EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
Produits appartenant à la catégorie "EGFR"
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2H-1-Benzopyran-2-one, 7,8-dihydroxy-
CAS :Formule :C9H6O4Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :178.1415EGFR-IN-7
CAS :EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.Formule :C32H41BrN9O2PDegré de pureté :95.32% - 99.64%Couleur et forme :SolidMasse moléculaire :694.6Chalcone
CAS :Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively asFormule :C15H12ODegré de pureté :97.27%Couleur et forme :SolidMasse moléculaire :208.26Pelitinib
CAS :Formule :C24H23ClFN5O2Degré de pureté :>97.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :467.93ZM39923 hydrochloride
CAS :ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91Tesevatinib tosylate
CAS :Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.Formule :C31H33Cl2FN4O5SCouleur et forme :SolidMasse moléculaire :663.59EGFR-IN-5
CAS :EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.Formule :C31H38FN9ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :571.69Intetumumab
CAS :Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Couleur et forme :LiquidMasse moléculaire :145.6 (kDa)Desmethyl Erlotinib
CAS :Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).Formule :C21H21N3O4Degré de pureté :97.92% - 98.62%Couleur et forme :SolidMasse moléculaire :379.41Ref: TM-T6328
1mg52,00€2mg77,00€5mg115,00€10mg188,00€25mg331,00€50mg497,00€100mg720,00€1mL*10mM (DMSO)127,00€RTC-5
CAS :RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formule :C24H22ClF3N2O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :510.96Ref: TM-T12777
5mg52,00€10mg80,00€25mg169,00€50mg284,00€100mg411,00€500mg867,00€1mL*10mM (DMSO)59,00€Gefitinib hydrochloride
CAS :Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.Formule :C22H25Cl2FN4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :483.36Tyrphostin AG 528
CAS :Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).Formule :C18H14N2O3Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :306.32EGFR-IN-99
CAS :EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Formule :C25H22FN7O3Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :487.49AG1557
CAS :AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formule :C16H14IN3O2Degré de pureté :98.61% - 99.23%Couleur et forme :SolidMasse moléculaire :407.21Afatinib
CAS :Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Formule :C24H25ClFN5O3Degré de pureté :97.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94Ref: TM-T21312
5mg35,00€10mg51,00€25mg86,00€50mg115,00€100mg144,00€200mg177,00€500mg300,00€1mL*10mM (DMSO)52,00€SOS1/EGFR-IN-2
SOS1/EGFR-IN-2 (Compound 4) functions as a dual inhibitor of SOS1 and EGFR, exhibiting IC50 values of 8.3 and 14.6 nM, respectively. It demonstrates significant antiproliferative effects on cancer cells harboring various KRAS mutations.Formule :C25H29F3N4O3Couleur et forme :SolidMasse moléculaire :490.52Laprituximab
CAS :Laprituximab (J2898A) is a humanized anti-EGFR antibody used for synthesizing ADC compound Laprituximab emtansine.Degré de pureté :>95%Couleur et forme :LiquidCetuximab
CAS :Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).Formule :C107H179N35O36S7Degré de pureté :100.00% - SDS-PAGE:98.4%；SEC-HPLC: 99.7%Couleur et forme :LiquidMasse moléculaire :152 kDaEndoxifen (Z-isomer)
CAS :Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.Formule :C25H27NO2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :373.49Azerutamig
Azerutamig is a dual-specificity antibody targeting KLRK1/ERBB2 of type (H-γ1_L-κ)_scFvkh-H-γ1(h-CH2-CH3).Couleur et forme :Odour LiquidTyrphostin RG 14620
CAS :Formule :C14H8Cl2N2Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :275.13PD 174265
CAS :PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Formule :C17H15BrN4ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :371.23CH7233163
CH7233163 is a useful organic compound for research related to life sciences and the catalog number is T35334.Degré de pureté :98%Couleur et forme :SolidEGFR-IN-12
CAS :EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.Formule :C21H18F3N5ODegré de pureté :98.30% - 99.19%Couleur et forme :SolidMasse moléculaire :413.4Ref: TM-T5168
1mg82,00€5mg159,00€10mg259,00€25mg520,00€50mg740,00€100mg1.008,00€500mg2.015,00€1mL*10mM (DMSO)168,00€Sulforaphene
CAS :Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formule :C6H9NOS2Degré de pureté :98.01% - 99.19%Couleur et forme :Slightly Yellowish LiquidMasse moléculaire :175.27Ref: TM-TL0016
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg227,00€50mg338,00€100mg500,00€1mL*10mM (DMSO)69,00€SDZ281-977
CAS :SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formule :C18H20O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :316.35EGFR-TK-IN-5
EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.Formule :C26H20ClFN4OSCouleur et forme :SolidMasse moléculaire :490.98Mubritinib
CAS :Formule :C25H23F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.4709295999999Mutated EGFR-IN-2
CAS :Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formule :C29H35FN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.64Nazartinib
CAS :Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (Formule :C26H31ClN6O2Degré de pureté :98.31% - ≥95%Couleur et forme :Solid PowderMasse moléculaire :495.02Ref: TM-T3506
1mg37,00€5mg79,00€10mg119,00€25mg187,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)87,00€CL-387785
CAS :CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Formule :C18H13BrN4ODegré de pureté :96.68% - 98.09%Couleur et forme :SolidMasse moléculaire :381.23EGFR mutant-IN-1
EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.Formule :C34H39ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.17BMS-690514
CAS :BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.Formule :C19H24N6O2Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :368.43Astragaloside VI
CAS :Astragaloside VI could improve wound healing by activating the EGFR/ERK signaling pathway.Formule :C47H78O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :947.122EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Couleur et forme :Lyophilized PowderMasse moléculaire :71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-120 kDa based on Tris-Bis PAGE result.PD 158780
CAS :Formule :C14H12BrN5Degré de pureté :>97.0%(HPLC)Couleur et forme :White to Yellow to Green powder to crystalMasse moléculaire :330.19WAY-270360
CAS :WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.Formule :C22H19N3O3Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :373.4Protopine hydrochloride
CAS :Protopine inhibits thromboxane, lowers intracellular calcium, and reduces cell adhesion by altering adhesive factors.Formule :C20H20ClNO5Degré de pureté :98%Couleur et forme :Prisms From Alc SolidMasse moléculaire :389.83MAPK-IN-2
MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cellFormule :C20H11Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.23JCN037
CAS :JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Formule :C16H11BrFN3O2Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :376.18Ref: TM-T8431
2mg40,00€5mg74,00€10mg105,00€25mg178,00€50mg273,00€100mg391,00€200mg557,00€1mL*10mM (DMSO)84,00€Rilzabrutinib
CAS :Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).Formule :C36H40FN9O3Degré de pureté :97.87% - 99.76%Couleur et forme :SolidMasse moléculaire :665.76Ref: TM-T12542
1mg99,00€5mg235,00€10mg376,00€25mg655,00€50mg944,00€100mg1.320,00€500mg2.642,00€1mL*10mM (DMSO)344,00€WZ-3146
CAS :WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).Formule :C24H25ClN6O2Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :464.95Ref: TM-T6733
1mg52,00€2mg74,00€5mg97,00€10mg180,00€25mg319,00€50mg510,00€100mg730,00€1mL*10mM (DMSO)106,00€EGFR-IN-123
CAS :EGFR-IN-123 (compound D06) is an effective EGFR inhibitor. It exhibits inhibitory activity against several cell lines including PC-9G, A549, A431, and HCT116, with IC50 values of 0.74, 1.36, 1.20, and 2.53 μM respectively.Formule :C24H27F3N6OCouleur et forme :SolidMasse moléculaire :472.51BGB-102
CAS :BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.Formule :C22H25BrN4O2Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :457.36Erlotinib Hydrochloride
CAS :Formule :C22H23N3O4·HClDegré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :429.90WS3
CAS :WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formule :C28H30F3N7O3Degré de pureté :97.93% - 98.81%Couleur et forme :SolidMasse moléculaire :569.58DBPR112
CAS :DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formule :C32H31N5O3Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :533.62NSC 228155
CAS :NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formule :C11H6N4O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :290.25Ref: TM-T6908
2mg35,00€5mg50,00€10mg66,00€25mg125,00€50mg205,00€100mg369,00€200mg495,00€1mL*10mM (DMSO)52,00€SU5214
CAS :SU5214 is a modulator of tyrosine kinase signal transduction.Formule :C16H13NO2Degré de pureté :99.45% - 99.55%Couleur et forme :SolidMasse moléculaire :251.28JBJ-07-149
CAS :JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 μM when used alone, and 0.148 μM when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].Formule :C28H26N6O2SCouleur et forme :SolidMasse moléculaire :510.61
