NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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JSH-23
CAS :JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity without affecting IκB degradation. JSH-23 is an antioxidant. Cost effective and quality assured.Formule :C16H20N2Degré de pureté :98.03% - 99.67%Couleur et forme :SolidMasse moléculaire :240.34Ref: TM-T1930
1mg43,00€2mg57,00€5mg93,00€10mg119,00€25mg187,00€50mg283,00€100mg430,00€1mL*10mM (DMSO)93,00€Quinoclamine
CAS :Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.Formule :C10H6ClNO2Degré de pureté :99.13% - 99.28%Couleur et forme :Orange PowderMasse moléculaire :207.617,4'-Dihydroxyflavone
CAS :7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Formule :C15H10O4Degré de pureté :99.39% - 99.6%Couleur et forme :SolidMasse moléculaire :254.24Emlenoflast sodium
CAS :Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome,Formule :C19H24N4NaO3SCouleur et forme :SolidMasse moléculaire :411.47SjDX5-271
CAS :SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.Formule :C137H215N47O49SCouleur et forme :SolidMasse moléculaire :3336.52NF-κΒ activator 2
CAS :NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM.Formule :C16H11FN2O3Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :298.27Ref: TM-T39924
1mg94,00€2mg136,00€5mg226,00€10mg335,00€25mg538,00€50mg730,00€100mg938,00€1mL*10mM (DMSO)249,00€HS-1371
CAS :HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.Formule :C24H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.47Sulforaphene
CAS :Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formule :C6H9NOS2Degré de pureté :98.01% - 99.19%Couleur et forme :Slightly Yellowish LiquidMasse moléculaire :175.27Ref: TM-TL0016
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg227,00€50mg338,00€100mg500,00€1mL*10mM (DMSO)69,00€Ac2-26 acetate
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1).Formule :C141H210N32O44SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3089.43CORM-3
CAS :CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.Formule :C5H4ClNO5RuDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :294.61NF-κB-IN-1
CAS :NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFormule :C31H30O8Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :530.57Ref: TM-T9105
1mg166,00€5mg341,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€1mL*10mM (DMSO)398,00€Indacaterol
CAS :Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.Formule :C24H28N2O3Degré de pureté :100.00% - 99.63%Couleur et forme :SolidMasse moléculaire :392.49Sulfuretin
CAS :Sulfuretin protects HepG2 cells from oxidative damage by scavenging ROS and activating HO-1 via Nrf2/ARE and JNK/ERK pathways.Formule :C15H10O5Degré de pureté :100% - 98.91%Couleur et forme :SolidMasse moléculaire :270.24WITHAFERIN A
CAS :WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/Formule :C28H38O6Degré de pureté :97.41% - 99.83%Couleur et forme :SolidMasse moléculaire :470.6Ref: TM-T5687
1mg85,00€5mg265,00€10mg393,00€25mg653,00€50mg929,00€100mg1.254,00€500mg2.517,00€1mL*10mM (DMSO)304,00€IRAK4-IN-28
CAS :IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.Formule :C27H31N9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.59Isonardosinone
CAS :Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities.Formule :C15H22O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :250.33GSK8612
CAS :GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Formule :C17H17BrF3N7O2SDegré de pureté :99.46% - ≥98%Couleur et forme :SolidMasse moléculaire :520.33Ref: TM-T5540
1mg47,00€2mg59,00€5mg92,00€10mg131,00€25mg215,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)96,00€Ginsenoside Rg2
CAS :Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.Formule :C42H72O13Degré de pureté :99.5% - 99.77%Couleur et forme :SolidMasse moléculaire :785.01Ref: TM-T2873
2mg37,00€5mg52,00€10mg88,00€25mg131,00€50mg188,00€100mg279,00€500mg658,00€1mL*10mM (DMSO)87,00€Pratensein
CAS :Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Formule :C16H12O6Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :300.26γ-Tocotrienol
CAS :γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formule :C28H42O2Degré de pureté :97.27% - 98.13%Couleur et forme :SolidMasse moléculaire :410.63Ref: TM-T19768
1mg47,00€2mg62,00€5mg92,00€10mg144,00€25mg235,00€50mg350,00€100mg515,00€200mg743,00€1mL*10mM (DMSO)97,00€Tyrosol
CAS :Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present mostFormule :C8H10O2Degré de pureté :100% - 99.28%Couleur et forme :SolidMasse moléculaire :138.16Astaxanthin
CAS :Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Formule :C40H52O4Degré de pureté :95.1% - 99.79%Couleur et forme :Needles From Acetone/Light Petroleum SolidMasse moléculaire :596.84TRAF-STOP inhibitor 6877002
CAS :TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.Formule :C17H17NODegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :251.32Handelin
CAS :Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.Formule :C32H40O8Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :552.66RIPK2-IN-3
CAS :RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.Formule :C25H22N4O2Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :410.47GSK2983559 free acid
CAS :GSK2983559 free acid selectively inhibits RIP2, reducing inflammatory cytokines in human bowel disease.Formule :C21H23N4O7PS2Degré de pureté :97.87% - 98.61%Couleur et forme :SolidMasse moléculaire :538.53Narasin (sodium salt)
CAS :Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells andFormule :C43H71NaO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.01Oditrasertib
CAS :Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.Formule :C14H15F2N3O2Degré de pureté :98.65% - 99.65%Couleur et forme :SolidMasse moléculaire :295.28Naringin dihydrochalcone
CAS :Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Formule :C27H34O14Degré de pureté :99.07% - 99.16%Couleur et forme :Solid PowderMasse moléculaire :582.55Isodeoxyelephantopin
CAS :Isodeoxyelephantopin can inhibit the growth of various tumor cells.Formule :C19H20O6Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :344.36NIK SMI1
CAS :NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).Formule :C20H19N3O4Degré de pureté :99.04% - 99.99%Couleur et forme :SolidMasse moléculaire :365.38Ref: TM-T16290
1mg87,00€5mg183,00€10mg296,00€25mg593,00€50mg932,00€100mg1.501,00€200mg2.052,00€1mL*10mM (DMSO)432,00€NDMC101
CAS :NDMC101 suppresses dipeptidyl peptidase-IV, NFATc1, and NF-κB in human T cells, modulating immunity.Formule :C13H9ClFNO2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :265.67MRT67307
CAS :Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Formule :C26H36N6O2Degré de pureté :99.25% - 99.79%Couleur et forme :SolidMasse moléculaire :464.6GSK481
CAS :GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.Formule :C21H19N3O4Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :377.39COX-2-IN-48
COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.Couleur et forme :Odour SolidCOX-2-IN-32
CAS :COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.Formule :C25H24O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.45Methylthiouracil
CAS :Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Formule :C5H6N2OSDegré de pureté :100% - 99.89%Couleur et forme :Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Masse moléculaire :142.18α-Lipoic Acid
CAS :α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.Formule :C8H14O2S2Degré de pureté :98.39% - 99.73%Couleur et forme :Forms Yellowish Flakes Light Yellow To Yellow PowderMasse moléculaire :206.33Shikonin
CAS :Shikonin: TMEM16A inhibitor (IC50: 6.5μM), targets PKM2, suppresses NF-κB, inhibits TNF-α, and reduces exosome secretion.Formule :C16H16O5Degré de pureté :98.13% - 99.9%Couleur et forme :SolidMasse moléculaire :288.3Ref: TM-T1125
5mg34,00€10mg52,00€25mg87,00€50mg140,00€100mg215,00€200mg319,00€500mg533,00€1mL*10mM (DMSO)52,00€20(S)-Ginsenoside Rg3
CAS :20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formule :C42H72O13Degré de pureté :100% - 99.93%Couleur et forme :SolidMasse moléculaire :785.01UBS109
CAS :UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Formule :C18H17N3ODegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :291.35Ref: TM-T88314
2mg38,00€5mg57,00€10mg92,00€25mg166,00€50mg254,00€100mg389,00€200mg566,00€1mL*10mM (DMSO)63,00€ISOGINKGETIN
CAS :ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Formule :C32H22O10Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :566.51Denosumab
CAS :Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligandFormule :C6404H9912N1724O2004S50Degré de pureté :98.4% (SEC-HPLC) - 99.90%Couleur et forme :LiquidMasse moléculaire :144.71 kDaTrovafloxacin mesylate
CAS :Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formule :C21H19F3N4O6SDegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :512.46Selinidin
CAS :Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.Formule :C19H20O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.364Biricodar dicitrate
CAS :Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.Formule :C46H57N3O21Degré de pureté :98.67% - 99.34%Couleur et forme :SolidMasse moléculaire :987.95Ginsenoside Rg6
CAS :Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cellsFormule :C42H70O12Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :767Obtusifolin
CAS :Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.Formule :C16H12O5Degré de pureté :100% - 99.79%Couleur et forme :SolidMasse moléculaire :284.26Ref: TM-T4S0969
1mg70,00€5mg187,00€10mg279,00€25mg472,00€50mg658,00€100mg933,00€1mL*10mM (DMSO)187,00€Molsidomine
CAS :Molsidomine, an oral vasodilator, turns into linsidomine in the liver, releasing NO for prolonged effects.Formule :C9H14N4O4Degré de pureté :100% - 99.98%Couleur et forme :Colorless Or White Crystalline PowderMasse moléculaire :242.23Articaine hydrochloride
CAS :Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Formule :C13H21ClN2O3SDegré de pureté :99.76%Couleur et forme :White Crystalline PowderMasse moléculaire :320.84
