
Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase
- CDK
- Arrêt du cycle cellulaire
- Chk
- c-Myc
- Dynamine
- DYRK
- Ferroptose
- HSP
- Intégrine
- Kinésine
- KSP
- LIM Kinase
- Microtubules associés
- PKC
- PLK
- Rho
- ROCK
- Wee1
Affichez 11 plus de sous-catégories
Produits appartenant à la catégorie "Cycle cellulaire/point de contrôle"
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CDK9-IN-9
CAS :CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).Formule :C22H23F2N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.51GSK-923295
CAS :GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).Formule :C32H38ClN5O4Degré de pureté :96.22% - 98.02%Couleur et forme :SolidMasse moléculaire :592.13Ref: TM-T2039
1mg49,00€2mg70,00€5mg97,00€10mg168,00€25mg331,00€50mg510,00€100mg737,00€1mL*10mM (DMSO)136,00€Poloxin
CAS :Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Formule :C18H19NO3Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :297.35GSK 3008348 hydrochloride
CAS :GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Formule :C29H37N5O2xHClDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :0LY2812223
CAS :LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Formule :C10H12N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.29(R)-Enitociclib
CAS :(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity.Formule :C19H18F2N4O2SDegré de pureté :98.82%Couleur et forme :SoildMasse moléculaire :404.43CX-5461
CAS :CX5461 is an orally rRNA synthesis inhibitor that inhibits Pol I-driven rRNA transcription. CX5461 has antitumor activity. Cost-effective and quality-assured.Formule :C27H27N7O2SDegré de pureté :95.44% - 99.25%Couleur et forme :SolidMasse moléculaire :513.61IRE1α kinase-IN-1
CAS :IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM.Formule :C26H26ClFN8Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :504.99Ref: TM-T9564
1mg116,00€5mg283,00€10mg452,00€25mg707,00€50mg1.017,00€100mg1.406,00€1mL*10mM (DMSO)311,00€CRT0044876
CAS :CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.Formule :C9H6N2O4Degré de pureté :98.27% - 98.98%Couleur et forme :Brown PowderMasse moléculaire :206.15INCB086550
CAS :INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formule :C41H39N7O4Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :693.79Cdc7-IN-1
CAS :Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Formule :C21H16ClN3O4Couleur et forme :SolidMasse moléculaire :409.82BVDU 5′-Triphosphate
CAS :BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.Formule :C11H16BrN2O14P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.08Tirofiban hydrochloride monohydrate
CAS :Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.Formule :C22H39ClN2O6SDegré de pureté :95.83% - 99.94%Couleur et forme :White SolidMasse moléculaire :495.07S-Gem
CAS :S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR.Formule :C13H15F2N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.4CBFβ Inhibitor
CAS :CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.Formule :C12H14N2OSDegré de pureté :96.50%Couleur et forme :SolidMasse moléculaire :234.32Leucettinib-92
CAS :Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μMFormule :C21H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.49Poly(A) polymerase
CAS :Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP.Degré de pureté :98%Couleur et forme :Solid5-Fluoroorotic acid
CAS :5-Fluoroorotic acid is an inhibitor of thymidylate synthase.Formule :C5H3FN2O4Degré de pureté :100% - 99.7%Couleur et forme :White To Pale Yellow PowderMasse moléculaire :174.09MU147
CAS :MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.Formule :C19H13N3O3SCouleur et forme :SolidMasse moléculaire :363.39Deoxythymidine triphosphate
CAS :Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.Formule :C10H14N2Na3O14P3Degré de pureté :96.00%Couleur et forme :White Amorphous PowderMasse moléculaire :548.11PFM03
CAS :PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.Formule :C14H15NO2S2Degré de pureté :98.20% - 99.98%Couleur et forme :SolidMasse moléculaire :293.4TC-S 7005
CAS :TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Formule :C21H17N3O3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :359.38Ref: TM-T17008
1mg57,00€2mg84,00€5mg125,00€10mg188,00€25mg354,00€50mg532,00€100mg712,00€500mgÀ demander1mL*10mM (DMSO)138,00€Metarrestin
CAS :Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis.Formule :C31H30N4ODegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :474.6Ref: TM-T12006
1mg40,00€2mg52,00€5mg88,00€10mg144,00€25mg298,00€50mg512,00€100mg740,00€500mg1.539,00€RG7800 tetrahydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production.Formule :C24H32Cl4N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.362'-Deoxy-N4-methylcytidine
CAS :2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.Formule :C10H15N3O4Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :241.24HMN-176
CAS :HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Formule :C20H18N2O4SDegré de pureté :98.92% - 98.99%Couleur et forme :SolidMasse moléculaire :382.43Ref: TM-T3643
1mg43,00€2mg56,00€5mg88,00€10mg119,00€25mg188,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)79,00€SGC-CLK-1
CAS :SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formule :C19H15F3N6O2Couleur et forme :SolidMasse moléculaire :416.36APY29
CAS :APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Formule :C17H16N8Degré de pureté :96.51% - 98.46%Couleur et forme :SolidMasse moléculaire :332.36Ref: TM-T3654
2mg43,00€5mg65,00€10mg96,00€25mg177,00€50mg301,00€100mg543,00€500mg1.130,00€1mL*10mM (DMSO)71,00€Budigalimab
CAS :Budigalimab (ABBV 181) is a humanized monoclonal antibody targeting PD-1 with potential antitumor activity.Degré de pureté :95% - 95%Couleur et forme :LiquidHomouridine
CAS :Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).Formule :C10H14N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.23CDK5-IN-3
CAS :CDK5-IN-3 is a selective and potent CDK5 inhibitor that inhibits CDK5/p25 and CDK2/CycA, and can be used in the study of cancer.Formule :C22H26N4ODegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :362.47Avelumab
CAS :Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody. Avelumab shows potential antibody-dependent cell-mediated cytotoxicity.Degré de pureté :95% - 98.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :143.8 kDaDatelliptium chloride
CAS :Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.Formule :C23H28ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.94CK7
CAS :CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Formule :C14H12N6O2SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :328.35Ref: TM-T9615
1mg52,00€5mg120,00€10mg187,00€25mg376,00€50mg588,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)139,00€Barasertib
CAS :AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formule :C26H31FN7O6PDegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :587.54Simurosertib
CAS :Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).Formule :C17H19N5OSDegré de pureté :99.82% - 99.93%Couleur et forme :SolidMasse moléculaire :341.43Ref: TM-T12642L
1mg74,00€2mg96,00€5mg180,00€10mg250,00€25mg465,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)187,00€Acrixolimab
CAS :Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].Degré de pureté :98%Couleur et forme :Liquid6-Thioinosine
CAS :6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Formule :C10H12N4O4SDegré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :284.29Ref: TM-T7621
2mg51,00€5mg85,00€10mg119,00€25mg150,00€50mg188,00€100mg283,00€200mg432,00€1mL*10mM (DMSO)99,00€Natalizumab
CAS :Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Degré de pureté :98.00%Couleur et forme :LiquidMasse moléculaire :N/AKJ Pyr 9
CAS :KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Formule :C22H15N3O4Degré de pureté :98.07% - ≥98%Couleur et forme :SolidMasse moléculaire :385.37Ref: TM-T15665
2mg39,00€5mg57,00€10mg81,00€25mg145,00€50mg279,00€100mg510,00€200mg683,00€500mg1.064,00€1mL*10mM (DMSO)63,00€DNA Gyrase-IN-9
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase.Formule :C26H18ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.89IXA6
CAS :IXA6 is an IRE1/XBP1s agonist with potential vasoprotective activity for the study of neurodegenerative diseases such as Parkinson's disease.Formule :C22H20ClN3O3SDegré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :441.93CW-069
CAS :CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formule :C23H21IN2O3Degré de pureté :97.52% - 98.59%Couleur et forme :SolidMasse moléculaire :500.33Ref: TM-T6209
1mg43,00€5mg90,00€10mg125,00€25mg216,00€50mg306,00€100mg432,00€500mg938,00€1mL*10mM (DMSO)89,00€DNA Gyrase-IN-8
CAS :DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Formule :C19H14BrN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.25Cdc7-IN-7
CAS :Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.Formule :C21H22N4O5Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :410.42ZIM
CAS :ZIM, from 4-Aminoantipyrine, induces DNA and chromosomal damage, cell death, and phagocytosis, with potential in cancer therapy.Formule :C20H19N3O3Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :349.38Ref: TM-T72024
5mg39,00€10mg58,00€25mg105,00€50mg170,00€100mg271,00€200mg398,00€1mL*10mM (DMSO)52,00€Pyrintegrin
CAS :Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Formule :C23H25N5O3SDegré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :451.54Ref: TM-T16695
1mg82,00€2mg96,00€5mg159,00€10mg226,00€25mg435,00€50mg648,00€100mg924,00€200mg1.225,00€1mL*10mM (DMSO)168,00€Senexin B
CAS :Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Formule :C27H26N6ODegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :450.53Ref: TM-T8430
1mg97,00€2mg131,00€5mg188,00€10mg305,00€25mg487,00€50mg655,00€100mg905,00€1mL*10mM (DMSO)215,00€GDC-0575
CAS :GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Formule :C16H20BrN5ODegré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :378.27CCT-251921
CAS :CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formule :C21H23ClN6ODegré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :410.9Ref: TM-T14901
1mg95,00€5mg221,00€10mg324,00€25mg548,00€50mg785,00€100mg1.074,00€1mL*10mM (DMSO)202,00€PROTAC CDK9/CycT1 Degrader-2
PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].Formule :C30H36N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :612.76BMS-1001 hydrochloride
CAS :BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effectFormule :C35H35ClN2O7Degré de pureté :97.36%Couleur et forme :SolidMasse moléculaire :631.11Ref: TM-T10565
1mg56,00€5mg127,00€10mg197,00€25mg401,00€50mg645,00€100mg1.026,00€200mg1.378,00€1mL*10mM (DMSO)172,00€ZCL278
CAS :ZCL278 is a selective Cdc42 GTPase inhibitor.Formule :C21H19BrClN5O4S2Degré de pureté :96.29% - 99.72%Couleur et forme :SolidMasse moléculaire :584.89Ref: TM-T1855
5mg50,00€10mg79,00€25mg136,00€50mg221,00€100mg310,00€200mg497,00€500mg805,00€1mL*10mM (DMSO)79,00€CID 5951923
CAS :CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.Formule :C16H18N2O7SDegré de pureté :100.00%Couleur et forme :SolidMasse moléculaire :382.39Barasertib-HQPA
CAS :Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.Formule :C26H30FN7O3Degré de pureté :98.43% - 99.29%Couleur et forme :SolidMasse moléculaire :507.56TH588
CAS :TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.Formule :C13H12Cl2N4Degré de pureté :96.05% - 99.82%Couleur et forme :SolidMasse moléculaire :295.17AAPK-25
CAS :AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formule :C21H13Cl2N3O2SDegré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :442.32Ref: TM-T10215
1mg95,00€5mg202,00€10mg303,00€25mg550,00€50mg825,00€100mg1.198,00€1mL*10mM (DMSO)233,00€Palbociclib monohydrochloride
CAS :Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinasesFormule :C24H29N7O2·HClDegré de pureté :100% - 99.91%Couleur et forme :SolidMasse moléculaire :483.99JSH-150
CAS :JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Formule :C24H33ClN6O2SDegré de pureté :100% - 99.96%Couleur et forme :SolidMasse moléculaire :505.08LIMK-IN-22j
CAS :LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Formule :C20H21BrN8Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :453.34Cilengitide
CAS :Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formule :C27H40N8O7Degré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :588.66Ref: TM-T2494
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg274,00€50mg439,00€100mg632,00€1mL*10mM (DMSO)137,00€Mirvetuximab
CAS :Mirvetuximab, a monoclonal antibody targeting FOLR1/FRα, treats ovarian and FRα-positive cancers, often paired with platinum-based drugs.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :148 kDa (average)Ispinesib
CAS :Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplasticFormule :C30H33ClN4O2Degré de pureté :98% - 98.59%Couleur et forme :SolidMasse moléculaire :517.06Ref: TM-T2103
1mg39,00€2mg50,00€5mg79,00€10mg118,00€25mg210,00€50mg339,00€100mg557,00€500mg1.216,00€1mL*10mM (DMSO)89,00€CDK8/19-IN-1
CAS :CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Formule :C19H18N4O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.5Werner syndrome RecQ helicase-IN-1
CAS :Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomachFormule :C31H31ClF3N9O5Degré de pureté :98.74% - 99.62%Couleur et forme :SolidMasse moléculaire :702.08Ref: TM-T72107
1mg60,00€5mg125,00€10mg177,00€25mg296,00€50mg502,00€100mg803,00€500mg1.795,00€1mL*10mM (DMSO)822,00€CDK12-IN-E9
CAS :CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Formule :C24H30N6O2Couleur et forme :SolidMasse moléculaire :434.53Folinic Acid Calcium Salt Pentahydrate
CAS :Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.Formule :C20H21CaN7O7·5H2ODegré de pureté :100% - 99.17%Couleur et forme :Yellowish-White To Yellow PowderMasse moléculaire :601.58NITD-2
CAS :NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.Formule :C23H19N3O4SDegré de pureté :98.03% - 99.46%Couleur et forme :SolidMasse moléculaire :433.48Ref: TM-T8886
1mg74,00€5mg170,00€10mg274,00€25mg472,00€50mg655,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)188,00€GP-82996
CAS :GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.Formule :C27H32N6ODegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :456.58N6,N6-Dimethyladenosine
CAS :N6,N6-Dimethyladenosine is find in mycobacterium bovis Bacille Calmette-Guérin tRNA.Formule :C12H17N5O4Degré de pureté :98.79%Couleur et forme :White PowderMasse moléculaire :295.29Aurora kinase inhibitor-3
CAS :Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formule :C21H18F3N5ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :413.4Ref: TM-T5524
1mg78,00€2mg97,00€5mg188,00€10mg298,00€25mg500,00€50mg710,00€100mg938,00€200mg1.311,00€1mL*10mM (DMSO)215,00€HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Formule :C24H27FN4O5Couleur et forme :SolidMasse moléculaire :470.49RG7800
CAS :RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.Formule :C24H28N6ODegré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :416.52ART558
CAS :ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM).Formule :C21H21F3N4O2Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :418.41PD-1/PD-L1-IN-NP19
CAS :PD-1/PD-L1-IN-NP19: a PD-1/PD-L1 inhibitor with 12.5 nM IC50, may boost antitumor immunity.Formule :C33H31ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.06Doxifluridine
CAS :Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.Formule :C9H11FN2O5Degré de pureté :99.47% - 99.86%Couleur et forme :White SolidMasse moléculaire :246.192′-Deoxy-2′-fluoroguanosine
CAS :2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Formule :C10H12FN5O4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :285.23Raltitrexed
CAS :Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.Formule :C21H22N4O6SDegré de pureté :98.99% - 99.06%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :458.49SCH-1473759
CAS :SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formule :C20H26N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.54Cucurbitacin B
CAS :Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formule :C32H46O8Degré de pureté :97.10% - 99.33%Couleur et forme :SolidMasse moléculaire :558.7AZD-5597
CAS :AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potentFormule :C23H28FN7ODegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :437.51Ref: TM-T21544
1mg57,00€5mg120,00€10mg187,00€25mg416,00€50mg655,00€100mg924,00€1mL*10mM (DMSO)144,00€Sapacitabine
CAS :Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.Formule :C26H42N4O5Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :490.64T4 RNA ligase
T4 RNA ligase is an enzyme that facilitates the ligation of single-stranded DNA.Degré de pureté :98%Couleur et forme :Odour SolidMonastrol
CAS :Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formule :C14H16N2O3SDegré de pureté :98.59% - 99.19%Couleur et forme :SolidMasse moléculaire :292.35Ref: TM-T4048
1mg48,00€5mg78,00€10mg97,00€25mg188,00€50mg311,00€100mg502,00€500mg1.074,00€1mL*10mM (DMSO)87,00€Enrofloxacin
CAS :Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.Formule :C19H22FN3O3Degré de pureté :100% - 99.89%Couleur et forme :Pale Yellow CrystalsMasse moléculaire :359.39PF-06873600
CAS :PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Formule :C20H27F2N5O4SDegré de pureté :98.77% - 99.58%Couleur et forme :SolidMasse moléculaire :471.52Ref: TM-T8463
1mg57,00€5mg120,00€10mg188,00€25mg354,00€50mg588,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)131,00€Zimberelimab
CAS :Zimberelimab (GLS-010) is a humanized antibody targeting PD-1, with anticancer activity.Degré de pureté :95%Couleur et forme :Liquid7-Methylguanosine
CAS :7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor (IC50 : 87.8 ± 7.5 μM).Formule :C11H16N5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :298.282′-O-Methylcytidine
CAS :2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.Formule :C10H15N3O5Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :257.24Ilorasertib hydrochloride
CAS :Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formule :C25H22ClFN6O2SDegré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :525TK216
CAS :TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.Formule :C19H15Cl2NO3Degré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :376.23(S)-Monastrol
CAS :Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formule :C14H16N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.356-Mercaptopurine
CAS :6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.Formule :C5H4N4SDegré de pureté :99.53% - 99.63%Couleur et forme :Yellow Crystalline Powder SolidMasse moléculaire :152.18KIF18A-IN-15
CAS :KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.Formule :C25H33F3N6O5SCouleur et forme :SolidMasse moléculaire :586.63Voruciclib hydrochloride
CAS :Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Formule :C22H20Cl2F3NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.33-Methylcytidine
CAS :3-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.Formule :C10H15N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :257.24Kif15-IN-2
CAS :Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Formule :C20H20N6O4SDegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :440.48CDK1-IN-2
CAS :CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Formule :C17H11ClN2ODegré de pureté :98.41%Couleur et forme :SoildMasse moléculaire :294.73Ref: TM-T64373
1mg50,00€5mg107,00€10mg170,00€25mg354,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)103,00€NU6140
CAS :NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Formule :C23H30N6O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :422.52Ref: TM-T16359
2mg42,00€5mg64,00€10mg97,00€25mg187,00€50mg301,00€100mg437,00€200mg612,00€1mL*10mM (DMSO)71,00€Bisindolylmaleimide X hydrochloride
CAS :Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Formule :C26H25ClN4O2Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :460.96Etaracizumab
CAS :Etaracizumab (LM 609) is a humanized monoclonal antibody targeting integrin αvβ3, inhibiting angiogenesis and melanoma growth, used in the study of melanoma.Degré de pureté :>95% - >95%Couleur et forme :LiquidMasse moléculaire :144.3 (kDa)PT-129
PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.Formule :C46H48N8O12SCouleur et forme :SolidMasse moléculaire :936.98Dihydrobaicalein
CAS :Dihydrobaicalein is a natural product from Scutellaria baicalensis, a PLK1 inhibitor (IC50:6.3 μM).Dihydrobaicalein inhibits VRK2 and PLK2.Formule :C15H12O5Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :272.25SNS-314 Mesylate
CAS :SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formule :C18H15ClN6OS2·CH4O3SDegré de pureté :99.44% - 99.92%Couleur et forme :SolidMasse moléculaire :527.04Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formule :C27H21N3O3Degré de pureté :96.25%Couleur et forme :SolidMasse moléculaire :435.47Ref: TM-T35570
1mg90,00€5mg187,00€10mg305,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)215,00€LDC4297
CAS :LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.Formule :C23H28N8ODegré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :432.52N2-Isobutyryl-2-deoxyguanosine
CAS :N2-Isobutyryl-2-deoxyguanosine(iBu-dG) is a nucleoside analog that can be used to synthesize oligonucleotides.Formule :C14H19N5O5Degré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :337.33GS-9191
CAS :GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , whichFormule :C37H51N8O6PDegré de pureté :98.01% - 98.28%Couleur et forme :SolidMasse moléculaire :734.82Aurora kinase inhibitor-2
CAS :Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formule :C23H20N4O3Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :400.43Ref: TM-T9040
1mg66,00€5mg145,00€10mg212,00€25mg380,00€50mg562,00€100mg832,00€200mg1.121,00€1mL*10mM (DMSO)167,00€αvβ1 integrin-IN-2
CAS :αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.Formule :C29H38N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.64AZ3146
CAS :AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.Formule :C24H32N6O3Degré de pureté :100% - 97.84%Couleur et forme :SolidMasse moléculaire :452.55Palmatine
CAS :Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.Formule :C21H22NO4Degré de pureté :96.28% - 99.49%Couleur et forme :SolidMasse moléculaire :352.4αvβ6 integrin inhibitor 2
CAS :αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Formule :C21H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.49OSU-T315
CAS :OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Formule :C30H30F3N5ODegré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :533.59Ref: TM-T5485
1mg97,00€2mg144,00€5mg235,00€10mg378,00€25mg647,00€50mg920,00€100mg1.225,00€500mg2.498,00€1mL*10mM (DMSO)306,00€Cirtuvivint
CAS :Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.Formule :C24H25N7ODegré de pureté :100% - 100%Couleur et forme :SolidMasse moléculaire :427.5Taq DNA polymerase
CAS :Taq DNA polymerase is a thermostable enzyme utilized in polymerase chain reactions (PCR) to amplify DNA sequences [1].Degré de pureté :98%Couleur et forme :SolidPRT4165
CAS :PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.Formule :C15H9NO2Degré de pureté :98.91% - 99.6%Couleur et forme :SolidMasse moléculaire :235.24Ref: TM-T3110
5mg46,00€10mg51,00€25mg93,00€50mg118,00€100mg192,00€200mg268,00€500mg452,00€1mL*10mM (DMSO)49,00€(1E)-CFI-400437 dihydrochloride
CAS :(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Formule :C29H30Cl2N6O2Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :565.5AUNP-12 acetate
AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in additionFormule :C144H230N40O50Degré de pureté :95.07%Couleur et forme :SolidMasse moléculaire :3321.61PD-1/PD-L1-IN-53
CAS :PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.Formule :C31H37N3O4Couleur et forme :SolidMasse moléculaire :515.64Cyclo(-RGDfK)
CAS :Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.Formule :C27H41N9O7Degré de pureté :100% - 99.83%Couleur et forme :SolidMasse moléculaire :603.67NKP-1339
CAS :NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.Formule :C14H12Cl4N4NaRuDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.14MTH1 ligand 1
CAS :MTH1 ligand 1 functions as a target protein ligand for MTH1, and is utilized in the synthesis of PROTACaTAG 2139.Formule :C23H18N4O3Couleur et forme :SolidMasse moléculaire :398.41Rafoxanide
CAS :Rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer.Formule :C19H11Cl2I2NO3Degré de pureté :99.47%Couleur et forme :Slight Yellowish Brown Injectable Solution &White Oral SolutionMasse moléculaire :626.01ddUTP Lithium
ddUTP (lithium), at a concentration of 100mM in H20, serves as a nucleotide analog capable of being integrated into DNA, RNA, or other nucleic acids.Degré de pureté :98%Couleur et forme :Odour SolidCSI86
CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).Formule :C48H50F9N7O7SCouleur et forme :SolidMasse moléculaire :1040D-F07
CAS :D-F07 is a novel fluorescent IRE-1 RNase inhibitor and a tricyclic chromone with potential anticancer activity.Formule :C18H21NO6Degré de pureté :99.30% - 99.47%Couleur et forme :SoildMasse moléculaire :347.36PF 477736
CAS :PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formule :C22H25N7O2Degré de pureté :98.34% - 99.62%Couleur et forme :SolidMasse moléculaire :419.48SR31527
CAS :SR31527 chloride: potent KIFC1 inhibitor (IC50 6.6 µM), moderately impairs cell viability & colony growth.Formule :C15H14ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.81Nolatrexed dihydrochloride
CAS :Nolatrexed dihydrochloride (Thymitaq) is a soluble, lipophilic cancer drug that inhibits DNA replication, causing cell cycle arrest and apoptosis.Formule :C14H14Cl2N4OSDegré de pureté :97.02%Couleur et forme :Tan SolidMasse moléculaire :357.26SP-146
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).Formule :C25H20FN7ODegré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :453.47Ref: TM-T8685
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)177,00€KIRA6
CAS :KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response.Formule :C28H25F3N6ODegré de pureté :97.91%Couleur et forme :SolidMasse moléculaire :518.53MKLP2-IN-1
CAS :MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.Formule :C23H19BrFN3O2Couleur et forme :SolidMasse moléculaire :468.318TAK-901
CAS :TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFormule :C28H32N4O3SDegré de pureté :97.38% - 99.1%Couleur et forme :SolidMasse moléculaire :504.64BLU-222
CAS :BLU-222 is a potent, selective and orally active CDK2 inhibitor. BLU-222 shows robust antitumor activity.Formule :C15H17F2N7O2Degré de pureté :99.25% - 99.88%Couleur et forme :SoildMasse moléculaire :365.34Ref: TM-T84321
1mg120,00€5mg283,00€10mg502,00€25mg937,00€50mg1.264,00€100mg1.700,00€1mL*10mM (DMSO)319,00€CLK1/2-IN-3
CAS :CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.Formule :C21H21N5O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :375.42PTC-209
CAS :PTC-209 is a potent and selective BMI-1 inhibitor.Formule :C17H13Br2N5OSDegré de pureté :99.43% - 99.60%Couleur et forme :SolidMasse moléculaire :495.19MLS000532223
CAS :MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).Formule :C15H9NO3Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :251.24Ref: TM-T8473
1mg130,00€2mg183,00€5mg306,00€10mg462,00€25mg755,00€50mg1.035,00€100mg1.415,00€1mL*10mM (DMSO)319,00€E7820
CAS :E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).Formule :C17H12N4O2SDegré de pureté :98.31% - 99.11%Couleur et forme :SolidMasse moléculaire :336.37Ref: TM-T4435
1mg35,00€2mg52,00€5mg69,00€10mg88,00€25mg144,00€50mg210,00€100mg339,00€200mg502,00€1mL*10mM (DMSO)85,00€Roniciclib
CAS :Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.Formule :C18H21F3N4O3SDegré de pureté :98% - 98.63%Couleur et forme :SolidMasse moléculaire :430.44BMVC-8C3O
CAS :BMVC-8C3O is a DNA G-quadruplex (G4) ligand.Cost-effective and quality-assured.Formule :C42H53I3N4O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :1042.61Ref: TM-T13584
1mg106,00€5mg202,00€10mg301,00€25mg487,00€50mg658,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)393,00€WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Formule :C30H31N5O3Couleur et forme :SolidMasse moléculaire :509.6RO0270608
CAS :RO0270608 is an α4β1/α4β7 integrin antagonist with anti-inflammatory activity for the study of allergic inflammatory responses.Formule :C24H19Cl3N2O4Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :505.781A-116
CAS :1A-116 is a specific Rac1 inhibitor.Formule :C16H16F3N3Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :307.31Ref: TM-T14004
1mg50,00€5mg111,00€10mg166,00€25mg283,00€50mg444,00€100mg655,00€200mg924,00€1mL*10mM (DMSO)123,00€MKC9989
CAS :MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.Formule :C17H20O7Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :336.34Ref: TM-T12071
1mg51,00€5mg156,00€10mg226,00€25mg376,00€50mg543,00€100mg730,00€1mL*10mM (DMSO)140,00€JH-RE-06
CAS :JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ.Formule :C20H16Cl3N3O4Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :468.72Ref: TM-T15611
1mg47,00€5mg87,00€10mg160,00€25mg354,00€50mg620,00€100mg1.103,00€1mL*10mM (DMSO)90,00€CDK9-IN-23
CAS :CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].Formule :C22H25ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.91LY3177833
CAS :LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Formule :C16H12FN5ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :309.3Ref: TM-T7810
1mg40,00€5mg85,00€10mg115,00€25mg224,00€50mg335,00€100mg502,00€200mg715,00€1mL*10mM (DMSO)92,00€ZN-c3
CAS :Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.Formule :C29H34N8O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :526.63Ref: TM-T9643
1mg96,00€5mg227,00€10mg354,00€25mg655,00€50mg1.035,00€100mg1.549,00€200mg2.080,00€1mL*10mM (DMSO)264,00€WRN inhibitor 1
CAS :WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.Formule :C16H13FN2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.35Dithranol
CAS :Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especiallyFormule :C14H10O3Degré de pureté :93.49% - ≥98%Couleur et forme :Physical Description Lemon Yellow Leaflets Or Plates Or An Orange Powder MeltingMasse moléculaire :226.23Centrinone
CAS :Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Formule :C26H25F2N7O6S2Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :633.65Zeltociclib
CAS :Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.Formule :C18H20F3N4O2PCouleur et forme :SolidMasse moléculaire :412.346CDK8-IN-4
CAS :CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Formule :C20H18N4OCouleur et forme :SolidMasse moléculaire :330.38EN4
CAS :EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Formule :C25H24N2O4Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :416.47TAME
CAS :Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor.Formule :C14H22N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.41Amenamevir
CAS :Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mLFormule :C24H26N4O5SDegré de pureté :99.00% - 99.86%Couleur et forme :SolidMasse moléculaire :482.55Ref: TM-T4226
1mg60,00€2mg79,00€5mg124,00€10mg197,00€25mg325,00€50mg505,00€100mg730,00€500mg1.501,00€1mL*10mM (DMSO)140,00€Palmatine chloride
CAS :Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formule :C21H22ClNO4Degré de pureté :97.9% - 99.47%Couleur et forme :SolidMasse moléculaire :387.857Indisulam
CAS :Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Formule :C14H12ClN3O4S2Degré de pureté :98.68% - 99.77%Couleur et forme :SolidMasse moléculaire :385.85Ref: TM-T4321
1mg35,00€2mg46,00€5mg66,00€10mg93,00€25mg137,00€50mg210,00€100mg314,00€1mL*10mM (DMSO)72,00€TR-14035
CAS :TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Formule :C24H21Cl2NO5Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :474.33Ref: TM-T5310
1mg52,00€5mg105,00€10mg170,00€25mg298,00€50mg430,00€100mg605,00€200mg815,00€1mL*10mM (DMSO)111,00€Tegafur
CAS :Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity.Formule :C8H9FN2O3Degré de pureté :99.16% - 99.89%Couleur et forme :White Crystalline PowderMasse moléculaire :200.17BWC0977
CAS :BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Formule :C22H21FN6O5Couleur et forme :SolidMasse moléculaire :468.44Mycro 3
CAS :Mycro 3 is potent and selective for c-Myc in whole cell assays.Formule :C24H17ClF2N6O4Degré de pureté :97.87% - 99.51%Couleur et forme :SolidMasse moléculaire :526.88Ref: TM-T4367
1mg49,00€5mg99,00€10mg168,00€25mg335,00€50mg477,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)116,00€TASIN-30
CAS :TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.Formule :C18H30N2O3SCouleur et forme :SolidMasse moléculaire :354.51ITX3
CAS :ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.Formule :C22H17N3OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :371.45GSK_WRN4
CAS :GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer researchFormule :C16H20N2O4SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :336.41Cyclo(RGDyK) trifluoroacetate
CAS :Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formule :C31H43F6N9O12Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :847.72Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Formule :C21H25FN4O2Couleur et forme :SolidMasse moléculaire :384.45Eg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.Formule :C23H16ClFN4ODegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :418.85ASC-69
CAS :ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].Formule :C19H19N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.4T56-LIMKi
CAS :T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formule :C19H14F3N3O3Degré de pureté :98.39% - 98.61%Couleur et forme :SolidMasse moléculaire :389.33IMT1B
CAS :IMT1B (LDC203974) is an oral POLRMT inhibitor that curbs mtDNA expression and has anti-cancer properties.Formule :C24H21ClFNO6Degré de pureté :98.26% - 99.64%Couleur et forme :SolidMasse moléculaire :473.88Ref: TM-T8842
1mg145,00€5mg311,00€10mg533,00€25mg775,00€50mg938,00€100mg1.320,00€1mL*10mM (DMSO)325,00€CDK-IN-10
CAS :CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Formule :C18H18N4O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :322.36SP-96
CAS :SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Formule :C25H20FN7ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :453.47Ref: TM-T41256
1mg73,00€5mg160,00€10mg250,00€25mg445,00€50mg625,00€100mg909,00€200mg1.216,00€1mL*10mM (DMSO)170,00€Valacyclovir hydrochloride
CAS :Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an acyclovir prodrug that inhibits viral DNA replication after metabolization.Formule :C13H20N6O4·HClDegré de pureté :100% - ≥95%Couleur et forme :White To Off-White Crystalline PowerMasse moléculaire :360.8Ref: TM-T1087
1g299,00€10mg47,00€25mg69,00€50mg85,00€100mg97,00€200mg127,00€500mg202,00€1mL*10mM (DMSO)47,00€Netivudine
CAS :Netivudine, a potent NRTI with anti-varicella activity, treats HIV by inhibiting reverse transcriptase, reducing viral load.Formule :C12H14N2O6Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :282.25GW779439X
CAS :GW779439X is an inhibitor of CDK.Formule :C22H21F3N8Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :454.45Ref: TM-T8866
1mg62,00€2mg87,00€5mg119,00€10mg188,00€25mg425,00€50mg625,00€100mg892,00€1mL*10mM (DMSO)131,00€Rinatabart
Rinatabart is a humanized IgG1κ antibody that targets FOLR1. The corresponding isotype control is HumanIgG1kappa, Isotype Control.Couleur et forme :Odour LiquidTHZ2
CAS :THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Formule :C31H28ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.05RWJ 50271
CAS :RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Formule :C18H17F3N4O2SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :410.41Ref: TM-T12783
1mg127,00€5mg311,00€10mg472,00€25mg747,00€50mg1.017,00€100mg1.311,00€200mg1.786,00€1mL*10mM (DMSO)344,00€Etrolizumab
CAS :MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Degré de pureté :95% - 95%Couleur et forme :LiquidBMS202 hydrochloride (1675203-84-5(free base))
CAS :BMS202 hydrochloride (1675203-84-5) is a potent PD-1/PD-L1 inhibitor (IC50: 18 nM) that promotes PD-L1 dimerization, blocking PD1 binding.Formule :C25H30ClN3O3Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :455.97Ref: TM-T4696
1mg51,00€2mg63,00€5mg100,00€10mg160,00€25mg306,00€50mg548,00€100mg785,00€1mL*10mM (DMSO)100,00€CDK9/PARP-IN-1
CAS :CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.Formule :C38H34F2N8O3Couleur et forme :SolidMasse moléculaire :688.725αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Formule :C25H30F3N3O3Couleur et forme :SolidMasse moléculaire :477.52Elarofiban TFA
CAS :Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Formule :C26H34F6N4O8Degré de pureté :100%Couleur et forme :SoildMasse moléculaire :644.56Ribociclib succinate hydrate
CAS :Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).Formule :C27H38N8O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :570.651CCT244747
CAS :CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Formule :C20H24N8O2Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :408.46CDK6-IN-1
CAS :CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Formule :C30H23N5Couleur et forme :SolidMasse moléculaire :453.5411α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS :11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphomaFormule :C28H40O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.61Ara-G
CAS :Ara-G, a deoxyguanosine analog, inhibits DNA synthesis, targeting T cell leukemia by converting to araGTP.Formule :C10H13N5O5Degré de pureté :99.93%Couleur et forme :Slightly Off White To White PowderMasse moléculaire :283.24Sorivudine
CAS :Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.Formule :C11H13BrN2O6Degré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :349.13Apcin A HCL
CAS :Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.Formule :C10H15Cl4N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :379.07AUZ 454
CAS :AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.Formule :C24H26F3N7O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :501.5Tozasertib
CAS :Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formule :C23H28N8OSDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :464.59AS-136A
CAS :AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.Formule :C17H19F3N4O3SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :416.42WRN inhibitor 16
WRN inhibitor 16 (Example 83) is an orally active WRN inhibitor. In a SW48 xenograft mouse tumor model, WRN inhibitor 16 did not cause tumor regression.Formule :C31H30F4N4O5SCouleur et forme :SolidMasse moléculaire :646.65CDK9-IN-7
CAS :CDK9-IN-7: selective, oral CDK9/cyclin T inhibitor with 11 nM IC50, stronger than CDK4/6.Formule :C29H37N7O2SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :547.71Ref: TM-T10745
1mg116,00€5mg298,00€10mg432,00€25mg652,00€50mg900,00€100mg1.206,00€500mg2.432,00€1mL*10mM (DMSO)325,00€Penpulimab
CAS :Penpulimab is a monoclonal antibody targeting PD-1 with antitumor activity, used in studies of pancreatic cancer.Degré de pureté :95% - 95%Couleur et forme :LiquidTadocizumab
CAS :Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Couleur et forme :LiquidAurora B inhibitor 1
CAS :Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Formule :C25H26ClF2N7O2Degré de pureté :98.37%Couleur et forme :SolidMasse moléculaire :529.97