
Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase
- CDK
- Arrêt du cycle cellulaire
- Chk
- c-Myc
- Dynamine
- DYRK
- Ferroptose
- HSP
- Intégrine
- Kinésine
- KSP
- LIM Kinase
- Microtubules associés
- PKC
- PLK
- Rho
- ROCK
- Wee1
Affichez 11 plus de sous-catégories
Produits appartenant à la catégorie "Cycle cellulaire/point de contrôle"
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LY3143921 hydrate
CAS :LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Formule :C16H14FN5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :327.31CDK2-IN-39
CAS :CDK2-IN-39 (compound 4) is a CDK2 inhibitor.Formule :C14H15N3O4SCouleur et forme :SolidMasse moléculaire :321.352COH29
CAS :COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.Formule :C22H16N2O5SDegré de pureté :97.04% - 98.92%Couleur et forme :SolidMasse moléculaire :420.44Ref: TM-T3157
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg217,00€50mg354,00€100mg590,00€1mL*10mM (DMSO)87,00€5'-Azido-5'-deoxythymidine
CAS :5'-Azido-5'-deoxythymidine is a nucleoside analog with potential anti-tuberculosis activity and an inhibitor of TMPKmt in Mycobacterium tuberculosis.Formule :C10H13N5O4Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :267.24NSC23005 Sodium
CAS :NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Formule :C13H16NNaO4SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :305.32Ref: TM-T3589
1mg47,00€2mg59,00€5mg93,00€10mg115,00€25mg245,00€50mg437,00€100mg625,00€1mL*10mM (DMSO)93,00€CCT241533
CAS :CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formule :C23H27FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.48BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
CAS :BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (Formule :C41H45Cl3N4O5Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :780.18TASIN-1 Hydrochloride
CAS :TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncatedFormule :C18H29ClN2O3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :388.95Ref: TM-T24855
1mg78,00€5mg143,00€10mg197,00€25mg335,00€50mg477,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)150,00€Abemaciclib methanesulfonate
CAS :Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).Formule :C27H32F2N8·CH4O3SDegré de pureté :98.69% - 99.44%Couleur et forme :SolidMasse moléculaire :602.7CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formule :C24H22FN7O2Couleur et forme :SolidMasse moléculaire :459.48WRN inhibitor 12
CAS :WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formule :C33H33ClF3N9O5Couleur et forme :SolidMasse moléculaire :728.12Cilengitide TFA
CAS :Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Formule :C29H41F3N8O9Couleur et forme :SolidMasse moléculaire :702.68WAY-322243
CAS :WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Formule :C18H18N2O2SDegré de pureté :99.47%Couleur et forme :SoildMasse moléculaire :326.41TP-353
CAS :TP-353 (EOS-61973) is a CDK7 inhibitor.Formule :C35H30FNO3Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :531.62Ref: TM-T22440
1mg59,00€2mg80,00€5mg108,00€10mg187,00€25mg341,00€50mg472,00€100mg652,00€200mg899,00€1mL*10mM (DMSO)158,00€CDK12/13 ligand 1
CAS :ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formule :C26H26BrN5OCouleur et forme :SolidMasse moléculaire :504.42D-I03
CAS :D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM.Formule :C23H36N6SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :428.64Ref: TM-T10936
1mg37,00€2mg52,00€5mg77,00€10mg126,00€25mg283,00€50mg390,00€100mg567,00€1mL*10mM (DMSO)85,00€NY2267
CAS :NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFormule :C38H43N3O6Degré de pureté :99.16% - 99.27%Couleur et forme :SolidMasse moléculaire :637.76Ref: TM-T9093
1mg87,00€5mg187,00€10mg298,00€25mg525,00€50mg747,00€100mg1.017,00€1mL*10mM (DMSO)264,00€WEE1-IN-11
CAS :WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Formule :C26H29FN8OS2Couleur et forme :SolidMasse moléculaire :552.69Blinatumomab
CAS :Blinatumomab (AMG-10,MT-103) is a CD19/CD3 bispecific B-cell and T-cell binding antibody that in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.Couleur et forme :LiquidAPE1-IN-1
CAS :APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cellsFormule :C19H21N3OS2Degré de pureté :98.50%Couleur et forme :SolidMasse moléculaire :371.52Plogosertib
CAS :Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.Formule :C34H48N8O3Degré de pureté :99.15% - 99.85%Couleur et forme :SolidMasse moléculaire :616.797P18IN003
CAS :P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFormule :C17H16N2O3Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :296.32AM5992
CAS :AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.Formule :C27H33FN8ODegré de pureté :98%Couleur et forme :SoildMasse moléculaire :504.6Synstatin (92-119)
CAS :Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFormule :C133H207N35O46Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3032.27GLPG0187
CAS :GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Formule :C29H37N7O5SDegré de pureté :100% - 99.70%Couleur et forme :SolidMasse moléculaire :595.71P18IN011
CAS :P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).Formule :C15H12N2O5SDegré de pureté :97.63%Couleur et forme :SolidMasse moléculaire :332.33Ref: TM-T8576
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)178,00€Ethynylcytidine
CAS :Ethynylcytidine is a nucleoside antimetabolite.Formule :C11H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.24TMX-3013
CAS :TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Formule :C17H14BrFN6O3SCouleur et forme :SolidMasse moléculaire :481.3UMK57
CAS :UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Formule :C17H17N3SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :295.4PD-1/PD-L1-IN-32
PD-1/PD-L1-IN-32 (compound A56) is a potent inhibitor of PD-1/PD-L1, displaying pronounced anticancer activity with an IC50 value of 2.4 nM.Degré de pureté :98%Couleur et forme :Odour SolidTMPyP4 tosylate
CAS :TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Formule :C72H66N8O12S4Degré de pureté :99.11% - 99.85%Couleur et forme :SolidMasse moléculaire :1363.6GSK4418959
CAS :GSK4418959 (IDE275) is an oral, non-covalent, reversible, and selective WRN helicase inhibitor.inhibits ATPase and DNA unwinding functions. MSI-H.Formule :C31H30F4N4O5SCouleur et forme :SoildMasse moléculaire :646.65AVG-233
CAS :AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.Formule :C26H22ClN5O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :487.94GW8510
CAS :GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Formule :C21H15N5O3S2Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :449.51Ref: TM-T24125
1mg52,00€5mg97,00€10mg169,00€25mg329,00€50mg537,00€100mg868,00€200mg1.169,00€1mL*10mM (DMSO)111,00€IMMH 010 maleate
CAS :IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.Formule :C36H36BrClN2O9Couleur et forme :SoildMasse moléculaire :756.04NCGC00029283
CAS :NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μMFormule :C18H12FN3O3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :337.3Ref: TM-T40823
1mg111,00€2mg163,00€5mg264,00€10mg432,00€25mg747,00€50mg1.103,00€100mg1.539,00€1mL*10mM (DMSO)283,00€Docosanoic acid
CAS :Docosanoic acid (Behenic Acid) is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.Formule :C22H44O2Degré de pureté :100%Couleur et forme :Waxy Solid Liquid Othersolid PelletslargecrystalsMasse moléculaire :340.58N6-Methyladenine
CAS :N6-Methyladenine (6-(Methylamino)Purine) is a modified purine commonly found in genomes of prokaryotes, protists, and plants.Formule :C6H7N5Degré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :149.15Vaccarin
CAS :Vaccarin, a key flavonoid glycoside in Vaccariae semen, undergoes methylation, hydroxylation, glycosylation, and deglycosylation.Formule :C32H38O19Degré de pureté :99.16% - 99.97%Couleur et forme :SolidMasse moléculaire :726.63Poloxin-2
CAS :Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Formule :C16H15NO3Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :269.3Ref: TM-T25969
1mg333,00€5mg922,00€10mg1.140,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.664,00€2′-C-Methyl-6-O-methylinosine
CAS :6-MeO-9-(2-C-methyl-β-D-ribofuranosyl)purine is a hypoxanthine analog used in tumor disease research.Formule :C12H16N4O5Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :296.28Abrilumab
CAS :Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.Couleur et forme :LiquidXPW1
CAS :XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Formule :C36H39ClFN7O2Degré de pureté :98.08%Couleur et forme :SoildMasse moléculaire :656.19Peldesine
CAS :Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.Formule :C12H11N5ODegré de pureté :99.27% - 99.95%Couleur et forme :SolidMasse moléculaire :241.25Ref: TM-T12399
1mg114,00€5mg274,00€10mg439,00€25mg727,00€50mg1.017,00€100mg1.378,00€500mg2.737,00€1mL*10mM (DMSO)303,00€Kinesore
CAS :Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.Formule :C20H16Br2N4O4Degré de pureté :97.24%Couleur et forme :SolidMasse moléculaire :536.17Ref: TM-T15663
2mg43,00€5mg66,00€10mg94,00€25mg159,00€50mg230,00€100mg346,00€200mg520,00€1mL*10mM (DMSO)74,00€c-Myc inhibitor 12
Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.478-Azaguanine
CAS :8-Azaguanine (SK 1150) is a purine analogue with potential antineoplastic activity.Formule :C4H4N6ODegré de pureté :100% - 99.89%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :152.11Clofarabine-5'-diphosphate
CAS :Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formule :C10H13ClFN5O9P2Couleur et forme :SolidMasse moléculaire :463.64MC180295
CAS :MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.Formule :C17H18N4O3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :358.41Ref: TM-T5533
1mg56,00€5mg131,00€10mg187,00€25mg319,00€50mg449,00€100mg638,00€200mg842,00€1mL*10mM (DMSO)143,00€2'-Deoxycytidine hydrochloride
CAS :2'-Deoxycytidine hydrochloride is an important deoxyribonucleoside analog and protects mice from the lethal toxicity of cytosine arabinoside(araC).Formule :C9H14ClN3O4Degré de pureté :98.96%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :263.68GW406108X
CAS :GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.Formule :C20H11Cl2NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.21Hycanthone
CAS :Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.Formule :C20H24N2O2SDegré de pureté :98.78%Couleur et forme :Yellow-Orange Powder (Ntp 1992)Masse moléculaire :356.48Z62954982
CAS :Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteriesFormule :C20H21N3O5SDegré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :415.46Ref: TM-T37113
1mg38,00€5mg80,00€10mg111,00€25mg183,00€50mg269,00€100mg393,00€200mg560,00€1mL*10mM (DMSO)92,00€10058-F4
CAS :10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.Formule :C12H11NOS2Degré de pureté :98% - 99.82%Couleur et forme :SolidMasse moléculaire :249.35Ezabenlimab
CAS :Ezabenlimab (BI-754091) is an anti-PD-1 mAb, Kd 6 nM, blocks PD-1/PD-Ls, boosts T-cell IFN-γ, inhibits tumors in vivo.Degré de pureté :95% - 95%Couleur et forme :LiquidLY2334737
CAS :LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.Formule :C17H25F2N3O5Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :389.39Ref: TM-T4061
1mg62,00€5mg131,00€10mg205,00€25mg378,00€50mg562,00€100mg777,00€200mg1.074,00€1mL*10mM (DMSO)166,00€PF-2771
CAS :PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.Formule :C29H36ClN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :554.08BS-181 hydrochloride
CAS :BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Formule :C22H32N6·HClDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :416.99Ref: TM-T6162
1mg37,00€2mg52,00€5mg79,00€10mg126,00€25mg274,00€50mg454,00€100mg655,00€1mL*10mM (DMSO)87,00€CD532
CAS :CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Formule :C26H25F3N8ODegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :522.52TC-A 2317 hydrochloride
CAS :TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93Alisertib
CAS :Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formule :C27H20ClFN4O4Degré de pureté :100% - 99.82%Couleur et forme :SolidMasse moléculaire :518.92Ref: TM-T2241
5mg55,00€10mg96,00€25mg155,00€50mg226,00€100mg354,00€200mg454,00€500mg743,00€1mL*10mM (DMSO)63,00€4μ8C
CAS :4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Formule :C11H8O4Degré de pureté :97.48% - 98.45%Couleur et forme :SolidMasse moléculaire :204.18CDK-IN-15
CAS :CDK-IN-15 (Compound 456) is an effective inhibitor of Cyclin A, exhibiting an IC50 value of 0.14 μM.Formule :C45H63Cl2F4N7O8Couleur et forme :SolidMasse moléculaire :976.92GDC0575 monohydrochloride
CAS :GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formule :C16H21BrClN5ODegré de pureté :97.85%Couleur et forme :SolidMasse moléculaire :414.73Ref: TM-T27407
1mg46,00€2mg58,00€5mg85,00€10mg108,00€25mg187,00€50mg269,00€100mg376,00€200mg548,00€1mL*10mM (DMSO)87,00€CDK9-IN-2
CAS :CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formule :C23H25ClFN5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :425.93Ref: TM-T14918
1mg88,00€5mg187,00€10mg281,00€25mg487,00€50mg705,00€100mg998,00€1mL*10mM (DMSO)207,00€Emzadirib
CAS :Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.Formule :C27H40N4O6S2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :580.7610074-A4
CAS :10074-A4 is a c-Myc binding compound that associates with c-Myc370-409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features fromFormule :C18H14Cl2N2O3SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :409.29Ref: TM-T9628
1mg71,00€5mg135,00€10mg197,00€25mg335,00€50mg480,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)156,00€BI-1950
CAS :BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formule :C32H26Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.5MYCi975
CAS :MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Formule :C25H16Cl2F6N2O2Degré de pureté :99.3% - 99.58%Couleur et forme :SolidMasse moléculaire :561.3AG-024322
CAS :AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases.Formule :C23H20F2N6Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :418.44TG003
CAS :TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Formule :C13H15NO2SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :249.33Ref: TM-T60367
1mg50,00€5mg97,00€10mg159,00€25mg281,00€50mg465,00€100mg558,00€200mg810,00€1mL*10mM (DMSO)170,00€PHA-680632
CAS :PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Formule :C28H35N7O2Degré de pureté :98.20%Couleur et forme :SolidMasse moléculaire :501.62T4 UvsX Recombinase
T4 UvsX Recombinase initiates DNA replication on double-stranded templates by catalyzing synapsis with a homologous primer single strand.Degré de pureté :98%Couleur et forme :Odour SoliddGTP
CAS :dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFormule :C10H16N5O13P3Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :507.18Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFormule :C13H12ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :317.73RI-2
CAS :RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR repair.Formule :C21H18Cl2N2O4Degré de pureté :98.85% - 99.86%Couleur et forme :SolidMasse moléculaire :433.28Ref: TM-T2628
1mg73,00€2mg97,00€5mg160,00€10mg281,00€25mg435,00€50mg640,00€100mg910,00€1mL*10mM (DMSO)170,00€CDK9-IN-29
CAS :CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Formule :C29H33F2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.6PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Couleur et forme :Odour SolidBMS-8
CAS :BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.Formule :C27H28BrNO3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :494.42Ref: TM-T26859
1mg39,00€5mg84,00€10mg131,00€25mg269,00€50mg432,00€100mg638,00€200mg909,00€1mL*10mM (DMSO)96,00€Reversine
CAS :Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formule :C21H27N7ODegré de pureté :98% - 99.75%Couleur et forme :SolidMasse moléculaire :393.49Ref: TM-T1825
1mg38,00€2mg49,00€5mg70,00€10mg88,00€25mg164,00€50mg224,00€100mg393,00€1mL*10mM (DMSO)70,00€10074-G5
CAS :10074-G5 is an inhibitor of c-Myc-Max dimerization.Formule :C18H12N4O3Degré de pureté :97.22% - 99.67%Couleur et forme :SolidMasse moléculaire :332.31Ref: TM-T3686
2mg42,00€5mg63,00€10mg88,00€25mg142,00€50mg225,00€100mg396,00€200mg565,00€500mg900,00€1mL*10mM (DMSO)69,00€9-Isopropylolomoucine
CAS :9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Formule :C17H22N6ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :326.4Ref: TM-T23589
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)642,00€PD-1/PD-L1-IN-27
CAS :PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.Formule :C44H35NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.75Gantofiban
CAS :Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.Formule :C21H29N5O6Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :447.48CAN508
CAS :CAN508: potent CDK9/T1 inhibitor; IC50 0.35 μM, Cdk2/E; Ki 13.3 μM, IC50 20 μM; 38x selective; antitumor.Formule :C9H10N6ODegré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :218.22H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS :RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Formule :C23H38N10O10Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :614.61CDK9 ligand 3
CAS :CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Formule :C18H18BrCl2N5O3Couleur et forme :SolidMasse moléculaire :503.177MLN0905
CAS :MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formule :C24H25F3N6SDegré de pureté :97.17% - 98%Couleur et forme :SolidMasse moléculaire :486.56Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Formule :C55H103N15O14Degré de pureté :96.21%Couleur et forme :SolidMasse moléculaire :1198.5R-10015
CAS :R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Formule :C20H19ClN6O2Degré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :410.86Ref: TM-T12609
1mg75,00€5mg170,00€10mg256,00€25mg423,00€50mg562,00€100mg792,00€200mg1.074,00€1mL*10mM (DMSO)182,00€PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.Couleur et forme :Odour SolidAKI603
CAS :AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.Formule :C19H23N9O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :409.45Ref: TM-T64338
1mg66,00€5mg145,00€10mg212,00€25mg380,00€50mg562,00€100mg792,00€200mg1.064,00€1mL*10mM (DMSO)160,00€Triazavirin
CAS :Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Formule :C5H7N6NaO5SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :286.2DNA Gyrase-IN-13
CAS :DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.Formule :C15H21N3O3SCouleur et forme :SolidMasse moléculaire :323.41Quarfloxin
CAS :Quarfloxin (CX-3543), a fluoroquinolone, inhibits neuroblastoma with nanomolar IC50, disrupting nucleolin and G-quadruplex DNA.Formule :C35H33FN6O3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :604.67Ref: TM-T16703
1mg119,00€5mg169,00€10mg264,00€25mg487,00€50mg652,00€100mg847,00€1mL*10mM (DMSO)234,00€LY3295668
CAS :LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formule :C24H26ClF2N5O2Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :489.95iRGD peptide
CAS :iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Formule :C35H57N13O14S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :948.04XL228
CAS :XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formule :C22H31N9ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :437.54Ref: TM-T17267
1mg56,00€2mg78,00€5mg99,00€10mg149,00€25mg258,00€50mg393,00€100mg582,00€1mL*10mM (DMSO)110,00€Sasanlimab
CAS :Sasanlimab (PF-06801591), a humanized IgG4-κ antibody, selectively targets PD-1 and is primarily produced in Chinese Hamster Ovary (CHO) cells [1].Degré de pureté :98%Couleur et forme :Liquid(2S,3R)-Voruciclib
CAS :(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.Formule :C22H19ClF3NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.84CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.43Gallium maltolate
CAS :Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.Formule :C18H15GaO9Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :445.03Pyridostatin TFA
CAS :Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-Formule :C37H35F9N8O11Degré de pureté :97.09% - 99.84%Couleur et forme :SolidMasse moléculaire :938.71TMX-2039
CAS :TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Formule :C17H20BrFN6O3SCouleur et forme :SolidMasse moléculaire :487.347Stigmatellin
CAS :Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.Formule :C30H42O7Couleur et forme :SolidMasse moléculaire :514.65MGB-BP-3
CAS :MGB-BP-3 is a synthetic antibiotic with bactericidal activity that inhibits bacterial DNA replication and can be used to study recurrent C. difficile infections.Formule :C36H37N7O4Degré de pureté :97.06% - 98.92%Couleur et forme :SolidMasse moléculaire :631.72STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Degré de pureté :95% - 95%Couleur et forme :Odour Liquid2',3'-Dideoxyuridine
CAS :2',3'-Dideoxyuridine is a purine nucleoside analog with potential antitumor activity.Formule :C9H12N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :212.2WRN inhibitor 11
CAS :WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.15C16Y
CAS :C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Formule :C78H115N17O17Couleur et forme :SolidMasse moléculaire :1562.85EMD534085
CAS :EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).Formule :C25H31F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.535-Methylcytosine
CAS :5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA.Formule :C5H7N3ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :125.13SRI-29329
CAS :SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Formule :C20H26ClN7Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :399.92Ref: TM-T8801
1mg92,00€5mg188,00€10mg306,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)215,00€3-AP
CAS :3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).Formule :C7H9N5SDegré de pureté :97.33% - 99.75%Couleur et forme :SolidMasse moléculaire :195.24Ref: TM-T1982
2mg39,00€5mg57,00€10mg69,00€25mg150,00€50mg264,00€100mg400,00€500mg909,00€1mL*10mM (DMSO)57,00€Human PD-L1 inhibitor V
CAS :Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFormule :C65H104N20O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1485.71T521
CAS :T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Formule :C17H14FNO5S2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :395.43AZ5576
CAS :AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].Formule :C21H24FN3O3Degré de pureté :99.88%Couleur et forme :SoildMasse moléculaire :385.43Ref: TM-T60152
1mg35,00€5mg80,00€10mg113,00€25mg221,00€50mg331,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)87,00€PROTAC CDK9 degrader-11
CAS :PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formule :C39H48Cl2N10O5Couleur et forme :SolidMasse moléculaire :807.768SCH900776 (S-isomer)
CAS :SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formule :C15H18BrN7Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :376.25Ref: TM-T3700
1mg49,00€2mg70,00€5mg96,00€10mg155,00€25mg264,00€50mg424,00€100mg627,00€1mL*10mM (DMSO)114,00€Senexin C
CAS :Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formule :C28H27N5ODegré de pureté :97.91%Couleur et forme :SolidMasse moléculaire :449.55DAM-IN-1
CAS :DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Formule :C16H17NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.31Aminopurvalanol A
CAS :Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1Formule :C19H26ClN7ODegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :403.91Ref: TM-T22260
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg284,00€100mg411,00€200mg585,00€1mL*10mM (DMSO)65,00€Sintilimab
CAS :Sintilimab (IBI308), an IgG4 monoclonal antibody, blocks PD-1, enhancing T-cell anti-tumor response; treats Hodgkin's, lung, and esophageal cancers.Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :144.04 kDaAtuveciclib S-Enantiomer
CAS :Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43PD-1-IN-22
CAS :PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).Formule :C25H25N5O4Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :459.5Ref: TM-T12379
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)299,00€CFI-402257
CAS :CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.Formule :C28H30N6O3Degré de pureté :96.66% - 99.51%Couleur et forme :SolidMasse moléculaire :498.58CDK9-Cyclin T1 PPI-IN-1
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBCDegré de pureté :98%Couleur et forme :Odour SolidDamnacanthal
CAS :Damnacanthal is a natural anthraquinone with potential anticancer property, inhibiting a variety of protein kinases such as LIMK1, LIMK2 and Lck.Formule :C16H10O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.25RNA polymerase II-IN-1
CAS :RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.Formule :C38H53N11O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :887.96SAR-020106
CAS :SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Formule :C19H19ClN6ODegré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :382.85CDK4-IN-1
CAS :CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formule :C22H29ClN8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.97Aurora A inhibitor 3
Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-Degré de pureté :98%Couleur et forme :Odour SolidProguanil
CAS :Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the DHFR enzyme .Formule :C11H16ClN5Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :253.73KW-2449
CAS :KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formule :C20H20N4ODegré de pureté :98.43% - 99.89%Couleur et forme :SolidMasse moléculaire :332.45-Aza-7-deazaguanine
CAS :5-Aza-7-deazaguanine is a non-natural substituted nucleobase with potential antiviral activity, used in cancer and bacterial infection research.Formule :C5H5N5ODegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :151.138-Azaguanosine
CAS :8-Azaguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity and is used in the study of a variety of tumor diseases.Formule :C9H12N6O5Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :284.23BI8622
CAS :BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.Formule :C25H26N6ODegré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :426.51(S)-Enitociclib
CAS :(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.Formule :C19H18F2N4O2SDegré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :404.43Nicotinamide N-oxide
CAS :Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Formule :C6H6N2O2Degré de pureté :99.61% - 99.9%Couleur et forme :SolidMasse moléculaire :138.12AS2863619
CAS :AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formule :C16H14Cl2N8ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :405.24Ref: TM-T8378
1mg131,00€2mg180,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)303,00€CDK8/19-IN-51
CAS :CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Formule :C23H22N6O2Degré de pureté :100% - 98.65%Couleur et forme :SoildMasse moléculaire :414.46KOdiA-PC
CAS :KOdiA-PC is a truncated oxidized phospholipid and a CD36-targeting ligand found on oxLDL. It inhibits activation of TLR4 signaling components.Formule :C32H58NO11PCouleur et forme :SolidMasse moléculaire :663.78Envafolimab
CAS :Envafolimab (ASC 22) is a humanized antibody targeting PD-L1, with anticancer activity, blocking the PD-L1 and PD-1 interaction.Degré de pureté :95%Couleur et forme :LiquidLY2880070
CAS :LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formule :C19H23N7O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :381.43Ref: TM-T9252
1mg131,00€5mg286,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)316,00€WAY-647802
CAS :WAY-647802 is a CDK inhibitor.Formule :C11H14N4O3Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :250.25Madrasin
CAS :Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.Formule :C16H17N5O2Degré de pureté :99.44% - 99.61%Couleur et forme :SolidMasse moléculaire :311.34PD-1/PD-L1-IN-51
PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.Couleur et forme :Odour SolidCCT 137690
CAS :CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).Formule :C26H31BrN8ODegré de pureté :98.51% - 99.82%Couleur et forme :SolidMasse moléculaire :551.485'-O-DMT-N4-Bz-5-Me-dC
CAS :5'-O-DMT-N4-Bz-5-Me-dC (DMT-NBZ-5-METHYL DC) is a modified nucleoside used in the synthesis of nucleoside phosphoramidites.Formule :C38H37N3O7Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :647.72Efalizumab
CAS :Efalizumab: humanized monoclonal antibody CD11a; modulates T cell activation/adhesion; for plaque psoriasis, psoriatic arthritis research.Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.77%Couleur et forme :LiquidMasse moléculaire :146.14 kDaSR 11302
CAS :SR 11302 is an inhibitor of activator protein-1 (AP-1).Formule :C26H32O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.53Ref: TM-T23384
1mg137,00€5mg492,00€10mg797,00€25mg1.385,00€50mgÀ demander100mgÀ demander1mL*10mM (DMSO)550,00€Nedaplatin
CAS :Nedaplatin, a cisplatin derivative, induces tumor DNA damage (IC50: 94 μM) through platinum-DNA cross-links, causing apoptosis.Formule :C2H8N2O3PtDegré de pureté :100% - 98.69%Couleur et forme :Straw Yellow PowderMasse moléculaire :303.17A-205804
CAS :A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Formule :C15H12N2OS2Degré de pureté :98.07% - 98.52%Couleur et forme :SolidMasse moléculaire :300.4Ref: TM-T2254
2mg44,00€5mg52,00€10mg81,00€25mg160,00€50mg271,00€100mg532,00€500mg1.169,00€1mL*10mM (DMSO)71,00€N-6-Furfurylguanosine
CAS :N-6-Furfurylguanosine (kinetin riboside) is a purine nucleoside analog with cytotoxicity, inhibiting the growth of cancer cells.Formule :C15H18N6O5Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :362.34Ancitabine hydrochloride
CAS :Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.Formule :C9H12ClN3O4Degré de pureté :99.02% - 99.37%Couleur et forme :White SolidMasse moléculaire :261.66Uridine-5-acetic acid
CAS :Uridine-5-acetic acid (5-Carboxymethyluridine) is a nucleoside formed during RNA transfer processes in yeast and wheat embryos.Formule :C11H14N2O8Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :302.24PolQi2
CAS :PolQi2 is a Polθ inhibitor that suppresses the helicase activity of Polθ, and when combined with AZD7648.Formule :C21H16ClN5O3SDegré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :453.9Ref: TM-T84770
1mg92,00€5mg188,00€10mg313,00€25mg603,00€50mg840,00€100mg1.169,00€200mg1.586,00€1mL*10mM (DMSO)216,00€CHK1 inhibitor
CAS :CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formule :C17H21BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.28Saccharin 1-methylimidazole
CAS :Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.Formule :C7H5NO3S·C4H6N2Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :265.29THZ1
CAS :THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Formule :C31H28ClN7O2Degré de pureté :95.09% - 99.27%Couleur et forme :SolidMasse moléculaire :566.05Antiviral agent 36
Antiviral agent 36 (compound 27), a potent inhibitor of both dengue (DENV) and Zika (ZIKV) viruses, demonstrates replication inhibition with EC50 values of 100Formule :C30H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :496.6m-Se3
CAS :m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Formule :C29H23IN2SeDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :605.37CDK2-IN-4
CAS :CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Formule :C23H18N6O2SDegré de pureté :97.24% - 99.10%Couleur et forme :SolidMasse moléculaire :442.49Ref: TM-T14916
1mg87,00€5mg202,00€10mg321,00€25mg550,00€50mg753,00€100mg1.074,00€1mL*10mM (DMSO)240,00€Bersiporocin
CAS :Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.Formule :C15H19Cl2N3ODegré de pureté :100% - 98.88%Couleur et forme :SolidMasse moléculaire :328.24ON-013100
CAS :ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formule :C19H22O7SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :394.44Ref: TM-T16391
1mg50,00€5mg74,00€10mg105,00€25mg182,00€50mg283,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)64,00€ICAM-1-IN-1
CAS :ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.Formule :C15H11BrN2O2SDegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :363.23Ref: TM-T13147
1mg185,00€5mg393,00€10mg587,00€25mg935,00€50mg1.264,00€100mg1.700,00€500mg3.410,00€1mL*10mM (DMSO)432,00€CDK2-IN-40
CAS :CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Formule :C16H21N7O2Couleur et forme :SolidMasse moléculaire :343.384MYCi361
CAS :MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).Formule :C26H16ClF9N2O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :594.86Dimethylenastron
CAS :Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Formule :C16H18N2O2SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :302.39Ref: TM-T3118
1mg35,00€2mg48,00€5mg62,00€10mg87,00€25mg156,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)67,00€Ribociclib succinate
CAS :Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formule :C27H36N8O5Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :552.63Ref: TM-T15732
2mg35,00€5mg51,00€10mg73,00€25mg97,00€50mg115,00€100mg168,00€200mg271,00€500mg484,00€1mL*10mM (DMSO)64,00€HAMNO
CAS :HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Formule :C17H13NO2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :263.29BML-259
CAS :BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Formule :C14H16N2OSDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :260.35Ref: TM-T36964
5mg50,00€10mg85,00€25mg169,00€50mg279,00€100mg487,00€500mg1.035,00€1mL*10mM (DMSO)52,00€WRN inhibitor 14
WRN inhibitor 14 (compound S35) is an orally administered WRN inhibitor with anticancer properties. It effectively suppresses tumor growth in the SW48 xenograft model in BALB/c nude mice.Formule :C35H40F4N10O5Couleur et forme :SolidMasse moléculaire :756.75Bimosiamose disodium
CAS :Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Formule :C46H52Na2O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :906.888-Bromoadenosine
CAS :8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.Formule :C10H12BrN5O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :346.14SEL120-34A
CAS :SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formule :C15H18Br2N4Degré de pureté :100% - 99.7%Couleur et forme :SolidMasse moléculaire :414.14NSAH
CAS :NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Formule :C18H14N2O3Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :306.32Ref: TM-T8800
5mg70,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)77,00€CDK8-IN-1
CAS :CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Formule :C11H8F3N3ODegré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :255.2Ref: TM-T10740
1mg87,00€5mg216,00€10mg311,00€25mg525,00€50mg707,00€100mg944,00€1mL*10mM (DMSO)240,00€Rifalazil
CAS :Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Formule :C51H64N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.07GTSE1-IN-1
CAS :GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Formule :C21H24FN7Couleur et forme :SolidMasse moléculaire :393.46Rifapentine
CAS :Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.Formule :C47H64N4O12Degré de pureté :95.74% - ≥98%Couleur et forme :SolidMasse moléculaire :877.032-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS :2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Formule :C22H17N3O2Couleur et forme :SolidMasse moléculaire :355.39Ganciclovir
CAS :Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus.Formule :C9H13N5O4Degré de pureté :99.4% - 99.55%Couleur et forme :White PowderMasse moléculaire :255.23Werner syndrome RecQ helicase-IN-2
CAS :Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formule :C32H34F3N9O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :681.67Digeranyl bisphosphonate
CAS :Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.DigeranylFormule :C21H34Na4O6P2Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :536.4Cyclapolin 9
CAS :Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Formule :C9H4F3N3O4SDegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :307.21Ref: TM-T22700
1mg92,00€5mg216,00€10mg338,00€25mg540,00€50mg747,00€100mg1.017,00€500mg2.043,00€1mL*10mM (DMSO)240,00€Seliciclib
CAS :Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Formule :C19H26N6ODegré de pureté :97.15% - 99.88%Couleur et forme :White To Off-White SolidMasse moléculaire :354.45NVP-LCQ195
CAS :NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Formule :C17H19Cl2N5O4SDegré de pureté :100% - 99.36%Couleur et forme :SolidMasse moléculaire :460.33Ref: TM-TQ0068
1mg48,00€5mg97,00€10mg145,00€25mg269,00€50mg395,00€100mg563,00€200mg743,00€1mL*10mM (DMSO)99,00€Deoxyguanosine triphosphate trisodium salt
CAS :Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) is a nucleotide precursor for DNA synthesis in cells and can beFormule :C10H13N5Na3O13P3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :573.13WRN inhibitor 18
CAS :WRN inhibitor 18 (compound 306) is an orally active inhibitor of WRN with demonstrated anticancer activity in vivo.Formule :C35H35F6N5O5SCouleur et forme :SolidMasse moléculaire :751.747-Methylxanthine
CAS :7-Methylxanthine, a xanthine methyl derivative, prevents FDM by altering the sclera in rabbits. It's a purine in kidney stones.Formule :C6H6N4O2Degré de pureté :97.66% - 98.58%Couleur et forme :SolidMasse moléculaire :166.14sAJM589
CAS :sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Formule :C16H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.266-Mercaptopurine hydrate
CAS :6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.Formule :C5H6N4OSDegré de pureté :97.54% - 99.14%Couleur et forme :Light Yellow Crystalline PowderMasse moléculaire :170.19Nusinersen
CAS :Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Couleur et forme :SolidMirvetuximab soravtansine
CAS :Mirvetuximab soravtansine (IMGN853) is an antibody-drug coupling that targets FRα, inhibits cell growth, and can be used to study drug-resistant ovarian cancerDegré de pureté :95%Couleur et forme :LiquidButyrolactone I
CAS :Butyrolactone I (Olomoucin) inhibits CDKs, blocks cdc2 kinases, and shows antitumor activity in lung and prostate cancers.Formule :C24H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :424.44CDK4/6-IN-17
CAS :CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formule :C27H28F4N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.56CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Formule :C27H31N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.55PD-1/PD-L1-IN-34
CAS :PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1Formule :C35H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.1CDK9-IN-28
PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor, serves as a target protein ligand for PROTAC synthesis.Formule :C32H40N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :640.81