Pim
Les kinases Pim sont une famille de kinases sérine/thréonine qui jouent un rôle clé dans la survie cellulaire, la prolifération et l'apoptose. Ces kinases sont des effecteurs en aval de la voie de signalisation JAK/STAT et sont impliquées dans divers processus physiologiques, y compris les réponses immunitaires et l'hématopoïèse. La surexpression des kinases Pim a été associée au développement du cancer, ce qui en fait des cibles importantes pour l'intervention thérapeutique. Chez CymitQuimica, nous proposons une variété d'inhibiteurs et de modulateurs de kinases Pim de haute qualité pour soutenir vos recherches en oncologie, biologie cellulaire et transduction du signal.
Produits appartenant à la catégorie "Pim"
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Pim-1 kinase inhibitor 5
CAS :Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Formule :C22H13Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.26TP-3654
CAS :TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Formule :C22H25F3N4ODegré de pureté :97.72% - 99.95%Couleur et forme :SolidMasse moléculaire :418.46PIM1-IN-1
CAS :PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formule :C25H30N8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.56HS94
CAS :HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.Formule :C15H15N5O2SDegré de pureté :95.04%Couleur et forme :SolidMasse moléculaire :329.38Pim-1 kinase inhibitor 8
CAS :Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Formule :C14H17N3O3Degré de pureté :99.81%Couleur et forme :SoildMasse moléculaire :275.3Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Couleur et forme :Odour SolidSMI-16a
CAS :SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formule :C13H13NO3SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :263.31Ref: TM-T3989
1mg35,00€2mg48,00€5mg70,00€10mg87,00€25mg160,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)92,00€TCS PIM-1 1
CAS :TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Formule :C18H11BrN2O2Degré de pureté :97% - 99.64%Couleur et forme :SolidMasse moléculaire :367.2Ref: TM-T2253
1mg35,00€5mg64,00€10mg88,00€25mg187,00€50mg284,00€100mg424,00€200mg612,00€1mL*10mM (DMSO)97,00€TCS-PIM-1-4a
CAS :SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formule :C11H6F3NO2SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :273.23PIM1-IN-4
CAS :PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Formule :C27H25BrCl2CuN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :663.88PIM-IN-2
CAS :PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Formule :C19H22N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.4AZD1208
CAS :AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :SolidMasse moléculaire :379.48Ref: TM-T2300
2mg38,00€5mg51,00€10mg74,00€25mg118,00€50mg213,00€100mg378,00€200mg495,00€500mg792,00€1mL*10mM (DMSO)57,00€PIM-1 Inhibitor 2
CAS :PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Formule :C17H11ClN4ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :322.75GNE-955
CAS :GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formule :C22H24N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.48AZD-1897
CAS :AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Formule :C18H23N3O3SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :361.46M-110
CAS :M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Formule :C22H28ClN5O3Degré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :445.94HJ-PI01
CAS :HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Formule :C14H11NO2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :225.24Ref: TM-T9583
1mg35,00€5mg80,00€10mg116,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)77,00€Pim-1/2 kinase inhibitor 1
CAS :Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formule :C11H9NO3SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :235.26SGI-1776
CAS :SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formule :C20H22F3N5ODegré de pureté :100% - 99.84%Couleur et forme :SolidMasse moléculaire :405.42GDC-0339
CAS :GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Formule :C20H22F3N7OSCouleur et forme :SolidMasse moléculaire :465.5
