STAT
Les protéines STAT sont des composants critiques de la voie de signalisation JAK/STAT, qui transmet les signaux extracellulaires des cytokines et des facteurs de croissance au noyau cellulaire, influençant ainsi l'expression génique. Les protéines STAT sont impliquées dans la régulation des réponses immunitaires, de la croissance cellulaire, de la différenciation et de la survie. La dérégulation de la signalisation STAT est impliquée dans diverses maladies, y compris le cancer, les troubles auto-immuns et l'inflammation chronique. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de la voie STAT pour soutenir vos recherches en transduction de signal, immunologie et développement thérapeutique.
Produits appartenant à la catégorie "STAT"
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Neocucurbitacin A
CAS :Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].Formule :C31H42O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.66FLLL32
CAS :FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formule :C28H32O6Degré de pureté :96.39% - 97.90%Couleur et forme :SolidMasse moléculaire :464.55Ref: TM-T6838
2mg46,00€5mg66,00€10mg93,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)72,00€Homoharringtonine
CAS :Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.Formule :C29H39NO9Degré de pureté :98.21% - 99.54%Couleur et forme :Off-White CrystMasse moléculaire :545.62STAT6-IN-3
CAS :STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.Formule :C32H35IN3O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :731.51W1131 TFA
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models ofDegré de pureté :98%Couleur et forme :Odour SolidHO-3867
CAS :HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.Formule :C28H30F2N2O2Degré de pureté :91.18% - 99.21%Couleur et forme :SolidMasse moléculaire :464.55STAT3-IN-39
CAS :STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.Formule :C20H17F3N2O3SCouleur et forme :SolidMasse moléculaire :422.42RSVA405
CAS :RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFormule :C17H20N4O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :312.37STAT6-IN-2
CAS :STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.Formule :C28H31N5O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :469.58Fludarabine
CAS :Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.Formule :C10H12FN5O4Degré de pureté :100% - 99.88%Couleur et forme :White SolidMasse moléculaire :285.23L002
CAS :L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.Formule :C15H15NO5SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :321.35inS3-54-A26
CAS :inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.Formule :C25H19ClN2O2Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :414.88Ref: TM-T27613
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€500mgÀ demanderSTAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Formule :C16H15NO3SCouleur et forme :SolidMasse moléculaire :301.36Saikosaponin D
CAS :Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.Formule :C42H68O13Degré de pureté :98.34% - 99.73%Couleur et forme :White PowderMasse moléculaire :780.98Brevilin A
CAS :Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formule :C20H26O5Degré de pureté :100% - 99.74%Couleur et forme :SolidMasse moléculaire :346.42Ref: TM-T4672
1mg96,00€5mg215,00€10mg369,00€25mg610,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)235,00€STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Formule :C25H27N5OCouleur et forme :SolidMasse moléculaire :413.51TLC1566-0618
CAS :TLC1566-0618 shows antitumor activity and targets stat.Formule :C20H15NO3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.53NSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :96.16%Couleur et forme :SolidMasse moléculaire :387.43Ref: TM-T9949
5mg70,00€10mg119,00€25mg250,00€50mg424,00€100mg627,00€500mg1.320,00€1mL*10mM (DMSO)77,00€Balsalazide
CAS :Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Formule :C17H15N3O6Degré de pureté :99.31%Couleur et forme :Yellow To Orange Crystalline PowderMasse moléculaire :357.32STAT3-IN-1
CAS :STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumorFormule :C28H29NO6Degré de pureté :95.89% - 95.89%Couleur et forme :SolidMasse moléculaire :475.53Ref: TM-T13009
1mg60,00€2mg88,00€5mg131,00€10mg192,00€25mg349,00€50mg523,00€100mg753,00€500mg1.549,00€1mL*10mM (DMSO)137,00€
