClFN5O11Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :706.1Ref: TM-T8751
1mg88,00€5mg172,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)255,00€Caxmotabart
Caxmotabart is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.Couleur et forme :Odour LiquidAnti-Phospho-EGFR (Tyr1092) Antibody (9I899)
Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) is an antibody targeting Phospho-EGFR (Tyr1092). Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) can be used in ELISA, WB.Couleur et forme :Odour LiquidMubritinib
CAS :Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.Formule :C25H23F3N4O2Degré de pureté :98.61% - 99.87%Couleur et forme :SolidMasse moléculaire :468.47Daphnetin
CAS :Formule :C9H6O4Degré de pureté :>90.0%(HPLC)Couleur et forme :White to Light yellow to Light red powder to crystalMasse moléculaire :178.14DZD1516
CAS :DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in bothFormule :C28H27F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.56SKLB 1028
CAS :SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.Formule :C24H29N9Degré de pureté :99.71% - 99.85%Couleur et forme :SolidMasse moléculaire :443.55Ref: TM-T34656
1mg56,00€5mg119,00€10mg187,00€25mg378,00€50mg560,00€100mg800,00€500mg1.644,00€1mL*10mM (DMSO)143,00€(E/Z)-CP-724714
CAS :(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formule :C27H27N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54Limertinib
CAS :Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Formule :C29H32ClN7O2Degré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :546.06Ref: TM-T35897
1mg90,00€5mg187,00€10mg316,00€25mg637,00€50mg827,00€100mg1.169,00€200mg1.586,00€1mL*10mM (DMSO)250,00€Tuxobertinib
CAS :Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.Formule :C29H29ClN6O4Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :561.03Ref: TM-T9072
2mg40,00€5mg60,00€10mg96,00€25mg188,00€50mg354,00€100mg525,00€200mg752,00€1mL*10mM (DMSO)74,00€EGFR-IN-149
CAS :EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.Formule :C16H15N3OSCouleur et forme :SolidMasse moléculaire :297.375Matuzumab
CAS :Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :145.9 kDaNorcantharidin
CAS :Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.Formule :C8H8O4Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :168.15Sunvozertinib
CAS :Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.Formule :C29H35ClFN7O3Degré de pureté :98.11% - 99.71%Couleur et forme :SolidMasse moléculaire :584.08Ref: TM-T64124
1mg35,00€5mg64,00€10mg89,00€25mg131,00€50mg212,00€100mg373,00€500mg1.388,00€1mL*10mM (DMSO)159,00€ZM323881 hydrochloride
CAS :ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formule :C22H19ClFN3O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :411.86Genistein
CAS :Formule :C15H10O5Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :270.24WS6
CAS :WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formule :C29H31F3N6O3Degré de pureté :97.23% - 99.83%Couleur et forme :SolidMasse moléculaire :568.59(Rac)-JBJ-04-125-02
CAS :(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.Formule :C29H26FN5O3SDegré de pureté :95.85%Couleur et forme :SolidMasse moléculaire :543.61Ref: TM-T8872
1mg105,00€5mg216,00€10mg354,00€25mg597,00€50mg852,00€100mg1.159,00€1mL*10mM (DMSO)263,00€TYRPHOSTIN RG 13022
CAS :Formule :C16H14N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :266.29456000000005AV-412
CAS :AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Formule :C41H44ClFN6O7S2Degré de pureté :99.85% - 99.92%Couleur et forme :SolidMasse moléculaire :851.41Ref: TM-T10419
1mg44,00€2mg58,00€5mg95,00€10mg144,00€25mg254,00€50mg424,00€100mg613,00€1mL*10mM (DMSO)136,00€MAZ51
CAS :MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formule :C21H18N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :314.38D-69491 hydrochloride
CAS :D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.Formule :C25H26Cl2FN7O3Couleur et forme :SolidMasse moléculaire :562.42Petosemtamab
CAS :Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :145.97 kDaTyrphostin AG 879
CAS :Formule :C18H24N2OSDegré de pureté :>98.0%(HPLC)Couleur et forme :Light yellow to Yellow to Orange powder to crystalMasse moléculaire :316.46AZD3759 hydrochloride
CAS :AZD3759 hydrochloride is an oral, CNS-penetrant EGFR inhibitor with IC50s of 0.2/0.3/0.2 nM.Formule :C22H24Cl2FN5O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :496.36Ref: TM-T4249
2mg35,00€5mg48,00€10mg65,00€25mg99,00€50mg170,00€100mg280,00€200mg406,00€1mL*10mM (DMSO)51,00€Tyrphostin AG 112
CAS :Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formule :C13H8N4ODegré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :236.23Allitinib
CAS :Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Formule :C24H18ClFN4O2Degré de pureté :99.10% - 99.28%Couleur et forme :SolidMasse moléculaire :448.88Ref: TM-T14336
1mg52,00€5mg111,00€10mg175,00€25mg329,00€50mg494,00€100mg700,00€1mL*10mM (DMSO)135,00€Alflutinib mesylate
CAS :Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.Formule :C29H35F3N8O5SDegré de pureté :97.94% - 99.81%Couleur et forme :SolidMasse moléculaire :664.7
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