
Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase
- CDK
- Arrêt du cycle cellulaire
- Chk
- c-Myc
- Dynamine
- DYRK
- Ferroptose
- HSP
- Intégrine
- Kinésine
- KSP
- LIM Kinase
- Microtubules associés
- PKC
- PLK
- Rho
- ROCK
- Wee1
Affichez 11 plus de sous-catégories
Produits appartenant à la catégorie "Cycle cellulaire/point de contrôle"
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2'-O-(2-Azidoethyl)adenosine
CAS :2'-O-(2-azidoethyl)adenosine is a purine nucleoside analog with potential antitumor activity.Formule :C12H16N8O4Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :336.31N-desmethyl Netupitant
CAS :N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.Formule :C29H30F6N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.57PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Formule :C19H15F3N4O2Couleur et forme :SolidMasse moléculaire :388.34NSC23005
CAS :NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Formule :C13H17NO4SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :283.34WEE1-IN-3
CAS :WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Formule :C28H31N7O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :497.59Ref: TM-T8916
1mg70,00€5mg156,00€10mg239,00€25mg419,00€50mg562,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€A-286982
CAS :A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Formule :C24H27N3O4SDegré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :453.55Ref: TM-T21781
1mg35,00€2mg50,00€5mg74,00€10mg107,00€25mg210,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)81,00€CDK2-IN-19
CDK2-IN-19 (Compound 32) is a selective, orally active inhibitor of CDK2 (K i: 0.18 nM) that exhibits anticancer activity in mice with OVCAR3 tumors [1].Formule :C20H21FN6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.48CC-671
CAS :CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Formule :C28H28N6O4Degré de pureté :98.35% - 98.65%Couleur et forme :SolidMasse moléculaire :512.56Ref: TM-T4482
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg540,00€100mg775,00€500mg1.596,00€1mL*10mM (DMSO)127,00€Rhosin
CAS :Rhosin is a specific inhibitor of RhoA GTPases (Kd: ~0.4 uM), blocking RhoA-GEF interaction, not affecting Cdc42/Rac1/LARG, and induces apoptosis.Formule :C20H18N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :358.43MB-PP1
CAS :3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Formule :C17H21N5Degré de pureté :99.97%Couleur et forme :White SolidMasse moléculaire :295.38Ref: TM-T21678
5mg52,00€10mg96,00€25mg170,00€50mg269,00€100mg394,00€500mgÀ demander1mL*10mM (DMSO)58,00€2-Chloropyrazine
CAS :2-Chloropyrazine is used in chemical industry.Formule :C4H3ClN2Degré de pureté :98.98% - 99.81%Couleur et forme :Clear Colorless To Yellowish LiquidMasse moléculaire :114.53Trilaciclib
CAS :Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).Formule :C24H30N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.55NG 52
CAS :NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Formule :C16H19ClN6ODegré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :346.81Ref: TM-T2028
1mg74,00€2mg97,00€5mg158,00€10mg269,00€25mg515,00€50mg743,00€100mg1.035,00€500mg2.080,00€1mL*10mM (DMSO)158,00€5-Bromouridine
CAS :5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.Formule :C9H11BrN2O6Degré de pureté :99.89%Couleur et forme :White PowderMasse moléculaire :323.1CDK9-IN-15
CAS :CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Formule :C16H11N3OSDegré de pureté :97.24%Couleur et forme :SolidMasse moléculaire :293.34Ref: TM-T60619
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg273,00€100mg393,00€200mg550,00€1mL*10mM (DMSO)62,00€Fosifloxuridine nafalbenamide
CAS :Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.Formule :C29H29FN3O9PDegré de pureté :95.87%Couleur et forme :SolidMasse moléculaire :613.53Ref: TM-T33762
1mg88,00€5mg160,00€10mg216,00€25mg393,00€50mg550,00€100mg753,00€500mg1.549,00€1mL*10mM (DMSO)210,00€Retifanlimab
CAS :Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.Degré de pureté :95% - 95%Couleur et forme :Liquid2'-O-Methyl-2-thiouridine
CAS :2'-O-Methyl-2-thiouridine, a purine nucleoside analog present in synthetic thermophilic bacterial tRNAs, is more selective for A than unmodified U.Formule :C10H14N2O5SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :274.292'-O-Methylinosine
CAS :2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally bioavailable purine nucleoside analog with antihypertensive activity.Formule :C11H14N4O5Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :282.25B I09
CAS :B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.Formule :C16H17NO5Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :303.31Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.Formule :C93H134N22O25Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :1960.19ML-60218
CAS :ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.Formule :C19H15Cl2N3O2S2Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :452.38Ref: TM-T40661
1mg56,00€5mg119,00€10mg187,00€25mg411,00€50mg638,00€100mg908,00€200mg1.225,00€1mL*10mM (DMSO)131,00€Filanesib
CAS :Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.Formule :C20H22F2N4O2SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :420.48Rabusertib
CAS :Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.Formule :C18H22BrN5O3Degré de pureté :98.86% - 99.63%Couleur et forme :SolidMasse moléculaire :436.3BMS-1166
CAS :BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.Formule :C36H33ClN2O7Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :641.11Ref: TM-T5697
1mg74,00€5mg155,00€10mg225,00€25mg429,00€50mg635,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)208,00€6-AZATHYMINE
CAS :6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.Formule :C4H5N3O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :127.1CHK1-IN-3
CAS :CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Formule :C20H23N9ODegré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :405.46Ref: TM-T10791
1mg185,00€2mg279,00€5mg424,00€10mg627,00€25mg938,00€50mg1.311,00€100mg1.795,00€1mL*10mM (DMSO)470,00€Y16 acetate(429653-73-6 free base)
Y16 acetate(429653-73-6 free base) is a G-protein-coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoAFormule :C51H74N14O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1091.24Sangivamycin
CAS :Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formule :C12H15N5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :309.28Ref: TM-T9605
1mg126,00€5mg274,00€10mg416,00€25mg677,00€50mg944,00€100mg1.264,00€1mL*10mM (DMSO)360,00€Thiarabine
CAS :Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Formule :C9H13N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :259.28CP-07
CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formationFormule :C45H48N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :800.95,6-Dihydro-5-methyluracil
CAS :5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine.Formule :C5H8N2O2Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :128.13Dostarlimab
CAS :Dostarlimab (TSR-042) is an immune checkpoint inhibitor targeting PD-1, blocking its interaction with its ligands PD-L1 and PD-L2.Degré de pureté :>95%Couleur et forme :LiquidGW406108X(Z/E)
CAS :GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Formule :C20H11Cl2NO4Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :400.21Ref: TM-T9207L
1mg131,00€5mg286,00€10mg430,00€25mg647,00€50mg969,00€100mg1.301,00€1mL*10mM (DMSO)283,00€MBQ-167
CAS :MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formule :C22H18N4Degré de pureté :98.07% - 98.74%Couleur et forme :SolidMasse moléculaire :338.41Ref: TM-T16021
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg208,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)87,00€RP-6685
CAS :RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.Formule :C22H14F7N5ODegré de pureté :98.34%Couleur et forme :SoildMasse moléculaire :497.37Ref: TM-T60187
1mg88,00€5mg160,00€10mg230,00€25mg378,00€50mg538,00€100mg755,00€1mL*10mM (DMSO)170,00€dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formule :C52H53Cl2FN8O12Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :1071.93CDK9-IN-35
CDK9-IN-35 (compound 10j) acts as an inhibitor of CDK9/CyclinT1, exhibiting an IC50 of 10.2 nM. It also shows an IC50 of 20 nM against the HCT-116 cell line.Formule :C26H24ClFN4O4SCouleur et forme :SolidMasse moléculaire :543.01Anticancer agent 73
CAS :Anticancer agent 73 inhibits TRBP, disrupting TRBP-Dicer, and hinders HCC growth and spread by altering HCC miRNA and protein expression.Formule :C14H15NO4Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :261.27Rifaximin
CAS :Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.Formule :C43H51N3O11Degré de pureté :98.05% - 99.40%Couleur et forme :Red-Orange Crystalline PowderMasse moléculaire :785.88Men 10376
CAS :Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.Formule :C57H68N12O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1081.22Nivolumab
CAS :Nivolumab is a monoclonal antibody, a humanized IgG4 antibody to PD-1. Nivolumab has antitumor activity. Cost-effective and quality-assured.Degré de pureté :98% - 98%Couleur et forme :LiquidMasse moléculaire :146 kDa2',3'-Bis-(O-t-butyldimethylsilyl)uridine
CAS :2',3'-Bis-(O-t-butyldimethylsilyl)uridine is a nucleoside derivative protect the NH2/OH groups of nucleosides.inhibitory on viral replication,AIDS and herpes.Formule :C21H40N2O6Si2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :472.72Ref: TM-TNU1182
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Vitamin D2
CAS :Ergocaliferol (Vitamin D2), derived from ergosterol by UV, inhibits bladder tumor promotion and leukemia, and blocks DNA Polymerase.Formule :C28H44ODegré de pureté :98.73% - ≥98%Couleur et forme :Prisms From Acetone 1998)Masse moléculaire :396.65Aurora Kinases-IN-4
CAS :Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Formule :C26H28N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.55P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Formule :C53H81N13O11Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :1076.29Beaucage reagent
CAS :Beaucage reagent, which is found to be effective in causing DNA cleavage.Formule :C7H4O3S2Degré de pureté :95.19%Couleur et forme :White To Off-White PowderMasse moléculaire :200.23Abemaciclib metabolite M20
CAS :Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂,可用于癌症治疗的相关研究。Formule :C27H32F2N8ODegré de pureté :98.32% - 99.29%Couleur et forme :SolidMasse moléculaire :522.59CDK2/Bcl2-IN-1
CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells.Formule :C35H56O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :668.88RAD51-IN-1
CAS :Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.Formule :C22H16ClN3ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :373.833-Deazauridine
CAS :3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.Formule :C10H13NO6Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :243.21Mevociclib
CAS :Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formule :C31H35ClN8O2Degré de pureté :98.02% - 98.02%Couleur et forme :SolidMasse moléculaire :587.112-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78GS-443902
CAS :Remdesivir triphosphate (GS-443902) inhibits RSV/HCV RdRp with IC50s: 1.1/5 µM.Formule :C12H16N5O13P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.2MU1409
CAS :MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.Formule :C20H14BrN3O3SCouleur et forme :SolidMasse moléculaire :456.312Senexin A
CAS :Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Formule :C17H14N4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :274.32Ref: TM-T5673
1mg37,00€5mg77,00€10mg99,00€25mg187,00€50mg340,00€100mg485,00€200mg657,00€1mL*10mM (DMSO)74,00€Centrinone-B
CAS :Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formule :C27H27F2N7O5S2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :631.67PD-1/PD-L1-IN-9
CAS :PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction.Formule :C22H24N2O2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T9651
1mg60,00€2mg89,00€5mg134,00€10mg188,00€25mg314,00€50mg429,00€100mg565,00€500mg1.121,00€1mL*10mM (DMSO)148,00€T7 RNA polymerase
CAS :T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcriptionDegré de pureté :98%Couleur et forme :SolidPD-L1-IN-7
CAS :PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Formule :C46H50N6O7Couleur et forme :SolidMasse moléculaire :798.93BET/Aurora kinase-IN-1
CAS :BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Formule :C25H30FN7OCouleur et forme :SolidMasse moléculaire :463.555-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS :5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formule :C8H13N3SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :183.27PD-1/PD-L1 inhibitory peptide C8
PD-1/PD-L1 inhibitory peptide C8 disrupts the PD-1/PD-L1 interaction, leading to the activation of CD8+ and CD4+ T cells and an increase in IFN-γ secretion. In mouse models, PD-1/PD-L1 inhibitory peptide C8 has demonstrated antitumor activity.Formule :C51H72N14O14S2Couleur et forme :SolidMasse moléculaire :1169.33MRK-952
MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.Formule :C20H20ClF3N6Couleur et forme :SolidMasse moléculaire :436.861CKK-E12
CAS :CKK-E12 is an ionizable lipid for RNA delivery via lipid nanoparticles, with high liver cell selectivity in vivo.Formule :C60H120N4O6Degré de pureté :98.328%Couleur et forme :SolidMasse moléculaire :993.62AZA197
CAS :AZA197 (AZA-197) is a selective Cdc42 inhibitor.Formule :C24H36N6Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :408.58Lobucavir
CAS :Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).Formule :C11H15N5O3Couleur et forme :SolidMasse moléculaire :265.27CCG-257081
CAS :CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.Formule :C24H19ClF3N3O2Degré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :473.87TCS7010
CAS :TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Formule :C31H31ClFN7O2Degré de pureté :98.49% - 99.62%Couleur et forme :SolidMasse moléculaire :588.07Risdiplam
CAS :Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Formule :C22H23N7ODegré de pureté :98.68% - 99.43%Couleur et forme :SolidMasse moléculaire :401.46GSK3335103
CAS :GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59(S)-DI-87
CAS :(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor,reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.Formule :C23H30N6O3S2Degré de pureté :99.42%Couleur et forme :SoildMasse moléculaire :502.65Ref: TM-T39550L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€KWR095
CAS :KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105Thymectacin
CAS :Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.Formule :C21H25BrN3O9PDegré de pureté :98.41% - 99.82%Couleur et forme :SolidMasse moléculaire :574.32Voruciclib
CAS :Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Formule :C22H19ClF3NO5Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :469.84CDK4/6-IN-6
CAS :CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.Formule :C22H27ClFN5O3Degré de pureté :95.63%Couleur et forme :SolidMasse moléculaire :463.93Ref: TM-T39957
Produit arrêtéDNA polymerase-IN-3
CAS :DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications inFormule :C13H12O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.23ARB-272572 hydrochloride
CAS :ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formule :C32H36N6O4·xClHDegré de pureté :99%Couleur et forme :SoildMasse moléculaire :568.68(Free base)5-OHdU
CAS :5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.Formule :C9H12N2O6Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :244.2Ref: TM-T19152
1mg47,00€2mg60,00€5mg89,00€10mg131,00€25mg212,00€50mg316,00€100mg474,00€1mL*10mM (DMSO)90,00€Palbociclib
CAS :Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Formule :C24H29N7O2Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :447.53Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formule :C10H10ClFN5Na3O9P2Couleur et forme :SolidMasse moléculaire :529.58BRD9876
CAS :BRD9876 is a selective inhibitor of MM1S growth.Formule :C16H14N2Degré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :234.3Bractoppin
CAS :Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibitsFormule :C25H23FN4ODegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :414.47Ref: TM-T8873
1mg49,00€5mg104,00€10mg166,00€25mg325,00€50mg490,00€100mg737,00€500mg1.483,00€1mL*10mM (DMSO)115,00€Werner syndrome RecQ helicase-IN-4
CAS :Werner syndrome RecQ helicase-IN-4 is a WRN inhibitor with anticancer and anti-proliferative activity, used in colorectal and gastric cancer research.Formule :C32H33F3N8O5Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :666.65YKL-5-124
CAS :YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFormule :C28H33N7O3Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :515.61Ref: TM-T22461
1mg96,00€2mg135,00€5mg188,00€10mg341,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)225,00€SNX7
CAS :SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formule :C15H14N2ODegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :238.28MIRA-1
CAS :MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activityFormule :C8H9NO4Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :183.16CDK4/6/1 Inhibitor
CAS :CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Formule :C28H30F2N6Degré de pureté :97.99% - 99.26%Couleur et forme :SolidMasse moléculaire :488.57TAK-632
CAS :TAK-632 is a potent pan-Raf inhibitor.Formule :C27H18F4N4O3SDegré de pureté :98% - 98.92%Couleur et forme :SolidMasse moléculaire :554.52bio-THZ1
CAS :bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).Formule :C52H65ClN12O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1053.67Roxifiban acetate
CAS :Roxifiban acetate(DMP 754 acetate) is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFormule :C23H33N5O8Degré de pureté :99.33% - 99.56%Couleur et forme :SolidMasse moléculaire :507.54CDK2-IN-31
CAS :CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Formule :C37H52N6O5Couleur et forme :SolidMasse moléculaire :660.85Levomefolate calcium
CAS :Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.Formule :C20H23CaN7O6Degré de pureté :97.35% - 98%Couleur et forme :Off-White To Pale Yellow SolidMasse moléculaire :497.52Deoxycytidine triphosphate trisodium salt
CAS :Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.Formule :C9H13N3Na3O13P3Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :533.1ZYN57939
CAS :ZYN57939 (MTR-106), an RNA polymerase I inhibitor, treats related diseases with a 0.855 μM IC50 against HT-29 cells.Formule :C28H27N7O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :525.62Trifluridine/tipiracil hydrochloride mixture
CAS :Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in aFormule :C29H34Cl2F6N8O12Degré de pureté :99.37% - ≥98%Couleur et forme :SolidMasse moléculaire :871.53Ref: TM-T3658
2mg39,00€5mg57,00€10mg87,00€25mg157,00€50mg250,00€100mg378,00€200mg568,00€500mg889,00€1mL*10mM (DMSO)78,00€PD173952
CAS :PD173952 is a Src kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.Formule :C24H21Cl2N5O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :482.36BMS-3
CAS :BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formule :C17H12Cl2F2N4OSDegré de pureté :99.19% - 99.31%Couleur et forme :SolidMasse moléculaire :429.27Avotaciclib
CAS :Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastaticFormule :C13H11N7ODegré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :281.27Ac-rC Phosphoramidite
CAS :Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.Formule :C47H64N5O9PSiDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :902.1Pyridostatin
CAS :Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFormule :C31H32N8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.64SB273005
CAS :SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Formule :C22H24F3N3O4Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :451.44Ribociclib hydrochloride
CAS :Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formule :C23H31ClN8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471PD-1/PD-L1-IN-33
CAS :PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formule :C26H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.53KIF18A-IN-14
CAS :KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.Formule :C26H32F3N5O6SCouleur et forme :SolidMasse moléculaire :599.62MK-5108
CAS :MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formule :C22H21ClFN3O3SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :461.94Farletuzumab
CAS :Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.36 kDa8-Azahypoxanthine
CAS :8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.Formule :C4H3N5ODegré de pureté :≥98%Couleur et forme :Light Yellow To Light Beige Fine CrystallineMasse moléculaire :137.1Ref: TM-T20102
5mg48,00€10mg66,00€25mg104,00€50mg154,00€100mg216,00€200mg324,00€1mL*10mM (DMSO)48,00€Datelliptium chloride hydrochloride
CAS :Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.Formule :C23H29Cl2N3ODegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :434.4ZM-447439
CAS :ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formule :C29H31N5O4Degré de pureté :98.53% - 99.11%Couleur et forme :Pale Yellow SolidMasse moléculaire :513.59MBM-17
CAS :MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM).Formule :C28H28N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.56Dalpiciclib
CAS :Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.Formule :C25H30N6O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :446.54BVDV-IN-1
CAS :BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.Formule :C20H22N4ODegré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :334.41Ref: TM-T9103
1mg40,00€5mg90,00€10mg131,00€25mg255,00€50mg375,00€100mg535,00€200mg725,00€1mL*10mM (DMSO)90,00€KSI-3716
CAS :KSI-3716 is a c-Myc inhibitor, a bladder chemotherapy agent that blocks the formation of complexes between c-MYC/MAX and target gene promoters.Formule :C17H11BrCl2N2O2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :426.09IIIM-290
CAS :IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formule :C23H21Cl2NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.32Rabacfosadine
CAS :Rabacfosadine (GS-9219) is a novel prodrug of PMEG, an acyclic nucleotide phosphonate, with antitumor activity for the study of lymphoma.Formule :C21H35N8O6PDegré de pureté :98.75% - 99.43%Couleur et forme :SolidMasse moléculaire :526.53CHK1-IN-2
CAS :CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Formule :C20H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.48THZ531
CAS :THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Formule :C30H32ClN7O2Degré de pureté :97.17% - 99.86%Couleur et forme :SolidMasse moléculaire :558.07Ref: TM-T4293
1mg63,00€2mg90,00€5mg111,00€10mg153,00€25mg329,00€50mg472,00€100mg687,00€500mg1.415,00€1mL*10mM (DMSO)137,00€IRE1α kinase-IN-8
CAS :IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α.Formule :C23H22N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.43SY-5609
CAS :SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formule :C23H26F3N6OPDegré de pureté :99.32% - 99.34%Couleur et forme :SolidMasse moléculaire :490.46Ref: TM-T36038
1mg139,00€2mg200,00€5mg343,00€10mg553,00€25mgÀ demander50mgÀ demander1mL*10mM (DMSO)399,00€BRD4 Inhibitor-40
CAS :BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.Formule :C27H32N8OCouleur et forme :SolidMasse moléculaire :484.596PD-1/PD-L1-IN-26
CAS :PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.Formule :C43H52N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :752.89Briciclib
CAS :Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.Formule :C19H23O10PSDegré de pureté :98% - 99.84%Couleur et forme :SolidMasse moléculaire :474.42Ref: TM-T3207
1mg47,00€2mg57,00€5mg88,00€10mg126,00€25mg250,00€50mg376,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)87,00€8-Chloroinosine
CAS :8-Chloroinosine is a purine nucleoside analog and a metabolite of the anticancer compound 8-chloro-adenosine.Formule :C10H11ClN4O5Degré de pureté :99.37% - 99.56%Couleur et forme :SolidMasse moléculaire :302.67H3B-968
CAS :H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFormule :C22H18F6N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.46CLT-28643
CAS :CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formule :C19H17N3O4Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :351.36CHK-IN-1
CAS :CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Formule :C18H19ClFN5OSDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :407.891-Methylinosine
CAS :1-Methylinosine (N1-Methylinosine) is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA and has a role as a metabolite.Formule :C11H14N4O5Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :282.25CDK9-IN-27
CDK9-IN-27 (Compound 6a), a CDK9 inhibitor with an IC50 of 0.424 μM, induces apoptosis and S-phase cell cycle arrest.Formule :C23H18ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.87CCG-100602
CAS :CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formule :C21H17ClF6N2O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :478.82Ref: TM-T22062
5mg38,00€10mg57,00€25mg114,00€50mg188,00€100mg303,00€200mg449,00€1mL*10mM (DMSO)43,00€Ro3280
CAS :Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formule :C27H35F2N7O3Degré de pureté :100% - 98%Couleur et forme :SolidMasse moléculaire :543.61CDK7-IN-31
CAS :CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Formule :C27H32F5N6O2PCouleur et forme :SolidMasse moléculaire :598.55SR18662
SR18662, improved ML264 derivative, inhibits KLF5 at 4.4 nM IC50; curbs colorectal cancer cell growth and triggers apoptosis.Formule :C16H19Cl2N3O4SDegré de pureté :98.97% - 99.2%Couleur et forme :SolidMasse moléculaire :420.31Ref: TM-T22429
1mg48,00€5mg96,00€10mg160,00€25mg311,00€50mg502,00€100mg718,00€200mg938,00€500mg1.454,00€1mL*10mM (DMSO)105,00€InhA-IN-2
CAS :N-[3-(Aminomethyl)phenyl]-5-chloro-3-methyl-benzo[b]thiophene-2-sulfonamide inhibits InhA without KatG activation.Formule :C16H15ClN2O2S2Degré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :366.89Ref: TM-T9734
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)197,00€Y-33075
CAS :Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formule :C16H16N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :280.32DDRI-18
CAS :DDRI-18 is an inhibitor that regulates the DNA damage response, has anticancer activity, and inhibits non-homologous end-joining (NHEJ) DNA repair.Formule :C26H20N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.48N-deacetylated BMS-202
CAS :N-deacetylated BMS-202 is an inhibitor of PD-1/PD-L1 interaction with potential anticancer activity for cancer research.Formule :C23H27N3O2Degré de pureté :98.13% - 98.13%Couleur et forme :SolidMasse moléculaire :377.48ILK-IN-3
CAS :ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formule :C10H12N6ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :232.24NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formule :C24H30N6OCouleur et forme :SolidMasse moléculaire :418.535SWS1
CAS :SWS1, a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM), displays anticancer activity by augmenting tumor-infiltrating lymphocytes and demonstrating antiFormule :C47H53ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :849.48CCT251455
CAS :CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.Formule :C26H26ClN7O2Degré de pureté :99.1% - 99.1%Couleur et forme :SolidMasse moléculaire :503.98P162-0948
CAS :P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.Formule :C20H15FN4O2Couleur et forme :SolidMasse moléculaire :362.357Silver sulfadiazine
CAS :Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.Formule :C10H9AgN4O2SDegré de pureté :99.04% - 99.58%Couleur et forme :SolidMasse moléculaire :357.14Vedolizumab
CAS :Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.Degré de pureté :SDS-PAGE:98.4%;SEC-HPLC:99.1%Couleur et forme :LiquidMasse moléculaire :146.80 kDaMK-8745
CAS :MK-8745 is a potent and selective Aurora A inhibitor.Formule :C20H19ClFN5OSDegré de pureté :98.94% - 99.31%Couleur et forme :SolidMasse moléculaire :431.913-Hydroxyxanthone
CAS :3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormule :C13H8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :212.2Pyridostatin Trihydrochloride
CAS :Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Formule :C31H35Cl3N8O5Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :706.02Enocitabine
CAS :Enocitabine is a nucleoside analog.Formule :C31H55N3O6Degré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :565.78AZD4573
CAS :AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Formule :C22H28ClN5O2Degré de pureté :99.23% - 99.63%Couleur et forme :SolidMasse moléculaire :429.94CCG-203971
CAS :CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formule :C23H21ClN2O3Degré de pureté :98.82% - 99.35%Couleur et forme :SolidMasse moléculaire :408.88Eg5 Inhibitor V, trans-24
CAS :Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formule :C26H21N3O3Degré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :423.46Ref: TM-T11155
1mg92,00€5mg205,00€10mg305,00€25mg495,00€50mg677,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)227,00€NU6102
CAS :NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.Formule :C18H22N6O3SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :402.47CDK-IN-2
CAS :CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Formule :C18H19ClFN3O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :363.81Ref: TM-TQ0078
1mg40,00€2mg54,00€5mg92,00€10mg145,00€25mg271,00€50mg398,00€100mg562,00€500mg1.121,00€1mL*10mM (DMSO)97,00€PTC-209 hydrobromide
CAS :PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results inFormule :C17H13Br2N5OS·HBrDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.1SHR5428
SHR5428 is an orally active, selective, noncovalent inhibitor of CDK7, displaying potent enzymatic inhibition (IC50 = 2.3 nM) and effectively suppressingDegré de pureté :98%Couleur et forme :Odour Solid5-Aminouridine
CAS :5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA.Formule :C9H13N3O6Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :259.22LTB
LTB is a prodrug formed through the conjugation of the glycolysis inhibitor (Lonidamine) and the PD1/PDL1 blocker (BMS-1) via a thioketal bond. LTB can encapsulate the photosensitizer Chlorin e6 (Ce6), constructing a co-delivery photodynamic nanoplatfform through self-assembly (LTB-6 NPs).Formule :C53H59Cl2N3O7S2Couleur et forme :SolidMasse moléculaire :985.09Cytembena
CAS :Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.Formule :C11H8BrNaO4Degré de pureté :99.53%Couleur et forme :White PowderMasse moléculaire :307.07CDK12-IN-3
CAS :CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Formule :C23H28F2N8ODegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :470.52Ref: TM-T14990
1mg130,00€5mg311,00€10mg512,00€25mg1.074,00€50mg1.795,00€100mg2.375,00€1mL*10mM (DMSO)344,00€PD 407824
CAS :PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Formule :C20H12N2O3Degré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :328.32AMG 900
CAS :AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Formule :C28H21N7OSDegré de pureté :98.35% - 98.9%Couleur et forme :SolidMasse moléculaire :503.58Ref: TM-T6380
1mg52,00€5mg97,00€10mg166,00€25mg303,00€50mg467,00€100mg682,00€500mg1.415,00€1mL*10mM (DMSO)105,00€GSK461364
CAS :GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formule :C27H28F3N5O2SDegré de pureté :98.85% - 99.5%Couleur et forme :SolidMasse moléculaire :543.6Ref: TM-T6282
1mg37,00€2mg52,00€5mg74,00€10mg124,00€25mg207,00€50mg374,00€100mg557,00€200mg797,00€500mg1.216,00€β-catenin-IN-8
CAS :β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Formule :C15H12ClN3O2SCouleur et forme :SolidMasse moléculaire :333.79Socazolimab
CAS :Socazolimab (ZKAB001) is a monoclonal antibody targeting PD-L1 with antitumor activity, used in studies of recurrent or metastatic cervical cancer.Degré de pureté :95%Couleur et forme :LiquidPS423
CAS :PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Formule :C25H23F3O9Degré de pureté :98.81% - 99.26%Couleur et forme :SolidMasse moléculaire :524.442'-Deoxy-2'-fluoroarabinoadenosine
CAS :2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue with extensive anti-tumor activity and can be used for the study of tumor diseases.Formule :C10H12FN5O3Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :269.23PMT-O9-1A
PMT-O9-1A is an effective PD-L1 degrader that reduces PD-L1 protein expression and exhibits cytotoxic properties. Additionally, PMT-O9-1A possesses anticancer activity.Formule :C22H25ClN2O4Couleur et forme :SolidMasse moléculaire :416.90Trilaciclib hydrochloride
CAS :Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Formule :C24H32Cl2N8ODegré de pureté :98.61% - 99.69%Couleur et forme :SolidMasse moléculaire :519.47Fadraciclib
CAS :Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Formule :C21H31N7ODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :397.52Ref: TM-TQ0053
1mg48,00€5mg101,00€10mg178,00€25mg304,00€50mg437,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)111,00€KIF18A-IN-3
CAS :KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Formule :C28H38N4O5S2Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :574.76Ro5-3335
CAS :Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.Formule :C13H10ClN3ODegré de pureté :99.42% - 99.50%Couleur et forme :SolidMasse moléculaire :259.69(S)-PF-06873600
CAS :(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Formule :C20H27F2N5O4SDegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :471.52Orotic acid zinc
CAS :Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.Formule :C10H6N4O8ZnDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :188.79VVD-214
CAS :VVD-214 (RO7589831) is a WRN deconjugation enzyme lethal-mutagenic inhibitor that can be used to study proliferative diseases.Formule :C20H21F2N3O4SDegré de pureté :99.24%Couleur et forme :SoildMasse moléculaire :437.46N-Nitrosonornicotine
CAS :N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.Formule :C9H11N3OCouleur et forme :SolidMasse moléculaire :177.2ARQ 621
CAS :ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.Formule :C28H24Cl2FN5O2Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :552.43Lifitegrast
CAS :Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Formule :C29H24Cl2N2O7SDegré de pureté :99.39% - 99.66%Couleur et forme :SolidMasse moléculaire :615.48Cdc7-IN-7c
CAS :Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.Formule :C15H17N5OSDegré de pureté :99.31% - 99.77%Couleur et forme :SolidMasse moléculaire :315.39Ref: TM-T23867
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)633,00€CDK12-IN-2
CAS :CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.Formule :C32H32N6O2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :532.64Ref: TM-T39752
1mg92,00€5mg216,00€10mg376,00€25mg620,00€50mg889,00€100mg1.198,00€1mL*10mM (DMSO)255,00€Cyclo(-RGDfK) TFA
CAS :Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formule :C29H42F3N9O9Degré de pureté :98.99% - 99.54%Couleur et forme :SolidMasse moléculaire :717.69TH-257
CAS :TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formule :C24H26N2O3SDegré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :422.54Peresolimab
CAS :Peresolimab, a humanized IgG1-κ antibody, targets PD-1 and may activate physiological immune inhibitory pathways, thereby restoring immune homeostasis [1] [2].Degré de pureté :98%Couleur et forme :Liquid10-Formyl-5,8-dideazafolic acid
CAS :10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.Formule :C22H21N5O7Degré de pureté :96.04%Couleur et forme :SolidMasse moléculaire :467.43CWHM-12
CAS :CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Formule :C26H32BrN5O6Degré de pureté :98.05% - 98.5%Couleur et forme :SolidMasse moléculaire :590.47Ref: TM-TQ0250
1mg40,00€2mg52,00€5mg88,00€10mg126,00€25mg221,00€50mg369,00€100mg550,00€1mL*10mM (DMSO)96,00€2',5-Difluoro-2'-deoxy-1-arabinosyluracil
CAS :2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepilepticFormule :C9H10F2N2O5Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :264.18FIT-039
CAS :FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Formule :C17H18FN3SDegré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :315.41KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105PD-1/PD-L1-IN-31
PD-1/PD-L1-IN-31 is a potent inhibitor of PD-1/PD-L1 (IC50=2.2 nM) that enhances IFN-γ secretion and activates the immune response of peripheral bloodFormule :C24H24ClFN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.915'-O-DMT-N2-ibu-dG
CAS :5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.Formule :C35H37N5O7Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :639.7Isoindigotin
CAS :Isoindigotin is used in the therapy of Y.Formule :C16H10N2O2Degré de pureté :97.52% - ≥95%Couleur et forme :SolidMasse moléculaire :262.26Tislelizumab
CAS :Tislelizumab, a PD-1 receptor monoclonal antibody, reduces Fcγ interaction and T cell clearance in advanced squamous NSCLC research.Degré de pureté :95%Couleur et forme :LiquidDebio-0123
CAS :Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Formule :C26H28Cl2N6ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :511.45Ref: TM-T9864
1mg95,00€5mg227,00€10mg359,00€25mg607,00€50mg868,00€100mg1.169,00€1mL*10mM (DMSO)255,00€BCH001
CAS :BCH001 is a specific small-molecule inhibitor of PAPD5.Formule :C20H15F3N2O5Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :420.34Human membrane-bound PD-L1 polypeptide
CAS :Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formule :C85H140N26O36SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2134.24GSK-1070916
CAS :GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formule :C30H33N7ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :507.63Adenine hydrochloride
CAS :Adenine hydrochloride (6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry.Formule :C5H5N5·HClDegré de pureté :98.86%Couleur et forme :White To Light Yellow Crystal PowderMasse moléculaire :171.59RS-1
CAS :RS-1 is a RAD51 activator. RS-1 also increases CRISPR/Cas9-mediated knock-in efficiencies.Formule :C20H16Br2N2O3SDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :524.23Ref: TM-T6972
5mg51,00€10mg79,00€25mg126,00€50mg210,00€100mg354,00€200mg517,00€500mg825,00€1mL*10mM (DMSO)59,00€TREX1-IN-4
CAS :TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.Formule :C24H19ClN6O4Couleur et forme :SolidMasse moléculaire :490.898Balamapimod
CAS :Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Formule :C30H32ClN7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.14