JAK
Les inhibiteurs de la kinase Janus (JAK) sont des composés qui ciblent la voie de signalisation JAK-STAT, impliquée dans la croissance cellulaire, la réponse immunitaire et l'angiogenèse. En inhibant JAK, ces composés peuvent réduire la signalisation qui conduit à la formation de nouveaux vaisseaux sanguins dans les tumeurs, inhibant ainsi la croissance tumorale. Les inhibiteurs de JAK sont importants dans le traitement des cancers et des maladies inflammatoires. Chez CymitQuimica, nous offrons une gamme diversifiée d'inhibiteurs de JAK de haute qualité pour soutenir vos recherches en oncologie, immunologie et angiogenèse.
Produits appartenant à la catégorie "JAK"
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JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).Formule :C22H23FN4O3SDegré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :442.51Ref: TM-T35899
5mg47,00€10mg79,00€25mg144,00€50mg250,00€100mg424,00€200mg568,00€1mL*10mM (DMSO)50,00€Londamocitinib
CAS :Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Formule :C28H31F2N7O4SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :599.65Ref: TM-T11706
1mg180,00€5mg439,00€10mg597,00€25mg905,00€50mg1.169,00€100mg1.568,00€1mL*10mM (DMSO)567,00€(R)-9b
CAS :(R)-9b is an effective inhibitor of the ACK1 tyrosine kinase (IC50=56 nM) and exhibits anticancer activity. It selectively targets ACK1 but also inhibits kinases in the JAK family, specifically JAK2 and Tyk2. (R)-9b is used in research related to hormone-regulated cancers, such as prostate cancer and breast cancer.Formule :C20H27ClN6OCouleur et forme :SolidMasse moléculaire :402.92WHI-P154
CAS :Formule :C16H14BrN3O3Degré de pureté :>98.0%(HPLC)Couleur et forme :White to Yellow to Orange powder to crystalMasse moléculaire :376.21SD-1029
CAS :SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Formule :C25H32Br2Cl2N2O3Couleur et forme :SolidMasse moléculaire :639.25JAK-IN-14
CAS :JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.Formule :C19H15FN4ODegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :334.35Ref: TM-T9764
1mg139,00€5mg330,00€10mg492,00€25mg797,00€50mg1.103,00€100mg1.491,00€200mg1.985,00€1mL*10mM (DMSO)340,00€Abrocitinib
CAS :Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formule :C14H21N5O2SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :323.41Ref: TM-TQ0037
1mg85,00€2mg107,00€5mg167,00€10mg284,00€25mg467,00€50mg692,00€100mg938,00€1mL*10mM (DMSO)188,00€CEP-33779
CAS :CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.Formule :C24H26N6O2SDegré de pureté :98.81% - ≥95%Couleur et forme :SolidMasse moléculaire :462.57Ref: TM-T6122
1mg46,00€2mg59,00€5mg87,00€10mg144,00€25mg245,00€50mg376,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)97,00€JAK1-IN-11
CAS :JAK1-IN-11 (compound 11) serves as a potent inhibitor of Janus kinases, exhibiting nanomolar inhibitory concentrations with IC50 values of 0.02 nM (JAK1) and 0.Formule :C26H36N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.67Lorpucitinib
CAS :Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.Formule :C22H28N6O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :408.5Izencitinib
CAS :Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formule :C22H26N8Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :402.50Ref: TM-T35898
1mg88,00€5mg187,00€10mg298,00€25mg597,00€50mg938,00€100mg1.510,00€200mg2.072,00€1mL*10mM (DMSO)207,00€JAK-IN-30
CAS :JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Formule :C19H26N8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.53GS-829845
CAS :GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-lifeFormule :C17H19N5O2SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :357.43JDTic dihydrochloride
CAS :JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.Formule :C28H41Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.55JAK-IN-25
CAS :JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Formule :C19H17N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.37JAK-IN-5
CAS :JAK-IN-5 is a JAK inhibitor.Formule :C27H31FN6ODegré de pureté :97.78% - 98.78%Couleur et forme :SolidMasse moléculaire :474.57Ref: TM-T11710
1mg187,00€5mg391,00€10mg582,00€25mg929,00€50mg1.254,00€100mg1.691,00€500mg3.382,00€1mL*10mM (DMSO)567,00€WHI-P154
CAS :Formule :C16H14BrN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.2047JI069
CAS :JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.Formule :C15H12Cl2N2O4SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :387.24Ginsenoside Rk1
CAS :Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formule :C42H70O12Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :767Baricitinib phosphate
CAS :Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Formule :C16H20N7O6PSDegré de pureté :98.87% - 99.68%Couleur et forme :SolidMasse moléculaire :469.41
