MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
Produits appartenant à la catégorie "MAPK"
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Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.Formule :C55H95N19O13Degré de pureté :96.63%Couleur et forme :SolidMasse moléculaire :1230.46D-JNKI-1
CAS :D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44KS-58
CAS :KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.Formule :C64H89FN12O14S2Couleur et forme :SolidMasse moléculaire :1333.59ERK5-IN-6
CAS :ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Formule :C23H21N3Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :339.43CK1δ-IN-9
CAS :CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.Formule :C16H12FN5Couleur et forme :SolidMasse moléculaire :293.298JNK-IN-13
CAS :JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Formule :C13H7ClN4SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :286.74Nothofagin
CAS :Nothofagin: Antioxidant, anti-inflammatory, prevents clotting, inhibits leukocyte activity, may treat vascular inflammation.Formule :C21H24O10Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :436.41Ref: TM-TN1996
1mg279,00€5mg620,00€10mg843,00€25mg1.264,00€50mg1.663,00€100mg2.262,00€1mL*10mM (DMSO)702,00€JNK3 inhibitor-3
CAS :JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formule :C26H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :467.52Rosin
CAS :Rosin is a natural product,may have therapeutic potential for the treatment of inflammationFormule :C15H20O6Degré de pureté :99.75% - 99.85%Couleur et forme :SolidMasse moléculaire :296.32SR-3306
CAS :SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formule :C28H26N8ODegré de pureté :99.50% - 99.81%Couleur et forme :SolidMasse moléculaire :490.56Ref: TM-T16927
1mg52,00€5mg103,00€10mg160,00€25mg304,00€50mg550,00€100mg882,00€500mg1.768,00€1mL*10mM (DMSO)114,00€PD 198306
CAS :PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formule :C18H16F3IN2O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :476.23Ref: TM-T21980
1mg64,00€5mg138,00€10mg188,00€25mg330,00€50mg472,00€100mg655,00€500mg1.293,00€1mL*10mM (DMSO)160,00€CMPD1
CAS :CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).Formule :C22H20FNO2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :349.4Ref: TM-T14988
1mg37,00€5mg104,00€10mg160,00€25mg281,00€50mg442,00€100mg685,00€500mg1.605,00€1mL*10mM (DMSO)114,00€Licochalcone D
CAS :Licochalcone D may treat melanoma and heart injury, halt cell spread, and reduce inflammation and allergies.Formule :C21H22O5Degré de pureté :99.03% - 99.9%Couleur et forme :SolidMasse moléculaire :354.4KRas G12C inhibitor 3
CAS :KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Formule :C32H36ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.13SM-7368
CAS :The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Formule :C10H5ClN4O5SDegré de pureté :99.64% - 99.64%Couleur et forme :SolidMasse moléculaire :328.69Ref: TM-T22115
5mg47,00€10mg74,00€25mg135,00€50mg188,00€100mg283,00€200mg411,00€1mL*10mM (DMSO)50,00€DL-Sulforaphane N-acetyl-L-cysteine
CAS :DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).Formule :C11H20N2O4S3Couleur et forme :SolidMasse moléculaire :340.48NG25
CAS :NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.Formule :C29H30F3N5O2Degré de pureté :97.59% - ≥95%Couleur et forme :SolidMasse moléculaire :537.58Ref: TM-T5643
1mg87,00€5mg160,00€10mg250,00€25mg502,00€50mg715,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)185,00€DS12881479
CAS :DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Formule :C16H19N3OSDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :301.41TH-Z827
CAS :TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).Formule :C30H38N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.66Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Couleur et forme :Odour Solid
