Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
Produits appartenant à la catégorie "Récepteur des androgènes"
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AR antagonist 10
CAS :AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.Formule :C18H17ClN4O3SCouleur et forme :SolidMasse moléculaire :404.871Dehydroisoandrosterone 3-acetate
CAS :Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.Formule :C21H30O3Degré de pureté :100% - 99.81%Couleur et forme :SolidMasse moléculaire :330.46ONC1-13B
CAS :ONC1-13B, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.Formule :C22H16F4N4O3SDegré de pureté :99.45% - 99.85%Couleur et forme :SolidMasse moléculaire :492.45ARD-2585
CAS :ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.Formule :C41H43ClN8O5Couleur et forme :SolidMasse moléculaire :763.28LY2452473
CAS :LY2452473 (OPK 88004) is an orally available and selective androgen receptor modulator with potential anticancer activity for the study of prostate cancer.Formule :C22H22N4O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :374.44Ref: TM-T15804
1mg35,00€5mg74,00€10mg97,00€25mg149,00€50mg188,00€100mg281,00€200mg429,00€1mL*10mM (DMSO)81,00€p,p'-DDE
CAS :p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDTFormule :C14H8Cl4Degré de pureté :99.68%Couleur et forme :White Crystalline Solid Physical Description White Crystalline Solid Or White Powder (Ntp 1992)Masse moléculaire :318.03Androgen receptor antagonist 12
CAS :Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.Formule :C12H8F3N3O2Couleur et forme :SolidMasse moléculaire :283.21LX1
CAS :LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Formule :C22H15F6NO2Couleur et forme :SolidMasse moléculaire :439.35CTK8A3536
CAS :CTK8A3536 ((2-MORPHOLIN-4-YL-4-PHENYL-1,3-THIAZOL-5-YL)METHANOL) is an inhibitor of Androgen receptor.Formule :C14H16N2O2SDegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :276.35Ref: TM-T8592
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)169,00€Pentomone
CAS :Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Formule :C24H26O5Couleur et forme :SolidMasse moléculaire :394.46Zanoterone
CAS :Zanoterone is an AR antagonist (androgen receptor).Zanoterone has antitumor activity for the treatment of genitourinary disorders and oncological disorders andFormule :C23H32N2O3SDegré de pureté :99.85% - 99.96%Couleur et forme :SoildMasse moléculaire :416.58Bavdegalutamide
CAS :Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR).Formule :C41H43ClFN9O6Degré de pureté :97.17% - 99.04%Couleur et forme :SolidMasse moléculaire :812.29ARD-2128
CAS :ARD-2128: potent oral PROTAC that degrades AR, curbing prostate cancer growth with no toxicity.Formule :C45H50ClN7O6Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :820.37Bifluranol
CAS :Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostaticFormule :C17H18F2O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :292.32Gridegalutamide
CAS :Gridegalutamide exhibits anti-androgen and anti-tumor activities.Formule :C41H45F3N8O5SCouleur et forme :SolidMasse moléculaire :818.91Vosilasarm
CAS :RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.Formule :C20H16ClN5O2Degré de pureté :99.01% - 99.6%Couleur et forme :A Crystalline SolidMasse moléculaire :393.82(+)-JJ-74-138
CAS :(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).Formule :C22H22F8N2OSCouleur et forme :SolidMasse moléculaire :514.48YXG-158
CAS :YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1Formule :C30H36FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.62ACP-105
CAS :ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgenFormule :C16H19ClN2ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :290.79Ref: TM-T14116
2mg38,00€5mg58,00€10mg90,00€25mg164,00€50mg226,00€100mg325,00€200mg455,00€1mL*10mM (DMSO)65,00€MI-136
CAS :MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.Formule :C23H21F3N6SDegré de pureté :97.08% - 98.63%Couleur et forme :SolidMasse moléculaire :470.51Ref: TM-T6889
1mg47,00€5mg87,00€10mg147,00€25mg279,00€50mg472,00€100mg730,00€200mg1.017,00€1mL*10mM (DMSO)97,00€BMS-641988
CAS :BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.Formule :C20H20F3N3O5SDegré de pureté :100% - 100%Couleur et forme :SoildMasse moléculaire :471.45N-desmethyl Enzalutamide
CAS :N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide.Formule :C20H14F4N4O2SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :450.41Ref: TM-T19450
2mg34,00€5mg52,00€10mg74,00€25mg138,00€50mg255,00€100mg375,00€200mg532,00€1mL*10mM (DMSO)58,00€Enzalutamide
CAS :Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP).Formule :C21H16F4N4O2SDegré de pureté :100% - 99.7%Couleur et forme :SolidMasse moléculaire :464.44Ref: TM-T6002
5mg48,00€10mg56,00€25mg74,00€50mg96,00€100mg154,00€200mg187,00€500mg274,00€1mL*10mM (DMSO)52,00€Triptophenolide
CAS :Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.Formule :C20H24O3Degré de pureté :98.07% - ≥95%Couleur et forme :White PowderMasse moléculaire :312.4Anti-Androgen receptor Antibody (7Q574)
Anti-Androgen receptor Antibody (7Q574) is an antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (7Q574) can be used in ELISA, WB, IHC.Couleur et forme :Odour LiquidGLPG0492
CAS :GLPG0492 is a novel selective androgen receptor modulator.Formule :C19H14F3N3O3Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :389.33Ref: TM-T11410L
1mg74,00€5mg164,00€10mg235,00€25mg378,00€50mg543,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)170,00€Androgen receptor degrader-5
CAS :Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.Formule :C29H25F4N5O2Couleur et forme :SolidMasse moléculaire :551.53GDC-2992
CAS :GDC-2992 is a selective and oral AR (androgen receptor) degrader that, degrades AR and inhibits proliferation in VCaP cells, prostate cancer (CRPC).Formule :C45H51ClN8O5Couleur et forme :SoildMasse moléculaire :819.39Androgen receptor degrader-2
CAS :Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].Formule :C16H16ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.77UT-34
CAS :UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormule :C15H12F4N4O2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :356.27Ref: TM-T13273
1mg52,00€5mg119,00€10mg187,00€25mg354,00€50mg533,00€100mg825,00€1mL*10mM (DMSO)131,00€Ailanthone
CAS :Ailanthone (Δ13-Dehydrochaparrinone) is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated ARFormule :C20H24O7Degré de pureté :99.71% - 99.96%Couleur et forme :SolidMasse moléculaire :376.4ARD-266
CAS :ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase that induces the degradation of AR proteins and is useful in prostate cancer research.Formule :C52H59ClN6O7Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :915.51Andarine
CAS :Andarine (GTx-007) (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).Formule :C19H18F3N3O6Degré de pureté :99.84%Couleur et forme :Pale Yellow SolidMasse moléculaire :441.36DSRM-3716
CAS :Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery ofFormule :C9H6INDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :255.063,3'-Diindolylmethane
CAS :3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.Formule :C17H14N2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :246.31Ligandrol
CAS :Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.Formule :C14H12F6N2ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :338.25Masofaniten
CAS :Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancer.Formule :C24H24Cl2N4O4SDegré de pureté :98.42% - 98.66%Couleur et forme :SolidMasse moléculaire :535.44Nilutamide
CAS :Nilutamide, a nonsteroidal anti-androgen, treats prostate cancer by blocking androgen receptors, not affecting other hormone receptors.Formule :C12H10F3N3O4Degré de pureté :98.45% - 98.67%Couleur et forme :Crystalline SolidMasse moléculaire :317.22Enzalutamide carboxylic acid
CAS :Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .Formule :C20H13F4N3O3SDegré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :451.39Ref: TM-T8217
1mg66,00€2mg93,00€5mg126,00€10mg187,00€25mg315,00€50mg439,00€100mg648,00€1mL*10mM (DMSO)140,00€Androgen receptor-IN-5
CAS :Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties.Formule :C22H10Cl2F4N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.31EPI-001
CAS :EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.Formule :C21H27ClO5Degré de pureté :99% - 99.28%Couleur et forme :SolidMasse moléculaire :394.89Ref: TM-T6829
2mg35,00€5mg50,00€10mg77,00€25mg127,00€50mg202,00€100mg303,00€200mg449,00€1mL*10mM (DMSO)51,00€RU 58841
CAS :RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen; RU 58841(PSK-3841) has a significant effect on hair regrowth.Formule :C17H18F3N3O3Degré de pureté :99.31% - 99.70%Couleur et forme :SolidMasse moléculaire :369.34Spironolactone
CAS :Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.Formule :C24H32O4SDegré de pureté :99.87%Couleur et forme :White PowderMasse moléculaire :416.57Dimethylcurcumin
CAS :Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer.Formule :C23H24O6Degré de pureté :97.36% - 98.96%Couleur et forme :SolidMasse moléculaire :396.432,2,5,7,8-Pentamethyl-6-Chromanol
CAS :2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation andFormule :C14H20O2Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :220.31VPC-13566
CAS :VPC-13566 is a BF3-specific small molecule, which effectively inhibited the androgen receptor transcriptional activity and displaced the BAG1L peptide from theFormule :C18H14N2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :258.32Ref: TM-T29111
1mg48,00€2mg65,00€5mg97,00€10mg160,00€25mg329,00€50mg540,00€100mg847,00€500mg1.730,00€1mL*10mM (DMSO)114,00€Rezvilutamide
CAS :Rezvilutamide (SHR3680) is an orally available androgen receptor inhibitor that crosses the blood-brain barrier and has antitumor activity.Formule :C22H20F3N3O4SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :479.47ARD-1676
CAS :ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand.Formule :C44H46ClN7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :788.33AC-262536
CAS :AC-262536 is a selective androgen receptor (SAR) modulator and exhibits potent agonist activity at the androgen receptor.Formule :C18H18N2ODegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :278.35Ref: TM-T26539
5mg46,00€10mg74,00€25mg145,00€50mg240,00€100mg359,00€200mg510,00€1mL*10mM (DMSO)49,00€Boldenone Undecylenate
CAS :Boldenone Undecylenate (Parenabol) is a synthetic steroid.Formule :C30H44O3Degré de pureté :99.39%Couleur et forme :Light Yellow Oily MatterMasse moléculaire :452.67Ref: TM-T3137
1mg35,00€2mg48,00€5mg52,00€10mg85,00€25mg140,00€50mg246,00€100mg396,00€500mg939,00€1mL*10mM (DMSO)52,00€
