NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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HPN-01
CAS :HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formule :C19H16ClN3O3SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :401.87OT-551 HCl
CAS :OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macularFormule :C13H24ClNO3Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :277.79Ref: TM-T28273L
1mg115,00€5mg245,00€10mg363,00€25mg562,00€50mg802,00€100mg1.111,00€200mg1.491,00€1mL*10mM (DMSO)295,00€Theophylline
CAS :Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFormule :C7H8N4O2Degré de pureté :99.47% - 99.97%Couleur et forme :White Solid PowderMasse moléculaire :180.16HOIPIN-8 sodium
CAS :HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Formule :C23H15F2N4NaO3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :456.38BAY32-5915
CAS :BAY32-5915 is a selective inhibitor of IKKalpha.Formule :C10H7NO3Degré de pureté :96.48% - 97.00%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :189.17Betulinic acid
CAS :Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formule :C30H48O3Degré de pureté :99.12% - 99.7%Couleur et forme :White Crystalline PowderMasse moléculaire :456.7Anti-inflammatory agent 50
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, andFormule :C40H55N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.88Caffeic Acid Phenethyl Ester
CAS :CAPE, in propolis, blocks NF-kappa B, suppresses p70S6K/Akt pathways, and inhibits PDGF, aiding in cancer protection and immune modulation.Formule :C17H16O4Degré de pureté :99.18% - 99.35%Couleur et forme :Less Transparent Liquid Colorless Transparent LiquidMasse moléculaire :284.31Specnuezhenide
CAS :Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling.Cost-effective and quality-assured.Formule :C31H42O17Degré de pureté :98% - 99.12%Couleur et forme :SolidMasse moléculaire :686.66Ref: TM-T3803
2mg38,00€5mg52,00€10mg88,00€25mg164,00€50mg233,00€100mg344,00€500mg830,00€1mL*10mM (DMSO)82,00€Damascenone
CAS :Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.Formule :C13H18ODegré de pureté :98.03%Couleur et forme :Colorless LiquidMasse moléculaire :190.28NP3-146
CAS :NP3-146 (NLRP3-IN-5) is an inflammasome NLRP3 inhibitor with potential anti-inflammatory activity for the study of autoimmune diseases.Formule :C20H27ClN2O5SDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :442.96RIPK2-IN-5
CAS :RIPK2-IN-5 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with potential anti-inflammatory activity for the study of diseases caused by immune dysfunctions.Formule :C21H14N4SDegré de pureté :98.85%Couleur et forme :SoildMasse moléculaire :354.43Sappanone A
CAS :Sappanone A is a high isoflavanone with anti-inflammatory properties.Sappanone A reduces allergic airway inflammation in ovalbumin-induced asthma.Formule :C16H12O5Degré de pureté :97.48% - 99.18%Couleur et forme :SolidMasse moléculaire :284.26Pinocembrin
CAS :Pinocembrin (5,7-Dihydroxyflavanone) is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.Formule :C15H12O4Degré de pureté :100% - 99.61%Couleur et forme :SolidMasse moléculaire :256.25NF-κB/MAPK-IN-1
CAS :NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).Formule :C27H27NO7Degré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :477.51Ref: TM-T63119
1mg47,00€2mg60,00€5mg87,00€10mg154,00€25mg329,00€50mg492,00€100mg710,00€1mL*10mM (DMSO)93,00€CBL0137 hydrochloride
CAS :CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB.Cost-effective and quality-assured.Formule :C21H25ClN2O2Degré de pureté :98.59% - 99.35%Couleur et forme :SolidMasse moléculaire :372.88Nimbolide
CAS :Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Formule :C27H30O7Degré de pureté :95.84% - 99.4%Couleur et forme :SolidMasse moléculaire :466.52Ref: TM-T16324
1mg88,00€5mg216,00€10mg376,00€25mg810,00€50mg1.074,00€100mg1.454,00€200mg1.882,00€1mL*10mM (DMSO)235,00€IRAK-1-4 Inhibitor I
CAS :IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.Formule :C20H21N5O4Degré de pureté :100% - 99.89%Couleur et forme :SolidMasse moléculaire :395.41Ref: TM-T2457
1mg44,00€5mg79,00€10mg110,00€25mg224,00€50mg376,00€100mg540,00€500mg1.130,00€1mL*10mM (DMSO)79,00€Stipuleanoside R2
CAS :Stipuleanoside R2 is a triterpenoid saponin that inhibits NF-κB activation and has potential applications in inflammation, immunology, and cancer research.Formule :C53H84O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1089.22Esculentoside H
CAS :Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Formule :C48H76O21Degré de pureté :98.04% - 99.3%Couleur et forme :SolidMasse moléculaire :989.1Sootepin D
CAS :Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.Formule :C31H48O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.71IMD-0560
CAS :IMD-0560 is a novel inhibitor of IκB kinase β.Formule :C15H8BrF6NO2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :428.12Sulindac
CAS :Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Formule :C20H17FO3SDegré de pureté :99.09% - 99.15%Couleur et forme :Yellow SolidMasse moléculaire :356.41Goshonoside F5
CAS :Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.Formule :C32H54O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.771CID-2858522
CAS :CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).Formule :C28H39N3O3Degré de pureté :96.11%Couleur et forme :SolidMasse moléculaire :465.63Kuromanin chloride
CAS :Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transductionFormule :C21H21ClO11Degré de pureté :97.27% - 98.69%Couleur et forme :SolidMasse moléculaire :484.84Ref: TM-T3406
1mg35,00€2mg50,00€5mg82,00€10mg110,00€25mg207,00€50mg306,00€100mg459,00€1mL*10mM (DMSO)88,00€IRAK4-IN-27
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM.Formule :C23H22N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.46Cantleyoside
CAS :Cantleyoside, a natural cyclic enol ether terpene glycoside from Pterocephalus hookeri, can activate of the AMPK/Sirt1/NF-κB signaling pathway.Formule :C33H46O19Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :746.71TNFα activity modulator 3
CAS :TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.Formule :C27H24F2N6O2Couleur et forme :SolidMasse moléculaire :502.52BAL-0028
CAS :BAL-0028 is a potent inhibitor of NLRP3 activation (IC50: 25 nM) with anti-inflammatory activity for cancer research.Formule :C24H22FN3O2Degré de pureté :99.16%Couleur et forme :SoildMasse moléculaire :403.45Physalin O
CAS :Physalin O has anti-inflammatory properties, binds with GSH, and inhibits NO production.Formule :C28H32O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.554JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Formule :C17H13NaO4Degré de pureté :95.08%Couleur et forme :SolidMasse moléculaire :304.27Parthenolide
CAS :Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB and HDAC1 inhibitor with anti-inflammatory effect. Cost-effective and quality-assured.Formule :C15H20O3Degré de pureté :99.10% - 99.46%Couleur et forme :White To Pale Yellow Crystalline PowderMasse moléculaire :248.32GSK547
CAS :GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.Formule :C20H18F2N6ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :396.39Gliotoxin
CAS :Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formule :C13H14N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.39NLRP3-IN-51
NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.Couleur et forme :Odour SolidHS-243
CAS :HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Formule :C17H16N4O3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :324.33RIP1 kinase inhibitor 4
CAS :RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].Formule :C23H23N5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.46CHPG sodium salt
CAS :CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways.Formule :C8H7ClNNaO3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :223.59IRAK4-IN-8
CAS :IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.Formule :C23H23F2N7O2SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :499.54Ref: TM-T63388
1mg825,00€2mg1.130,00€5mg1.681,00€10mg2.270,00€25mg3.372,00€50mg4.541,00€100mg6.146,00€Rhynchophylline
CAS :Rhynchophylline (Mitrinermine) is an alkaloid isolated from Crocus sativus and is widely used in anti-inflammatory and neuroprotective studies.Formule :C22H28N2O4Degré de pureté :99.44%Couleur et forme :Red Brown Or White Fine PowderMasse moléculaire :384.47Indole-3-carbinol
CAS :Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinaseFormule :C9H9NODegré de pureté :100% - 97.06%Couleur et forme :SolidMasse moléculaire :147.17Coronalolic acid
CAS :Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.Formule :C30H46O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.681-Isomangostin
CAS :1-Isomangostin has cytotoxic and anticomplementary activities.Formule :C24H26O6Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :410.462,5-Dihydroxyacetophenone
CAS :2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formule :C8H8O3Degré de pureté :99.75%Couleur et forme :Yellow PowderMasse moléculaire :152.15NF-κB-IN-12
NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].Formule :C30H26N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.63Zimlovisertib
CAS :Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4).Formule :C18H20FN3O4Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :361.37Ref: TM-TQ0167
1mg35,00€5mg67,00€10mg115,00€25mg224,00€50mg404,00€100mg655,00€200mg910,00€1mL*10mM (DMSO)73,00€IRAK4-IN-25
IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatoryFormule :C23H25N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.48JC124
CAS :JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.Formule :C17H19ClN2O4SDegré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :382.86Ref: TM-T25548
1mg64,00€5mg145,00€10mg226,00€25mg379,00€50mg538,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)160,00€RIPK3-IN-4
CAS :RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage.Formule :C24H18BrFN4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :541.39
