
NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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INH14
CAS :INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formule :C15H16N2ODegré de pureté :95.41%Couleur et forme :SolidMasse moléculaire :240.3Ref: TM-T5209
2mg38,00€5mg56,00€10mg84,00€25mg120,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)58,00€TH023
TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.Formule :C22H21ClF2N4OCouleur et forme :SolidMasse moléculaire :430.88SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Formule :C131H234N36O31SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :2841.55Asperulosidic acid
CAS :Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.Formule :C18H24O12Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :432.38SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Formule :C129H230N36O29S·XCF3COOHCouleur et forme :SolidMasse moléculaire :2781.5 (free base)CLEFMA
CAS :CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Formule :C23H17Cl2NO4Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :442.29Ref: TM-T9582
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)219,00€Tectochrysin
CAS :Tectochrysin: antioxidant, hinders ABCG2 transport, induces apoptosis in NSC-LC by blocking STAT3 and activating DR3/Fas.Formule :C16H12O4Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :268.26RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.Formule :C24H16N4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54IRAK4-IN-10
CAS :IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.Formule :C22H24N8Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :400.48Polygalasaponin F
CAS :Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Formule :C53H86O23Degré de pureté :98% - 99.83%Couleur et forme :SolidMasse moléculaire :1091.24Fibrinogen
CAS :Fibrinogen is a heterodimeric protein that can be cleaved by thrombin.Couleur et forme :SolidHesperidin methylchalcone
CAS :Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Formule :C29H36O15Degré de pureté :99.53%Couleur et forme :Yellow PowderMasse moléculaire :624.59(Rac)-Benpyrine
CAS :(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.Formule :C16H16N6ODegré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :308.34Ref: TM-T8692
1mg73,00€5mg124,00€10mg187,00€25mg376,00€50mg562,00€100mg802,00€500mg1.644,00€1mL*10mM (DMSO)137,00€(−)-N-Hydroxyapiosporamide
CAS :(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo.Formule :C24H31NO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.51Iron sucrose
CAS :Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.Formule :C18H24Fe2O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :736.1MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Formule :C26H37ClN6O2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :501.07ALPK1-IN-3
CAS :ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-inducedFormule :C20H16F2N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.43Ginsenoside Rb1
CAS :Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formule :C54H92O23Degré de pureté :99.12% - 99.76%Couleur et forme :SolidMasse moléculaire :1109.29Eurycomalactone
CAS :Eurycomalactone, from Eurycoma longifolia, inhibits NF-κB (IC50 0.5 μM), stops protein synthesis and cyclin D1, spares IκBα and IKK.Formule :C19H24O6Degré de pureté :98.98% - 99.87%Couleur et forme :SolidMasse moléculaire :348.39Morusin
CAS :Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formule :C25H24O6Degré de pureté :98.68% - 99.8%Couleur et forme :SolidMasse moléculaire :420.45Sodium Aescinate
CAS :Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.Formule :C54H83NaO23Degré de pureté :95.17%Couleur et forme :SolidMasse moléculaire :1123.21Dehydrodiisoeugenol
CAS :Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.Formule :C20H22O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :326.39Deoxyelephantopin
CAS :Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Formule :C19H20O6Degré de pureté :99.6% - 99.71%Couleur et forme :SolidMasse moléculaire :344.36EUK-134
CAS :EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formule :C18H18ClMnN2O4Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :416.74Ref: TM-T6495
10mg35,00€25mg66,00€50mg104,00€100mg160,00€200mg230,00€500mg378,00€1mL*10mM (DMSO)47,00€GSK-872
CAS :GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.Formule :C19H17N3O2S2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :383.49Ref: TM-T4074
1mg38,00€5mg79,00€10mg119,00€25mg188,00€50mg321,00€100mg494,00€200mg705,00€1mL*10mM (DMSO)86,00€Anatabine dicitrate
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.Formule :C22H28N2O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.46Necrostatin-34
CAS :Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying aFormule :C18H16N4O2S2Degré de pureté :98.66% - 98.80%Couleur et forme :SolidMasse moléculaire :384.48Ref: TM-T9095
1mg52,00€5mg116,00€10mg170,00€25mg305,00€50mg442,00€100mg615,00€200mg832,00€1mL*10mM (DMSO)135,00€HOIPIN-1
CAS :HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formule :C17H13NaO4Degré de pureté :98.83%Couleur et forme :SoildMasse moléculaire :304.27Mangiferin
CAS :Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Formule :C19H18O11Degré de pureté :96.74% - 98.30%Couleur et forme :Light Yellow PowderMasse moléculaire :422.34Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFormule :C24H21Cl2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.33CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formule :C28H28N2O6SCouleur et forme :SolidMasse moléculaire :520.6GTCpFE
CAS :GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formule :C22H20O8Couleur et forme :SolidMasse moléculaire :412.39Oxaprozin
CAS :Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formule :C18H15NO3Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :293.32Rucaparib Phosphate
CAS :Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Formule :C19H18FN3O·H3PO4Degré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :421.36Ref: TM-T6127
1mg38,00€2mg49,00€5mg79,00€10mg115,00€25mg188,00€50mg248,00€100mg393,00€200mg585,00€1mL*10mM (DMSO)79,00€Dehydroevodiamine
CAS :Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressantFormule :C19H15N3ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :301.34GSK583
CAS :GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).Formule :C20H19FN4O2SDegré de pureté :98.68% - 99.06%Couleur et forme :SolidMasse moléculaire :398.45Ref: TM-T3537
1mg50,00€2mg71,00€5mg116,00€10mg190,00€25mg319,00€50mg465,00€100mg690,00€500mg1.444,00€1mL*10mM (DMSO)116,00€Moslosooflavone
CAS :Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Formule :C17H14O5Degré de pureté :98% - 99.78%Couleur et forme :SolidMasse moléculaire :298.29IKK2-IN-4
CAS :IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formule :C12H11N3O2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :261.3Ref: TM-T36524
1mg163,00€5mg395,00€10mg605,00€25mg938,00€50mg1.264,00€100mg1.700,00€200mg2.270,00€500µg111,00€Astilbin
CAS :Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.Formule :C21H22O11Degré de pureté :97% - 99.76%Couleur et forme :White PowderMasse moléculaire :450.39Ref: TM-T2794
5mg52,00€10mg77,00€25mg140,00€50mg224,00€100mg334,00€200mg477,00€500mg778,00€1mL*10mM (DMSO)51,00€Rucaparib monocamsylate
CAS :Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.Formule :C29H34FN3O5SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :555.66Ref: TM-T16807
5mg60,00€10mg96,00€25mg160,00€50mg235,00€100mg354,00€200mg522,00€1mL*10mM (DMSO)74,00€Avicularin
CAS :Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Formule :C20H18O11Degré de pureté :97.02% - 99.94%Couleur et forme :White PowderMasse moléculaire :434.35Ref: TM-T6S0117
1mg58,00€5mg97,00€10mg160,00€25mg283,00€50mg418,00€100mg615,00€200mg878,00€1mL*10mM (DMSO)111,00€Sinomenine hydrochloride
CAS :Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Formule :C19H24ClNO4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :365.851(R)-(-)-Ibuprofen
CAS :(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Formule :C13H18O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :206.28Bay 65-1942 hydrochloride
CAS :Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formule :C22H26ClN3O4Couleur et forme :SolidMasse moléculaire :431.91Kaempferol-3-O-glucorhamnoside
CAS :Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFormule :C27H30O15Degré de pureté :96.96% - 98.17%Couleur et forme :SolidMasse moléculaire :594.5Ref: TM-T5S0089
1mg50,00€5mg97,00€10mg143,00€25mg226,00€50mg340,00€100mg495,00€200mg682,00€1mL*10mM (DMSO)129,00€Berbamine dihydrochloride
CAS :Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Formule :C37H42Cl2N2O6Degré de pureté :95% - 99.38%Couleur et forme :SolidMasse moléculaire :681.65Dauricine
CAS :1.Formule :C38H44N2O6Degré de pureté :99.04% - 99.38%Couleur et forme :White PowderMasse moléculaire :624.77JH-X-119-01
CAS :JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.Formule :C25H20N6O3Degré de pureté :97.1%Couleur et forme :SolidMasse moléculaire :452.46Ref: TM-T9203
1mg66,00€2mg96,00€5mg144,00€10mg210,00€25mg376,00€50mg562,00€100mg780,00€1mL*10mM (DMSO)159,00€Diethylmaleate
CAS :Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.Formule :C8H12O4Degré de pureté :98%Couleur et forme :Colourless LiquidMasse moléculaire :172.1818α-Glycyrrhetinic acid
CAS :18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Formule :C30H46O4Degré de pureté :98.54% - 99.68%Couleur et forme :SolidMasse moléculaire :470.68Tenuigenin
CAS :Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.Formule :C30H45ClO6Degré de pureté :98.9% - 99.53%Couleur et forme :SolidMasse moléculaire :537.13Ref: TM-T3907
2mg37,00€5mg52,00€10mg77,00€25mg111,00€50mg160,00€100mg227,00€200mg335,00€1mL*10mM (DMSO)66,00€RIPK1-IN-7
CAS :RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.Formule :C25H22F3N5O2Degré de pureté :98.02% - 98.18%Couleur et forme :SolidMasse moléculaire :481.47Ref: TM-T12731
1mg92,00€5mg216,00€10mg329,00€25mg512,00€50mg707,00€100mg944,00€1mL*10mM (DMSO)233,00€Sciadopitysin
CAS :Sciadopitysin may thwart diabetic bone disease, boost mitochondria, protect osteoblasts, and hinder Aβ aggregation/neurotoxicity.Formule :C33H24O10Degré de pureté :98.14% - 99.17%Couleur et forme :SolidMasse moléculaire :580.54Ref: TM-T5S2129
1mg52,00€5mg95,00€10mg162,00€25mg304,00€50mg455,00€100mg653,00€500mg1.349,00€1mL*10mM (DMSO)130,00€Sarsasapogenin
CAS :Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.Formule :C27H44O3Degré de pureté :90% - 99.73%Couleur et forme :White Or Off-Withe PowderMasse moléculaire :416.64MLN120B
CAS :MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formule :C19H15ClN4O2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :366.8Ref: TM-TQ0306
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg329,00€50mg567,00€100mg777,00€1mL*10mM (DMSO)116,00€DRI-C21045
CAS :Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Formule :C32H24N2O7SDegré de pureté :98.10%Couleur et forme :SolidMasse moléculaire :580.61IQ-1S free acid
CAS :IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Formule :C15H9N3ODegré de pureté :97.92% - 99.05%Couleur et forme :SolidMasse moléculaire :247.25Ref: TM-T3627
5mg47,00€10mg52,00€25mg96,00€50mg169,00€100mg304,00€200mg454,00€500mg733,00€1mL*10mM (DMSO)50,00€NF-κΒ activator 1
CAS :NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Formule :C16H11FN2O2SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :314.33Ref: TM-T39965
1mg95,00€5mg202,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€500mg2.213,00€1mL*10mM (DMSO)224,00€Dehydrocostus Lactone
CAS :Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.Formule :C15H18O2Degré de pureté :99.86% - 99.98%Couleur et forme :SolidMasse moléculaire :230.3Theophylline monohydrate
CAS :Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFormule :C7H8N4O2·H2ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :198.18Chelidonic acid
CAS :Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.Formule :C7H4O6Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :184.1Cyclo(his-pro)
CAS :Cyclo(his-pro) is a cyclic dipeptide that shields against oxidative damage by activating Nrf2.Formule :C11H14N4O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :234.25Tripeptide-41
CAS :Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formule :C29H30N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.57Zabedosertib
CAS :Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.Formule :C20H21F3N4O4SDegré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :470.47Ref: TM-T37076
1mg43,00€5mg96,00€10mg135,00€25mg220,00€50mg323,00€100mg450,00€500mgÀ demander1mL*10mM (DMSO)96,00€NF-κB-IN-11
CAS :NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.Formule :C19H18O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.34Kamebakaurin
CAS :Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.Formule :C20H30O5Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :350.45NIK-IN-2
CAS :NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formule :C20H22N4O3Couleur et forme :SolidMasse moléculaire :366.41CAY10575
CAS :CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formule :C22H21N3O6S2Couleur et forme :SolidMasse moléculaire :487.55Zharp2-1
CAS :Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).Formule :C19H18N3O2PSDegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :383.4Prostratin
CAS :Prostratin is an orally active PKC activator,an NF-κB activator and activates HIV expression. Induces KRAS phosphorylation and inhibits tumor growth.Formule :C22H30O6Degré de pureté :98%Couleur et forme :White To Off-White PowderMasse moléculaire :390.47Baicalin
CAS :Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormule :C21H18O11Degré de pureté :90.08% - 99.25%Couleur et forme :Yellow PowderMasse moléculaire :446.36CAFESTOL
CAS :Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.Formule :C20H28O3Degré de pureté :97.06% - 99.08%Couleur et forme :SolidMasse moléculaire :316.43NFATc1-IN-1
CAS :NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Formule :C13H8F2INO2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :375.11Cyclo(L-Pro-L-Val)
CAS :Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.Formule :C10H16N2O2Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :196.25CDDO-dhTFEA
CAS :CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Formule :C33H45F3N2O3Degré de pureté :95.61% - 99.59%Couleur et forme :SolidMasse moléculaire :574.72Ref: TM-T13604
1mg70,00€2mg92,00€5mg153,00€10mg255,00€25mg512,00€50mg738,00€100mg1.035,00€500mg2.062,00€1mL*10mM (DMSO)187,00€Rucaparib
CAS :Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.Formule :C19H18FN3ODegré de pureté :98.37% - 99.80%Couleur et forme :SolidMasse moléculaire :323.36Ref: TM-T4463
2mg48,00€5mg73,00€10mg115,00€25mg173,00€50mg235,00€100mg364,00€200mg540,00€500mg869,00€1mL*10mM (DMSO)81,00€SC75741
CAS :SC75741 is a potent P65 inhibitor with IC50 of 200 nMFormule :C29H23N7O2S2Degré de pureté :99.44% - 99.82%Couleur et forme :SolidMasse moléculaire :565.67Edecesertib
CAS :Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.Formule :C22H22FN7O2Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :435.45ANTHRAQUINONE-2-CARBOXYLIC ACID
CAS :Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role ofFormule :C15H8O4Degré de pureté :99.08% - 99.83%Couleur et forme :SolidMasse moléculaire :252.22Rocaglamide
CAS :Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formule :C29H31NO7Degré de pureté :95.32% - 98.46%Couleur et forme :SolidMasse moléculaire :505.56Muscone
CAS :Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.Formule :C16H30ODegré de pureté :99.28%Couleur et forme :Colourless Liquid LiquidMasse moléculaire :238.41TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formule :C27H37N7O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :491.63Zingerone
CAS :Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale with potent anti-inflammatory, antidiabetic and anti-tumor properties.Formule :C11H14O3Degré de pureté :99.38% - 99.85%Couleur et forme :Clear Slightly Yellow LiquidMasse moléculaire :194.23PROTAC IRAK4 degrader-8
CAS :PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].Formule :C43H50ClF2N11O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :874.38WAY-169916
CAS :WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Formule :C17H13F3N2O2Degré de pureté :98.63% - 98.64%Couleur et forme :SolidMasse moléculaire :334.29Ref: TM-T8981
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg329,00€100mg475,00€200mg655,00€1mL*10mM (DMSO)94,00€Gue1654
CAS :Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formule :C23H17N3OS3Degré de pureté :98.02% - 98.31%Couleur et forme :SolidMasse moléculaire :447.6Malachite green oxalate
CAS :Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Formule :C23H25N2·C2HO4C2H2O4Couleur et forme :Dark Green Crystals With A Metallic LusterMasse moléculaire :463.51IMD-0354
CAS :IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formule :C15H8ClF6NO2Degré de pureté :99.56% - 99.71%Couleur et forme :SolidMasse moléculaire :383.67Ref: TM-T6141
2mg48,00€5mg66,00€10mg92,00€25mg163,00€50mg221,00€100mg310,00€500mg753,00€1mL*10mM (DMSO)69,00€RIP2 Kinase Inhibitor 3
CAS :RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.Formule :C19H24N4O3SDegré de pureté :98.28% - 98.35%Couleur et forme :SolidMasse moléculaire :388.48Benzoyloxypaeoniflorin
CAS :Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Formule :C30H32O13Degré de pureté :97.64% - 98.7%Couleur et forme :SolidMasse moléculaire :600.57Ref: TM-T4S1658
1mg127,00€5mg298,00€10mg432,00€25mg697,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)378,00€GSK319347A
CAS :GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formule :C22H19N3O5S2Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :469.53Ref: TM-T15558
1mg73,00€5mg153,00€10mg255,00€25mg535,00€50mg910,00€100mg1.216,00€1mL*10mM (DMSO)340,00€RIPK1-IN-16
CAS :RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Formule :C20H19N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.46IRAK4-IN-20
CAS :IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Formule :C22H25F3N4O3Degré de pureté :97.32%Couleur et forme :SolidMasse moléculaire :450.45Asatone
CAS :Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formule :C24H32O8Degré de pureté :99.84% - 99.92%Couleur et forme :SolidMasse moléculaire :448.51Ref: TM-T10383
1mg88,00€5mg202,00€10mg303,00€25mg509,00€50mg725,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)198,00€BMS-345541 hydrochloride
CAS :BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formule :C14H18ClN5Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :291.78Ref: TM-T8542
1mg40,00€2mg52,00€5mg87,00€10mg126,00€25mg225,00€50mg376,00€100mg563,00€1mL*10mM (DMSO)55,00€Velutin
CAS :Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well asFormule :C17H14O6Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :314.29AZD3264
CAS :AZD3264 is a new type IKK2 inhibitor.Formule :C21H23N5O4SDegré de pureté :98.98% - 99.17%Couleur et forme :SolidMasse moléculaire :441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€IMM-H007
CAS :IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormule :C22H23N5O8Degré de pureté :97.73%Couleur et forme :SolidMasse moléculaire :485.45Ref: TM-T9010
1mg40,00€5mg96,00€10mg135,00€25mg226,00€50mg320,00€100mg434,00€200mg602,00€1mL*10mM (DMSO)131,00€PROTAC IRAK4 degrader-12
CAS :PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)Formule :C46H50ClF2N11O6Couleur et forme :SolidMasse moléculaire :926.41BI-69A11
CAS :BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.Formule :C25H16ClN3O2Degré de pureté :96.97%Couleur et forme :SolidMasse moléculaire :425.87Ref: TM-T25150
1mg46,00€2mg57,00€5mg82,00€10mg96,00€25mg180,00€50mg259,00€100mg369,00€1mL*10mM (DMSO)93,00€PROTAC IRAK4 ligand-4
CAS :PROTAC IRAK4 ligand-4, a Ligand for Target Protein for PROTAC (Ligand for Target Protein for PROTAC), exhibits anti-tumor activity and is utilized in synthesizing PROTAC IRAK4 degrader-12. This compound serves as a targeted ligand with specific applications in the development of cancer therapeutics.Formule :C24H26F2N6O3Couleur et forme :SolidMasse moléculaire :484.5INF 195
CAS :INF 195 is an inflammasome NLRP3 inhibitor that can be used to study myocardial ischemia and myocardial infarction.Formule :C17H22ClNO3Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :323.81Stachydrine Hydrochloride
CAS :Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.Formule :C7H14ClNO2Degré de pureté :99.53% - 99.71%Couleur et forme :Light Yellow PasteMasse moléculaire :179.64Vanillic Acid
CAS :Vanillic Acid (Acide vanillique) is used as a condiment in food, which used in wine. It is an intermediate in the production of vanillin from ferulic acid.Formule :C8H8O4Degré de pureté :99.82%Couleur et forme :White Odourless Crystals Or PowderMasse moléculaire :168.15Indacaterol maleate
CAS :Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.Formule :C28H32N2O7Degré de pureté :99.03% - 99.67%Couleur et forme :SolidMasse moléculaire :508.56Anti-inflammatory agent 51
CAS :Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.Formule :C22H22N6O6SDegré de pureté :99.46%Couleur et forme :SoildMasse moléculaire :498.512-Hydroxychalcone
CAS :2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated. It inhibits invasion of breast cancer cells.Formule :C15H12O2Degré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :224.25Maslinic acid
CAS :Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.Formule :C30H48O4Degré de pureté :98.1% - 99.98%Couleur et forme :SolidMasse moléculaire :472.7Guaiacol
CAS :Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.Formule :C7H8O2Degré de pureté :99.83%Couleur et forme :Colourless To Pale Yellow Solid CrystallineMasse moléculaire :124.14ZB-R-55
CAS :ZB-R-55 is an oral and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.Formule :C25H23N5O3Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :441.48Sinomenine
CAS :Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.Formule :C19H23NO4Degré de pureté :99.02% - 99.89%Couleur et forme :White PowderMasse moléculaire :329.39Karacoline
CAS :Karacolinem: natural compound, inhibits ECM breakdown in IDD through NF-κB pathway.Formule :C22H35NO4Degré de pureté :99.64% - 99.75%Couleur et forme :SolidMasse moléculaire :377.52Urolithin B
CAS :Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormule :C13H8O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :212.2Selnoflast
CAS :Selnoflast (RO-7486967) is an orally active, potent and selective NLRP3 inhibitor for the study of coronary arteries and ulcerative colitis.Formule :C20H29N3O3SDegré de pureté :100% - 99.82%Couleur et forme :SolidMasse moléculaire :391.53Neferine
CAS :Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.Formule :C38H44N2O6Degré de pureté :98.81% - 99.18%Couleur et forme :SolidMasse moléculaire :624.77anemarsaponin B
CAS :Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activityFormule :C45H74O18Degré de pureté :99.06% - 99.81%Couleur et forme :SolidMasse moléculaire :903.06(S)-(+)-Ibuprofen
CAS :(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).Formule :C13H18O2Degré de pureté :99.51% - 99.86%Couleur et forme :Colourless Crystalline SolidMasse moléculaire :206.28GSK2982772
CAS :GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.Formule :C20H19N5O3Degré de pureté :99.27% - 99.31%Couleur et forme :SolidMasse moléculaire :377.4Bay 65-1942 free base
CAS :Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formule :C22H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.45HOMOPLANTAGININ
CAS :Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and showsFormule :C22H22O11Degré de pureté :97.63% - 99.66%Couleur et forme :SolidMasse moléculaire :462.4Ref: TM-T4S0217
5mg50,00€10mg74,00€25mg140,00€50mg226,00€100mg324,00€200mg464,00€1mL*10mM (DMSO)52,00€Saikosaponin A
CAS :Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-Formule :C42H68O13Degré de pureté :99.57% - 99.88%Couleur et forme :White PowderMasse moléculaire :780.98IR-Crizotinib
CAS :IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranialFormule :C53H57Cl2FIN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1024.88RIP1 kinase inhibitor 5
CAS :RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) inFormule :C13H17F2NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :257.28NLRP3-IN-9
CAS :NLRP3-IN-9 (INF-4E) irreversibly inhibits NLRP3 ATPase, caspase-1, and prevents pyroptosis in THP-1 cells.Formule :C12H13ClO3Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :240.68NF-κB-IN-8
CAS :NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.Formule :C24H21N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.44Ginsenoside Rb3
CAS :Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity.Formule :C53H90O22Degré de pureté :98% - 99.98%Couleur et forme :SolidMasse moléculaire :1079.27Aristolochic acid A
CAS :Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort family of plants.Formule :C17H11NO7Degré de pureté :99.85% - 99.97%Couleur et forme :Yellow PowderMasse moléculaire :341.27IRAK inhibitor 3
CAS :IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.Formule :C21H21N5O4SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :439.493'-Sialyllactose sodium
CAS :3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.Formule :C23H38NNaO19Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :655.53GSK963
CAS :GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).Formule :C14H18N2ODegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :230.31Ref: TM-T5054
1mg35,00€2mg50,00€5mg79,00€10mg119,00€25mg235,00€50mg378,00€100mg552,00€1mL*10mM (DMSO)87,00€Pyrrolidinedithiocarbamate ammonium
CAS :Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxideFormule :C5H12N2S2Degré de pureté :100% - ≥98%Couleur et forme :Off-White To Pale Yellow CrystalsMasse moléculaire :164.29Myrcene
CAS :Myrcene is a terpene that has been found in Cannabis and has antioxidative properties.Formule :C10H16Degré de pureté :75%Couleur et forme :Colourless Slightly Amber Coloured LiquidMasse moléculaire :136.23Soyasaponin Bb
CAS :1.Formule :C48H78O18Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :943.12IMD-biphenylC
CAS :IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.Formule :C35H33N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.674-Octylphenol
CAS :4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.Formule :C14H22OCouleur et forme :SolidMasse moléculaire :206.32Armepavine
CAS :Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.Formule :C19H23NO3Degré de pureté :95.00%Couleur et forme :SolidMasse moléculaire :313.39Micheliolide
CAS :Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.Formule :C15H20O3Degré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :248.32Ref: TM-T5688
1mg47,00€5mg119,00€10mg187,00€25mg316,00€50mg472,00€100mg658,00€500mg1.378,00€1mL*10mM (DMSO)131,00€2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS :2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.Formule :C11H10N2OSDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :218.27Rubiadin-1-methyl ether
CAS :Rubiadin-1-methyl ether: a natural inhibitor of bone resorption, blocking NF-κB p65 phosphorylation and IκBα degradation.Formule :C16H12O4Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :268.26Saikosaponin D
CAS :Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.Formule :C42H68O13Degré de pureté :98.34% - 99.73%Couleur et forme :White PowderMasse moléculaire :780.98SZM679
SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.Formule :C27H18F5N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.51IRAK4-IN-26
IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%.Formule :C22H23N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45Engeletin
CAS :1.Formule :C21H22O10Degré de pureté :99.72% - 99.99%Couleur et forme :SolidMasse moléculaire :434.39Antiproliferative agent-22
CAS :Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Formule :C17H13N3O3Degré de pureté :99.20% - 99.30%Couleur et forme :SolidMasse moléculaire :307.31-Caffeoylquinic acid
CAS :1-Caffeoylquinic acid: a lignin precursor with anti-influenza, antioxidant properties, and moderates post-meal glucose release.Formule :C16H18O9Degré de pureté :98.77% - 99.16%Couleur et forme :SolidMasse moléculaire :354.31Ref: TM-TN1051
1mg90,00€5mg243,00€10mg351,00€25mg548,00€50mg735,00€100mgÀ demander1mL*10mM (DMSO)225,00€ETHYL CAFFEATE
CAS :Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.Formule :C11H12O4Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :208.21AZ1495
CAS :AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Formule :C21H31N5O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :385.5Ref: TM-T14367
1mg87,00€5mg164,00€10mg259,00€25mg369,00€50mg520,00€100mg792,00€200mg1.064,00€1mL*10mM (DMSO)178,00€(E/Z)-IT-603
CAS :(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor. IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding activity.Formule :C11H9BrN2O3SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :329.17Ref: TM-T8799
1mg59,00€5mg126,00€10mg202,00€25mg406,00€50mg607,00€100mg845,00€500mg1.738,00€1mL*10mM (DMSO)140,00€Myrislignan
CAS :Myrislignan exhibits anti-inflammatory, anti-cancer properties, hinders NF-κB pathway, curbs A549 cell growth, and triggers apoptosis and cell cycle arrest.Formule :C21H26O6Degré de pureté :98.77% - 99.41%Couleur et forme :SolidMasse moléculaire :374.43Ref: TM-T4S1540
1mg47,00€5mg93,00€10mg144,00€25mg250,00€50mg406,00€100mg592,00€1mL*10mM (DMSO)107,00€CBL0137
CAS :CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM).Formule :C21H24N2O2Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :336.434-Aminosalicylic acid
CAS :4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.Formule :C7H7NO3Degré de pureté :97.07%Couleur et forme :Minute Crystals From Alc SolidMasse moléculaire :153.14IRAK-4 protein kinase inhibitor 2
CAS :IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).Formule :C14H10N4O3Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :282.25BMS986299
CAS :BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be used in studies about NLRP3 signaling and the treatment of associated diseases.Formule :C18H19N7ODegré de pureté :99.93% - 99.93%Couleur et forme :SolidMasse moléculaire :349.39Esculentoside A
CAS :Esculentoside A dampens inflammation in ALI, modulates T cells, and could treat autoimmune diseases and BXSB mice by adjusting cytokines and renal cells.Formule :C42H66O16Degré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :826.96Dendrophenol
CAS :Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Formule :C17H20O5Degré de pureté :98.2% - 98.96%Couleur et forme :SolidMasse moléculaire :304.34Ref: TM-T3S1707
1mg104,00€2mg145,00€5mg227,00€10mg338,00€25mg558,00€50mg797,00€100mg1.074,00€1mL*10mM (DMSO)246,00€NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFormule :C26H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53DHMEQ racemate
CAS :DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Formule :C13H11NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :261.23NLRP3-IN-13
CAS :NLRP3-IN-13 is an NLRP3 inhibitor that inhibits NLRP3-associated inflammation.NLRP3-IN-13 can be used in the study of neurological disorders and inflammation.Formule :C19H15N3O3SDegré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :365.41E3330
CAS :E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formule :C21H30O6Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :378.46Ref: TM-T6823
1mg50,00€2mg72,00€5mg107,00€10mg167,00€25mg304,00€50mg500,00€100mg725,00€200mg1.017,00€500mg1.510,00€1mL*10mM (DMSO)88,00€Ginsenoside Rk3
CAS :Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.Formule :C36H60O8Degré de pureté :99.33% - 99.88%Couleur et forme :SolidMasse moléculaire :620.86Ref: TM-T6S1495
1mg85,00€5mg172,00€10mg255,00€25mg426,00€50mg630,00€100mg898,00€1mL*10mM (DMSO)283,00€IVMT-Rx-3
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin.Formule :C69H90F3N13O24Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :1542.54Sauchinone
CAS :Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.Formule :C20H20O6Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :356.37Gypenoside L
CAS :Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formule :C42H72O14Degré de pureté :99.42% - 99.65%Couleur et forme :SolidMasse moléculaire :801.01GSK840
CAS :GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinaseFormule :C21H23N3O3Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :365.43Flizasertib
CAS :Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.Formule :C15H14FN3ODegré de pureté :100% - 99.39%Couleur et forme :SolidMasse moléculaire :271.29Adelmidrol
CAS :Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.Formule :C13H26N2O4Degré de pureté :99.35% - 99.73%Couleur et forme :SolidMasse moléculaire :274.36Eudebeiolide B
CAS :Eudebeiolide B, isolated from Salvia plebeia R.Formule :C15H18O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :262.3Tizoxanide
CAS :Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formule :C10H7N3O4SDegré de pureté :98.89% - 99.28%Couleur et forme :SolidMasse moléculaire :265.25BOT-64
CAS :BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormule :C15H15NO2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :273.35Ref: TM-T8705
1mg52,00€5mg116,00€10mg178,00€25mg340,00€50mg520,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)107,00€BMS-066
CAS :BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Formule :C19H21N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.42Robinin
CAS :Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formule :C33H40O19Degré de pureté :98.78% - 99.13%Couleur et forme :SolidMasse moléculaire :740.66IMD-biphenylB
CAS :IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Formule :C35H33N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.67Usnoflast
CAS :Usnoflast (ZYIL1) is an NLRP3 inhibitor, inhibiting NLRP3 inflammasome activation, used in neurological disease research.Formule :C21H29N3O3SDegré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :403.54AP-1/NF-κB activation inhibitor 1
CAS :AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basalFormule :C13H11F3N4O4Degré de pureté :100% - 99.74%Couleur et forme :SolidMasse moléculaire :344.25Ref: TM-T9656
1mg73,00€2mg96,00€5mg160,00€10mg216,00€25mg354,00€50mg525,00€100mg730,00€500mg1.483,00€1mL*10mM (DMSO)170,00€Edasalonexent
CAS :Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Formule :C31H42N2O3Degré de pureté :100% - 98.69%Couleur et forme :SolidMasse moléculaire :490.68Ref: TM-T15198
1mg99,00€2mg144,00€5mg235,00€10mg376,00€25mg677,00€50mg1.064,00€1mL*10mM (DMSO)254,00€HS271
CAS :HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).Formule :C21H24F3N5O2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :435.44Ref: TM-T37082
1mg62,00€2mg89,00€5mg135,00€10mg212,00€25mg368,00€50mg510,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)149,00€5-Aminosalicylic Acid
CAS :5-ASA, an anti-inflammatory salicylate, treats inflammatory bowel disease, active part of sulphalazine.Formule :C7H7NO3Degré de pureté :98.88% - 99.98%Couleur et forme :Purplish-Tan Solid PowderMasse moléculaire :153.14Cornuside
CAS :Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Formule :C24H30O14Degré de pureté :100% - 99.57%Couleur et forme :SolidMasse moléculaire :542.49Ref: TM-T4S2326
1mg96,00€5mg264,00€10mg415,00€25mg677,00€50mg935,00€100mg1.254,00€500mg2.527,00€1mL*10mM (DMSO)315,00€Isoquercetin
CAS :1.Formule :C21H20O12Degré de pureté :98.08% - 99.29%Couleur et forme :SolidMasse moléculaire :464.38Ref: TM-T5S0754
5mg49,00€10mg65,00€25mg97,00€50mg153,00€100mg221,00€200mg329,00€1mL*10mM (DMSO)50,00€Isoliquiritin apioside
CAS :Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Formule :C26H30O13Degré de pureté :98.84% - 99.27%Couleur et forme :SolidMasse moléculaire :550.51Tyloxapol
CAS :Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.Formule :C70H124O13Degré de pureté :polymer - polymerCouleur et forme :Clear Light Yellow Viscous LiquidMasse moléculaire :137.18Isovitexin
CAS :1.Formule :C21H20O10Degré de pureté :98.24% - 99.79%Couleur et forme :SolidMasse moléculaire :432.38Ref: TM-T6S1371
1mg52,00€5mg97,00€10mg140,00€25mg274,00€50mg411,00€100mg597,00€500mg1.225,00€1mL*10mM (DMSO)105,00€Demethyleneberberine
CAS :Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFormule :C19H18NO4Degré de pureté :98.08% - 99.18%Couleur et forme :SolidMasse moléculaire :324.35Theaflavin 3,3'-digallate
CAS :Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormule :C43H32O20Degré de pureté :98.71% - 99.86%Couleur et forme :SolidMasse moléculaire :868.7Ocadusertib
CAS :Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Formule :C25H25N5O4Couleur et forme :SolidMasse moléculaire :459.50Eclitasertib
CAS :Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).Formule :C19H18N6O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :378.38Ref: TM-T9702
1mg106,00€2mg150,00€5mg227,00€10mg359,00€25mg652,00€50mg905,00€100mg1.293,00€1mL*10mM (DMSO)250,00€BX795
CAS :BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formule :C23H26IN7O2SDegré de pureté :98% - 99.57%Couleur et forme :SolidMasse moléculaire :591.47Ref: TM-T1830
5mg59,00€10mg97,00€25mg210,00€50mg343,00€100mg513,00€200mg740,00€500mg1.121,00€1mL*10mM (DMSO)88,00€CL075
CAS :CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 toFormule :C13H13N3SDegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :243.33Flaconitine
CAS :Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.Formule :C36H49NO12Degré de pureté :98% - 99.84%Couleur et forme :SolidMasse moléculaire :687.77Flavanomarein
CAS :Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Formule :C21H22O11Degré de pureté :97.53% - 98.63%Couleur et forme :SolidMasse moléculaire :450.39Ginsenoside Re
CAS :Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Formule :C48H82O18Degré de pureté :100% - 99.78%Couleur et forme :White PowderMasse moléculaire :947.15B022
CAS :B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Formule :C19H16ClN5OSDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :397.88Mitogen-activated protein kinase 1
CAS :Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Degré de pureté :98%Couleur et forme :SolidRIPK1-IN-9
CAS :RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Formule :C26H25FN6O2Degré de pureté :98.7%Couleur et forme :SolidMasse moléculaire :472.51Ref: TM-T63055
1mg205,00€5mg495,00€10mg677,00€25mg1.008,00€50mg1.349,00€100mg1.833,00€200mg2.452,00€1mL*10mM (DMSO)568,00€Gossypin
CAS :Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.Formule :C21H20O13Degré de pureté :97.57% - 98.97%Couleur et forme :SolidMasse moléculaire :480.38NLRP3-IN-10
CAS :NLRP3-IN-10 (ZVN26391) is a strong NLRP3 inhibitor, IC50 251.1 nM, that reduces IL-1β and ASC speck, hindering inflammasome activation.Formule :C17H14BrFO3Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :365.19Ref: TM-T61392
5mg47,00€10mg70,00€25mg126,00€50mg187,00€100mg311,00€200mg465,00€1mL*10mM (DMSO)65,00€2,4-Diamino-6-hydroxypyrimidine
CAS :2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesisFormule :C4H6N4ODegré de pureté :99.82%Couleur et forme :White Solid CrystalsMasse moléculaire :126.12NLRP3-IN-11
CAS :NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.Formule :C17H17ClN4O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :344.8GSK2983559 active metabolite
CAS :GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.Formule :C21H22N4O4S2Degré de pureté :97.07% - 98.48%Couleur et forme :SolidMasse moléculaire :458.55Convallatoxin
CAS :Convallatoxin is a natural product.Formule :C29H42O10Degré de pureté :99.27%Couleur et forme :Prisms From Methanol + Ether SolidMasse moléculaire :550.64