FAK
Les inhibiteurs de la kinase d'adhésion focale (FAK) ciblent la FAK, une kinase impliquée dans l'adhésion cellulaire, la migration et l'angiogenèse. La FAK est fréquemment surexprimée dans les tumeurs et contribue à la formation de nouveaux vaisseaux sanguins qui alimentent la tumeur en nutriments. L'inhibition de la FAK peut perturber ces processus, faisant des inhibiteurs de la FAK des outils précieux en thérapie anticancéreuse et en recherche sur l'angiogenèse. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la FAK de haute qualité pour soutenir vos recherches en biologie cellulaire, cancer et angiogenèse.
Produits appartenant à la catégorie "FAK"
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50 produits dans cette catégorie.
Corosolic acid
CAS :Corosolic acid inhibits angiogenesis, suppresses FAK, fights various cancers, induces apoptosis, and degrades β-catenin.Formule :C30H48O4Degré de pureté :99.46% - 99.88%Couleur et forme :Fine-Brown Yellow PowderMasse moléculaire :472.7FAK-IN-21
CAS :FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.Formule :C22H22F2N8O3SCouleur et forme :SolidMasse moléculaire :516.52FAK-IN-12
FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM.Degré de pureté :98%Couleur et forme :Odour SolidRoslin 2 bromide
CAS :Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.Formule :C13H19BrN4Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :311.22Defactinib hydrochloride
CAS :Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Formule :C20H22ClF3N8O3SDegré de pureté :98.06% - 98.78%Couleur et forme :SolidMasse moléculaire :546.95Ifebemtinib
CAS :Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Formule :C28H28F4N6O4Degré de pureté :98.07% - 99.82%Couleur et forme :SolidMasse moléculaire :588.55NAMI-A
CAS :NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Formule :C8H15Cl4N4ORuSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.18AMP-945
CAS :AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.Formule :C28H32F3N5O2Degré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :527.58Ref: TM-T9576
1mg97,00€5mg188,00€10mg311,00€25mg533,00€50mg755,00€100mg1.035,00€1mL*10mM (DMSO)254,00€Adhesamine diTFA
CAS :Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.Formule :C28H32Cl2F6N8O6S2Couleur et forme :SolidMasse moléculaire :825.63FAK-IN-7
CAS :FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.Formule :C16H13N3OSDegré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :295.36GSK2256098
CAS :GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.Formule :C20H23ClN6O2Degré de pureté :99.46% - 99.52%Couleur et forme :SolidMasse moléculaire :414.89Ref: TM-T2281
1mg47,00€2mg60,00€5mg88,00€10mg137,00€25mg263,00€50mg449,00€100mg660,00€500mg1.388,00€1mL*10mM (DMSO)88,00€MY-1576
MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.Formule :C25H29ClN8O2Couleur et forme :SolidMasse moléculaire :509PF-03814735
CAS :PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48PND-1186
CAS :PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Formule :C25H26F3N5O3Degré de pureté :99.14% - 99.75%Couleur et forme :SolidMasse moléculaire :501.5PF-573228
CAS :PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.Formule :C22H20F3N5O3SDegré de pureté :96.58% - 98.86%Couleur et forme :SolidMasse moléculaire :491.49Anti-PTK2 Antibody (4T687)
Anti-PTK2 Antibody (4T687) is an antibody targeting PTK2. Anti-PTK2 Antibody (4T687) can be used in ELISA, IHC.Couleur et forme :Odour LiquidNVP-TAE 226
CAS :NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Formule :C23H25ClN6O3Degré de pureté :98.07% - 98.78%Couleur et forme :SolidMasse moléculaire :468.94Ref: TM-T1918
1mg48,00€2mg63,00€5mg101,00€10mg163,00€25mg264,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)101,00€FAK-IN-14
CAS :FAK-IN-14 is a FAK inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has a more significant inhibitory effect on FAK, FGFR1 and Pyk2.Formule :C21H24BrN7OSDegré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :502.43PF-562271
CAS :PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Formule :C21H20F3N7O3SDegré de pureté :100% - 97.65%Couleur et forme :SolidMasse moléculaire :507.49Ref: TM-T2465
1mg59,00€5mg127,00€10mg159,00€25mg240,00€50mg378,00€100mg567,00€200mg793,00€1mL*10mM (DMSO)140,00€Batatasin III
CAS :Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancerFormule :C15H16O3Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :244.29FAK-IN-15
FAK-IN-15 is a highly potent focal adhesion kinase (FAK) inhibitor with antitumor activity.Formule :C21H24ClN7OSDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :457.98Chloropyramine hydrochloride
CAS :Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.Formule :C16H20ClN3·HClDegré de pureté :99.45% - 99.8%Couleur et forme :SolidMasse moléculaire :326.26Defactinib analogue-1
CAS :Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.Formule :C20H20F3N5O3SCouleur et forme :SolidMasse moléculaire :467.47Conteltinib
CAS :Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Formule :C32H45N9O3SDegré de pureté :98.12% - 99.54%Couleur et forme :SolidMasse moléculaire :635.82Ref: TM-T14997
1mg77,00€5mg167,00€10mg240,00€25mg409,00€50mg572,00€100mg800,00€1mL*10mM (DMSO)227,00€PF-431396
CAS :PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).Formule :C22H21F3N6O3SDegré de pureté :98.83% - 99.82%Couleur et forme :SolidMasse moléculaire :506.5Nitidine chloride
CAS :1.Formule :C21H18ClNO4Degré de pureté :96.59% - 98.91%Couleur et forme :SolidMasse moléculaire :383.82ALK inhibitor 1
CAS :ALK inhibitor 1 is a selective ALK kinase inhibitor.Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :562.48Ref: TM-T10285
1mg52,00€5mg116,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)143,00€FAK-IN-11
FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation.Formule :C25H41NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.6Ifebemtinib hydrochloride
Ifebemtinib (BI-853520) hydrochloride is a potent FAK (focal adhesion kinase) inhibitor with oral bioavailability, exhibiting an IC50 of 1 nM for recombinant FAK. Ifebemtinib hydrochloride demonstrates antiproliferative activity against cancer cells.Formule :C28H29ClF4N6O4Couleur et forme :SolidMasse moléculaire :625.01GSK215
CAS :GSK215: potent, selective PROTAC degrader of FAK (pDC50=8.4), combines FAK inhibitor VS-4718 and VHL E3 ligase binder, causes fast, lasting FAK degradation.Formule :C50H59F3N10O6SDegré de pureté :99.3%Couleur et forme :SoildMasse moléculaire :985.13PF-562271 hydrochloride
CAS :PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.Formule :C21H20F3N7O3SHClDegré de pureté :98.52%Couleur et forme :SolidMasse moléculaire :543.95Defactinib
CAS :Defactinib (VS-6063) is a second-generation inhibitor of FAK. Defactinib has potential antitumor activity. Cost-effective and quality-assured.Formule :C20H21F3N8O3SDegré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :510.49ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Formule :C29H32FN3OCouleur et forme :SolidMasse moléculaire :457.58Y15
CAS :Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,Formule :C6H14Cl4N4Degré de pureté :98% - 98%Couleur et forme :Dark Brown CrystalsMasse moléculaire :284.01Ref: TM-T7119
10mg50,00€25mg69,00€50mg82,00€100mg137,00€200mg188,00€500mg331,00€1mL*10mM (DMSO)48,00€FAK activator 1
CAS :ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.Formule :C23H26F3N3O3Degré de pureté :98.85%Couleur et forme :SoildMasse moléculaire :449.47Ref: TM-T77665
1mg99,00€5mg229,00€10mg383,00€25mg627,00€50mg1.005,00€100mg1.589,00€200mg2.078,00€1mL*10mM (DMSO)296,00€Masitinib
CAS :Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Formule :C28H30N6OSDegré de pureté :100% - 99.55%Couleur et forme :SolidMasse moléculaire :498.642119738-71-3
CAS :Compound 2119738-71-3 interacts with the FAK receptor.Formule :C25H29ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.99Compound 1T-0219 (SC)
CAS :Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620Formule :C20H19N3O7Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :413.38ALK inhibitor 2
CAS :ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formule :C23H28ClN7O3SDegré de pureté :99% - 99.77%Couleur et forme :SolidMasse moléculaire :518.03(R)-Fangchinoline
CAS :(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.Formule :C37H40N2O6Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :608.72FAK inhibitor 7
CAS :FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.Formule :C32H37N7O3Couleur et forme :SolidMasse moléculaire :567.68PF-562271 besylate
CAS :PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Formule :C21H20F3N7O3S·C6H6O3SDegré de pureté :97.65% - 99.01%Couleur et forme :SolidMasse moléculaire :665.66Ref: TM-T6177
1mg38,00€5mg79,00€10mg88,00€25mg145,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)95,00€FAK-IN-10
CAS :FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.Formule :C15H10BrN3O2SDegré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :376.23BI-4464
CAS :BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTACFormule :C28H28F3N5O4Degré de pureté :97.43%Couleur et forme :SolidMasse moléculaire :555.55SU6656
CAS :SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.Formule :C19H21N3O3SDegré de pureté :97% - 98.21%Couleur et forme :SolidMasse moléculaire :371.45Ref: TM-T6997
1mg40,00€2mg51,00€5mg85,00€10mg139,00€25mg269,00€50mg449,00€100mg667,00€1mL*10mM (DMSO)88,00€Fangchinoline
CAS :Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.Formule :C37H40N2O6Degré de pureté :98.81% - 99.86%Couleur et forme :SolidMasse moléculaire :608.72OXA-11
CAS :OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.Formule :C37H49F3N7O5PDegré de pureté :98.70% - 99.20%Couleur et forme :SolidMasse moléculaire :759.8Si306
CAS :Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).Formule :C25H26BrClN6OSCouleur et forme :SolidMasse moléculaire :573.94Ifebemtinib FA
BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.Formule :C29H30F4N6O6Degré de pureté :98.40% - 99.62%Couleur et forme :SolidMasse moléculaire :634.58CEP-37440
CAS :CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formule :C30H38ClN7O3Degré de pureté :98.86% - 99.98%Couleur et forme :SolidMasse moléculaire :580.12
