EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
Produits appartenant à la catégorie "EGFR"
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AG-1478
CAS :AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.Formule :C16H14ClN3O2Degré de pureté :99.03% - 99.71%Couleur et forme :SolidMasse moléculaire :315.75EGFR-IN-147
CAS :EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.Formule :C13H13N5OCouleur et forme :SolidMasse moléculaire :255.275Neratinib
CAS :Formule :C30H29ClN6O3Degré de pureté :>95.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :557.05Tyrphostin A1
CAS :Formule :C11H8N2ODegré de pureté :>98.0%(GC)Couleur et forme :Light orange to Yellow to Green powder to crystalMasse moléculaire :184.20Lapatinib ditosylate monohydrate
CAS :Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.Formule :C29H26ClFN4O4S·2(C7H8O3S)·H2ODegré de pureté :98% - 99.41%Couleur et forme :Colourless To Light-Yellow CrystalMasse moléculaire :943.47TX1-85-1
CAS :TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Formule :C32H36N8O3Degré de pureté :98.12% - 98.12%Couleur et forme :SolidMasse moléculaire :580.68WHI-P154
CAS :WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formule :C16H14BrN3O3Degré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :376.2Sapitinib
CAS :Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib orFormule :C23H25ClFN5O3Degré de pureté :98.89% - 99.83%Couleur et forme :SolidMasse moléculaire :473.93Alflutinib
CAS :Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.Formule :C28H31F3N8O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :568.59Ref: TM-T22254
1mg213,00€5mg435,00€10mg620,00€25mg938,00€50mg1.320,00€100mg1.786,00€1mL*10mM (DMSO)560,00€EGFR-IN-128
EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.Formule :C27H20N4OCouleur et forme :SolidMasse moléculaire :416.47Nezutatug
CAS :Nezutatug, an anti-HER3 antibody, serves as a research tool in cancer studies [1].Degré de pureté :98%Couleur et forme :LiquidBPI-15086
CAS :BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.Formule :C29H33ClN8O4Couleur et forme :SolidMasse moléculaire :593.08FRF-06-057
FRF-06-057 is an allosteric ATP EGFR inhibitor targeting both wild-type and mutant EGFR, with IC50 values of 17 nM (LR/TM), 29 nM (LR/TM/CS), 220 nM (LR), and >1000 nM (WT).Formule :C19H13N3O3SCouleur et forme :SolidMasse moléculaire :363.39Tyrphostin AG30
CAS :Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.Formule :C10H7NO4Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :205.17Labuxtinib
CAS :Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formule :C20H16FN5O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :377.37Ref: TM-T79851
1mg139,00€5mg338,00€10mg540,00€25mg1.074,00€50mg1.549,00€100mg2.080,00€200mg2.802,00€1mL*10mM (DMSO)374,00€Anti-EGFR Monoclonal Antibody-AF488
Anti-EGFR Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF488 can be used in FACS.Degré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaDacomitinib
CAS :Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.Formule :C24H25ClFN5O2Degré de pureté :100% - 99.72%Couleur et forme :SolidMasse moléculaire :469.94Ref: TM-T2483
1mg38,00€2mg49,00€5mg79,00€10mg127,00€25mg173,00€50mg227,00€100mg354,00€200mg444,00€500mg730,00€1mL*10mM (DMSO)79,00€Rezivertinib
CAS :Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formule :C27H30N6O3Degré de pureté :99.43% - 99.89%Couleur et forme :SolidMasse moléculaire :486.57Ref: TM-T36644
1mg99,00€5mg226,00€10mg364,00€25mg702,00€50mg947,00€100mg1.264,00€200mg1.700,00€1mL*10mM (DMSO)47,00€JH-XI-10-02
CAS :JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.Formule :C53H69N5O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :920.161EGFR/BRAFV600E-IN-2
E07 Aptamer, targeting the human epidermal growth factor receptor (hEGFR), competes with epidermal growth factor (EGF) for binding to a unique epitope on EGFR.Formule :C25H18N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.44BGB-8035
CAS :BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.Formule :C24H31N5O4Degré de pureté :96.74%Couleur et forme :SolidMasse moléculaire :453.53Larotinib
CAS :Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.Formule :C24H26ClFN4O4Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :488.94BEBT-109
CAS :BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.Formule :C27H32N8O3Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :516.6EGFR-IN-61
CAS :EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Formule :C33H37ClN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.15GW 583340
CAS :GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.Formule :C28H25ClFN5O3S2Degré de pureté :98.68%Couleur et forme :SoildMasse moléculaire :598.11Ref: TM-T22827L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Biochanin A
CAS :Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.Formule :C16H12O5Degré de pureté :97.1% - 98.97%Couleur et forme :SolidMasse moléculaire :284.26BKI-1369
CAS :BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51Anti-EGFR Monoclonal Antibody-PE
Anti-EGFR Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-PE can be used in FACS.Degré de pureté :> 95% as determined by SDS-PAGE.Couleur et forme :LiquidMasse moléculaire :150 kDaPD 153035 Hydrochloride
CAS :Formule :C16H14BrN3O2·HClDegré de pureté :>97.0%(HPLC)Couleur et forme :White to Light yellow to Light orange powder to crystalMasse moléculaire :396.67Calotatug ginistinag
CAS :Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate (ADC) aimed at targeting HER2. It is connected by a linker (XMT-1519 conjugate-1) to an effective payload that includes a STING agonist (STING agonist-20), presenting potential in immune activation and anti-tumor activity.Couleur et forme :LiquidEGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.Couleur et forme :Lyophilized PowderMasse moléculaire :90-120 KDa (reducing condition)EGFR-IN-90
EGFR-IN-90 (compound 34), an orally active EGFR inhibitor, demonstrates potent activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and effectivelyDegré de pureté :98%Couleur et forme :Odour SolidEpertinib
CAS :Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formule :C30H27ClFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02SU5204
CAS :SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFormule :C17H15NO2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :265.31PAT-505
CAS :PAT-505 is an autologous epidermal growth factor inhibitor.Formule :C23H18ClF2N3O2SDegré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :473.92Tesevatinib
CAS :Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.Formule :C24H25Cl2FN4O2Degré de pureté :97.89% - 97.89%Couleur et forme :SolidMasse moléculaire :491.39Ref: TM-TQ0166
1mg107,00€2mg156,00€5mg236,00€10mg457,00€25mg750,00€50mg1.026,00€1mL*10mM (DMSO)255,00€NS-062
CAS :NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.Formule :C28H30Cl2F2N6O4Couleur et forme :SolidMasse moléculaire :623.48ZD-4190
CAS :ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.Formule :C19H16BrFN6O2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :459.27Ref: TM-T5475
1mg85,00€5mg183,00€10mg275,00€25mg437,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)185,00€TAK-285
CAS :TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formule :C26H25ClF3N5O3Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :547.96Depatuxizumab MMAF
Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.Couleur et forme :LiquidMasse moléculaire :148.24 kDaCP-724714
CAS :CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2Formule :C27H27N5O3Degré de pureté :97.10% - 98.82%Couleur et forme :SolidMasse moléculaire :469.54Ref: TM-T4014
1mg44,00€2mg58,00€5mg95,00€10mg157,00€25mg273,00€50mg454,00€100mg660,00€1mL*10mM (DMSO)89,00€EAI001
CAS :EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formule :C19H15N3O2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :349.41Lazertinib
CAS :Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Formule :C30H34N8O3Degré de pureté :98.7% - 99.53%Couleur et forme :SolidMasse moléculaire :554.64Self-assembling peptide pY1
Self-assembling peptide pY1, which aggregates around cancer cells, specifically targets the EGFR receptor. When co-cultured with Ovalbumin (OVA), pY1 effectively inhibits the endocytosis of OVA.Formule :C104H125N24O29PCouleur et forme :SolidMasse moléculaire :2206.22EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :69.8 kDa (predicted). Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result.YS-363
CAS :YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), exhibiting half-maximal inhibitory concentrations (Formule :C30H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.58EGFR-IN-88
CAS :EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosisFormule :C22H18Cl2N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.37JGK-068S
CAS :Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].Formule :C22H23BrFN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.35Tyrphostin AG 1478
CAS :Formule :C16H14ClN3O2Degré de pureté :>98.0%(HPLC)Couleur et forme :Light orange to Yellow to Green powder to crystalMasse moléculaire :315.76
