mAPK p38
Les p38 MAPK sont un sous-groupe de MAPK qui répondent aux signaux de stress et sont impliqués dans la régulation de l'inflammation, de la différenciation cellulaire, de l'apoptose et de l'autophagie. La signalisation p38 MAPK est cruciale dans les réponses immunitaires et est impliquée dans diverses maladies, y compris les affections inflammatoires chroniques, le cancer et les troubles neurodégénératifs. Chez CymitQuimica, nous proposons une gamme complète d'inhibiteurs et de modulateurs de p38 MAPK pour soutenir vos recherches sur l'inflammation, la réponse au stress et le développement thérapeutique.
Produits appartenant à la catégorie "mAPK p38"
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p38 MAPK Inhibitor
CAS :p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.Formule :C20H13ClFN3ODegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :365.79Ref: TM-T36010
1mg96,00€5mg294,00€10mg459,00€25mg677,00€50mg929,00€100mg1.235,00€200mg1.681,00€500µg59,00€WYE-687
CAS :WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formule :C28H32N8O3Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :528.61EO-1606
CAS :EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.Formule :C21H17ClFNODegré de pureté :98.84% - 99.27%Couleur et forme :SolidMasse moléculaire :353.82R1487 Hydrochloride
CAS :R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.Formule :C19H19ClF2N4O3Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :424.83TA-01
CAS :TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Formule :C20H12F3N3Degré de pureté :98.77% - 99.94%Couleur et forme :SolidMasse moléculaire :351.32Ref: TM-T4645
2mg35,00€5mg52,00€10mg85,00€25mg156,00€50mg235,00€100mg329,00€200mg464,00€1mL*10mM (DMSO)71,00€TAK-715
CAS :TAK-715 is a p38 MAPK inhibitor for p38α.Formule :C24H21N3OSDegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :399.51Ref: TM-T6150
1mg40,00€2mg52,00€5mg87,00€10mg99,00€25mg170,00€50mg324,00€100mg507,00€1mL*10mM (DMSO)96,00€Sertaconazole nitrate
CAS :Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Formule :C20H15Cl3N2OS·HNO3Degré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :500.78Kaempferol-3-O-glucorhamnoside
CAS :Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFormule :C27H30O15Degré de pureté :96.96% - 98.17%Couleur et forme :SolidMasse moléculaire :594.5Ref: TM-T5S0089
1mg50,00€5mg97,00€10mg143,00€25mg226,00€50mg340,00€100mg495,00€200mg682,00€1mL*10mM (DMSO)129,00€Scio-323
CAS :Scio-323是一种可口服的 p38丝裂原活化蛋白(MAPK)激酶抑制剂。Formule :C27H30FN3O4Degré de pureté :100.00%Couleur et forme :SolidMasse moléculaire :479.54Ref: TM-T68139
1mg115,00€5mg245,00€10mg363,00€25mg562,00€50mg775,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)294,00€(-)-Bornyl acetate
CAS :L-(-)-Bornyl acetate, an enantiomer from hyssop oil, offers antifungal, skin-whitening, and antioxidant benefits, and reduces inflammation.Formule :C12H20O2Degré de pureté :≥98%Couleur et forme :LiquidMasse moléculaire :196.29Anti-osteoporosis agent-11
CAS :Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Formule :C23H17NO2Se2Couleur et forme :SolidMasse moléculaire :497.31FR 167653
CAS :FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.Formule :C24H20FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.51Esculin sesquihydrate
CAS :Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimentalFormule :C15H16O9H2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.31p38α inhibitor 5
CAS :The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.Formule :C26H23BrF2N2O3Couleur et forme :SolidMasse moléculaire :529.37PF-03715455
CAS :PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.Formule :C35H34ClN7O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :700.27UM-164
CAS :UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Formule :C30H31F3N8O3SDegré de pureté :98.72% - 99.52%Couleur et forme :SolidMasse moléculaire :640.68UR13870
CAS :UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.Formule :C24H16F2N4Degré de pureté :100% - 98.92%Couleur et forme :SolidMasse moléculaire :398.41Quercetin
CAS :Produit contrôléFormule :C15H10O7Couleur et forme :Yellow Crystalline PowderMasse moléculaire :302.24AMG-548
CAS :AMG-548, oral p38α inhibitor (Ki=0.5 nM), >1000x selectivity over p38γ/δ, blocks TNFα (IC50=3 nM), also inhibits Wnt/Casein kinase 1δ/ε.Formule :C29H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.56p38-α MAPK-IN-9
CAS :p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.Formule :C19H20N8O2Couleur et forme :SolidMasse moléculaire :392.414
