
NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
Trier par
INH14
CAS :INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formule :C15H16N2ODegré de pureté :95.41%Couleur et forme :SolidMasse moléculaire :240.3Ref: TM-T5209
2mg38,00€5mg56,00€10mg84,00€25mg120,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)58,00€TH023
TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.Formule :C22H21ClF2N4OCouleur et forme :SolidMasse moléculaire :430.88SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Formule :C131H234N36O31SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :2841.55Asperulosidic acid
CAS :Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.Formule :C18H24O12Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :432.38SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Formule :C129H230N36O29S·XCF3COOHCouleur et forme :SolidMasse moléculaire :2781.5 (free base)CLEFMA
CAS :CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Formule :C23H17Cl2NO4Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :442.29Ref: TM-T9582
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)219,00€Tectochrysin
CAS :Tectochrysin: antioxidant, hinders ABCG2 transport, induces apoptosis in NSC-LC by blocking STAT3 and activating DR3/Fas.Formule :C16H12O4Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :268.26RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.Formule :C24H16N4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54IRAK4-IN-10
CAS :IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.Formule :C22H24N8Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :400.48Polygalasaponin F
CAS :Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Formule :C53H86O23Degré de pureté :98% - 99.83%Couleur et forme :SolidMasse moléculaire :1091.24Fibrinogen
CAS :Fibrinogen is a heterodimeric protein that can be cleaved by thrombin.Couleur et forme :SolidHesperidin methylchalcone
CAS :Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Formule :C29H36O15Degré de pureté :99.53%Couleur et forme :Yellow PowderMasse moléculaire :624.59(Rac)-Benpyrine
CAS :(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.Formule :C16H16N6ODegré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :308.34Ref: TM-T8692
1mg73,00€5mg124,00€10mg187,00€25mg376,00€50mg562,00€100mg802,00€500mg1.644,00€1mL*10mM (DMSO)137,00€(−)-N-Hydroxyapiosporamide
CAS :(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo.Formule :C24H31NO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.51Iron sucrose
CAS :Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.Formule :C18H24Fe2O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :736.1MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Formule :C26H37ClN6O2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :501.07ALPK1-IN-3
CAS :ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-inducedFormule :C20H16F2N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.43Ginsenoside Rb1
CAS :Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formule :C54H92O23Degré de pureté :99.12% - 99.76%Couleur et forme :SolidMasse moléculaire :1109.29Eurycomalactone
CAS :Eurycomalactone, from Eurycoma longifolia, inhibits NF-κB (IC50 0.5 μM), stops protein synthesis and cyclin D1, spares IκBα and IKK.Formule :C19H24O6Degré de pureté :98.98% - 99.87%Couleur et forme :SolidMasse moléculaire :348.39Morusin
CAS :Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formule :C25H24O6Degré de pureté :98.68% - 99.8%Couleur et forme :SolidMasse moléculaire :420.45Sodium Aescinate
CAS :Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.Formule :C54H83NaO23Degré de pureté :95.17%Couleur et forme :SolidMasse moléculaire :1123.21Dehydrodiisoeugenol
CAS :Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.Formule :C20H22O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :326.39Deoxyelephantopin
CAS :Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Formule :C19H20O6Degré de pureté :99.6% - 99.71%Couleur et forme :SolidMasse moléculaire :344.36EUK-134
CAS :EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formule :C18H18ClMnN2O4Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :416.74Ref: TM-T6495
10mg35,00€25mg66,00€50mg104,00€100mg160,00€200mg230,00€500mg378,00€1mL*10mM (DMSO)47,00€GSK-872
CAS :GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.Formule :C19H17N3O2S2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :383.49Ref: TM-T4074
1mg38,00€5mg79,00€10mg119,00€25mg188,00€50mg321,00€100mg494,00€200mg705,00€1mL*10mM (DMSO)86,00€Anatabine dicitrate
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.Formule :C22H28N2O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.46Necrostatin-34
CAS :Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying aFormule :C18H16N4O2S2Degré de pureté :98.66% - 98.80%Couleur et forme :SolidMasse moléculaire :384.48Ref: TM-T9095
1mg52,00€5mg116,00€10mg170,00€25mg305,00€50mg442,00€100mg615,00€200mg832,00€1mL*10mM (DMSO)135,00€HOIPIN-1
CAS :HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formule :C17H13NaO4Degré de pureté :98.83%Couleur et forme :SoildMasse moléculaire :304.27Mangiferin
CAS :Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Formule :C19H18O11Degré de pureté :96.74% - 98.30%Couleur et forme :Light Yellow PowderMasse moléculaire :422.34Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFormule :C24H21Cl2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.33CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formule :C28H28N2O6SCouleur et forme :SolidMasse moléculaire :520.6GTCpFE
CAS :GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formule :C22H20O8Couleur et forme :SolidMasse moléculaire :412.39Oxaprozin
CAS :Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formule :C18H15NO3Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :293.32Rucaparib Phosphate
CAS :Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Formule :C19H18FN3O·H3PO4Degré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :421.36Ref: TM-T6127
1mg38,00€2mg49,00€5mg79,00€10mg115,00€25mg188,00€50mg248,00€100mg393,00€200mg585,00€1mL*10mM (DMSO)79,00€Dehydroevodiamine
CAS :Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressantFormule :C19H15N3ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :301.34GSK583
CAS :GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).Formule :C20H19FN4O2SDegré de pureté :98.68% - 99.06%Couleur et forme :SolidMasse moléculaire :398.45Ref: TM-T3537
1mg50,00€2mg71,00€5mg116,00€10mg190,00€25mg319,00€50mg465,00€100mg690,00€500mg1.444,00€1mL*10mM (DMSO)116,00€Moslosooflavone
CAS :Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Formule :C17H14O5Degré de pureté :98% - 99.78%Couleur et forme :SolidMasse moléculaire :298.29IKK2-IN-4
CAS :IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formule :C12H11N3O2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :261.3Ref: TM-T36524
1mg163,00€5mg395,00€10mg605,00€25mg938,00€50mg1.264,00€100mg1.700,00€200mg2.270,00€500µg111,00€Astilbin
CAS :Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.Formule :C21H22O11Degré de pureté :97% - 99.76%Couleur et forme :White PowderMasse moléculaire :450.39Ref: TM-T2794
5mg52,00€10mg77,00€25mg140,00€50mg224,00€100mg334,00€200mg477,00€500mg778,00€1mL*10mM (DMSO)51,00€Rucaparib monocamsylate
CAS :Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.Formule :C29H34FN3O5SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :555.66Ref: TM-T16807
5mg60,00€10mg96,00€25mg160,00€50mg235,00€100mg354,00€200mg522,00€1mL*10mM (DMSO)74,00€Avicularin
CAS :Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Formule :C20H18O11Degré de pureté :97.02% - 99.94%Couleur et forme :White PowderMasse moléculaire :434.35Ref: TM-T6S0117
1mg58,00€5mg97,00€10mg160,00€25mg283,00€50mg418,00€100mg615,00€200mg878,00€1mL*10mM (DMSO)111,00€Sinomenine hydrochloride
CAS :Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Formule :C19H24ClNO4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :365.851(R)-(-)-Ibuprofen
CAS :(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Formule :C13H18O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :206.28Bay 65-1942 hydrochloride
CAS :Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formule :C22H26ClN3O4Couleur et forme :SolidMasse moléculaire :431.91Kaempferol-3-O-glucorhamnoside
CAS :Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFormule :C27H30O15Degré de pureté :96.96% - 98.17%Couleur et forme :SolidMasse moléculaire :594.5Ref: TM-T5S0089
1mg50,00€5mg97,00€10mg143,00€25mg226,00€50mg340,00€100mg495,00€200mg682,00€1mL*10mM (DMSO)129,00€Berbamine dihydrochloride
CAS :Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Formule :C37H42Cl2N2O6Degré de pureté :95% - 99.38%Couleur et forme :SolidMasse moléculaire :681.65Dauricine
CAS :1.Formule :C38H44N2O6Degré de pureté :99.04% - 99.38%Couleur et forme :White PowderMasse moléculaire :624.77JH-X-119-01
CAS :JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.Formule :C25H20N6O3Degré de pureté :97.1%Couleur et forme :SolidMasse moléculaire :452.46Ref: TM-T9203
1mg66,00€2mg96,00€5mg144,00€10mg210,00€25mg376,00€50mg562,00€100mg780,00€1mL*10mM (DMSO)159,00€Diethylmaleate
CAS :Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.Formule :C8H12O4Degré de pureté :98%Couleur et forme :Colourless LiquidMasse moléculaire :172.1818α-Glycyrrhetinic acid
CAS :18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Formule :C30H46O4Degré de pureté :98.54% - 99.68%Couleur et forme :SolidMasse moléculaire :470.68