
IκB/IKK
Le complexe IκB/IKK est un régulateur clé de la voie de signalisation NF-κB, qui contrôle l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation et la survie cellulaire. Les protéines IκB inhibent l'activité de NF-κB en le séquestrant dans le cytoplasme, tandis que les IKK phosphorylent IκB, conduisant à sa dégradation et à l'activation de NF-κB. La dérégulation de la voie IκB/IKK est liée à l'inflammation chronique, au cancer et aux maladies auto-immunes. Chez CymitQuimica, nous offrons une sélection de modulateurs IκB/IKK de haute qualité pour soutenir vos recherches en transduction de signal, inflammation et développement thérapeutique.
Produits appartenant à la catégorie "IκB/IKK"
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42 produits dans cette catégorie.
SC-514
CAS :SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Formule :C9H8N2OS2Degré de pureté :100% - 99.88%Couleur et forme :SolidMasse moléculaire :224.3Vinpocetine
CAS :Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Formule :C22H26N2O2Degré de pureté :99.85% - 99.98%Couleur et forme :White Crystalline SolidMasse moléculaire :350.45BMS-345541
CAS :BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Formule :C14H17N5Degré de pureté :98.74% - 99.74%Couleur et forme :SolidMasse moléculaire :255.32INH14
CAS :INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formule :C15H16N2ODegré de pureté :95.41%Couleur et forme :SolidMasse moléculaire :240.3Ref: TM-T5209
2mg38,00€5mg56,00€10mg84,00€25mg120,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)58,00€MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Formule :C26H37ClN6O2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :501.07Selinidin
CAS :Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.Formule :C19H20O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.364ACHP Hydrochloride
CAS :ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Formule :C21H25ClN4O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :400.9Ref: TM-T10237
1mg66,00€5mg144,00€10mg227,00€25mg375,00€50mg540,00€100mg777,00€500mg1.549,00€1mL*10mM (DMSO)159,00€IKK2-IN-4
CAS :IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formule :C12H11N3O2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :261.3Ref: TM-T36524
1mg163,00€5mg395,00€10mg605,00€25mg938,00€50mg1.264,00€100mg1.700,00€200mg2.270,00€500µg111,00€Cudraflavone B
CAS :Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells andFormule :C25H24O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.45BAY-985
CAS :BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formule :C27H30F3N9ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :553.58Ref: TM-T10477
1mg172,00€5mg354,00€10mg567,00€25mg905,00€50mg1.225,00€100mg1.644,00€1mL*10mM (DMSO)430,00€Bay 65-1942 hydrochloride
CAS :Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formule :C22H26ClN3O4Couleur et forme :SolidMasse moléculaire :431.91TBK1/IKKε-IN-1
CAS :TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formule :C28H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.53Dehydrocostus Lactone
CAS :Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.Formule :C15H18O2Degré de pureté :99.86% - 99.98%Couleur et forme :SolidMasse moléculaire :230.3GS143
CAS :GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Formule :C28H19FN2O4Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :466.46Ref: TM-T25465
2mg38,00€5mg58,00€10mg92,00€25mg170,00€50mg259,00€100mg378,00€200mg548,00€1mL*10mM (DMSO)60,00€CAY10575
CAS :CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formule :C22H21N3O6S2Couleur et forme :SolidMasse moléculaire :487.55TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formule :C27H37N7O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :491.63MLN120B
CAS :MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formule :C19H15ClN4O2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :366.8Ref: TM-TQ0306
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg329,00€50mg567,00€100mg777,00€1mL*10mM (DMSO)116,00€Armepavine
CAS :Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.Formule :C19H23NO3Degré de pureté :95.00%Couleur et forme :SolidMasse moléculaire :313.39IMD-0354
CAS :IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formule :C15H8ClF6NO2Degré de pureté :99.56% - 99.71%Couleur et forme :SolidMasse moléculaire :383.67Ref: TM-T6141
2mg48,00€5mg66,00€10mg92,00€25mg163,00€50mg221,00€100mg310,00€500mg753,00€1mL*10mM (DMSO)69,00€GSK319347A
CAS :GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formule :C22H19N3O5S2Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :469.53Ref: TM-T15558
1mg73,00€5mg153,00€10mg255,00€25mg535,00€50mg910,00€100mg1.216,00€1mL*10mM (DMSO)340,00€BMS-345541 hydrochloride
CAS :BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formule :C14H18ClN5Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :291.78Ref: TM-T8542
1mg40,00€2mg52,00€5mg87,00€10mg126,00€25mg225,00€50mg376,00€100mg563,00€1mL*10mM (DMSO)55,00€AZD3264
CAS :AZD3264 is a new type IKK2 inhibitor.Formule :C21H23N5O4SDegré de pureté :98.98% - 99.17%Couleur et forme :SolidMasse moléculaire :441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€BOT-64
CAS :BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormule :C15H15NO2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :273.35Ref: TM-T8705
1mg52,00€5mg116,00€10mg178,00€25mg340,00€50mg520,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)107,00€BMS-066
CAS :BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Formule :C19H21N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.42Bay 65-1942 free base
CAS :Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formule :C22H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.45Isophysalin A
CAS :Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) productionFormule :C28H30O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :526.532-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS :2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.Formule :C11H10N2OSDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :218.27IKK 16
CAS :IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Formule :C28H29N5OSDegré de pureté :98.76% - 99.61%Couleur et forme :SolidMasse moléculaire :483.63Ref: TM-T6176
1mg40,00€2mg52,00€5mg88,00€10mg139,00€25mg245,00€50mg406,00€100mg607,00€200mg845,00€1mL*10mM (DMSO)87,00€BX795
CAS :BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formule :C23H26IN7O2SDegré de pureté :98% - 99.57%Couleur et forme :SolidMasse moléculaire :591.47Ref: TM-T1830
5mg59,00€10mg97,00€25mg210,00€50mg343,00€100mg513,00€200mg740,00€500mg1.121,00€1mL*10mM (DMSO)88,00€TBK1/IKKε-IN-2
CAS :TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formule :C26H27N5O3Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :457.52Ref: TM-T15559
1mg92,00€5mg188,00€10mg305,00€25mg487,00€50mg660,00€100mg847,00€1mL*10mM (DMSO)188,00€HPN-01
CAS :HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formule :C19H16ClN3O3SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :401.87IKK-IN-1
CAS :IKK-IN-1 is an inhibitor of IKK.Formule :C22H26ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.91(Rac)-BAY-985
CAS :(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formule :C27H30F3N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.58NF-κB-IN-1
CAS :NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFormule :C31H30O8Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :530.57Ref: TM-T9105
1mg166,00€5mg341,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€1mL*10mM (DMSO)398,00€GSK8612
CAS :GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Formule :C17H17BrF3N7O2SDegré de pureté :99.46% - ≥98%Couleur et forme :SolidMasse moléculaire :520.33Ref: TM-T5540
1mg47,00€2mg59,00€5mg92,00€10mg131,00€25mg215,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)96,00€HOIPIN-8 sodium
CAS :HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Formule :C23H15F2N4NaO3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :456.38BAY32-5915
CAS :BAY32-5915 is a selective inhibitor of IKKalpha.Formule :C10H7NO3Degré de pureté :96.48% - 97.00%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :189.17MRT67307
CAS :Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Formule :C26H36N6O2Degré de pureté :99.25% - 99.79%Couleur et forme :SolidMasse moléculaire :464.6IMD-0560
CAS :IMD-0560 is a novel inhibitor of IκB kinase β.Formule :C15H8BrF6NO2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :428.12Goshonoside F5
CAS :Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.Formule :C32H54O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.771Physalin O
CAS :Physalin O has anti-inflammatory properties, binds with GSH, and inhibits NO production.Formule :C28H32O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.554JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Formule :C17H13NaO4Degré de pureté :95.08%Couleur et forme :SolidMasse moléculaire :304.27