CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
Produits appartenant à la catégorie "CXCR"
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IT1t dihydrochloride
CAS :IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Formule :C21H36Cl2N4S2Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :479.57Ref: TM-T11693L
1mg42,00€5mg89,00€10mg144,00€25mg283,00€50mg510,00€100mg740,00€500mg1.510,00€1mL*10mM (DMSO)88,00€SB-265610
CAS :SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.Formule :C14H9BrN6ODegré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :357.16Ref: TM-T16850
1mg56,00€5mg119,00€10mg187,00€25mg376,00€50mg560,00€100mg800,00€500mg1.644,00€1mL*10mM (DMSO)131,00€SCH 563705
CAS :SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48NUCC-390
CAS :NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Formule :C23H33N5ODegré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :395.54Ref: TM-T12269
1mg115,00€5mg274,00€10mg432,00€25mg772,00€50mg1.074,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)283,00€TAK-779
CAS :TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formule :C33H39ClN2O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :531.13SLW131
CAS :SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535ACT-1004-1239
CAS :ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.Formule :C27H28F2N6O3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :522.55Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Formule :C39H57N13O8S2·xC2HF3O2Masse moléculaire :900.08 (free base)AMG 487
CAS :AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Formule :C32H28F3N5O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :603.59Ref: TM-T10297L
1mg52,00€5mg115,00€10mg164,00€25mg263,00€50mg369,00€100mg587,00€200mg835,00€1mL*10mM (DMSO)154,00€Reparixin
CAS :Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Formule :C14H21NO3SDegré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :283.39Ref: TM-T4163
1mg52,00€2mg79,00€5mg119,00€10mg187,00€25mg393,00€50mg587,00€100mg835,00€500mg1.663,00€1mL*10mM (DMSO)111,00€MSX-122
CAS :MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Formule :C16H16N6Degré de pureté :97.02% - 98.78%Couleur et forme :SolidMasse moléculaire :292.34Ref: TM-T3992
1mg35,00€5mg64,00€10mg97,00€25mg188,00€50mg311,00€100mg487,00€200mg682,00€1mL*10mM (DMSO)67,00€Plerixafor
CAS :Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Formule :C28H54N8Degré de pureté :100% - 99.81%Couleur et forme :SolidMasse moléculaire :502.78LIT927
CAS :LIT927 (LIT-927) is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).Formule :C17H13ClN2O3Degré de pureté :99.57% - 99.73%Couleur et forme :SolidMasse moléculaire :328.75MSX-127
CAS :MSX-127 elicites positive response in peptide CXCR4.Formule :C16H24N2O4Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :308.37CXCR7 antagonist-1
CAS :CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7.Formule :C21H19FN6ODegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :390.41CXCR2-IN-1
CAS :CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formule :C19H20Cl2FN3O4SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :476.35E6130
CAS :E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formule :C28H37ClF3N3O3Couleur et forme :SolidMasse moléculaire :556.06VUF11207 fumarate
CAS :VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Formule :C31H39FN2O8Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :586.65Ref: TM-T13324
1mg43,00€2mg55,00€5mg88,00€10mg137,00€25mg273,00€50mg472,00€100mg680,00€200mg947,00€1mL*10mM (DMSO)97,00€CXCR4 antagonist 10
CAS :CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formule :C18H18N4O4Couleur et forme :SolidMasse moléculaire :354.36SRT3190
CAS :SRT3190 is an antagonist of CXCR2.Formule :C18H23F2N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.53
