EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
Produits appartenant à la catégorie "EGFR"
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Osimertinib dimesylate
CAS :Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Formule :C30H41N7O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :691.82PD-161570
CAS :PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formule :C26H35Cl2N7ODegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :532.51Ref: TM-T23127
1mg35,00€5mg92,00€10mg149,00€25mg305,00€50mg492,00€100mg700,00€200mg938,00€1mL*10mM (DMSO)125,00€AG 555
CAS :AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.Formule :C19H18N2O3Degré de pureté :100% - 99.51%Couleur et forme :SolidMasse moléculaire :322.36Chamigrenal
CAS :β-Chamigrenal: Anti-inflammatory, inhibits NO and PGE2 in macrophages, PAF antagonist (IC50=1.2x10^-4 M), weakly cytotoxic to MCF-7 (IC50=30.50 uM).Formule :C15H22ODegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :218.33EGFR-IN-76
CAS :EGFR-IN-76 is a potent EGFR inhibitor.Formule :C30H30ClFN6O2Degré de pureté :97.02% - 97.72%Couleur et forme :SolidMasse moléculaire :561.05U3-1565
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.Couleur et forme :LiquidMasse moléculaire :144.82 kDa (Predicted)AV-412 free base
CAS :AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Formule :C27H28ClFN6OCouleur et forme :SolidMasse moléculaire :507Leptomycin B
CAS :Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formule :C33H48O6Degré de pureté :99.04% - 99.71%Couleur et forme :White Crystalline SolidMasse moléculaire :540.73Ref: TM-T15735
1mg202,00€2mg341,00€5mg620,00€10mg882,00€25mg1.320,00€50mg1.776,00€100mg2.403,00€1mL*10mM (DMSO)283,00€PF-6274484
CAS :PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Formule :C18H14ClFN4O2Degré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :372.78Ref: TM-T22396
2mg40,00€5mg60,00€10mg92,00€25mg187,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)66,00€EGFR-IN-1
CAS :EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.Formule :C28H30N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58Anti-EGFR Monoclonal Antibody-AF555
Anti-EGFR Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF555 can be used in FACS.Degré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaAlmonertinib
CAS :Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.Formule :C30H35N7O2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :525.64Ref: TM-T5462
1mg89,00€5mg197,00€10mg311,00€25mg525,00€50mg757,00€100mg1.035,00€500mg2.110,00€1mL*10mM (DMSO)249,00€EBE-A22
CAS :EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.Formule :C17H16BrN3O2Degré de pureté :99.85% - 99.88%Couleur et forme :SolidMasse moléculaire :374.234-Epidoxycycline
CAS :4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.Formule :C22H24N2O8Couleur et forme :SolidMasse moléculaire :444.44EGFR-IN-132
CAS :EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.Formule :C27H31N7O3Couleur et forme :SolidMasse moléculaire :501.58AEE 788
CAS :Formule :C27H32N6Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :440.60Pyrotinib dimaleate
CAS :Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.Formule :C40H39ClN6O11Degré de pureté :98.07% - 99.52%Couleur et forme :SolidMasse moléculaire :815.22Ref: TM-T12594
1mg155,00€5mg457,00€10mg610,00€25mg947,00€50mg1.301,00€100mg1.758,00€1mL*10mM (DMSO)620,00€(E)-AG 556
CAS :AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.Formule :C20H20N2O3Degré de pureté :99.48%Couleur et forme :Light Yellow PowderMasse moléculaire :336.38JAK 3 inhibitor IV
CAS :JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found toFormule :C16H19NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :241.33PP 3
CAS :PP 3 is a Negative control for the Src kinase inhibitor PP 2Formule :C11H9N5Degré de pureté :98.61%Couleur et forme :Whit To Off-White SolidMasse moléculaire :211.22Ref: TM-T23176
5mg51,00€10mg79,00€25mg140,00€50mg202,00€100mg305,00€500mg733,00€1mL*10mM (DMSO)55,00€AG-494
CAS :AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Formule :C16H12N2O3Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :280.28(±)-Norcantharidin
CAS :(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.Formule :C8H8O4Degré de pureté :99.43% - ≥98%Couleur et forme :SolidMasse moléculaire :168.15Mubritinib
CAS :Formule :C25H23F3N4O2Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Gray to Brown powder to crystalMasse moléculaire :468.48A-935142
CAS :A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formule :C18H19F3N2O2Degré de pureté :100% - 100%Couleur et forme :SolidMasse moléculaire :352.35Tyrphostin AG 490
CAS :Formule :C17H14N2O3Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :294.31EGFR-IN-1 hydrochloride
CAS :EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.Formule :C28H31ClN6O4Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :551.04Ref: TM-T11157L
1mg65,00€5mg150,00€10mg215,00€25mg338,00€50mg452,00€100mg620,00€200mg838,00€1mL*10mM (DMSO)202,00€Mavelertinib
CAS :Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Formule :C18H22FN9O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :415.42Lumretuzumab
CAS :Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.Couleur et forme :LiquidEGFR-IN-82
CAS :EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/Formule :C32H41BrN9O2PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :694.6Almonertinib mesylate
CAS :Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Formule :C31H39N7O5SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :621.75Ref: TM-T9865
1mg55,00€5mg116,00€10mg187,00€25mg319,00€50mg449,00€100mg638,00€200mg840,00€1mL*10mM (DMSO)170,00€EGFR-IN-126
CAS :EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.Formule :C28H28BrFN4O3Couleur et forme :SolidMasse moléculaire :567.45Gefitinib-based PROTAC 3
CAS :Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).Formule :C47H57ClFN7O8SDegré de pureté :97.29% - 98.25%Couleur et forme :SolidMasse moléculaire :934.51HKI-357
CAS :HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.Formule :C31H29ClFN5O3Degré de pureté :95.11%Couleur et forme :SolidMasse moléculaire :574.05Ref: TM-T11569
1mg79,00€5mg153,00€10mg227,00€25mg462,00€50mg662,00€100mg938,00€1mL*10mM (DMSO)187,00€Vandetanib
CAS :Formule :C22H24BrFN4O2Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :475.36EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formule :C50H49N11O5SCouleur et forme :SolidMasse moléculaire :916.062-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-
CAS :Formule :C18H13BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.226Osimertinib
CAS :Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.Formule :C28H33N7O2Degré de pureté :100% - 99.83%Couleur et forme :SolidMasse moléculaire :499.61Ref: TM-T2490
1g154,00€2mg38,00€5mg52,00€10mg62,00€25mg74,00€50mg88,00€100mg103,00€200mg115,00€500mg127,00€1mL*10mM (DMSO)52,00€Barecetamab
CAS :Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Couleur et forme :LiquidWHI-P154
CAS :Formule :C16H14BrN3O3Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Yellow to Orange powder to crystalMasse moléculaire :376.21Dacomitinib hydrate
CAS :Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family ofFormule :C24H27ClFN5O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :487.96Ref: TM-T19965
5mg50,00€10mg80,00€25mg105,00€50mg140,00€100mg212,00€200mg311,00€1mL*10mM (DMSO)60,00€4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-
CAS :Formule :C16H14ClN3O2Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :315.75426000000004Propanedinitrile,2-[(4-methoxyphenyl)methylene]-
CAS :Formule :C11H8N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :184.194EGFR-IN-8
CAS :EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLCFormule :C32H23ClF3N7O4Degré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :662.02GW 583340 dihydrochloride
CAS :GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03PD168393
CAS :PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formule :C17H13BrN4ODegré de pureté :99.13% - 99.7%Couleur et forme :SolidMasse moléculaire :369.22Ref: TM-T6932
1mg39,00€2mg49,00€5mg66,00€10mg89,00€25mg155,00€50mg222,00€100mg310,00€1mL*10mM (DMSO)56,00€MTX-211
CAS :MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.Formule :C20H14Cl2FN5O2SDegré de pureté :100% - 97.28%Couleur et forme :SolidMasse moléculaire :478.33Ref: TM-T4296
1mg64,00€5mg187,00€10mg284,00€25mg467,00€50mg645,00€100mg873,00€200mg1.159,00€1mL*10mM (DMSO)190,00€EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :60-90 KDa (reducing condition)Trastuzumab rezetecan
CAS :Trastuzumab rezetecan (SHR-A1811) is an antibody-drug conjugate (ADC) targeting HER2. It is composed of a humanized anti-HER2 antibody, a cleavable linker MC-Gly-Gly-Phe-Gly, and an effective payload of the topoisomerase I inhibitor Rezetecán. Trastuzumab rezetecan is utilized in the research of HER2-positive breast cancer.Couleur et forme :LiquidEpertinib hydrochloride
CAS :Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.Formule :C30H28Cl2FN5O3Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :596.48Ref: TM-T11213
1mg92,00€5mg188,00€10mg311,00€25mg533,00€50mg755,00€100mg1.017,00€500mg2.043,00€1mL*10mM (DMSO)255,00€Benidipine hydrochloride
CAS :Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.Formule :C28H32ClN3O6Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :542.03
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