
NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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Tenuigenin
CAS :Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.Formule :C30H45ClO6Degré de pureté :98.9% - 99.53%Couleur et forme :SolidMasse moléculaire :537.13Ref: TM-T3907
2mg37,00€5mg52,00€10mg77,00€25mg111,00€50mg160,00€100mg227,00€200mg335,00€1mL*10mM (DMSO)66,00€RIPK1-IN-7
CAS :RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.Formule :C25H22F3N5O2Degré de pureté :98.02% - 98.18%Couleur et forme :SolidMasse moléculaire :481.47Ref: TM-T12731
1mg92,00€5mg216,00€10mg329,00€25mg512,00€50mg707,00€100mg944,00€1mL*10mM (DMSO)233,00€Sciadopitysin
CAS :Sciadopitysin may thwart diabetic bone disease, boost mitochondria, protect osteoblasts, and hinder Aβ aggregation/neurotoxicity.Formule :C33H24O10Degré de pureté :98.14% - 99.17%Couleur et forme :SolidMasse moléculaire :580.54Ref: TM-T5S2129
1mg52,00€5mg95,00€10mg162,00€25mg304,00€50mg455,00€100mg653,00€500mg1.349,00€1mL*10mM (DMSO)130,00€Sarsasapogenin
CAS :Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.Formule :C27H44O3Degré de pureté :90% - 99.73%Couleur et forme :White Or Off-Withe PowderMasse moléculaire :416.64MLN120B
CAS :MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formule :C19H15ClN4O2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :366.8Ref: TM-TQ0306
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg329,00€50mg567,00€100mg777,00€1mL*10mM (DMSO)116,00€DRI-C21045
CAS :Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Formule :C32H24N2O7SDegré de pureté :98.10%Couleur et forme :SolidMasse moléculaire :580.61IQ-1S free acid
CAS :IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Formule :C15H9N3ODegré de pureté :97.92% - 99.05%Couleur et forme :SolidMasse moléculaire :247.25Ref: TM-T3627
5mg47,00€10mg52,00€25mg96,00€50mg169,00€100mg304,00€200mg454,00€500mg733,00€1mL*10mM (DMSO)50,00€NF-κΒ activator 1
CAS :NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Formule :C16H11FN2O2SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :314.33Ref: TM-T39965
1mg95,00€5mg202,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€500mg2.213,00€1mL*10mM (DMSO)224,00€Dehydrocostus Lactone
CAS :Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.Formule :C15H18O2Degré de pureté :99.86% - 99.98%Couleur et forme :SolidMasse moléculaire :230.3Theophylline monohydrate
CAS :Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFormule :C7H8N4O2·H2ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :198.18Chelidonic acid
CAS :Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.Formule :C7H4O6Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :184.1Cyclo(his-pro)
CAS :Cyclo(his-pro) is a cyclic dipeptide that shields against oxidative damage by activating Nrf2.Formule :C11H14N4O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :234.25Tripeptide-41
CAS :Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formule :C29H30N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.57Zabedosertib
CAS :Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.Formule :C20H21F3N4O4SDegré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :470.47Ref: TM-T37076
1mg43,00€5mg96,00€10mg135,00€25mg220,00€50mg323,00€100mg450,00€500mgÀ demander1mL*10mM (DMSO)96,00€NF-κB-IN-11
CAS :NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.Formule :C19H18O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.34Kamebakaurin
CAS :Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.Formule :C20H30O5Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :350.45NIK-IN-2
CAS :NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formule :C20H22N4O3Couleur et forme :SolidMasse moléculaire :366.41CAY10575
CAS :CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formule :C22H21N3O6S2Couleur et forme :SolidMasse moléculaire :487.55Zharp2-1
CAS :Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).Formule :C19H18N3O2PSDegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :383.4Prostratin
CAS :Prostratin is an orally active PKC activator,an NF-κB activator and activates HIV expression. Induces KRAS phosphorylation and inhibits tumor growth.Formule :C22H30O6Degré de pureté :98%Couleur et forme :White To Off-White PowderMasse moléculaire :390.47Baicalin
CAS :Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormule :C21H18O11Degré de pureté :90.08% - 99.25%Couleur et forme :Yellow PowderMasse moléculaire :446.36CAFESTOL
CAS :Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.Formule :C20H28O3Degré de pureté :97.06% - 99.08%Couleur et forme :SolidMasse moléculaire :316.43NFATc1-IN-1
CAS :NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Formule :C13H8F2INO2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :375.11Cyclo(L-Pro-L-Val)
CAS :Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.Formule :C10H16N2O2Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :196.25CDDO-dhTFEA
CAS :CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Formule :C33H45F3N2O3Degré de pureté :95.61% - 99.59%Couleur et forme :SolidMasse moléculaire :574.72Ref: TM-T13604
1mg70,00€2mg92,00€5mg153,00€10mg255,00€25mg512,00€50mg738,00€100mg1.035,00€500mg2.062,00€1mL*10mM (DMSO)187,00€Rucaparib
CAS :Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.Formule :C19H18FN3ODegré de pureté :98.37% - 99.80%Couleur et forme :SolidMasse moléculaire :323.36Ref: TM-T4463
2mg48,00€5mg73,00€10mg115,00€25mg173,00€50mg235,00€100mg364,00€200mg540,00€500mg869,00€1mL*10mM (DMSO)81,00€SC75741
CAS :SC75741 is a potent P65 inhibitor with IC50 of 200 nMFormule :C29H23N7O2S2Degré de pureté :99.44% - 99.82%Couleur et forme :SolidMasse moléculaire :565.67Edecesertib
CAS :Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.Formule :C22H22FN7O2Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :435.45ANTHRAQUINONE-2-CARBOXYLIC ACID
CAS :Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role ofFormule :C15H8O4Degré de pureté :99.08% - 99.83%Couleur et forme :SolidMasse moléculaire :252.22Rocaglamide
CAS :Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formule :C29H31NO7Degré de pureté :95.32% - 98.46%Couleur et forme :SolidMasse moléculaire :505.56Muscone
CAS :Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.Formule :C16H30ODegré de pureté :99.28%Couleur et forme :Colourless Liquid LiquidMasse moléculaire :238.41TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formule :C27H37N7O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :491.63Zingerone
CAS :Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale with potent anti-inflammatory, antidiabetic and anti-tumor properties.Formule :C11H14O3Degré de pureté :99.38% - 99.85%Couleur et forme :Clear Slightly Yellow LiquidMasse moléculaire :194.23PROTAC IRAK4 degrader-8
CAS :PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].Formule :C43H50ClF2N11O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :874.38WAY-169916
CAS :WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Formule :C17H13F3N2O2Degré de pureté :98.63% - 98.64%Couleur et forme :SolidMasse moléculaire :334.29Ref: TM-T8981
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg329,00€100mg475,00€200mg655,00€1mL*10mM (DMSO)94,00€Gue1654
CAS :Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formule :C23H17N3OS3Degré de pureté :98.02% - 98.31%Couleur et forme :SolidMasse moléculaire :447.6Malachite green oxalate
CAS :Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Formule :C23H25N2·C2HO4C2H2O4Couleur et forme :Dark Green Crystals With A Metallic LusterMasse moléculaire :463.51IMD-0354
CAS :IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formule :C15H8ClF6NO2Degré de pureté :99.56% - 99.71%Couleur et forme :SolidMasse moléculaire :383.67Ref: TM-T6141
2mg48,00€5mg66,00€10mg92,00€25mg163,00€50mg221,00€100mg310,00€500mg753,00€1mL*10mM (DMSO)69,00€RIP2 Kinase Inhibitor 3
CAS :RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.Formule :C19H24N4O3SDegré de pureté :98.28% - 98.35%Couleur et forme :SolidMasse moléculaire :388.48Benzoyloxypaeoniflorin
CAS :Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Formule :C30H32O13Degré de pureté :97.64% - 98.7%Couleur et forme :SolidMasse moléculaire :600.57Ref: TM-T4S1658
1mg127,00€5mg298,00€10mg432,00€25mg697,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)378,00€GSK319347A
CAS :GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formule :C22H19N3O5S2Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :469.53Ref: TM-T15558
1mg73,00€5mg153,00€10mg255,00€25mg535,00€50mg910,00€100mg1.216,00€1mL*10mM (DMSO)340,00€RIPK1-IN-16
CAS :RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Formule :C20H19N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.46IRAK4-IN-20
CAS :IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Formule :C22H25F3N4O3Degré de pureté :97.32%Couleur et forme :SolidMasse moléculaire :450.45Asatone
CAS :Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formule :C24H32O8Degré de pureté :99.84% - 99.92%Couleur et forme :SolidMasse moléculaire :448.51Ref: TM-T10383
1mg88,00€5mg202,00€10mg303,00€25mg509,00€50mg725,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)198,00€BMS-345541 hydrochloride
CAS :BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formule :C14H18ClN5Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :291.78Ref: TM-T8542
1mg40,00€2mg52,00€5mg87,00€10mg126,00€25mg225,00€50mg376,00€100mg563,00€1mL*10mM (DMSO)55,00€Velutin
CAS :Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well asFormule :C17H14O6Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :314.29AZD3264
CAS :AZD3264 is a new type IKK2 inhibitor.Formule :C21H23N5O4SDegré de pureté :98.98% - 99.17%Couleur et forme :SolidMasse moléculaire :441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€IMM-H007
CAS :IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormule :C22H23N5O8Degré de pureté :97.73%Couleur et forme :SolidMasse moléculaire :485.45Ref: TM-T9010
1mg40,00€5mg96,00€10mg135,00€25mg226,00€50mg320,00€100mg434,00€200mg602,00€1mL*10mM (DMSO)131,00€PROTAC IRAK4 degrader-12
CAS :PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)Formule :C46H50ClF2N11O6Couleur et forme :SolidMasse moléculaire :926.41BI-69A11
CAS :BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.Formule :C25H16ClN3O2Degré de pureté :96.97%Couleur et forme :SolidMasse moléculaire :425.87Ref: TM-T25150
1mg46,00€2mg57,00€5mg82,00€10mg96,00€25mg180,00€50mg259,00€100mg369,00€1mL*10mM (DMSO)93,00€