Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
Produits appartenant à la catégorie "Ras"
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pan-KRAS degrader 1
CAS :Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.Formule :C22H26N8OSCouleur et forme :SolidMasse moléculaire :450.56BQU57
CAS :BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Formule :C16H13F3N4ODegré de pureté :97.45% - 98.72%Couleur et forme :SolidMasse moléculaire :334.3CCG-100602
CAS :CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formule :C21H17ClF6N2O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :478.82Ref: TM-T22062
5mg38,00€10mg57,00€25mg114,00€50mg188,00€100mg303,00€200mg449,00€1mL*10mM (DMSO)43,00€KRAS inhibitor-31
CAS :KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.Formule :C33H30F3N5O4Couleur et forme :SolidMasse moléculaire :617.62CCG-203971
CAS :CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formule :C23H21ClN2O3Degré de pureté :98.82% - 99.35%Couleur et forme :SolidMasse moléculaire :408.88MC 976
CAS :MC 976 is a derivative of Vitamin D3.Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63BI-3406
CAS :BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formule :C23H25F3N4O3Degré de pureté :99.20% - 99.66%Couleur et forme :SolidMasse moléculaire :462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Formule :C13H11F3N2OSCouleur et forme :SolidMasse moléculaire :300.3Methylophiopogonanone B
CAS :1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.Formule :C19H20O5Degré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :328.36ADT-007
CAS :ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formule :C26H24FNO5Degré de pureté :97.75%Couleur et forme :SoildMasse moléculaire :449.47Ref: TM-T85316
1mg49,00€5mg92,00€10mg131,00€25mg212,00€50mg373,00€100mg635,00€200mg1.035,00€1mL*10mM (DMSO)110,00€Arglabin
CAS :Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.Formule :C15H18O3Degré de pureté :99.62% - 99.62%Couleur et forme :SolidMasse moléculaire :246.3Ref: TM-TQ0165
1mg104,00€5mg240,00€10mg360,00€25mg520,00€50mg692,00€100mg1.035,00€1mL*10mM (DMSO)310,00€1-(4-methansulfinylphenyl)ethanone
CAS :The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Formule :C9H10O2SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :182.24Ref: TM-T8870
1mg51,00€5mg153,00€10mg207,00€25mg288,00€50mg404,00€100mg562,00€200mg758,00€1mL*10mM (DMSO)101,00€KRas G12C inhibitor 3
CAS :KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Formule :C32H36ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.13ARS-853
CAS :ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellsFormule :C22H29ClN4O3Degré de pureté :96.64% - 97.43%Couleur et forme :SolidMasse moléculaire :432.94Ref: TM-T7414
1mg150,00€5mg373,00€10mg553,00€25mg890,00€50mg1.206,00€100mg1.634,00€500mg3.258,00€1mL*10mM (DMSO)356,00€KRAS inhibitor-35
CAS :KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.Formule :C38H32F4N6O3SCouleur et forme :SolidMasse moléculaire :728.76pan-KRAS-IN-3
CAS :Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Formule :C33H32F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.63KRAS G12D inhibitor 26
CAS :KRAS G12D inhibitor 26 serves as a modulator of Kras and specifically targets Kras(G12D) with an IC50 of less than or equal to 100 nM.Formule :C35H44ClFN8O2Couleur et forme :SolidMasse moléculaire :663.228CCG-1423
CAS :CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.Formule :C18H13ClF6N2O3Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :454.75CID44216842
CAS :CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Formule :C22H20BrN3O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :486.38Ref: TM-T8930
2mg35,00€5mg52,00€10mg89,00€25mg167,00€50mg258,00€100mg379,00€200mg540,00€1mL*10mM (DMSO)58,00€HJC0197
CAS :HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Formule :C19H21N3OSDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :339.45Ref: TM-T15485
2mg38,00€5mg54,00€10mg86,00€25mg135,00€50mg188,00€100mg283,00€200mg426,00€1mL*10mM (DMSO)64,00€
