RCC
Les récepteurs des chimiokines C-C (CCRs) sont un groupe de GPCR qui répondent aux chimiokines, des molécules de signalisation qui guident la migration des cellules immunitaires vers les sites d'inflammation ou d'infection. Les CCR jouent un rôle crucial dans les réponses immunitaires, l'inflammation et le développement de diverses maladies, y compris les troubles auto-immuns et le cancer. La modulation de l'activité des CCR est explorée comme une stratégie thérapeutique pour des affections telles que la polyarthrite rhumatoïde, la sclérose en plaques et l'infection par le VIH. Chez CymitQuimica, nous offrons une gamme de modulateurs de CCR de haute qualité pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
Produits appartenant à la catégorie "RCC"
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71 produits dans cette catégorie.
AZD-5672
CAS :AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.Formule :C32H38F2N2O5S2Degré de pureté :95.58%Couleur et forme :SolidMasse moléculaire :632.78Ref: TM-T30260
1mg202,00€5mg459,00€10mg643,00€25mg938,00€50mg1.311,00€100mg1.786,00€1mL*10mM (DMSO)560,00€C-021 dihydrochloride
CAS :C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Formule :C27H43Cl2N5O2Degré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :540.57ZK 756326
CAS :ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Formule :C21H28N2O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :356.46CCR1 antagonist 6
CAS :CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).Formule :C21H23ClN4O3SDegré de pureté :98.40% - 99.26%Couleur et forme :SolidMasse moléculaire :446.95Maraviroc
CAS :Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s-MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.Formule :C29H41F2N5ODegré de pureté :100% - 99.55%Couleur et forme :Brown SolidMasse moléculaire :513.67Ref: TM-T6016
5mg51,00€10mg95,00€25mg160,00€50mg273,00€100mg492,00€200mg633,00€500mg998,00€1mL*10mM (DMSO)59,00€7,4'-Dihydroxyflavone
CAS :7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Formule :C15H10O4Degré de pureté :99.39% - 99.6%Couleur et forme :SolidMasse moléculaire :254.24CCR1 antagonist 8
CAS :CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).Formule :C22H18FN5O3SCouleur et forme :SolidMasse moléculaire :451.47J-113863
CAS :J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).Formule :C30H37Cl2IN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :655.44Ref: TM-T11699
1mg59,00€2mg87,00€5mg126,00€10mg169,00€25mg304,00€50mg527,00€100mg758,00€1mL*10mM (DMSO)180,00€AZD-4818
CAS :AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Formule :C27H32Cl2N2O7Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :567.46R243
CAS :R243 is CCR8 signaling and chemotaxis inhibitor.Formule :C21H27NO4Degré de pureté :97.86%Couleur et forme :SolidMasse moléculaire :357.44Ref: TM-T24700
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg220,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)95,00€YM022
CAS :YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.Formule :C32H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.59CCR1 antagonist 7
CAS :CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Formule :C21H24ClN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.96BMS-813160
CAS :BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.Formule :C25H40N8O2Degré de pureté :99.66% - 99.78%Couleur et forme :SolidMasse moléculaire :484.64Ref: TM-T4584
1mg63,00€5mg137,00€10mg187,00€25mg341,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)145,00€Cenicriviroc
CAS :Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.Formule :C41H52N4O4SDegré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :696.94Ref: TM-TQ0297
1mg69,00€5mg149,00€10mg235,00€25mg470,00€50mg610,00€100mg793,00€200mg1.064,00€1mL*10mM (DMSO)221,00€BMS CCR2 22
CAS :BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Formule :C28H34F3N5O4SDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :593.66Ref: TM-T14688
1mg58,00€5mg116,00€10mg183,00€25mg368,00€50mg562,00€100mg758,00€200mg1.017,00€1mL*10mM (DMSO)156,00€CCR4 antagonist 3-1
CAS :CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.Formule :C14H12N2SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :240.32MLN-3897
CAS :MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Formule :C30H31ClN2O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :519.03IPG7236
CAS :IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFormule :C23H31N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.58Denikitug
Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Couleur et forme :Odour LiquidNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour LiquidLanerkitug
Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour LiquidINCB3344
CAS :INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Formule :C29H34F3N3O6Degré de pureté :98.00% - 98.2%Couleur et forme :SolidMasse moléculaire :577.59Ref: TM-TQ0103
1mg70,00€5mg153,00€10mg243,00€25mg411,00€50mg610,00€100mg868,00€1mL*10mM (DMSO)188,00€PF-4136309
CAS :PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Formule :C29H31F3N6O3Degré de pureté :98.85% - 99.47%Couleur et forme :SolidMasse moléculaire :568.59BI-6901
CAS :BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Formule :C23H27N5O3SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :453.56CCX140
CAS :CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.Formule :C20H13ClF3N5O3SDegré de pureté :97.58% - 99.95%Couleur et forme :SolidMasse moléculaire :495.86Vercirnon
CAS :Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Formule :C22H21ClN2O4SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :444.93Ref: TM-T17225
1mg105,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€500mg2.593,00€1mL*10mM (DMSO)363,00€CCR8 antagonist 1
CAS :CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Formule :C26H29N3O5SDegré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :495.59Vicriviroc maleate
CAS :Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.Formule :C32H42F3N5O6Degré de pureté :97.51% - 98.16%Couleur et forme :SolidMasse moléculaire :649.7RE-640
CAS :NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Formule :C20H16Cl2N4Degré de pureté :99.60% - 99.87%Couleur et forme :SolidMasse moléculaire :383.27MLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Formule :C32H32ClF3N2O6Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :633.05SB-649701
CAS :SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Formule :C27H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54SB297006
CAS :SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.Formule :C18H18N2O5Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :342.35AZD2098
CAS :AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.Formule :C11H9Cl2N3O3SDegré de pureté :99.80% - 99.92%Couleur et forme :SolidMasse moléculaire :334.18Ref: TM-T4300
1mg35,00€5mg70,00€10mg111,00€25mg230,00€50mg354,00€100mg530,00€500mg1.121,00€1mL*10mM (DMSO)78,00€CCR6 inhibitor 1
CAS :CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.Formule :C24H23F3N4O3SDegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :504.52Ref: TM-T10715
1mg116,00€5mg283,00€10mg424,00€25mg682,00€50mg934,00€100mg1.301,00€500mg2.612,00€1mL*10mM (DMSO)311,00€TAK-779
CAS :TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formule :C33H39ClN2O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :531.13CCR2 antagonist 1
CAS :CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).Formule :C28H32BrF3N2OCouleur et forme :SolidMasse moléculaire :549.47BX471
CAS :BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Formule :C21H24ClFN4O3Degré de pureté :98% - 99.94%Couleur et forme :SolidMasse moléculaire :434.89Ref: TM-T2375
1mg38,00€5mg90,00€10mg124,00€25mg212,00€50mg329,00€100mg515,00€200mg782,00€1mL*10mM (DMSO)90,00€DAPTA
CAS :DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.Formule :C35H56N10O15Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :856.88Bindarit
CAS :Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.Formule :C19H20N2O3Degré de pureté :98.35% - 98.71%Couleur et forme :SolidMasse moléculaire :324.37Ref: TM-T6413
1mg57,00€5mg123,00€10mg187,00€25mg315,00€50mg472,00€100mg677,00€500mg1.388,00€1mL*10mM (DMSO)137,00€CCR3 antagonist 1
CAS :CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Formule :C19H21Cl2N3O4S2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :490.42Ref: TM-T10156
1mg92,00€5mg188,00€10mg305,00€25mg489,00€50mg655,00€100mg883,00€1mL*10mM (DMSO)224,00€CCX354
CAS :CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Formule :C22H22ClN7O2Degré de pureté :99% - 99.28%Couleur et forme :SolidMasse moléculaire :451.91RS102895 hydrochloride
CAS :RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).Formule :C21H22ClF3N2O2Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :426.86MK-0812
CAS :MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Formule :C24H34F3N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54NI-0701
NI-0701 is a humanized antibody targeting CCL5/RANTES.Couleur et forme :LiquidMasse moléculaire :145.5Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Couleur et forme :Odour SolidCCR8 agonist 1
CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.Formule :C22H29NO3Couleur et forme :SolidMasse moléculaire :355.47ML604086
CAS :ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.Formule :C27H32N4O4SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :508.63MK-0812 Succinate
CAS :MK-0812 Succinate is an effective and selective CCR2 antagonist.Formule :C28H40F3N3O7Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :587.63CCR2 antagonist 5
CAS :JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Formule :C22H25F3N4O3SDegré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :482.52GSK2239633A
CAS :GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Formule :C24H25ClN4O5S2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :549.06Ref: TM-T11481
1mg38,00€5mg84,00€10mg125,00€25mg259,00€50mg375,00€100mg545,00€500mgÀ demander1mL*10mM (DMSO)93,00€Nifeviroc
CAS :Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.Formule :C33H42N4O6Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :590.71CCR2 antagonist 4
CAS :CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFormule :C21H21ClF3N3O2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :439.86Ref: TM-T13114
1mg52,00€5mg120,00€10mg188,00€25mg329,00€50mg490,00€100mg697,00€1mL*10mM (DMSO)133,00€AZ084
CAS :AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.Formule :C26H34N4O2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :434.57Ref: TM-T10425
1mg88,00€5mg170,00€10mg259,00€25mg429,00€50mg605,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)182,00€RS 504393
CAS :RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Formule :C25H27N3O3Degré de pureté :98.49% - 98.64%Couleur et forme :SolidMasse moléculaire :417.5CCR2 antagonist 3
CAS :CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Formule :C17H25FN2O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :308.39Ref: TM-T10712
1mg70,00€5mg156,00€10mg239,00€25mg419,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)170,00€CMPD167
CAS :CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Formule :C35H47FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.77Cenicriviroc Mesylate
CAS :Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.Formule :C42H56N4O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :793.05PF-04634817
CAS :PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Formule :C25H36F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.58AZD2423
CAS :AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFormule :C20H29ClFN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.93C-021
CAS :C 021 dihydrochloride is a potent CCR4 antagonist.Formule :C27H41N5O2Degré de pureté :100.00% - 99.74%Couleur et forme :SolidMasse moléculaire :467.65Ref: TM-T21870
1mg51,00€2mg71,00€5mg96,00€10mg153,00€25mg303,00€50mg469,00€100mg655,00€1mL*10mM (DMSO)96,00€Azirkitug
Azirkitug is a humanized IgG1κ antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour LiquidRS102895
CAS :RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.Formule :C21H21F3N2O2Degré de pureté :97.64%Couleur et forme :SolidMasse moléculaire :390.4CCR2-RA-[R]
CAS :CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).Formule :C18H19ClFNO3Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :351.8CCR6 antagonist 1
CAS :CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.Formule :C17H12F3NO2Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :319.28Ref: TM-T60145
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg227,00€50mg329,00€100mg510,00€200mg722,00€1mL*10mM (DMSO)87,00€SB 328437
CAS :SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Formule :C21H18N2O5Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :378.38BMS-817399
CAS :BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.Formule :C23H36ClN3O4Degré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :454Ref: TM-T26861
1mg160,00€5mg338,00€10mg512,00€25mg812,00€50mg1.093,00€100mg1.473,00€1mL*10mM (DMSO)376,00€CCR1 antagonist 9
CAS :CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).Formule :C20H16FN5O3SCouleur et forme :SolidMasse moléculaire :425.44GW 766994
CAS :GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.Formule :C21H24Cl2N4O3Couleur et forme :SolidMasse moléculaire :451.35Cafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour LiquidDenrakibart
Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.Couleur et forme :Odour LiquidINCB 3284
CAS :INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.Formule :C26H31F3N4O4Degré de pureté :99.55% - 99.82%Couleur et forme :SolidMasse moléculaire :520.54
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