Récepteur des glucocorticoïdes
Le récepteur des glucocorticoïdes (GR) est un récepteur hormonal nucléaire qui médie les effets des glucocorticoïdes, une classe d'hormones stéroïdes impliquées dans la régulation du métabolisme, de la réponse immunitaire et du stress. Les agonistes et antagonistes du récepteur des glucocorticoïdes sont largement utilisés dans le traitement des maladies inflammatoires et auto-immunes, ainsi que dans la thérapie contre le cancer. Les modulateurs du GR sont également des outils importants pour étudier les rôles physiologiques et pathologiques des glucocorticoïdes. Chez CymitQuimica, nous offrons une large gamme de modulateurs du récepteur des glucocorticoïdes de haute qualité pour soutenir vos recherches en endocrinologie, immunologie et régulation hormonale.
Produits appartenant à la catégorie "Récepteur des glucocorticoïdes"
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Medrysone
CAS :Medrysone is a synthetic glucocorticoid for topical use with anti-inflammatory and anti-allergic effects, altering gene expression to reduce inflammation.Formule :C22H32O3Degré de pureté :97.72% - 99.91%Couleur et forme :SolidMasse moléculaire :344.49Prednisolone hemisuccinate
CAS :Prednisolone hemisuccinate is a soluble glucocorticoid and cortisol exerts anti-inflammatory, immunosuppressive, and antiallergic by binding to GR receptor.Formule :C25H32O8Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :460.52Dexamethasone acetate
CAS :Dexamethasone acetate (NSC 39471) is a potent anti-inflammatory steroid, blocks NF-kB, and lacks salt-retention.Formule :C24H31FO6Degré de pureté :99.22% - 99.65%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :434.5GSK9027
CAS :GSK9027, a nonsteroidal GR agonist, is a partial 2×GRE reporter gene activator, less potent than dexamethasone.Formule :C27H19F4N3O2SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :525.52N-Demethyl Mifepristone
CAS :N-Demethyl Mifepristone (RU 42633), an active metabolite of Mifepristone, exhibits 61% of the affinity for the glucocorticoid receptor relative to Mifepristone'Formule :C28H33NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.57Apararenone
CAS :Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy.Formule :C17H17FN2O4SDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :364.3922-Hydroxy mifepristone
CAS :22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.Formule :C29H35NO3Couleur et forme :SolidMasse moléculaire :445.59Prednisolone acetate
Prednisolone acetate (Omnipred) is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Formule :C23H30O6Degré de pureté :98.26% - 98.85%Couleur et forme :White Crystalline PowderMasse moléculaire :402.48Fluticasone furoate
CAS :Fluticasone furoate (Avamys), a potent, trifluorinated steroid with anti-inflammatory effects, treats allergic rhinitis.Formule :C27H29F3O6SDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :538.58Ref: TM-T21404
4g2.663,00€5mg35,00€10mg52,00€25mg92,00€50mg137,00€100mg187,00€200mg279,00€500mg472,00€1mL*10mM (DMSO)58,00€Mifepristone
CAS :Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.Formule :C29H35NO2Degré de pureté :98.9% - ≥95%Couleur et forme :Pale Yellow SolidMasse moléculaire :429.59Fluocinolone (Acetonide)
CAS :Fluocinolone Acetonide (Flucort-N) is a glucocorticoid derivative used topically in the treatment of various skin disorders.Formule :C24H30F2O6Degré de pureté :99.29% - 99.66%Couleur et forme :Crystals From Acetone & Hexane SolidMasse moléculaire :452.49Miricorilant
CAS :Miricorilant (CORT 118335) is a glucocorticoid receptor modulator for the study of digestive and metabolic disorders.Formule :C24H23F3N2O2Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :428.45Fludrocortisone acetate
CAS :Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, andFormule :C23H31FO6Degré de pureté :96.92% - 98.03%Couleur et forme :Crystalline SolidMasse moléculaire :422.49Dexamethasone palmitate
CAS :DXP, a lipophilic prodrug of Dexamethasone, has 47x less glucocorticoid receptor affinity; it's an agonist & anti-inflammatory.Formule :C38H59FO6Degré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :630.87Triamcinolone hexacetonide
CAS :Triamcinolone hexacetonide, an exogenous synthetic corticosteroid, is a GR agonist used in the study of auto-reactive pericarditis and diabetic macular edema.Formule :C30H41FO7Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :532.64Amcinonide
CAS :Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.Formule :C28H35FO7Degré de pureté :98.33% - 99.62%Couleur et forme :SolidMasse moléculaire :502.57Budesonide
CAS :Budesonide (Pulmicort), an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide has extensively inhibitory effects against multiple cells types and mediators referred to allergic and nonallergic-mediated inflammatory. What's more, the anti-inflammatory action of budesonide has been revealed to contribute to the effectiveness of asthma.Formule :C25H34O6Degré de pureté :99.03% - 99.72%Couleur et forme :Crystals SolidMasse moléculaire :430.53Cortisone acetate
CAS :Cortisone Acetate is a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory andFormule :C23H30O6Degré de pureté :98.63% - 99.73%Couleur et forme :SolidMasse moléculaire :402.48Corticosterone
CAS :Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active.Formule :C21H30O4Degré de pureté :97.25% - ≥95%Couleur et forme :SolidMasse moléculaire :346.46Prednisolone
CAS :Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Formule :C21H28O5Degré de pureté :99.59% - 99.85%Couleur et forme :Crystals SolidMasse moléculaire :360.44(20S)-Protopanaxatriol
CAS :(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoidFormule :C30H52O4Degré de pureté :95% - 99%Couleur et forme :SolidMasse moléculaire :476.73Glucocorticoid receptor agonist-5
CAS :Glucocorticoid Receptoragonist-5 (compound 4) is an effective glucocorticoid molecule acting as a potent agonist for glucocorticoid receptors. It exhibits anti-inflammatory and immunosuppressive activities and serves as an ADC cytotoxin.Formule :C36H40O7Couleur et forme :SolidMasse moléculaire :584.7Triamcinolone acetonide
CAS :Triamcinolone acetonide (Azmacort) is a Corticosteroid.Formule :C24H31FO6Degré de pureté :99.61% - 99.91%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :434.5Triamcinolone
CAS :Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Formule :C21H27FO6Degré de pureté :98.59% - 99.60%Couleur et forme :SolidMasse moléculaire :394.43Hydrocortisone aceponate
CAS :Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid used in the form of a cream to treat various skinFormule :C26H36O7Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :460.56Glucocorticoid receptor agonist-1
CAS :Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM[1].Formule :C35H39NO6Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :569.69Ref: TM-T37908
1mg87,00€5mg172,00€10mg279,00€25mg553,00€50mg885,00€100mg1.415,00€200mg1.872,00€1mL*10mM (DMSO)217,00€Mirodenafil dihydrochloride
CAS :Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Formule :C26H39Cl2N5O5SDegré de pureté :99.64% - 99.78%Couleur et forme :SolidMasse moléculaire :604.59LY404039
CAS :LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).Formule :C7H9NO6SDegré de pureté :99% - 99.16%Couleur et forme :SolidMasse moléculaire :235.22AL 082D06
CAS :AL 082D06 (D-06), a selective nonsteroidal glucocorticoid receptor (GR) antagonist (Ki: 210 nM), exhibits outstanding selectivity against AR, ER, MR and PR.Formule :C23H24ClN3O2Degré de pureté :99.05% - 99.06%Couleur et forme :SolidMasse moléculaire :409.91Desonide
CAS :Desonide is a synthetic topical steroid that reduces inflammation by inhibiting key inflammatory mediators.Formule :C24H32O6Degré de pureté :99.29% - 99.5%Couleur et forme :SolidMasse moléculaire :416.51Methylprednisolone succinate
CAS :Methylprednisolone succinate (Methylprednisolone hemisuccinate) is a synthetic glucocorticoid and is widely used as an anti-inflammatory agent.Formule :C26H34O8Degré de pureté :98.41% - 99.82%Couleur et forme :White Or Almost-White Solid PowderMasse moléculaire :474.54Dexamethasone
CAS :Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.Formule :C22H29FO5Degré de pureté :98% - 99.91%Couleur et forme :Crystals From Ether (Ntp 1992)Masse moléculaire :392.46EX-A5386
CAS :EX-A5386 (Glucocorticoid receptor modulator-1) is a potent glucocorticoid receptor modulator, IC50/EC50<100nM.Formule :C29H27FN4O2Degré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :482.55Esaxerenone
CAS :Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.Formule :C22H21F3N2O4SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :466.47Ref: TM-T15246
1mg70,00€5mg144,00€10mg227,00€25mg439,00€50mg702,00€100mg1.103,00€500mg2.205,00€1mL*10mM (DMSO)159,00€Canrenoate potassium
CAS :Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity.Formule :C22H29KO4Degré de pureté :99.04% - 99.18%Couleur et forme :Light Yellow To Tan PowderMasse moléculaire :396.56Desisobutyryl-ciclesonide
CAS :Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor. a glucocorticoid with anti-inflammatory.Formule :C28H38O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.6Beclometasone
CAS :Beclometasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma.Formule :C22H29ClO5Degré de pureté :99.41% - 99.68%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :408.92NR3C1 Protein, Human, Recombinant (His)
NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene.Couleur et forme :Lyophilized PowderMasse moléculaire :10.95 kDa (predicted)Cort108297
CAS :Cort108297: selective GR modulator/antagonist, high GR affinity (Ki: 0.45nM), no other steroid receptor affinity.Formule :C26H25F4N3O3SDegré de pureté :100% - 98%Couleur et forme :SolidMasse moléculaire :535.55Ref: TM-T15000
1mg274,00€5mg622,00€10mg908,00€25mg1.415,00€50mg1.882,00€100mg2.745,00€1mL*10mM (DMSO)747,00€Prednisolone valerate acetate
CAS :Prednisolone valerate acetate is a prodrug anti-inflammatory and immunosuppressive,converted to the active form of Prednisolone and glucocorticoid receptor.Formule :C28H38O7Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :486.6Halcinonide
CAS :Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.Formule :C24H32ClFO5Degré de pureté :99.32% - 99.93%Couleur et forme :SolidMasse moléculaire :454.96Ref: TM-T0107
1g567,00€10mg48,00€25mg65,00€50mg81,00€100mg131,00€200mg205,00€500mg373,00€1mL*10mM (DMSO)44,00€Fluorometholone
CAS :Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery.Formule :C22H29FO4Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :376.46Megestrol acetate
CAS :Megestrol acetate (BDH1298) is an oral progestogen with anti-androgenic properties, used for endometrial and breast cancer, anorexia, and cachexia.Formule :C24H32O4Degré de pureté :99.46%Couleur et forme :Crystalline SolidMasse moléculaire :384.51Hydrocortisone
CAS :Hydrocortisone is a synthetic glucocorticoid that aids in metabolism, immunity, and inflammation control.Formule :C21H30O5Degré de pureté :98.4% - 99.95%Couleur et forme :Plates From Alc Or Iso-Propyl Alc SolidMasse moléculaire :362.46Eplerenone
CAS :Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension.Formule :C24H30O6Degré de pureté :99.75% - ≥98%Couleur et forme :White SolidMasse moléculaire :414.49Vamorolone
CAS :Vamorolone (VBP15) is a steroid-like drug that treats muscular dystrophy with fewer side effects and inhibits NF-κB.Formule :C22H28O4Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :356.46Ref: TM-T17217
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg188,00€50mg298,00€100mg444,00€200mg640,00€1mL*10mM (DMSO)87,00€Osilodrostat
CAS :Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2).Cost-effective and quality-assured.Formule :C13H10FN3Degré de pureté :99.10% - 99.31%Couleur et forme :SolidMasse moléculaire :227.24Clobetasol propionate
CAS :Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediatedFormule :C25H32ClFO5Degré de pureté :99.41%Couleur et forme :White Crystalline PowderMasse moléculaire :466.97Mometasone furoate
CAS :Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA andFormule :C27H30Cl2O6Degré de pureté :99.43% - 99.48%Couleur et forme :Distributed As 0 1% Ointment With A Petrolatum BaseMasse moléculaire :521.43Fluocinonide
CAS :Fluocinonide (Topsyn) (Vanos) is an effective glucocorticoid steroid, utilized in the treatment as the skin disorders anti-inflammatory agent.Formule :C26H32F2O7Degré de pureté :100% - 99.70%Couleur et forme :SolidMasse moléculaire :494.52
