PD-1/PD-L1
Les inhibiteurs de PD-1/PD-L1 sont des inhibiteurs de points de contrôle immunitaires qui bloquent l'interaction entre la protéine de mort cellulaire programmée 1 (PD-1) sur les cellules T et son ligand PD-L1 sur les cellules cancéreuses. Cette interaction supprime normalement la réponse immunitaire et permet aux cellules cancéreuses d'échapper à la détection immunitaire. En inhibant PD-1/PD-L1, ces inhibiteurs renforcent la capacité du système immunitaire à reconnaître et à détruire les cellules cancéreuses, induisant l'apoptose et la régression tumorale. Les inhibiteurs de PD-1/PD-L1 sont essentiels dans la recherche en immunothérapie et dans le traitement du cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de PD-1/PD-L1 de haute qualité pour soutenir vos recherches en immuno-oncologie, apoptose et thérapie contre le cancer.
Produits appartenant à la catégorie "PD-1/PD-L1"
Trier par
47 produits dans cette catégorie.
D5B
D5B is an effective and selective PD-L1 inhibitor that has been modified with DBCO. It degrades PD-L1 in 4T1 and B16-F10 tumor cells with EC50 values of 5.4 μM and 6.2 μM, respectively. D5B can block the PD-L1/PD-1 interaction and exhibits antitumor activity.Formule :C58H66N2O12Couleur et forme :SolidMasse moléculaire :983.15Anti-Mouse PD-1 (LALA-PG) Antibody (RMP1-14)
Anti-MousePD-1(LALA-PG) Antibody (RMP1-14) is an IgG2a, κ antibody inhibitor derived from mice that targets and inhibits mouse PD-1.Couleur et forme :Odour LiquidBMS-1001
CAS :BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction(IC50 : 2.25 nM, in a homogenous time-resolved fluorescence binding assay).Formule :C35H34N2O7Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :594.72-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS :2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Formule :C22H17N3O2Couleur et forme :SolidMasse moléculaire :355.39PD-1/PD-L1-IN-32
PD-1/PD-L1-IN-32 (compound A56) is a potent inhibitor of PD-1/PD-L1, displaying pronounced anticancer activity with an IC50 value of 2.4 nM.Degré de pureté :98%Couleur et forme :Odour SolidIMMH 010 maleate
CAS :IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.Formule :C36H36BrClN2O9Couleur et forme :SoildMasse moléculaire :756.04INCB086550
CAS :INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formule :C41H39N7O4Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :693.79PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Couleur et forme :Odour SolidBMS-8
CAS :BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.Formule :C27H28BrNO3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :494.42Ref: TM-T26859
1mg39,00€5mg84,00€10mg131,00€25mg269,00€50mg432,00€100mg638,00€200mg909,00€1mL*10mM (DMSO)96,00€PD-1/PD-L1-IN-27
CAS :PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.Formule :C44H35NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.75PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.Couleur et forme :Odour SolidPD-1-IN-22
CAS :PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).Formule :C25H25N5O4Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :459.5Ref: TM-T12379
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)299,00€PD-1/PD-L1-IN-51
PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.Couleur et forme :Odour SolidPD-1/PD-L1-IN-34
CAS :PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1Formule :C35H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.1BMS202 hydrochloride (1675203-84-5(free base))
CAS :BMS202 hydrochloride (1675203-84-5) is a potent PD-1/PD-L1 inhibitor (IC50: 18 nM) that promotes PD-L1 dimerization, blocking PD1 binding.Formule :C25H30ClN3O3Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :455.97Ref: TM-T4696
1mg51,00€2mg63,00€5mg100,00€10mg160,00€25mg306,00€50mg548,00€100mg785,00€1mL*10mM (DMSO)100,00€BMS-1001 hydrochloride
CAS :BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effectFormule :C35H35ClN2O7Degré de pureté :97.36%Couleur et forme :SolidMasse moléculaire :631.11Ref: TM-T10565
1mg56,00€5mg127,00€10mg197,00€25mg401,00€50mg645,00€100mg1.026,00€200mg1.378,00€1mL*10mM (DMSO)172,00€PD-1/PD-L1-IN-NP19
CAS :PD-1/PD-L1-IN-NP19: a PD-1/PD-L1 inhibitor with 12.5 nM IC50, may boost antitumor immunity.Formule :C33H31ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.06PD-L1-IN-3
CAS :PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.Formule :C19H15ClFN2OSDegré de pureté :99.47%Couleur et forme :SoildMasse moléculaire :373.85PD-1/PD-L1-IN-53
CAS :PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.Formule :C31H37N3O4Couleur et forme :SolidMasse moléculaire :515.64PD-L1/VISTA-IN-2
PD-L1/VISTA-IN-2 (Compound S8) is an orally active dual inhibitor targeting PD-L1 and VISTA, with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. This compound can activate the tumor immune microenvironment, exerting anticancer effects.Formule :C22H22N2O3Couleur et forme :SolidMasse moléculaire :362.42(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFormule :C72H99F3N20O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1669.67ASC-69
CAS :ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].Formule :C19H19N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.4PM-8002
PM-8002 is a bispecific antibody that targets PD-L1 and VEGF-A. It is applicable for research on solid tumors.Couleur et forme :Odour LiquidLon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Formule :C24H28Cl2N2O3S2Couleur et forme :SolidMasse moléculaire :527.53Anti-Mouse PD-1 Antibody (D265A) Antibody (RMP1-14)
Anti-Mouse PD-1 Antibody (D265A) is an IgG2a, κ antibody inhibitor derived from mice, specifically targeting mouse PD-1.Couleur et forme :Odour LiquidBMS-1166
CAS :BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.Formule :C36H33ClN2O7Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :641.11Ref: TM-T5697
1mg74,00€5mg155,00€10mg225,00€25mg429,00€50mg635,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)208,00€ARB-272572
CAS :ARB-272572 is a PD-L1 signaling inhibitor that produces immunostimulatory activity in human primary cells.Formule :C32H36N6O4Degré de pureté :97.36% - 98.07%Couleur et forme :SolidMasse moléculaire :568.67PD-1/PD-L1-IN-9
CAS :PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction.Formule :C22H24N2O2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T9651
1mg60,00€2mg89,00€5mg134,00€10mg188,00€25mg314,00€50mg429,00€100mg565,00€500mg1.121,00€1mL*10mM (DMSO)148,00€PD-L1-IN-7
CAS :PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Formule :C46H50N6O7Couleur et forme :SolidMasse moléculaire :798.93TQB-2858
TQB-2858 is a bifunctional fusion protein composed of an anti-PD-L1 monoclonal antibody fused with the extracellular domain of the TGF-β receptor. It exhibits high affinity for PD-L1, TGF-β1, and TGF-β3, and demonstrates a high target occupancy rate for PD-L1. TQB-2858 can be used in research on osteosarcoma and alveolar soft part sarcoma (ASPS).Couleur et forme :Odour LiquidPD-1/PD-L1-IN-26
CAS :PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.Formule :C43H52N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :752.89PD-1-IN-17
CAS :PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.Formule :C13H22N6O7Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :374.35PD-L1-IN-2
CAS :PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.Formule :C33H38N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.68LTB
LTB is a prodrug formed through the conjugation of the glycolysis inhibitor (Lonidamine) and the PD1/PDL1 blocker (BMS-1) via a thioketal bond. LTB can encapsulate the photosensitizer Chlorin e6 (Ce6), constructing a co-delivery photodynamic nanoplatfform through self-assembly (LTB-6 NPs).Formule :C53H59Cl2N3O7S2Couleur et forme :SolidMasse moléculaire :985.09PDL-1 cpd 10
CAS :PDL-1 cpd 10 is a novel small molecule PD-L1 inhititor.Formule :C21H23N5O2Degré de pureté :97.08%Couleur et forme :SolidMasse moléculaire :377.44Ref: TM-T9359
1mg55,00€5mg117,00€10mg187,00€25mg393,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)134,00€LP23
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/JurkatFormule :C27H27N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.59ARB-272572 hydrochloride
CAS :ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formule :C32H36N6O4·xClHDegré de pureté :99%Couleur et forme :SoildMasse moléculaire :568.68(Free base）2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc
2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc is the PD-L1 ligand-linker polymer of AUTACPD-L1degrader-3. It can be utilized in the synthesis of AUTAC.Formule :C35H45N5O6Couleur et forme :SolidMasse moléculaire :631.76PD-1/PD-L1-IN-33
CAS :PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formule :C26H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.53Enpp-1-IN-25
CAS :Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.Formule :C15H21N5O4SCouleur et forme :SolidMasse moléculaire :367.423N-deacetylated BMS-202
CAS :N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interaction with potential anticancer activity for cancer research.Formule :C23H27N3O2Degré de pureté :98.13% - 98.13%Couleur et forme :SolidMasse moléculaire :377.48SWS1
CAS :SWS1, a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM), displays anticancer activity by augmenting tumor-infiltrating lymphocytes and demonstrating antiFormule :C47H53ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :849.48PMT-O9-1A
PMT-O9-1A is an effective PD-L1 degrader that reduces PD-L1 protein expression and exhibits cytotoxic properties. Additionally, PMT-O9-1A possesses anticancer activity.Formule :C22H25ClN2O4Couleur et forme :SolidMasse moléculaire :416.90PD-1/PD-L1-IN-31
PD-1/PD-L1-IN-31 is a potent inhibitor of PD-1/PD-L1 (IC50=2.2 nM) that enhances IFN-γ secretion and activates the immune response of peripheral bloodFormule :C24H24ClFN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.91BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
CAS :BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (Formule :C41H45Cl3N4O5Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :780.18PD-1/PD-L1-IN-10
CAS :PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.Cost-effective and quality-assured.Formule :C33H31N3O7Degré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :581.62PD-L1/VISTA-IN-1
CAS :PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual inhibitor targeting PD-L1 and VISTA. It effectively hinders the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), leading to the reactivation of T cells. Additionally, PD-L1/VISTA-IN-1 exhibits antitumor activity.Formule :C22H24N4O4Couleur et forme :SolidMasse moléculaire :408.45
