EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
Produits appartenant à la catégorie "EGFR"
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EGFR/VEGFR2-IN-5
EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.Formule :C17H15N7O5SCouleur et forme :SolidMasse moléculaire :429.41EGFR-IN-136
EGFR-IN-136 (compound 21v) is a potent inhibitor of EGFR, demonstrating IC50 values of 20.2 nM, 1.2 nM, 2.3 nM, and 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, and EGFRLR/TM/CS, respectively. It exhibits antiproliferative and antitumor activities and holds potential for research in non-small cell lung cancer (NSCLC).Formule :C30H36N7O4PMasse moléculaire :589.625Cetuximab MMAE
Cetuximab-MMAE, an antibody-drug conjugate (ADC), combines an EGFR-targeting antibody with Monomethyl auristatin E (MMAE) to investigate colorectal and head and neck cancers.Couleur et forme :LiquidMasse moléculaire :150 kDaTyrphostin AG528
CAS :Formule :C18H14N2O3Degré de pureté :>97.0%(HPLC)Couleur et forme :Light yellow to Amber to Dark green powder to crystalMasse moléculaire :306.32Rociletinib
CAS :Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplasticFormule :C27H28F3N7O3Degré de pureté :98.39% - 99.25%Couleur et forme :SolidMasse moléculaire :555.55CNX-2006
CAS :CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.Formule :C26H27F4N7O2Degré de pureté :98.85% - 99.16%Couleur et forme :SolidMasse moléculaire :545.53Brivanib
CAS :Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFormule :C19H19FN4O3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :370.38Ref: TM-T6036
1mg47,00€5mg88,00€10mg144,00€25mg259,00€50mg375,00€100mg560,00€200mg815,00€1mL*10mM (DMSO)97,00€NRC-2694
CAS :NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Formule :C24H26N4O3Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :418.49Ref: TM-T16343
1mg85,00€5mg160,00€10mg250,00€25mg424,00€50mg562,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€Tyrphostin A25
CAS :Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Formule :C10H6N2O3Degré de pureté :98.76%Couleur et forme :Yellow Green Powder /Off-White SolidMasse moléculaire :202.17SHR-A1201
SHR-A1201 is an antibody-drug conjugate (ADC) targeting HER2. This compound is composed of a humanized anti-HER2 antibody, the linker SMCC, and the cytotoxic payload Mertansine, which is a microtubule inhibitor. SHR-A1201 is utilized in research for HER2-positive breast cancer.Formule :C50H63ClF3N5O12Couleur et forme :LiquidMasse moléculaire :1018.51MTX-241F
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families.Formule :C20H14ClFN6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.82Tyrphostin 23
CAS :Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.Formule :C10H6N2O2Degré de pureté :99.19% - 99.7%Couleur et forme :Yellow-Tan SolidMasse moléculaire :186.17Tarlox-TKI
CAS :Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formule :C19H18BrClN6ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :461.74Olmutinib
CAS :Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.Formule :C26H26N6O2SDegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :486.59Ref: TM-T6918
2mg39,00€5mg57,00€10mg88,00€25mg137,00€50mg180,00€100mg283,00€200mg462,00€1mL*10mM (DMSO)59,00€Almonertinib hydrochloride
CAS :Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.Formule :C30H36ClN7O2Degré de pureté :98.01% - 98.12%Couleur et forme :SolidMasse moléculaire :562.12′-Thioadenosine
CAS :2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM againstFormule :C10H13N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :283.31EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Couleur et forme :Lyophilized PowderMasse moléculaire :41.6 kDa (predicted)BI-4732
CAS :DL-Homocystine is a mutagen secreted by F. nucleatum.Formule :C32H36N10O2Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :592.69Olmutinib
CAS :Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorFormule :C26H26N6O2SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :486.59Ref: TM-T8460
2mg35,00€5mg57,00€10mg93,00€25mg131,00€50mg185,00€100mg283,00€200mg464,00€1mL*10mM (DMSO)63,00€AEE788
CAS :AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.Formule :C27H32N6Degré de pureté :100% - 98.94%Couleur et forme :SolidMasse moléculaire :440.58Ref: TM-T2116
2mg47,00€5mg70,00€10mg103,00€25mg188,00€50mg325,00€100mg490,00€500mg1.103,00€1mL*10mM (DMSO)77,00€
