aMPc
L'AMPc est un second messager important dans de nombreux processus biologiques, y compris la régulation du métabolisme, l'expression des gènes et la croissance cellulaire. Dans la voie de signalisation MAPK, l'AMPc peut moduler l'activité de diverses kinases, y compris la PKA, qui influence à son tour la cascade MAPK. La dérégulation de la signalisation de l'AMPc est impliquée dans diverses maladies, notamment le cancer et les troubles cardiovasculaires. Chez CymitQuimica, nous offrons une variété de modulateurs de l'AMPc pour soutenir vos recherches en transduction de signaux, métabolisme et pathologie des maladies.
Produits appartenant à la catégorie "aMPc"
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Torbafylline
CAS :Torbafylline is a xanthine-based PDE inhibitor reducing protein breakdown via PDE4/cAMP/EPAC/PI3K/Akt in rats with burns, cancer, or sepsis.Formule :C16H26N4O4Degré de pureté :98% - 99%Couleur et forme :SoildMasse moléculaire :338.4Ref: TM-T67965
1mg128,00€5mg304,00€10mg457,00€25mg747,00€50mg1.026,00€100mg1.406,00€500mg2.812,00€1mL*10mM (DMSO)314,00€BC 11-38
CAS :BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).Formule :C15H16N2OS2Degré de pureté :97.71% - 98.72%Couleur et forme :SolidMasse moléculaire :304.43Ref: TM-T21865
1mg35,00€5mg70,00€10mg97,00€25mg202,00€50mg329,00€100mg527,00€200mg747,00€1mL*10mM (DMSO)81,00€I942
CAS :I942 is a novel, selective ACyclic nucleotide (NCN) EPAC1 agonist that activates exchange proteins to regulate inflammatory gene expression in human umbilicalFormule :C20H19NO4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :369.43Catalpalactone
CAS :Catalpalactone: antitermitic, cytotoxic, inhibits NO in cells (IC50 9.80µM), reduces dopamine synthesis, hinders TPA-induced EBV-EA activation.Formule :C15H14O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.27RS-25344 hydrochloride
CAS :RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFormule :C19H14ClN5O4Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :411.8Ref: TM-T23256
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg259,00€100mg374,00€200mg545,00€1mL*10mM (DMSO)65,00€Rp-cAMPS sodium
CAS :Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a PKA inhibitor and cAMP antagonist that inhibits cAMP-dependent protein kinases.Formule :C10H11N5NaO5PSDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :367.250990CL
CAS :0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMPFormule :C21H21N5Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :343.42Ref: TM-T13983
1mg202,00€5mg512,00€10mg740,00€25mg1.121,00€50mg1.539,00€100mg2.072,00€1mL*10mM (DMSO)535,00€LGD-6972
CAS :LGD-6972 is an antagonist of glucagon receptor.Formule :C43H46N2O5SDegré de pureté :98.8% - 99.33%Couleur et forme :SolidMasse moléculaire :702.9Ref: TM-T11845
1mg88,00€5mg187,00€10mg274,00€25mg472,00€50mg692,00€100mg938,00€1mL*10mM (DMSO)283,00€GAT211
CAS :GAT211 (AZ-4) is a cannabinoid 1 receptor (CB1R) positive allosteric modulator (PAM) for the study of epilepsy.Formule :C22H18N2O2Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :342.39Ref: TM-T27405
1mg35,00€5mg70,00€10mg96,00€25mg157,00€50mg221,00€100mg328,00€500mg792,00€1mL*10mM (DMSO)78,00€LY404039
CAS :LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).Formule :C7H9NO6SDegré de pureté :99% - 99.16%Couleur et forme :SolidMasse moléculaire :235.22MRS-1706
CAS :MRS-1706: Ki of 1.39nM for A2B; selective inverse agonist; also affects A2A, A1, A3.Formule :C27H29N5O5Degré de pureté :97.95%Couleur et forme :SolidMasse moléculaire :503.55Ref: TM-T16136
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg240,00€50mg472,00€100mg687,00€1mL*10mM (DMSO)88,00€KI-7
CAS :KI-7 is an adenosine A2B receptor positive allosteric modulator.Formule :C23H18N2O2Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :354.4Ref: TM-T9238
2mg38,00€5mg58,00€10mg90,00€25mg182,00€50mg279,00€100mg420,00€200mg592,00€1mL*10mM (DMSO)65,00€CB1R Allosteric modulator 3
CAS :CB1R Allosteric modulator 3 is a CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP, and can be used for the study of obesity and nicotine addiction.Formule :C22H17ClN2O2Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :376.84Enoximone
CAS :Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Formule :C12H12N2O2SDegré de pureté :95.52%Couleur et forme :SolidMasse moléculaire :248.3Forskolin
CAS :Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Formule :C22H34O7Degré de pureté :98.83% - 99.86%Couleur et forme :Less Crystalline Solid Colorless Crystalline SolidMasse moléculaire :410.5Ref: TM-T2939
5mg43,00€10mg56,00€25mg86,00€50mg96,00€100mg144,00€200mg182,00€500mg306,00€1mL*10mM (DMSO)56,00€Piclamilast
CAS :Piclamilast (RP 73401) is a PDE4 inhibitor.Formule :C18H18Cl2N2O3Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :381.25Fargesone B
CAS :Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.Formule :C21H24O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.417SAX-187
CAS :SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.Formule :C15H13ClN4O2S2Degré de pureté :97.82% - 98%Couleur et forme :SolidMasse moléculaire :380.87Ref: TM-T3183
1mg84,00€5mg160,00€10mg259,00€25mg419,00€50mg562,00€100mg775,00€200mg1.026,00€1mL*10mM (DMSO)170,00€TDI-10229
CAS :TDI-10229: potent oral sAC inhibitor, IC50=195 nM. Good mouse pharmacokinetics for in vivo use.Formule :C16H16ClN5Degré de pureté :97.77%Couleur et forme :SoildMasse moléculaire :313.78Ref: TM-T64355
1mg42,00€5mg165,00€10mg235,00€25mg432,00€50mg648,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)177,00€TP-10
CAS :TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Formule :C26H19F3N4ODegré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :460.45Ref: TM-T13189
1mg92,00€2mg120,00€5mg187,00€10mg279,00€25mg487,00€50mg705,00€100mg998,00€500mg1.882,00€1mL*10mM (DMSO)188,00€
