Signalisation JAK/STAT
Les inhibiteurs de la signalisation JAK/STAT sont des composés qui perturbent la voie des kinases Janus (JAK) et du transducteur et activateur de transcription (STAT), impliquée dans la signalisation des cytokines, la croissance cellulaire et la réponse immunitaire. Ces inhibiteurs sont des outils importants pour étudier la régulation de cette voie et son rôle dans diverses maladies, notamment les cancers, les troubles immunitaires et les affections inflammatoires. Les inhibiteurs JAK/STAT sont également en cours de développement en tant que thérapies ciblées pour ces maladies. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité de la signalisation JAK/STAT pour soutenir vos recherches en biologie moléculaire, oncologie et immunologie.
Sous-catégories appartenant à la catégorie "Signalisation JAK/STAT"
Produits appartenant à la catégorie "Signalisation JAK/STAT"
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Pim-1 kinase inhibitor 8
CAS :Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Formule :C14H17N3O3Degré de pureté :99.81%Couleur et forme :SoildMasse moléculaire :275.3Golidocitinib
CAS :Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Formule :C25H31N9O2Degré de pureté :100% - 98.87%Couleur et forme :SolidMasse moléculaire :489.57Ref: TM-T10431
2mg96,00€5mg163,00€10mg268,00€25mg465,00€50mg618,00€100mg880,00€1mL*10mM (DMSO)170,00€Baricitinib phosphate
CAS :Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Formule :C16H20N7O6PSDegré de pureté :98.87% - 99.68%Couleur et forme :SolidMasse moléculaire :469.41Ritlecitinib
CAS :Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formule :C15H19N5ODegré de pureté :98.82% - 99.92%Couleur et forme :SolidMasse moléculaire :285.34Ref: TM-T5382
2mg47,00€5mg70,00€10mg111,00€25mg216,00€50mg329,00€100mg495,00€200mg705,00€500mg1.064,00€1mL*10mM (DMSO)77,00€Cucurbitacin I
CAS :Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formule :C30H42O7Degré de pureté :96.69% - 98.2%Couleur et forme :SolidMasse moléculaire :514.65ZM39923 hydrochloride
CAS :ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91YLIU-4-105-1
CAS :YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formule :C32H34F3N7O2Couleur et forme :SolidMasse moléculaire :605.65Itacitinib
CAS :Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.Formule :C26H23F4N9ODegré de pureté :96.4% - 99.01%Couleur et forme :SolidMasse moléculaire :553.51Ref: TM-T3998
1mg49,00€2mg71,00€5mg111,00€10mg180,00€25mg325,00€50mg543,00€100mg780,00€500mg1.549,00€1mL*10mM (DMSO)137,00€WHI-P97
CAS :WHI-P97 is a rationally designed potent inhibitor of JAK-3.Formule :C16H13Br2N3O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :455.1Ilginatinib maleate
CAS :Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C25H24FN7O4Degré de pureté :99.74% - 99.82%Couleur et forme :SolidMasse moléculaire :505.5Ref: TM-T12266L
1mg64,00€5mg138,00€10mg187,00€25mg273,00€50mg393,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)153,00€SMI-16a
CAS :SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formule :C13H13NO3SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :263.31Ref: TM-T3989
1mg35,00€2mg48,00€5mg70,00€10mg87,00€25mg160,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)92,00€FM-381
CAS :FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formule :C24H24N6O2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :428.49Lepzacitinib
CAS :Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39Ref: TM-T78207
1mg52,00€5mg116,00€10mg178,00€25mg359,00€50mg533,00€100mg750,00€200mg1.064,00€1mL*10mM (DMSO)127,00€WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Formule :C21H26ClN3O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :419.9JAK1-IN-16
JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.Formule :C20H15ClF3N3OSCouleur et forme :SolidMasse moléculaire :437.87Gusacitinib
CAS :Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Formule :C24H28N8O2Degré de pureté :98.06% - 99.94%Couleur et forme :SolidMasse moléculaire :460.53Ref: TM-T14331
1mg42,00€5mg88,00€10mg123,00€25mg188,00€50mg350,00€100mg522,00€200mg750,00€1mL*10mM (DMSO)116,00€(E/Z)-Zotiraciclib
CAS :(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formule :C23H24N4ODegré de pureté :97% - 98.03%Couleur et forme :SolidMasse moléculaire :372.46Ref: TM-T21503
1mg46,00€2mg59,00€5mg87,00€10mg119,00€25mg210,00€50mg349,00€100mg507,00€1mL*10mM (DMSO)96,00€Momelotinib sulfate
CAS :Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formule :C23H26N6O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :610.62JAK-IN-26
CAS :JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46JAK/HDAC-IN-4
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.Formule :C30H32N8O5SCouleur et forme :SolidMasse moléculaire :616.69JAK3i
CAS :JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formule :C18H15FN4O3Degré de pureté :98.61% - 99.81%Couleur et forme :SolidMasse moléculaire :354.34PIM-1 Inhibitor 2
CAS :PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Formule :C17H11ClN4ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :322.75Solcitinib
CAS :Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.Formule :C22H23N5O2Degré de pureté :99.61% - 99.82%Couleur et forme :SolidMasse moléculaire :389.45TCS-PIM-1-4a
CAS :SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formule :C11H6F3NO2SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :273.23JAK-IN-29
JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].Formule :C17H14ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.78JAK3/BTK-IN-1
CAS :JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two importantFormule :C25H28N8ODegré de pureté :97.89%Couleur et forme :SolidMasse moléculaire :456.54Ruxolitinib phosphate
CAS :Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Formule :C17H21N6O4PDegré de pureté :100% - 99.91%Couleur et forme :SolidMasse moléculaire :404.36Ref: TM-T3043
1g615,00€5mg52,00€10mg65,00€25mg82,00€50mg97,00€100mg145,00€200mg227,00€500mg418,00€1mL*10mM (DMSO)59,00€PIM1-IN-4
CAS :PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Formule :C27H25BrCl2CuN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :663.88Deucravacitinib
CAS :Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formule :C20H19D3N8O3Degré de pureté :100% - 99.43%Couleur et forme :SolidMasse moléculaire :425.46Ref: TM-T14687
1mg70,00€5mg153,00€10mg274,00€25mg432,00€50mg638,00€100mg908,00€200mg1.225,00€500mg1.825,00€1mL*10mM (DMSO)166,00€GDC-0214
CAS :GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Formule :C28H28ClF2N9O3Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :612.03Ref: TM-T9826
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)259,00€AMG-47a
CAS :AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56JAK2-IN-4
CAS :JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56JAK3-IN-1
CAS :JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Formule :C26H30ClN7O2Couleur et forme :SolidMasse moléculaire :508.02Ruxolitinib
CAS :Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.Formule :C17H18N6Degré de pureté :100% - 99.99%Couleur et forme :SolidMasse moléculaire :306.36Ref: TM-T1829
5mg58,00€10mg74,00€25mg92,00€50mg116,00€100mg155,00€200mg245,00€500mg414,00€1mL*10mM (DMSO)65,00€NVP-BSK805
CAS :NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Formule :C27H28F2N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.55SHR0302
CAS :SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formule :C18H22N8O2SDegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :414.48Ref: TM-T9195
1mg160,00€5mg393,00€10mg620,00€25mg1.035,00€50mg1.483,00€100mg1.882,00€1mL*10mM (DMSO)455,00€lirucitinib
CAS :Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.Formule :C16H25N5OSCouleur et forme :SolidMasse moléculaire :335.468Antitumor agent-195
Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 μM, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.Formule :C22H22N2O4Couleur et forme :SolidMasse moléculaire :378.42AZD1208
CAS :AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :SolidMasse moléculaire :379.48Ref: TM-T2300
2mg38,00€5mg51,00€10mg74,00€25mg118,00€50mg213,00€100mg378,00€200mg495,00€500mg792,00€1mL*10mM (DMSO)57,00€JAK-IN-27
CAS :JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nMFormule :C20H21F2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.42JAK2-IN-11
CAS :JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.Formule :C31H31F3N8O4Couleur et forme :SolidMasse moléculaire :639.64QL-1200186
CAS :QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormule :C26H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.54Fedratinib
CAS :Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formule :C27H36N6O3SDegré de pureté :98.23% - 99.96%Couleur et forme :SolidMasse moléculaire :524.68Ref: TM-T1995
1g625,00€5mg49,00€10mg69,00€50mg113,00€100mg134,00€200mg216,00€500mg472,00€1mL*10mM (DMSO)57,00€Pyridone 6
CAS :Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).Formule :C18H16FN3ODegré de pureté :97.10% - 98.74%Couleur et forme :SolidMasse moléculaire :309.34Ref: TM-T3080
1mg82,00€2mg106,00€5mg162,00€10mg221,00€25mg449,00€50mg658,00€100mg939,00€500mg1.882,00€1mL*10mM (DMSO)177,00€Baricitinib
CAS :Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formule :C16H17N7O2SDegré de pureté :100% - 99.79%Couleur et forme :SolidMasse moléculaire :371.42Ref: TM-T2485
5mg50,00€10mg73,00€25mg90,00€50mg115,00€100mg144,00€200mg188,00€500mg311,00€1mL*10mM (DMSO)69,00€Filgotinib
CAS :Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formule :C21H23N5O3SDegré de pureté :98.03% - ≥95%Couleur et forme :SolidMasse moléculaire :425.5JAK2 Inhibitor V
CAS :JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Formule :C23H24N2ODegré de pureté :96.69% - 99.15%Couleur et forme :SolidMasse moléculaire :344.45Ref: TM-T3042
2mg39,00€5mg57,00€10mg85,00€25mg157,00€50mg274,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)63,00€DPP
CAS :DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstratingFormule :C36H40Cl2N2O10PtDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :926.7AJI-100
CAS :AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Formule :C17H14FN5OCouleur et forme :SolidMasse moléculaire :323.32TCS 21311
CAS :TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formule :C27H25F3N4O4Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :526.51
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