PKC
Les inhibiteurs de la protéine kinase C (PKC) ciblent la famille des kinases PKC, qui sont impliquées dans un large éventail de processus cellulaires, notamment la régulation du cycle cellulaire, l'apoptose et la différenciation. La PKC joue un rôle clé dans les voies de transduction du signal qui influencent la prolifération et la survie des cellules. L'inhibition de la PKC peut entraîner des changements dans la progression du cycle cellulaire, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer, la neurobiologie et les maladies cardiovasculaires. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de PKC de haute qualité pour soutenir vos recherches en transduction du signal, régulation du cycle cellulaire et développement thérapeutique.
Produits appartenant à la catégorie "PKC"
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CGP60474
CAS :CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.Formule :C18H18ClN5ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :355.82Ref: TM-T14943
1mg35,00€2mg48,00€5mg74,00€10mg97,00€25mg187,00€50mg331,00€100mg547,00€1mL*10mM (DMSO)82,00€HA-100
CAS :HA-100 is an inhibitor of protein kinaseFormule :C13H15N3O2SDegré de pureté :99.44%Couleur et forme :Pale Yellow Crystalline SolidMasse moléculaire :277.34Taurochenodeoxycholic acid sodium
CAS :Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Formule :C26H44NNaO6SDegré de pureté :98.23% - 99.45%Couleur et forme :White To Off-White PowderMasse moléculaire :521.68Go 6983
CAS :Go 6983 is a pan-PKC inhibitor targeting PKCα, PKCβ, PKCγ, PKCδ, and PKCζ, exhibiting IC50 values of 7 nM, 7 nM, 6 nM, 10 nM, and 60 nM, respectively.Formule :C26H26N4O3Degré de pureté :98.41% - 99.04%Couleur et forme :SolidMasse moléculaire :442.51Ref: TM-T6313
1mg43,00€2mg55,00€5mg84,00€10mg126,00€25mg245,00€50mg388,00€100mg563,00€1mL*10mM (DMSO)88,00€Midostaurin
CAS :PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Formule :C35H30N4O4Degré de pureté :100% - 99.47%Couleur et forme :SolidMasse moléculaire :570.64Ref: TM-T3211
1mg51,00€5mg88,00€10mg126,00€25mg216,00€50mg328,00€100mg487,00€500mg1.093,00€1mL*10mM (DMSO)96,00€Ionomycin calcium
CAS :Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.Formule :C41H70CaO9Degré de pureté :98% - 98.11%Couleur et forme :SolidMasse moléculaire :747.07AJH-836
CAS :AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFormule :C22H38O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.53PKC-IN-1
CAS :PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formule :C25H37FN8O2Degré de pureté :98% - 98.79%Couleur et forme :SolidMasse moléculaire :500.61Bisindolylmaleimide III
CAS :Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6Formule :C23H20N4O2Degré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :384.43Phorbol 12,13-dibutyrate
CAS :Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Formule :C28H40O8Degré de pureté :100% - 99.32%Couleur et forme :SolidMasse moléculaire :504.61Ref: TM-T16526
1mg62,00€5mg169,00€10mg283,00€25mg557,00€50mg795,00€100mg1.074,00€1mL*10mM (DMSO)180,00€VTX-27
CAS :VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Formule :C20H24ClFN6ODegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :418.9Ref: TM-T13314
1mg93,00€2mg125,00€5mg244,00€10mg364,00€25mg562,00€50mg780,00€100mg1.035,00€1mL*10mM (DMSO)225,00€Ruboxistaurin hydrochloride
CAS :Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Formule :C28H28N4O3·HClDegré de pureté :98.44% - 99.22%Couleur et forme :SolidMasse moléculaire :505.01Ref: TM-T3689
1mg71,00€2mg93,00€5mg157,00€10mg256,00€25mg513,00€50mg740,00€100mg1.035,00€500mg2.072,00€1mL*10mM (DMSO)202,00€K-252b
CAS :K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.Formule :C26H19N3O5Degré de pureté :98%Couleur et forme :Ready-To-Use SolutionMasse moléculaire :453.45Delcasertib
CAS :Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Formule :C120H199N45O34S2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :2880.28Ref: TM-T11740
1mg202,00€5mg512,00€10mg740,00€25mg1.121,00€50mg1.539,00€100mg2.072,00€1mL*10mM (DMSO)1.691,00€1-Oleoyl-2-acetyl-sn-glycerol
CAS :1-Oleoyl-2-acetyl-sn-glycerol (1-oleoyl-2-acetyl-glycerol) is a PKC activator that induces superoxide production.Formule :C23H42O5Couleur et forme :SolidMasse moléculaire :398.58Hispidin
CAS :Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective propertiesFormule :C13H10O5Degré de pureté :98.27%Couleur et forme :White Crystalline PowderMasse moléculaire :246.22Ref: TM-T7792
1mg88,00€5mg187,00€10mg298,00€25mg533,00€50mg747,00€100mg1.017,00€1mL*10mM (DMSO)207,00€A-3 hydrochloride
CAS :A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Formule :C12H14Cl2N2O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :321.22Ref: TM-T14069
1mg35,00€5mg66,00€10mg96,00€25mg170,00€50mg274,00€100mg439,00€500mg938,00€1mL*10mM (DMSO)90,00€(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Couleur et forme :Odour Solid20-HETE
CAS :20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.Formule :C20H32O3Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :320.47Ref: TM-T14021
1mg (312.04μM*10mL in Ethanol)1.139,00€5mg (312.04μM*50mL in Ethanol)2.327,00€100μg (312.04μM*1mL in Ethanol)474,00€PKCiota-IN-2
CAS :PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).Formule :C24H21N5ODegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :395.46Ref: TM-T9863
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€1mL*10mM (DMSO)279,00€
