HSP
Les inhibiteurs des protéines de choc thermique (HSP) ciblent les HSP, une famille de chaperons moléculaires qui aident au repliement des protéines, à leur stabilité et à leur protection contre les dommages induits par le stress. Les HSP sont souvent surexprimées dans les cellules cancéreuses, les aidant à survivre dans des conditions stressantes telles que l'hypoxie et la chimiothérapie. Inhiber les HSP peut perturber ces mécanismes de protection, entraînant la mort cellulaire. Les inhibiteurs des HSP sont donc précieux dans la thérapie contre le cancer et la recherche sur les réponses au stress. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de HSP de haute qualité pour soutenir vos recherches sur l'homéostasie des protéines, les réponses au stress et l'oncologie.
Produits appartenant à la catégorie "HSP"
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Ganetespib
CAS :Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Formule :C20H20N4O3Degré de pureté :97.29% - 99.95%Couleur et forme :SolidMasse moléculaire :364.4Ref: TM-T2309
5mg66,00€10mg87,00€25mg133,00€50mg166,00€100mg250,00€200mg424,00€500mg702,00€1mL*10mM (DMSO)74,00€Teprenone
CAS :Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Formule :C23H38ODegré de pureté :99.76% - 99.96%Couleur et forme :SolidMasse moléculaire :330.55SMTIN-T140
CAS :SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Formule :C36H34BrClFN5OPDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :718.02Arimoclomol maleate
CAS :Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formule :C18H24ClN3O7Degré de pureté :99.9% - 99.98%Couleur et forme :SolidMasse moléculaire :429.85Alvespimycin hydrochloride
CAS :Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Formule :C32H48N4O8·HClDegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :653.21JG-231
CAS :JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.Formule :C22H18BrCl2N3OS4Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :619.47DDO-5936
CAS :DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Formule :C25H29N5O4SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :495.59Ref: TM-T9202
1mg37,00€5mg80,00€10mg126,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)88,00€HM03
CAS :HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.Formule :C26H27ClN4O2Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :462.97L-Alanyl-L-glutamine
CAS :L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Formule :C8H15N3O4Degré de pureté :99.71% - 99.97%Couleur et forme :SolidMasse moléculaire :217.22Palmitic acid
CAS :Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Formule :C16H32O2Degré de pureté :99.17% - 99.67%Couleur et forme :White Crystalline Scales SolidMasse moléculaire :256.42C086
CAS :C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Formule :C29H28O8Couleur et forme :SolidMasse moléculaire :504.53HSP90-IN-27
CAS :HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].Formule :C18H21N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.44Alvespimycin
CAS :Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.Formule :C32H48N4O8Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :616.75NPX800
CAS :NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Formule :C32H32FN5O4Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :569.63Ref: TM-T9804
1mg96,00€5mg240,00€10mg375,00€25mg627,00€50mg893,00€100mg1.216,00€1mL*10mM (DMSO)300,00€Radicicol
CAS :Radicicol is an antifungal antibiotic, a inhibitor of Hsp90 & FTO, Anti-malarial , inhibits iNOS gene expression by blocking the p38 kinase and NF-κB/Rel.Formule :C18H17ClO6Degré de pureté :98%Couleur et forme :White/Yellow PowderMasse moléculaire :364.78Azadiradione
CAS :Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indicaFormule :C28H34O5Degré de pureté :99.52% - 99.52%Couleur et forme :SolidMasse moléculaire :450.57Ref: TM-TN6729
1mg131,00€5mg286,00€10mg515,00€25mg777,00€50mg1.074,00€100mg1.454,00€1mL*10mM (DMSO)354,00€GRP78-IN-3
CAS :GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Formule :C17H18N4O2SDegré de pureté :99.11%Couleur et forme :SoildMasse moléculaire :342.42IPI-493
CAS :IPI-493 is a bioactive chemical.Formule :C28H39N3O8Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :545.62VER-49009
CAS :VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Formule :C19H18ClN3O4Degré de pureté :99.36% - 99.99%Couleur et forme :SolidMasse moléculaire :387.82Ref: TM-T3454
2mg46,00€5mg64,00€10mg92,00€25mg164,00€50mg259,00€100mg354,00€200mg500,00€1mL*10mM (DMSO)52,00€Pimitespib
CAS :Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Formule :C25H26N8ODegré de pureté :99.22% - 99.49%Couleur et forme :SolidMasse moléculaire :454.53NDNA4
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.Formule :C31H35F3N2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.68Paeoniflorin
CAS :Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Formule :C23H28O11Degré de pureté :96.9% - 97.16%Couleur et forme :White Fine PowderMasse moléculaire :480.46Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Formule :C24H18F3N5O3Couleur et forme :SolidMasse moléculaire :481.43Tanespimycin
CAS :Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).Formule :C31H43N3O8Degré de pureté :99.07% - 99.83%Couleur et forme :Dark Purple SolidMasse moléculaire :585.69KU-177
CAS :KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.Formule :C27H23NO8Degré de pureté :97.34% - 98.54%Couleur et forme :SolidMasse moléculaire :489.47Calyxin H
CAS :Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.Formule :C35H34O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.64SNX0723
CAS :SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.Formule :C22H26FN3O3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :399.46Ref: TM-T28824
1mg89,00€5mg188,00€10mg316,00€25mg512,00€50mg702,00€100mg940,00€500mgÀ demander1mL*10mM (DMSO)207,00€7-Aminocephalosporanic acid
CAS :7-Aminocephalosporanic acid (7-ACA) is used for synthesis of cephalosporin antibiotics and intermediates.Formule :C10H12N2O5SDegré de pureté :91.05% - 98.22%Couleur et forme :White Solid PowderMasse moléculaire :272.28HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Formule :C22H24N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.5DN401
CAS :DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Formule :C13H9BrClN5O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :382.6Ref: TM-T27193
1mg185,00€5mg409,00€10mg605,00€25mg938,00€50mg1.293,00€100mg1.738,00€500mg3.496,00€1mL*10mM (DMSO)406,00€TRAP1-IN-2
CAS :TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.Formule :C46H42F6N2O5P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :878.77Ethoxyquin
CAS :Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.Formule :C14H19NODegré de pureté :95.94%Couleur et forme :Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Masse moléculaire :217.31Dihydroberberine
CAS :Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Formule :C20H19NO4Degré de pureté :93.77%Couleur et forme :SolidMasse moléculaire :337.37Arimoclomol
CAS :Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Formule :C14H20ClN3O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :313.78Ref: TM-T13553
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)249,00€AT-533
CAS :AT-533 inhibits Hsp90, HSV, hinders HIF-1α/VEGF/VEGFR-2, Erk1/2, FAK, Akt/mTOR/p70S6K, and blocks tumor growth, angiogenesis, and HUVEC activities.Formule :C23H30N4O3Degré de pureté :99.54%Couleur et forme :SoildMasse moléculaire :410.51Ref: TM-T67836
1mg51,00€5mg111,00€10mg170,00€25mg313,00€50mg467,00€100mg672,00€200mg905,00€1mL*10mM (DMSO)117,00€Novobiocin Sodium
CAS :Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Formule :C31H35N2NaO11Degré de pureté :99% - 99.28%Couleur et forme :SolidMasse moléculaire :634.61Grp94 Inhibitor-1
CAS :Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Formule :C22H28N2O2Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :352.47PF-04929113 Mesylate
CAS :PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37Formule :C26H34F3N5O7SDegré de pureté :99% - 99.46%Couleur et forme :SolidMasse moléculaire :617.63Ref: TM-T4342
1mg78,00€2mg100,00€5mg159,00€10mg288,00€25mg419,00€50mg615,00€100mg878,00€500mg1.776,00€1mL*10mM (DMSO)233,00€HS-27
CAS :HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.Formule :C52H60N6O12SDegré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :993.13Ref: TM-T18018
1mg90,00€5mg215,00€10mg344,00€25mg612,00€50mg848,00€100mg1.159,00€1mL*10mM (DMSO)378,00€Onalespib
CAS :Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Formule :C24H31N3O3Degré de pureté :98.05% - 99.82%Couleur et forme :SolidMasse moléculaire :409.5217-AEP-GA
CAS :17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.Formule :C34H50N4O8Degré de pureté :97.77% - 99.56%Couleur et forme :SolidMasse moléculaire :642.78Apoptozole
CAS :Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.Formule :C33H25F6N3O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :625.56Ref: TM-T3293
2mg35,00€5mg50,00€10mg84,00€25mg137,00€50mg235,00€100mg349,00€200mg515,00€1mL*10mM (DMSO)66,00€VER49009
CAS :VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Formule :C19H18ClN3O4Degré de pureté :100% - 99.17%Couleur et forme :SolidMasse moléculaire :387.82Ref: TM-T2268
1mg60,00€2mg85,00€5mg111,00€10mg167,00€25mg283,00€50mg472,00€100mg643,00€1mL*10mM (DMSO)96,00€KU-32
CAS :KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Formule :C20H25NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.41HSP90-IN-22
CAS :HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM inFormule :C25H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53XL888
CAS :XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Formule :C29H37N5O3Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :503.64PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.Formule :C43H50N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :762.89VER-155008
CAS :VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.Formule :C25H23Cl2N7O4Degré de pureté :98.88% - 99.55%Couleur et forme :SolidMasse moléculaire :556.4Ref: TM-T7010
2mg47,00€5mg69,00€10mg93,00€25mg163,00€50mg283,00€100mg467,00€200mg653,00€1mL*10mM (DMSO)85,00€CYP51/Hsp90-IN-1
CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.Formule :C38H40F2N6O4Couleur et forme :SolidMasse moléculaire :682.76KW-2478
CAS :KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.Formule :C30H42N2O9Degré de pureté :98.68% - 99.52%Couleur et forme :SolidMasse moléculaire :574.66Ref: TM-T6558
1mg56,00€2mg81,00€5mg119,00€10mg187,00€25mg316,00€50mg472,00€100mg662,00€1mL*10mM (DMSO)205,00€2',4'-DIHYDROXYCHALCONE
CAS :2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effectsFormule :C15H12O3Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :240.25Ref: TM-T8829
2mg42,00€5mg62,00€10mg87,00€25mg154,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)65,00€Rocaglamide
CAS :Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formule :C29H31NO7Degré de pureté :95.32% - 98.46%Couleur et forme :SolidMasse moléculaire :505.56Feretoside
CAS :Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).Formule :C17H24O11Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :404.37Ref: TM-TQ0280
1mg85,00€5mg180,00€10mg274,00€25mg465,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)298,00€PU-H54
CAS :PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.Formule :C18H19N5SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :337.44PF04929113
CAS :PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.Formule :C25H30F3N5O4Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :521.53Ref: TM-T6341
1mg39,00€2mg49,00€5mg84,00€10mg119,00€25mg187,00€50mg354,00€100mg527,00€1mL*10mM (DMSO)96,00€HSP90-IN-19
CAS :HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.Formule :C29H38O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.61HSP90-IN-32
CAS :HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Formule :C33H40N2O4Couleur et forme :SolidMasse moléculaire :528.68NMS-E973
CAS :NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Formule :C22H22N4O7Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :454.43Ref: TM-T6609
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg310,00€100mg442,00€200mg622,00€1mL*10mM (DMSO)70,00€Calenduloside E
CAS :Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and byFormule :C36H56O9Degré de pureté :96.16%Couleur et forme :SolidMasse moléculaire :632.822-hexyl-4-Pentynoic Acid
CAS :2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Formule :C11H18O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :182.26Gedunin
CAS :Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Formule :C28H34O7Degré de pureté :99.38% - 99.68%Couleur et forme :SolidMasse moléculaire :482.57Ref: TM-T21883
1mg393,00€5mg1.169,00€10mg1.596,00€25mg2.365,00€50mg3.192,00€100mg4.304,00€1mL*10mM (DMSO)1.283,00€NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFormule :C28H32N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.63TRAP1-IN-1
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90.Formule :C45H39F7N2O4P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :866.74HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Formule :C29H48O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.69KUNG65
CAS :KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formule :C23H20ClFO4Couleur et forme :SolidMasse moléculaire :414.85PU-H71 HCl
CAS :PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.Formule :C18H22ClIN6O2SDegré de pureté :98.95%Couleur et forme :SoildMasse moléculaire :548.83Hsp90-IN-38
CAS :Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.Formule :C28H35N3O5Couleur et forme :SolidMasse moléculaire :493.595TRC051384
CAS :TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Formule :C25H31N5O4Degré de pureté :92.66%Couleur et forme :SolidMasse moléculaire :465.54Ref: TM-T3527
1mg37,00€5mg80,00€10mg111,00€25mg210,00€50mg298,00€100mg432,00€200mg622,00€1mL*10mM (DMSO)81,00€Geldanamycin
CAS :Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.Formule :C29H40N2O9Degré de pureté :98.83% - 99.27%Couleur et forme :Yellow To Orange PowderMasse moléculaire :560.64KRIBB11
CAS :KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Formule :C13H12N6O2Degré de pureté :97.25% - 99.91%Couleur et forme :SolidMasse moléculaire :284.27Ref: TM-T3652
5mg51,00€10mg77,00€25mg159,00€50mg263,00€100mg510,00€200mg717,00€500mg1.093,00€1mL*10mM (DMSO)52,00€Rifabutin
CAS :Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Formule :C46H62N4O11Degré de pureté :99.27% - 99.8%Couleur et forme :Red-Violet Crystalline PowderMasse moléculaire :847Tasiamide B
CAS :Tasiamide B is a linear peptide and Cathepsin D inhibitor discovered in the marine cyanobacterium Symploca sp. This compound serves as an excellent template for the development of aspartic protease inhibitors. Tasiamide B effectively targets skin cancer through its strong interaction with the protein HSP90.Formule :C50H74N8O12Couleur et forme :SolidMasse moléculaire :979.17AMP-PCP
CAS :AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.Formule :C11H18N5O12P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.212-Methoxyhydroquinone
CAS :2-Methoxyhydroquinone is a phenolic compound that reduces the production of TNF-α-induced chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. It also serves as a synthetic precursor to the Hsp90 inhibitor Geldanamycin.Formule :C7H8O3Couleur et forme :SolidMasse moléculaire :140.14MKT-077
CAS :MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Formule :C21H22ClN3OS2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :432BIIB021
CAS :BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Formule :C14H15ClN6ODegré de pureté :98% - 99.82%Couleur et forme :SolidMasse moléculaire :318.763-Phenyltoxoflavin
CAS :3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Formule :C13H11N5O2Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :269.26Ref: TM-T36123
1mg57,00€5mg120,00€10mg187,00€25mg338,00€50mg512,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)133,00€CH5138303
CAS :CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Formule :C19H18ClN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.9TRC051384 HCl
CAS :TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Formule :C25H32ClN5O4Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :502.01AMP-PCP disodium
CAS :AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Formule :C11H16N5Na2O12P3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :549.17VER-82576
CAS :VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Formule :C21H23Cl2N5O2SDegré de pureté :98% - 99.16%Couleur et forme :SolidMasse moléculaire :480.41HSP90-IN-35
CAS :HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Formule :C27H33N5O5Couleur et forme :SolidMasse moléculaire :507.58KNK437
CAS :KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Formule :C13H11NO4Degré de pureté :98.90%Couleur et forme :SolidMasse moléculaire :245.23H2-Gamendazole
CAS :H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.Formule :C18H13Cl2F3N2O2Degré de pureté :97.36%Couleur et forme :SolidMasse moléculaire :417.21Ref: TM-T72076
1mg78,00€5mg190,00€10mg284,00€25mg505,00€50mg677,00€100mg929,00€200mg1.225,00€1mL*10mM (DMSO)215,00€CC-99677
CAS :CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Formule :C22H20ClN5O3SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :469.94Debio 0932
CAS :Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formule :C22H30N6O2SDegré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :442.58NCT-58
CAS :NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.Formule :C27H34N2O5Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :466.57Ref: TM-T9996
2mg46,00€5mg85,00€10mg126,00€25mg259,00€50mg415,00€100mg662,00€200mg889,00€1mL*10mM (DMSO)207,00€Luminespib
CAS :Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Formule :C26H31N3O5Degré de pureté :98% - 99.26%Couleur et forme :SolidMasse moléculaire :465.54Ref: TM-T1989
5mg57,00€10mg81,00€25mg145,00€50mg221,00€100mg363,00€200mg540,00€500mg872,00€1mL*10mM (DMSO)63,00€HSF1A
CAS :HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formule :C21H19N3O2S2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :409.52Ref: TM-T4125
1mg55,00€2mg88,00€5mg139,00€10mg207,00€25mg462,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)130,00€Chetomin
CAS :Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolarFormule :C31H30N6O6S4Degré de pureté :98%Couleur et forme :Off-White To Fawn SolidMasse moléculaire :710.87SNX2112
CAS :SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.Formule :C23H27F3N4O3Degré de pureté :98.9% - 99.46%Couleur et forme :SolidMasse moléculaire :464.48Ref: TM-T6305
1mg40,00€5mg85,00€10mg127,00€25mg220,00€50mg334,00€100mg477,00€200mg662,00€1mL*10mM (DMSO)87,00€CCT251236
CAS :CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.Formule :C32H32N4O5Degré de pureté :98.82% - 99.89%Couleur et forme :SolidMasse moléculaire :552.62Ref: TM-T14905
1mg39,00€5mg116,00€10mg221,00€25mg457,00€50mg733,00€100mg1.111,00€200mg1.501,00€1mL*10mM (DMSO)144,00€HSP27 inhibitor J2
CAS :HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFormule :C13H12O4SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :264.3Ref: TM-T7265
1mg130,00€2mg185,00€5mg311,00€10mg472,00€25mg753,00€50mg1.064,00€100mg1.415,00€1mL*10mM (DMSO)455,00€HSP70-IN-1
CAS :HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).Formule :C24H28N6O2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :464.58Ref: TM-T3487
1mg96,00€5mg227,00€10mg354,00€25mg620,00€50mg847,00€100mg1.169,00€1mL*10mM (DMSO)230,00€Col003
CAS :Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Formule :C14H11NO4Degré de pureté :98.67% - 99.03%Couleur et forme :SolidMasse moléculaire :257.24Ref: TM-T10860
2mg47,00€5mg70,00€10mg107,00€25mg216,00€50mg350,00€100mg542,00€200mg778,00€500mg1.169,00€1mL*10mM (DMSO)70,00€Eupalinolide A
CAS :Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Formule :C24H30O9Degré de pureté :98.18% - 99.22%Couleur et forme :SolidMasse moléculaire :462.49NVP-HSP990
CAS :NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Formule :C20H18FN5O2Degré de pureté :97.63% - 99.32%Couleur et forme :SolidMasse moléculaire :379.39BX-2819
CAS :BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Formule :C21H24N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.51EC 144
CAS :EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Formule :C21H24ClN5O2Couleur et forme :SolidMasse moléculaire :413.9YUM70
CAS :YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Formule :C21H19ClN2O4Degré de pureté :97.25%Couleur et forme :SolidMasse moléculaire :398.84Ref: TM-T8901
1mg48,00€5mg96,00€10mg135,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)96,00€
