
NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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4-Aminosalicylic acid
CAS :4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.Formule :C7H7NO3Degré de pureté :97.07%Couleur et forme :Minute Crystals From Alc SolidMasse moléculaire :153.14IRAK-4 protein kinase inhibitor 2
CAS :IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).Formule :C14H10N4O3Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :282.25BMS986299
CAS :BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be used in studies about NLRP3 signaling and the treatment of associated diseases.Formule :C18H19N7ODegré de pureté :99.93% - 99.93%Couleur et forme :SolidMasse moléculaire :349.39Esculentoside A
CAS :Esculentoside A dampens inflammation in ALI, modulates T cells, and could treat autoimmune diseases and BXSB mice by adjusting cytokines and renal cells.Formule :C42H66O16Degré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :826.96Dendrophenol
CAS :Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Formule :C17H20O5Degré de pureté :98.2% - 98.96%Couleur et forme :SolidMasse moléculaire :304.34Ref: TM-T3S1707
1mg104,00€2mg145,00€5mg227,00€10mg338,00€25mg558,00€50mg797,00€100mg1.074,00€1mL*10mM (DMSO)246,00€NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFormule :C26H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53DHMEQ racemate
CAS :DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Formule :C13H11NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :261.23NLRP3-IN-13
CAS :NLRP3-IN-13 is an NLRP3 inhibitor that inhibits NLRP3-associated inflammation.NLRP3-IN-13 can be used in the study of neurological disorders and inflammation.Formule :C19H15N3O3SDegré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :365.41E3330
CAS :E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formule :C21H30O6Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :378.46Ref: TM-T6823
1mg50,00€2mg72,00€5mg107,00€10mg167,00€25mg304,00€50mg500,00€100mg725,00€200mg1.017,00€500mg1.510,00€1mL*10mM (DMSO)88,00€Ginsenoside Rk3
CAS :Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.Formule :C36H60O8Degré de pureté :99.33% - 99.88%Couleur et forme :SolidMasse moléculaire :620.86Ref: TM-T6S1495
1mg85,00€5mg172,00€10mg255,00€25mg426,00€50mg630,00€100mg898,00€1mL*10mM (DMSO)283,00€IVMT-Rx-3
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin.Formule :C69H90F3N13O24Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :1542.54Sauchinone
CAS :Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.Formule :C20H20O6Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :356.37Gypenoside L
CAS :Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formule :C42H72O14Degré de pureté :99.42% - 99.65%Couleur et forme :SolidMasse moléculaire :801.01GSK840
CAS :GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinaseFormule :C21H23N3O3Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :365.43Flizasertib
CAS :Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.Formule :C15H14FN3ODegré de pureté :100% - 99.39%Couleur et forme :SolidMasse moléculaire :271.29Adelmidrol
CAS :Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.Formule :C13H26N2O4Degré de pureté :99.35% - 99.73%Couleur et forme :SolidMasse moléculaire :274.36Eudebeiolide B
CAS :Eudebeiolide B, isolated from Salvia plebeia R.Formule :C15H18O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :262.3Tizoxanide
CAS :Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formule :C10H7N3O4SDegré de pureté :98.89% - 99.28%Couleur et forme :SolidMasse moléculaire :265.25BOT-64
CAS :BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormule :C15H15NO2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :273.35Ref: TM-T8705
1mg52,00€5mg116,00€10mg178,00€25mg340,00€50mg520,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)107,00€BMS-066
CAS :BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Formule :C19H21N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.42Robinin
CAS :Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formule :C33H40O19Degré de pureté :98.78% - 99.13%Couleur et forme :SolidMasse moléculaire :740.66IMD-biphenylB
CAS :IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Formule :C35H33N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.67Usnoflast
CAS :Usnoflast (ZYIL1) is an NLRP3 inhibitor, inhibiting NLRP3 inflammasome activation, used in neurological disease research.Formule :C21H29N3O3SDegré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :403.54AP-1/NF-κB activation inhibitor 1
CAS :AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basalFormule :C13H11F3N4O4Degré de pureté :100% - 99.74%Couleur et forme :SolidMasse moléculaire :344.25Ref: TM-T9656
1mg73,00€2mg96,00€5mg160,00€10mg216,00€25mg354,00€50mg525,00€100mg730,00€500mg1.483,00€1mL*10mM (DMSO)170,00€Edasalonexent
CAS :Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Formule :C31H42N2O3Degré de pureté :100% - 98.69%Couleur et forme :SolidMasse moléculaire :490.68Ref: TM-T15198
1mg99,00€2mg144,00€5mg235,00€10mg376,00€25mg677,00€50mg1.064,00€1mL*10mM (DMSO)254,00€HS271
CAS :HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).Formule :C21H24F3N5O2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :435.44Ref: TM-T37082
1mg62,00€2mg89,00€5mg135,00€10mg212,00€25mg368,00€50mg510,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)149,00€5-Aminosalicylic Acid
CAS :5-ASA, an anti-inflammatory salicylate, treats inflammatory bowel disease, active part of sulphalazine.Formule :C7H7NO3Degré de pureté :98.88% - 99.98%Couleur et forme :Purplish-Tan Solid PowderMasse moléculaire :153.14Cornuside
CAS :Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Formule :C24H30O14Degré de pureté :100% - 99.57%Couleur et forme :SolidMasse moléculaire :542.49Ref: TM-T4S2326
1mg96,00€5mg264,00€10mg415,00€25mg677,00€50mg935,00€100mg1.254,00€500mg2.527,00€1mL*10mM (DMSO)315,00€Isoquercetin
CAS :1.Formule :C21H20O12Degré de pureté :98.08% - 99.29%Couleur et forme :SolidMasse moléculaire :464.38Ref: TM-T5S0754
5mg49,00€10mg65,00€25mg97,00€50mg153,00€100mg221,00€200mg329,00€1mL*10mM (DMSO)50,00€Isoliquiritin apioside
CAS :Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Formule :C26H30O13Degré de pureté :98.84% - 99.27%Couleur et forme :SolidMasse moléculaire :550.51Tyloxapol
CAS :Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.Formule :C70H124O13Degré de pureté :polymer - polymerCouleur et forme :Clear Light Yellow Viscous LiquidMasse moléculaire :137.18Isovitexin
CAS :1.Formule :C21H20O10Degré de pureté :98.24% - 99.79%Couleur et forme :SolidMasse moléculaire :432.38Ref: TM-T6S1371
1mg52,00€5mg97,00€10mg140,00€25mg274,00€50mg411,00€100mg597,00€500mg1.225,00€1mL*10mM (DMSO)105,00€Demethyleneberberine
CAS :Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFormule :C19H18NO4Degré de pureté :98.08% - 99.18%Couleur et forme :SolidMasse moléculaire :324.35Theaflavin 3,3'-digallate
CAS :Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormule :C43H32O20Degré de pureté :98.71% - 99.86%Couleur et forme :SolidMasse moléculaire :868.7Ocadusertib
CAS :Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Formule :C25H25N5O4Couleur et forme :SolidMasse moléculaire :459.50Eclitasertib
CAS :Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).Formule :C19H18N6O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :378.38Ref: TM-T9702
1mg106,00€2mg150,00€5mg227,00€10mg359,00€25mg652,00€50mg905,00€100mg1.293,00€1mL*10mM (DMSO)250,00€BX795
CAS :BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formule :C23H26IN7O2SDegré de pureté :98% - 99.57%Couleur et forme :SolidMasse moléculaire :591.47Ref: TM-T1830
5mg59,00€10mg97,00€25mg210,00€50mg343,00€100mg513,00€200mg740,00€500mg1.121,00€1mL*10mM (DMSO)88,00€CL075
CAS :CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 toFormule :C13H13N3SDegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :243.33Flaconitine
CAS :Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.Formule :C36H49NO12Degré de pureté :98% - 99.84%Couleur et forme :SolidMasse moléculaire :687.77Flavanomarein
CAS :Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Formule :C21H22O11Degré de pureté :97.53% - 98.63%Couleur et forme :SolidMasse moléculaire :450.39Ginsenoside Re
CAS :Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Formule :C48H82O18Degré de pureté :100% - 99.78%Couleur et forme :White PowderMasse moléculaire :947.15B022
CAS :B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Formule :C19H16ClN5OSDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :397.88Mitogen-activated protein kinase 1
CAS :Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Degré de pureté :98%Couleur et forme :SolidRIPK1-IN-9
CAS :RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Formule :C26H25FN6O2Degré de pureté :98.7%Couleur et forme :SolidMasse moléculaire :472.51Ref: TM-T63055
1mg205,00€5mg495,00€10mg677,00€25mg1.008,00€50mg1.349,00€100mg1.833,00€200mg2.452,00€1mL*10mM (DMSO)568,00€Gossypin
CAS :Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.Formule :C21H20O13Degré de pureté :97.57% - 98.97%Couleur et forme :SolidMasse moléculaire :480.38NLRP3-IN-10
CAS :NLRP3-IN-10 (ZVN26391) is a strong NLRP3 inhibitor, IC50 251.1 nM, that reduces IL-1β and ASC speck, hindering inflammasome activation.Formule :C17H14BrFO3Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :365.19Ref: TM-T61392
5mg47,00€10mg70,00€25mg126,00€50mg187,00€100mg311,00€200mg465,00€1mL*10mM (DMSO)65,00€2,4-Diamino-6-hydroxypyrimidine
CAS :2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesisFormule :C4H6N4ODegré de pureté :99.82%Couleur et forme :White Solid CrystalsMasse moléculaire :126.12NLRP3-IN-11
CAS :NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.Formule :C17H17ClN4O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :344.8GSK2983559 active metabolite
CAS :GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.Formule :C21H22N4O4S2Degré de pureté :97.07% - 98.48%Couleur et forme :SolidMasse moléculaire :458.55Convallatoxin
CAS :Convallatoxin is a natural product.Formule :C29H42O10Degré de pureté :99.27%Couleur et forme :Prisms From Methanol + Ether SolidMasse moléculaire :550.64